Research Topics
| Reinald PamplonaSummaryAffiliation