Dolores Corella

Summary

Affiliation: University of Valencia
Country: Spain

Publications

  1. ncbi Common cholesteryl ester transfer protein gene variation related to high-density lipoprotein cholesterol is not associated with decreased coronary heart disease risk after a 10-year follow-up in a Mediterranean cohort: Modulation by alcohol consumption
    Dolores Corella
    Genetic and Molecular Epidemiology Unit, Department of Preventive Medicine, School of Medicine, University of Valencia, Valencia, Spain
    Atherosclerosis 211:531-8. 2010
  2. ncbi Gene-alcohol interactions in the metabolic syndrome
    Dolores Corella
    Genetic and Molecular Epidemiology Unit, Department of Preventive Medicine and Public Health, School of Medicine, University of Valencia, Avda Blasco Ibanez 15, 46010 Valencia, Spain
    Nutr Metab Cardiovasc Dis 17:140-7. 2007
  3. ncbi Dietary habits and epidemiology of gastric carcinoma
    D Corella
    Department of Preventive Medicine and Public Health, Nutrition and Toxicology, School of Medicine, University of Valencia, Valencia, Spain
    Hepatogastroenterology 48:1537-43. 2001
  4. ncbi Polymorphisms cyclooxygenase-2 -765G>C and interleukin-6 -174G>C are associated with serum inflammation markers in a high cardiovascular risk population and do not modify the response to a Mediterranean diet supplemented with virgin olive oil or nuts
    Dolores Corella
    Department of Preventive Medicine and Public Health, School of Medicine, University of Valencia, 46010 Valencia, Spain
    J Nutr 139:128-34. 2009
  5. ncbi Gender specific associations of the Trp64Arg mutation in the beta3-adrenergic receptor gene with obesity-related phenotypes in a Mediterranean population: interaction with a common lipoprotein lipase gene variation
    D Corella
    Department of Preventive Medicine and Public Health, Genetic and Molecular Epidemiology Unit, School of Medicine, University of Valencia, Valencia, Spain
    J Intern Med 250:348-60. 2001
  6. ncbi SINGLE NUCLEOTIDE POLYMORPHISMS THAT INFLUENCE LIPID METABOLISM: Interaction with Dietary Factors
    Dolores Corella
    Nutrition and Genomics Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA
    Annu Rev Nutr 25:341-90. 2005
  7. ncbi Gene-environment interactions of CETP gene variation in a high cardiovascular risk Mediterranean population
    Dolores Corella
    Department of Preventive Medicine and Public Health, School of Medicine, University of Valencia, Valencia, Spain
    J Lipid Res 51:2798-807. 2010
  8. ncbi Saturated fat intake and alcohol consumption modulate the association between the APOE polymorphism and risk of future coronary heart disease: a nested case-control study in the Spanish EPIC cohort
    Dolores Corella
    Genetic and Molecular Epidemiology Unit, Department of Preventive Medicine, University of Valencia, Valencia and CIBER Fisiopatología de la Obesidad y Nutrición, ISCIII, Spain
    J Nutr Biochem 22:487-94. 2011
  9. ncbi Association of the LCT-13910C>T polymorphism with obesity and its modulation by dairy products in a Mediterranean population
    Dolores Corella
    Department of Preventive Medicine and Public Health, Genetic and Molecular Epidemiology Unit School of Medicine, University of Valencia, Valencia, Spain
    Obesity (Silver Spring) 19:1707-14. 2011
  10. ncbi Cancer mortality and exposure to chemical carcinogens in the work place: an ecological study in the Valencian Community, Spain (1981-1995)
    D Corella
    Department of Preventive Medicine and Public Health, Universitat de Valencia, Spain
    Eur J Epidemiol 16:401-9. 2000

Detail Information

Publications112 found, 100 shown here

  1. ncbi Common cholesteryl ester transfer protein gene variation related to high-density lipoprotein cholesterol is not associated with decreased coronary heart disease risk after a 10-year follow-up in a Mediterranean cohort: Modulation by alcohol consumption
    Dolores Corella
    Genetic and Molecular Epidemiology Unit, Department of Preventive Medicine, School of Medicine, University of Valencia, Valencia, Spain
    Atherosclerosis 211:531-8. 2010
    ..We investigated the association between the CETP-TaqIB polymorphism, HDL-C and incident CHD in a Mediterranean population...
  2. ncbi Gene-alcohol interactions in the metabolic syndrome
    Dolores Corella
    Genetic and Molecular Epidemiology Unit, Department of Preventive Medicine and Public Health, School of Medicine, University of Valencia, Avda Blasco Ibanez 15, 46010 Valencia, Spain
    Nutr Metab Cardiovasc Dis 17:140-7. 2007
    ..However, this relationship is still confusing and the presence of gene-environment interactions has been suggested. Our aim is to summarize evidence for gene-alcohol interactions in the MetS...
  3. ncbi Dietary habits and epidemiology of gastric carcinoma
    D Corella
    Department of Preventive Medicine and Public Health, Nutrition and Toxicology, School of Medicine, University of Valencia, Valencia, Spain
    Hepatogastroenterology 48:1537-43. 2001
    ....
  4. ncbi Polymorphisms cyclooxygenase-2 -765G>C and interleukin-6 -174G>C are associated with serum inflammation markers in a high cardiovascular risk population and do not modify the response to a Mediterranean diet supplemented with virgin olive oil or nuts
    Dolores Corella
    Department of Preventive Medicine and Public Health, School of Medicine, University of Valencia, 46010 Valencia, Spain
    J Nutr 139:128-34. 2009
    ....
  5. ncbi Gender specific associations of the Trp64Arg mutation in the beta3-adrenergic receptor gene with obesity-related phenotypes in a Mediterranean population: interaction with a common lipoprotein lipase gene variation
    D Corella
    Department of Preventive Medicine and Public Health, Genetic and Molecular Epidemiology Unit, School of Medicine, University of Valencia, Valencia, Spain
    J Intern Med 250:348-60. 2001
    ..DESIGN AND SUBJECT: Cross-sectional study in 1063 (476 men and 587 women) randomly selected from this population (aged: 18-68 years)...
  6. ncbi SINGLE NUCLEOTIDE POLYMORPHISMS THAT INFLUENCE LIPID METABOLISM: Interaction with Dietary Factors
    Dolores Corella
    Nutrition and Genomics Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA
    Annu Rev Nutr 25:341-90. 2005
    ..In summary, there is need for both large population studies and well-standardized intervention studies...
  7. ncbi Gene-environment interactions of CETP gene variation in a high cardiovascular risk Mediterranean population
    Dolores Corella
    Department of Preventive Medicine and Public Health, School of Medicine, University of Valencia, Valencia, Spain
    J Lipid Res 51:2798-807. 2010
    ..In conclusion, the strong association of the CETP SNPs and HDL-C was not statistically modified by diet or by the other environmental factors...
  8. ncbi Saturated fat intake and alcohol consumption modulate the association between the APOE polymorphism and risk of future coronary heart disease: a nested case-control study in the Spanish EPIC cohort
    Dolores Corella
    Genetic and Molecular Epidemiology Unit, Department of Preventive Medicine, University of Valencia, Valencia and CIBER Fisiopatología de la Obesidad y Nutrición, ISCIII, Spain
    J Nutr Biochem 22:487-94. 2011
    ..In conclusion, in this Mediterranean population, the E2 allele is associated with lower CHD risk, and this association is modulated by saturated fat and alcohol consumption...
  9. ncbi Association of the LCT-13910C>T polymorphism with obesity and its modulation by dairy products in a Mediterranean population
    Dolores Corella
    Department of Preventive Medicine and Public Health, Genetic and Molecular Epidemiology Unit School of Medicine, University of Valencia, Valencia, Spain
    Obesity (Silver Spring) 19:1707-14. 2011
    ..In conclusion, despite not finding marked differences in dairy product consumption, this polymorphism was strongly associated with BMI and obesity and modulated by lactose intake in this Mediterranean population...
  10. ncbi Cancer mortality and exposure to chemical carcinogens in the work place: an ecological study in the Valencian Community, Spain (1981-1995)
    D Corella
    Department of Preventive Medicine and Public Health, Universitat de Valencia, Spain
    Eur J Epidemiol 16:401-9. 2000
    ..In conclusion, although the variability in cancer mortality in men was significantly associated with some occupational sectors in the VC, caution is needed when drawing conclusions about causation from ecological studies...
  11. ncbi [Apolipoprotein E gene polymorphism and risk of hypercholesterolemia: a case control study in a working population of Valencia]
    D Corella
    Departamento de Medicina Preventiva y Salud Publica, Universitat de Valencia
    Med Clin (Barc) 115:170-5. 2000
    ..The aim of this study was to estimate the association between these genetic variants and the risk of hypercholesterolemia in a Mediterranean Spanish population...
  12. ncbi APOA2, dietary fat, and body mass index: replication of a gene-diet interaction in 3 independent populations
    Dolores Corella
    Nutrition and Genomics Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, 711 Washington St, Boston, MA 02111 1524, USA
    Arch Intern Med 169:1897-906. 2009
    ..However, replication has been low. Our aim was to study interaction among a functional APOA2 polymorphism, food intake, and body mass index (BMI) in independent populations to replicate findings and to increase their evidence level...
  13. ncbi Adherence to a Mediterranean-type diet and reduced prevalence of clustered cardiovascular risk factors in a cohort of 3,204 high-risk patients
    Ana Sanchez-Tainta
    Department of Preventive Medicine and Public Health, Clinica Universitaria University of Navarra, Irunlarrea, Pamplona, Spain
    Eur J Cardiovasc Prev Rehabil 15:589-93. 2008
    ..Our objective was to estimate the association between adherence to MeDiet and the prevalence of risk factors in 3,204 asymptomatic high-risk patients...
  14. ncbi Dietary intake of n-6 fatty acids modulates effect of apolipoprotein A5 gene on plasma fasting triglycerides, remnant lipoprotein concentrations, and lipoprotein particle size: the Framingham Heart Study
    Chao Qiang Lai
    Nutrition and Genomics Laboratory, JM USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Circulation 113:2062-70. 2006
    ..Apolipoprotein A5 gene (APOA5) variation is associated with plasma triglycerides (TGs). However, little is known about whether dietary fat modulates this association...
  15. ncbi Predictors of adherence to a Mediterranean-type diet in the PREDIMED trial
    Itziar Zazpe
    Department of Preventive Medicine and Public Health, University of Navarra, Pamplona, Spain
    Eur J Nutr 49:91-9. 2010
    ..Determinants of dietary changes obtained with a nutritional intervention promoting the Mediterranean diet have been rarely evaluated...
  16. ncbi Impact of the -1438G>a polymorphism in the serotonin 2A receptor gene on anthropometric profile and obesity risk: a case-control study in a Spanish Mediterranean population
    Jose V Sorli
    Genetic and Molecular Epidemiology Unit, Department of Preventive Medicine and Public Health, Valencia University, Valencia, Spain
    Appetite 50:260-5. 2008
    ..011). In conclusion, although the -1438G>A polymorphism is not a relevant marker for obesity risk, this variant may play a role in determining BMI in obese subjects...
  17. ncbi Obese subjects carrying the 11482G>A polymorphism at the perilipin locus are resistant to weight loss after dietary energy restriction
    Dolores Corella
    Nutrition and Genomics Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, Massachusetts 02111, USA
    J Clin Endocrinol Metab 90:5121-6. 2005
    ..Adipose tissue has been the focus of efforts to identify candidate genes. Perilipin is a major protein found in adipocytes, and perilipin knockout mice are lean and resistant to diet-induced obesity...
  18. ncbi The effect of the APOE polymorphism on HDL-C concentrations depends on the cholesterol ester transfer protein gene variation in a Southern European population
    Jose V Sorli
    Department of Preventive Medicine and Public Health, Genetic and Molecular Epidemiology Unit, School of Medicine, University of Valencia, Avda Blasco Ibanez, 15, 46010 Valencia, Spain
    Clin Chim Acta 366:196-203. 2006
    ..We examined the gene-gene interaction between the common ApoE and the CETP polymorphisms in determining HDL-C concentrations in men and women from the general population...
  19. ncbi Polyunsaturated fatty acids interact with the PPARA-L162V polymorphism to affect plasma triglyceride and apolipoprotein C-III concentrations in the Framingham Heart Study
    E Shyong Tai
    Nutrition and Genomics Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111 1524, USA
    J Nutr 135:397-403. 2005
    ..Our data show that the effect of the L162V polymorphism on plasma TG and apoC-III concentrations depends on the dietary PUFA, with a high intake triggering lower TG in carriers of the 162V allele...
  20. ncbi Association between glucokinase regulatory protein (GCKR) and apolipoprotein A5 (APOA5) gene polymorphisms and triacylglycerol concentrations in fasting, postprandial, and fenofibrate-treated states
    Pablo Perez-Martinez
    Nutrition and Genomics Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    Am J Clin Nutr 89:391-9. 2009
    ..Hypertriglyceridemia is a risk factor for cardiovascular disease. Variation in the apolipoprotein A5 (APOA5) and glucokinase regulatory protein (GCKR) genes has been associated with fasting plasma triacylglycerol...
  21. ncbi Influence of the APOA5 locus on plasma triglyceride, lipoprotein subclasses, and CVD risk in the Framingham Heart Study
    Chao Qiang Lai
    Nutrition and Genomics Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    J Lipid Res 45:2096-105. 2004
    ..In women, the -1131C allele was associated with a higher hazard ratio for CVD (1.85; 95% confidence interval, 1.03-3.34; P = 0.04), in agreement with the association of this SNP with higher RLPs...
  22. ncbi The -256T>C polymorphism in the apolipoprotein A-II gene promoter is associated with body mass index and food intake in the genetics of lipid lowering drugs and diet network study
    Dolores Corella
    Nutrition and Genomics Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111 1524, USA
    Clin Chem 53:1144-52. 2007
    ..Apolipoprotein A-II (APOA2) plays an ambiguous role in lipid metabolism, obesity, and atherosclerosis...
  23. ncbi Dietary fat intake determines the effect of a common polymorphism in the hepatic lipase gene promoter on high-density lipoprotein metabolism: evidence of a strong dose effect in this gene-nutrient interaction in the Framingham Study
    Jose M Ordovas
    Nutrition and Genomics Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, Mass 02111, USA
    Circulation 106:2315-21. 2002
    ..This allele has been associated with decreased HL activity and increased HDL-C concentrations. However, the effect is variable among populations...
  24. ncbi Hyperlipidaemia and venous thromboembolism in patients lacking thrombophilic risk factors
    Amparo Vaya
    Thrombosis and Hemostasis Unit, Department of Clinical Pathology, Thrombosis Research Center, La Fe University Hospital, Valencia, Spain
    Br J Haematol 118:255-9. 2002
    ..In addition, cholesterolaemia levels of >or= 5.69 mmol/l constitute an independent risk factor for idiopathic DVT...
  25. ncbi APOA5 gene variation modulates the effects of dietary fat intake on body mass index and obesity risk in the Framingham Heart Study
    Dolores Corella
    Nutrition and Genomics Laboratory, JM USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111 1524, USA
    J Mol Med (Berl) 85:119-28. 2007
    ..In conclusion, the APOA5-1131T>C SNP, which is present in approximately 13% of this population, modulates the effect of fat intake on BMI and obesity risk in both men and women...
  26. ncbi Perilipin gene variation determines higher susceptibility to insulin resistance in Asian women when consuming a high-saturated fat, low-carbohydrate diet
    Dolores Corella
    Nutrition and Genomics Laboratory, JM USDA HNRCA at Tufts University, 711 Washington St, Boston, MA 02111, USA
    Diabetes Care 29:1313-9. 2006
    ..To investigate the association between genetic variation in the adipocyte protein perilipin (PLIN) and insulin resistance in an Asian population as well as to examine their modulation by macronutrient intake...
  27. ncbi Low-fat dairy products and blood pressure: follow-up of 2290 older persons at high cardiovascular risk participating in the PREDIMED study
    Estefania Toledo
    Department of Preventive Medicine and Public Health, School of Medicine Clinica Universitaria de Navarra, University of Navarra, Irunlarrea 1, 31080 Pamplona, Navarra, Spain
    Br J Nutr 101:59-67. 2009
    ..Intake of low-fat dairy products was inversely associated with BP in an older population at high cardiovascular risk, suggesting a possible protective effect against hypertension...
  28. ncbi Obesity modulates the association among APOE genotype, insulin, and glucose in men
    Roberto Elosua
    Nutrition and Genomics Laboratory and Lipid Metabolism Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA
    Obes Res 11:1502-8. 2003
    ..Obesity, insulin resistance, and apolipoprotein E (APOE) genotype have all been associated with coronary heart disease. We examined the interaction between obesity and APOE genotype in determining fasting insulin and glucose levels...
  29. ncbi Fenofibrate effect on triglyceride and postprandial response of apolipoprotein A5 variants: the GOLDN study
    Chao Qiang Lai
    Nutrition and Genomics Laboratory, JM USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington St, Boston, MA 02111, USA
    Arterioscler Thromb Vasc Biol 27:1417-25. 2007
    ..Apolipoprotein A5 (APOA5) is a key determinant of plasma triglyceride (TG) concentrations. Genetic variation at the APOA5 locus could be responsible for some of the observed differences in response to fenofibrate therapy...
  30. ncbi Intragenic linkage disequilibrium structure of the human perilipin gene (PLIN) and haplotype association with increased obesity risk in a multiethnic Asian population
    Lu Qi
    Nutrition and Genomics Laboratory, Lipid Metabolism Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    J Mol Med (Berl) 83:448-56. 2005
    ..28 (95% CI 1.45-3.57) and Indians OR 2.04 (95% CI 1.08-3.64). These results support the role of the PLIN locus as an ethnically dependent modulator of obesity risk in humans...
  31. ncbi Thrombophilic risk factors and homocysteine levels in Behçet's disease in eastern Spain and their association with thrombotic events
    Jose Ma Ricart
    Dermatology Service, La Fe University Hospital, Valencia, Spain
    Thromb Haemost 95:618-24. 2006
    ..When studies from Turkey were excluded from the meta-analysis, only the prothrombin G20210A mutation was associated with thrombosis...
  32. ncbi Haemorheological parameters in young patients with acute myocardial infarction
    Esther Zorio
    Intensive Care Unit, La Fe University Hospital, Valencia, Spain
    Clin Hemorheol Microcirc 39:33-41. 2008
    ....
  33. ncbi Erythrocyte membrane phosphatidylserine exposure in obesity
    Eva Sola
    Endocrinology Service, Doctor Peset University Hospital, Valencia, Spain
    Obesity (Silver Spring) 17:318-22. 2009
    ..Increased PS exposure could contribute to hypercoagulability in these patients. Weight loss obtained with diet treatment reduces PS exposure on erythrocyte membrane...
  34. ncbi The rs1466113 polymorphism in the somatostatin receptor 2 gene is associated with obesity and food intake in a Mediterranean population
    Mercedes Sotos-Prieto
    Genetic and Molecular Epidemiology Unit, Department of Preventive Medicine and Public Health, School of Medicine, University of Valencia, Blasco Ibañez 15, Valencia, Spain
    Ann Nutr Metab 57:124-31. 2010
    ..As replication is required, we examined the association between this polymorphism and anthropometric variables and food intake in a Mediterranean population...
  35. ncbi Effect of a traditional Mediterranean diet on apolipoproteins B, A-I, and their ratio: a randomized, controlled trial
    Rosa Solà
    Human Nutrition Department, School of Medicine, University Rovira i Virgili, Reus, Spain
    Atherosclerosis 218:174-80. 2011
    ..Our aim was to assess the effect of a traditional Mediterranean diet (TMD) on apolipoproteins...
  36. ncbi Plasma viscosity and related cardiovascular risk factors in a Spanish Mediterranean population
    Amparo Vaya
    Hemorheology and Thrombosis Unit, Department of Clinical Pathology, La Fe University Hospital, Valencia, Spain
    Thromb Res 120:489-95. 2007
    ..Therefore, our objective was to determine PV in a large sample of randomly selected subjects from the Spanish population and to study which demographic or cardiovascular risk factors (CVRF) influence levels of PV in this population...
  37. ncbi Effect of genetic variation in the leptin gene promoter and the leptin receptor gene on obesity risk in a population-based case-control study in Spain
    Olga Portoles
    Genetic and Molecular Epidemiology Unit Department of Preventive Medicine and Public Health School of Medicine, University of Valencia, Avda Blasco Ibanez 15, 46010 Valencia, Spain
    Eur J Epidemiol 21:605-12. 2006
    ..54; 95% CI: 0.32-0.89). In conclusion, the -2548G > A polymorphism is not a relevant obesity marker in this Mediterranean population, although Q223R does seen to be so...
  38. ncbi Influence of plasma and erythrocyte factors on red blood cell aggregation in survivors of acute myocardial infarction
    Amparo Vaya
    Hemorheology and Thrombosis Unit, Department of Clinical Pathology, La Fe University Hospital, Valencia, Spain
    Thromb Haemost 91:354-9. 2004
    ..Our results suggest that plasma lipids, predominantly triglycerides, and fibrinogen may not only enhance the development of ischaemic events by their recognized atherogenic mechanisms, but also by increasing EA...
  39. ncbi Genetic variation at the scavenger receptor class B type I gene locus determines plasma lipoprotein concentrations and particle size and interacts with type 2 diabetes: the framingham study
    Doreen Osgood
    Nutrition and Genomics Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA
    J Clin Endocrinol Metab 88:2869-79. 2003
    ..03 for interaction). Similar results were obtained for HDL(2)-C. In conclusion, SR-BI gene variation modulates the lipid profile, particularly in type 2 diabetes, contributing to the metabolic abnormalities in these subjects...
  40. ncbi [Low prevalence of the Leu7/Pro polymorphism in the signal peptide of preproneuropeptide Y in the Spanish Mediterranean population]
    Olga Portoles
    Unidad de Epidemiología Genética y Molecular, Departamento de Medicina Preventiva y Salud Publica, Universitat de Valencia, Valencia, Espana
    Med Clin (Barc) 120:337-9. 2003
    ..A common Leu7Pro polymorphism in the signal peptide of neuropeptide Y has been associated with increased plasma cholesterol and accelerated atherosclerosis in the Finnish population...
  41. ncbi Impact of cardiovascular risk factors on oxidative stress and DNA damage in a high risk Mediterranean population
    Marta Fandos
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, School of Medicine, University of Valencia, Valencia, Spain
    Free Radic Res 43:1179-86. 2009
    ..Among the main cardiovascular risk factors, hypertension was the strongest determinant of oxidative stress in high risk subjects studied at a primary prevention stage...
  42. ncbi Effect of a Mediterranean diet supplemented with nuts on metabolic syndrome status: one-year results of the PREDIMED randomized trial
    Jordi Salas-Salvado
    Human Nutrition Unit, School of Medicine, University of Rovira i Virgili, Reus, Spain
    Arch Intern Med 168:2449-58. 2008
    ..We compared the 1-year effect of 2 behavioral interventions to implement the MedDiet vs advice on a low-fat diet on MetS status...
  43. ncbi Haemorheological alterations in Behçet's disease are not related to a tendency for venous thrombosis
    Jose Ma Ricart
    Hemorheology and Thrombosis Unit, Department of Clinical Pathology, La Fe University Hospital, Valencia, Spain
    Thromb Res 115:399-404. 2005
    ..CONCLUSIONS: Although patients with BD show a moderate hyperviscosity syndrome, possibly related to chronic inflammation, this does not seem to play a role in the development of thrombotic events...
  44. ncbi Thrombotic events in systemic lupus erythematosus. Its association with acquired and inherited thrombophilic defects
    Amparo Vaya
    Hemorheology and Thrombosis Unit, Department of Clinical Pathology, La Fe University Hospital, and Department of Preventive Medicine, School of Medicine, University of Valencia, Valencia, Spain
    Clin Hemorheol Microcirc 40:79-87. 2008
    ..142, P=0.233, respectively). In addition inherited thrombophilic risk factors AT, PC, PS deficiencies, factor V Leiden and PT G20210A mutation do not seem to increase thrombotic risk in SLE patients...
  45. ncbi Gender-specific association of a perilipin gene haplotype with obesity risk in a white population
    Lu Qi
    Nutrition and Genomics Laboratories, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Obes Res 12:1758-65. 2004
    ..Our purpose was to examine the association between common single-nucleotide polymorphisms (SNPs) at the perilipin (PLIN) locus and obesity, as well as related phenotypes, in unrelated American adults...
  46. ncbi Genes, diet and plasma lipids: the evidence from observational studies
    Jose M Ordovas
    Nutrition and Genomics Laboratory, Jean Mayer-US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    World Rev Nutr Diet 93:41-76. 2004
  47. ncbi A large randomized individual and group intervention conducted by registered dietitians increased adherence to Mediterranean-type diets: the PREDIMED study
    Itziar Zazpe
    Department of Preventive Medicine and Public Health, University of Navarra, Pamplona, Spain
    J Am Diet Assoc 108:1134-44; discussion 1145. 2008
    ..To assess the effectiveness of an intervention aimed to increase adherence to a Mediterranean diet...
  48. ncbi Erythrocyte aggregability and AB0 blood groups
    Amparo Vaya
    Hemorheology and Thrombosis Unit, Department of Clinical Pathology, La Fe University Hospital, Valencia, Spain
    Clin Hemorheol Microcirc 41:67-72. 2009
    ..035; P = 0.030; P = 0.010, respectively). Erythrocyte aggregation does not seem to be associated with blood groups, but rather with plasma lipids and fibrinogen...
  49. ncbi Single tube optimisation of APOE genotyping based on melting curve analysis
    Francesc Frances
    Genetic and Molecular Epidemiology Unit, Department of Preventive Medicine, School of Medicine University of Valencia, Valencia, Spain
    Clin Biochem 41:923-6. 2008
    ..To develop and validate a single-tube protocol for APOE genotyping using fluorescent probes...
  50. ncbi Prothrombin G20210A mutation and oral contraceptive use increase upper-extremity deep vein thrombotic risk
    Amparo Vaya
    Thrombosis and Hemostasis Unit, Department of Clinical Pathology, La Fe University Hospital, Valencia, Spain
    Thromb Haemost 89:452-7. 2003
    ....
  51. ncbi Influence of plasmatic lipids on the hemorheological profile in healthy adults
    Teresa Contreras
    Thrombosis and Hemorheology Unit, La Fe University Hospital, Department of Clinical Pathology, Valencia, Spain
    Clin Hemorheol Microcirc 30:423-5. 2004
    ....
  52. ncbi [Effects of the apolipoprotein E polymorphism on plasma lipid levels and cardiovascular disease risk in a Mediterranean population]
    José Vicente Sorlí
    Unidad de Investigación en Epidemiología Genética y Molecular, Departamento de Medicina Preventiva y Salud Publica, Universitat de Valencia, Spain
    Med Clin (Barc) 118:569-74. 2002
    ..Our aim was to estimate the association of common apo E variants (epsilon2, epsilon3 and epsilon4 alleles) with plasma lipid concentrations and cardiovascular disease (CAD) risk in a Spanish Mediterranean population...
  53. ncbi The metabolic syndrome: a crossroad for genotype-phenotype associations in atherosclerosis
    Dolores Corella
    Nutrition and Genomics Laboratory, Jean Mayer-US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Curr Atheroscler Rep 6:186-96. 2004
    ....
  54. ncbi Associations of LPL and APOC3 gene polymorphisms on plasma lipids in a Mediterranean population: interaction with tobacco smoking and the APOE locus
    Dolores Corella
    Genetic and Molecular Epidemiology Unit, Department of Preventive Medicine and Public Health, University of Valencia, Valencia, Spain
    J Lipid Res 43:416-27. 2002
    ..Understanding this gene-gene-environmental interaction may facilitate preventive interventions to reduce coronary artery disease risk...
  55. ncbi Erythrocyte deformability in anaemic patients with reticulocytosis determined by means of ektacytometry techniques
    María Simó
    Hemorheology and Thrombosis Unit, Department of Clinical Pathology, La Fe University Hospital, Valencia, Spain
    Clin Hemorheol Microcirc 37:263-7. 2007
    ..Our results suggest that reticulocytes are responsible for the decreased ED observed in anaemic patients with peripheral reticulocytosis, when this hemorheological parameter is evaluated by means of ektacytometry techniques...
  56. ncbi Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans
    Sekar Kathiresan
    Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Nat Genet 40:189-97. 2008
    ..Understanding the molecular, cellular and clinical consequences of the newly identified loci may inform therapy and clinical care...
  57. ncbi Lack of association between hemorheological alterations and upper-extremity deep vein thrombosis
    Amparo Vaya
    Hemorheology and Thrombosis Unit, Department of Clinical Pathology, La Fe University Hospital, Valencia, Spain
    Clin Hemorheol Microcirc 41:279-85. 2009
    ....
  58. ncbi Metabolic syndrome pathophysiology: the role of adipose tissue
    Martin Laclaustra
    Nutrition and Genomics Laboratory, JM USDA HNRCA at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Nutr Metab Cardiovasc Dis 17:125-39. 2007
    ..Variations at multiple gene loci will be partially responsible for these interindividual differences. Two of those candidate genes, the adiponectin (APM1) and the perilipin (PLIN) genes, are discussed in more detail...
  59. ncbi A High Intake of Saturated Fatty Acids Strengthens the Association between the Fat Mass and Obesity-Associated Gene and BMI
    Dolores Corella
    Nutrition and Genomics Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA
    J Nutr 141:2219-25. 2011
    ..006 in BPRHS). No associations with BMI were found at lower SFA intakes. We found no significant interactions with carbohydrate intake. In conclusion, SFA intake modulates the association between FTO and BMI in American populations...
  60. ncbi Environmental factors modulate the effect of the APOE genetic polymorphism on plasma lipid concentrations: ecogenetic studies in a Mediterranean Spanish population
    D Corella
    Genetic and Molecular Epidemiology Unit, Department of Preventive Medicine and Public Health, Universitat de Valencia, Valencia, Spain
    Metabolism 50:936-44. 2001
    ..Our results indicate that environmental factors are important modulators of the effect of the APOE polymorphism on plasma lipid concentrations...
  61. ncbi The metabolic syndrome and its individual components: its association with venous thromboembolism in a Mediterranean population
    Amparo Vaya
    Hemostasis Unit, Service of Clinical Pathology, La Fe University Hospital, Avenida de Campanar 21, Valencia, Spain
    Metab Syndr Relat Disord 9:197-201. 2011
    ..We aimed to evaluate the impact of metabolic syndrome and its individual components on VTE risk...
  62. ncbi Nutrient-gene interactions in lipoprotein metabolism - an overview
    Jose M Ordovas
    Nutrition and Genomics Laboratory, USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Forum Nutr 60:102-9. 2007
  63. ncbi Xanthine oxidoreductase polymorphisms: influence in blood pressure and oxidative stress levels
    Felipe J Chaves
    Genetic Studies Laboratory, Research Foundation of Clinic University Hospital of Valencia, Valencia, Spain
    Pharmacogenet Genomics 17:589-96. 2007
    ..We analyzed the association between the -337GA and 565+64CT polymorphisms of the xanthine oxidoreductase gene with blood pressure and oxidative stress levels...
  64. ncbi Alcohol drinking determines the effect of the APOE locus on LDL-cholesterol concentrations in men: the Framingham Offspring Study
    D Corella
    Lipid Metabolism Laboratory and the Epidemiology Program, Jean Mayer-US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 73:736-45. 2001
    ..No significant associations were observed in men or women with the E3 allele. CONCLUSION: In men, the effects of alcohol intake on LDL cholesterol are modulated in part by variability at the APOE locus...
  65. ncbi Prevalence of the methylenetetrahydrofolate reductase 677C > T mutation in the Mediterranean Spanish population. Association with cardiovascular risk factors
    M Guillen
    Department of Preventive Medicine and Public Health, School of Medicine, Universitat de Valencia, Spain
    Eur J Epidemiol 17:255-61. 2001
    ..1 mmHg in CT and 128.5 mmHg in TT subjects; p for trend = 0.030). This association remained significant (p = 0.047) even after adjustment for age, BMI, alcohol consumption, tobacco smoking, education and physical activity...
  66. ncbi [Scientific evidence of the mediterranean diet effects in determining intermediate and final cardiovascular disease phenotypes]
    Mercedes Sotos-Prieto
    Departamento de Medicina Preventiva y Salud Publica, Universitat de València y CIBER Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Valencia, Espana
    Med Clin (Barc) 134:22-9. 2010
    ....
  67. ncbi Active oxygen doctors the evidence
    Ana Castelló
    Facultad de Medicina, University of Valencia EG, Av Blasco Ibanez, Valencia, Spain
    Naturwissenschaften 96:303-7. 2009
    ..This inability to locate bloodstains means that highly important evidence (e.g. a DNA profile) may be lost. Consequently, it is important that investigators are aware of this problem so as to compensate for it...
  68. ncbi [Impact of apolipoprotein A5 on cardiovascular risk. Genetic and environmental modulation]
    Mercedes Sotos-Prieto
    Departamento de Medicina Preventiva y Salud Publica, Ciencidas de la Alimentación, Toxicologia y Medicina Legal, Universitat de València y CIBER Fisiopatologla de la Obesidad y Nutrición, Instituto de Salud Carlos III
    Rev Med Chil 138:868-80. 2010
    ..To understand the impact of this gene on cardiovascular disease, we review the genetic functionality and variability of APOA5, its associations with intermediate and final phenotypes and gene-environment interactions detected...
  69. ncbi [Factor V Leiden (G1691A) and prothrombin-G20210A alleles among patients with deep venous thrombosis and in the general population from Spain]
    Francesc Frances
    Unidad de Epidemiología Genética y Molecular, Departament de Medicina Preventiva, Universitat de Valencia, Espana
    Rev Med Chil 134:13-20. 2006
    ..Factor V leiden and the -G20210A variant of prothrombin gene are associated to a higher risk of deep venous thrombosis...
  70. ncbi [Modulation of the phenotypic expression in the patient with cystinuria: influence of therapeutic intervention and diet]
    Francesc Frances
    Unidad de Epidemiología Genética y Molecular, Facultad de Medicina, Universidad de Valencia, Espana
    Arch Esp Urol 60:109-18. 2007
    ..The objective of this work is to study the effect of the modulation of some environmental factors (urinary pH, intake of liquids, pharmacological treatment and, specially, diet) on the final phenotype of the patient with cystinuria...
  71. ncbi Polymorphisms of the renin-angiotensin system influence height in normotensive women in a Spanish population
    F J Chaves
    Unidad Mixta de Investigacion, Hospital Clinico Universitario de Valencia, 46010 Valencia, Spain
    J Clin Endocrinol Metab 89:2301-5. 2004
    ....
  72. ncbi [Association of blood uric acid with other cardiovascular risk factors in the male working population in Valencia]
    D Corella
    Departamento de Medicina Preventiva y Salud Publica, Bromatologia, Toxicologia y Medicina Legal, Facultad de Medicina Universitat de València
    Rev Clin Esp 199:806-12. 1999
    ..The objective of the present work was to determine the prevalence of hyperuricemia in a large size sample of a healthy male population, as well as the association between uric acid and other cardiovascular risk factors...
  73. ncbi Identification of novel SLC3A1 gene mutations in Spanish cystinuria families and association with clinical phenotypes
    M Guillen
    Genetic and Molecular Epidemiology Unit, Department of Preventive Medicine and Public Health, Universitat de Valencia, 46010 Valencia, Spain
    Clin Genet 67:240-51. 2005
    ....
  74. ncbi Amelogenin test: From forensics to quality control in clinical and biochemical genomics
    F Frances
    Department of Preventive Medicine, Public Health and Legal Medicine, University of Valencia, Valencia, Spain
    Clin Chim Acta 386:53-6. 2007
    ..We have evaluated the usefulness of the amelogenin test for quality control in sample identification...
  75. ncbi [Phenotypical manifestations of cystinuria: a study of 20 families in the Community of Valencia]
    M Guillen
    Unidad de Epidemiología Genética y Molecular Departamento de Medicina Preventiva y Salud Pública Universitat de València Valencia
    Med Clin (Barc) 115:610-6. 2000
    ..The aim of this study was to classify phenotypically cystinuria patients in the Comunidad Valenciana using their genealogy and to study the large heterogeneity of the disease expression...
  76. ncbi PPAR-alpha L162V and PGC-1 G482S gene polymorphisms, but not PPAR-gamma P12A, are associated with alcohol consumption in a Spanish Mediterranean population
    F Frances
    Department of Preventive and Legal Medicine, School of Medicine, University of Valencia, Valencia, Spain
    Clin Chim Acta 398:70-4. 2008
    ..However, no studies in humans exist. Our aim is to estimate the possible association between polymorphisms in the PPAR-alpha, PPAR-gamma and PPAR-gamma co-activator 1A (PGC-1A) genes and alcohol consumption in humans...
  77. ncbi [Sensitivity, specificity and predictive value of the genetic analysis of SLC3A1 gene variants used for the diagnosis of cystinuria among the spanish population]
    M Guillen
    Unidad de Epidemiología Genética y Molecular, Departamento de Medicina Preventiva y Salud Publica, Universitat de Valencia, Valencia
    Rev Clin Esp 201:256-9. 2001
    ....
  78. ncbi [Coffee and tea consumption in a high cardiovascular risk Mediterranean population]
    M Sotos-Prieto
    Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III ISCIII, Spain
    Nutr Hosp 25:388-93. 2010
    ..Coffee and tea consumption recommendations for a healthy diet have been changing in recent years as it has increased the level of evidence on their benefits has increased...
  79. ncbi The 1258 G>A polymorphism in the neuropeptide Y gene is associated with greater alcohol consumption in a Mediterranean population
    F Frances
    Department of Preventive and Legal Medicine, School of Medicine, Avda, Blasco Ibañez, 15, University of Valencia, Valencia 46010, Spain
    Alcohol 45:131-6. 2011
    ..022) and women with moderate alcohol intake (7.3±5.5 g/day in AA as opposed to 4.6±3.9g/day in G carriers, P=.048). The 1258 G>A polymorphism in the NPY is associated with higher alcohol consumption in the Mediterranean population...
  80. ncbi Association of cholesteryl ester transfer protein-TaqIB polymorphism with variations in lipoprotein subclasses and coronary heart disease risk: the Framingham study
    J M Ordovas
    Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts, USA
    Arterioscler Thromb Vasc Biol 20:1323-9. 2000
    ..Moreover, these effects appear to translate into a lower CHD risk among those men with the B2 allele...
  81. ncbi Biological risk factors for deep vein trombosis
    Amparo Vaya
    Hemorheology and Thrombosis Unit, Department of Clinical Pathology, La Fe University Hospital, Valencia, Spain
    Clin Hemorheol Microcirc 26:41-53. 2002
    ..05). Our results suggest that hypercholesterolemia and hyperfibrinogenemia should be added to the list of known DVT risk factors and we recommend adopting measures to decrease these variables in the population with a high risk of DVT...
  82. ncbi Integration of environment and disease into 'omics' analysis
    Dolores Corella
    Jean Mayer-US Department of Agriculture Human Nutrition, Research Center on Aging at Tufts University, Nutrition and Genomics Laboratory, 711 Washington Street, Boston, MA 02111, USA
    Curr Opin Mol Ther 7:569-76. 2005
    ..The concept of gene-environment interaction, as well as the limitations, difficulties and urgent need to integrate environment into omics analysis are reviewed and discussed...
  83. ncbi Association between the PPARA L162V polymorphism and plasma lipid levels: the Framingham Offspring Study
    E S Tai
    Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Mass 02111, USA
    Arterioscler Thromb Vasc Biol 22:805-10. 2002
    ..This suggests that alterations in triglyceride-rich lipoprotein metabolism may be involved in the generation of the increase in LDL cholesterol observed with the L162V PPARA polymorphism...
  84. ncbi Apolipoprotein E genotype affects plasma lipid response to atorvastatin in a gender specific manner
    J Pedro-Botet
    Lipid Research Laboratory, Division of Endocrinology Metabolism and Molecular Biology, New England Medical Center, Boston, MA, USA
    Atherosclerosis 158:183-93. 2001
    ..In summary, atorvastatin treatment had similar effects on plasma lipid levels in both men and women; however, the apoE gene locus was a significant predictor of LDL-C and TG responses to atorvastatin therapy in men, but not in women...
  85. ncbi Genetic variation at the perilipin (PLIN) locus is associated with obesity-related phenotypes in White women
    L Qi
    The Nutrition and Genomics Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Clin Genet 66:299-310. 2004
    ..58, 95% confidence interval (CI): 0.38-0.93 and OR = 0.56, 95% CI: 0.36-0.89, respectively]. In summary, our data suggest that common alleles at the PLIN locus modulate body weight and metabolic variables in humans...
  86. ncbi Genetic variation and lipid metabolism: modulation by dietary factors
    Jose M Ordovas
    Nutrition and Genomics Laboratory, JM USDA HNRCA at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Curr Cardiol Rep 7:480-6. 2005
    ..In summary, there is need for both large population studies and well-standardized intervention studies...
  87. ncbi Influence of social factors on avoidable mortality: a hospital-based case-control study
    Daniel Bautista
    Department of Preventive Medicine, Dr Peset University Hospital, Valencia, Spain
    Public Health Rep 120:55-62. 2005
    ..The purpose of this study was to determine socioeconomic differences between those patients who die of avoidable causes and those who do not die...
  88. ncbi Nutritional genomics
    Jose M Ordovas
    Nutrition and Genomics Laboratory, Jean Mayer U S Department of Agriculture, Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts, USA
    Annu Rev Genomics Hum Genet 5:71-118. 2004
    ....
  89. ncbi Olive oil and health: summary of the II international conference on olive oil and health consensus report, Jaén and Córdoba (Spain) 2008
    J Lopez-Miranda
    Department of Medicine, Reina Sofia University Hospital, School of Medicine, Cordoba, Spain
    Nutr Metab Cardiovasc Dis 20:284-94. 2010
    ..Furthermore, results of case-control and cohort studies suggest that MUFA intake including OO is associated with a reduction in cancer risk (mainly breast, colorectal and prostate cancers)...
  90. ncbi Polyunsaturated fatty acids modulate the effects of the APOA1 G-A polymorphism on HDL-cholesterol concentrations in a sex-specific manner: the Framingham Study
    Jose M Ordovas
    Nutrition and Genomics Laboratory, the Lipid Metabolism Laboratory and the Epidemiology Program, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston 02111, USA
    Am J Clin Nutr 75:38-46. 2002
    ..The A allele was shown to be associated with higher HDL-cholesterol concentrations in some studies but not in others...
  91. ncbi Fibrinogen, plasma viscosity and blood viscosity in obesity. Relationship with insulin resistance
    E Sola
    Endocrinology Service, Doctor Peset University Hospital, Valencia, Spain
    Clin Hemorheol Microcirc 37:309-18. 2007
    ..050). Obese patients show increased fibrinogen levels, PV and cBV. These rheological disturbances seem to be associated with insulin resistance and the metabolic syndrome, and do not seem to improve with moderate weight loss...
  92. ncbi Polymorphisms at the SRBI locus are associated with lipoprotein levels in subjects with heterozygous familial hypercholesterolemia
    E S Tai
    Nutrition and Genomics Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Clin Genet 63:53-8. 2003
    ....
  93. ncbi Erythrocyte deformability in obesity measured by ektacytometric techniques
    E Sola
    Endocrinology Service, Doctor Peset University Hospital, Valencia, Spain
    Clin Hemorheol Microcirc 37:219-27. 2007
    ..031 respectively). Weight loss was not accompanied by any changes in these rheological parameters. Obesity itself does not seem to modify ED. However, metabolic syndrome seems to decrease ED, possibly through insulin resistance...
  94. ncbi A novel CYBA variant, the -675A/T polymorphism, is associated with essential hypertension
    Maria U Moreno
    Division of Cardiovascular Sciences, Centre for Applied Medical Research, University Clinic, University of Navarra, Pamplona, Spain
    J Hypertens 25:1620-6. 2007
    ..We searched for new polymorphisms within the CYBA promoter, the human gene that encodes the p22phox protein, and studied their potential association with essential hypertension...
  95. ncbi Arylesterase activity and antioxidant status depend on PON1-Q192R and PON1-L55M polymorphisms in subjects with increased risk of cardiovascular disease consuming walnut-enriched meat
    Meritxell Nus
    Departamento de Nutrición y Bromatología I Nutrición, Facultad de Farmacia, Universidad Complutense de Madrid, Madrid E 28040, Spain
    J Nutr 137:1783-8. 2007
    ..However, the PON1-Q192R polymorphism is more closely related to antioxidant status. Both polymorphisms modulate the effect of WM consumption on CVD biomarkers...
  96. ncbi The case for strategic international alliances to harness nutritional genomics for public and personal health
    Jim Kaput
    Center of Excellence in Nutritional Genomics, University of California, Davis, CA 95616, USA
    Br J Nutr 94:623-32. 2005
    ....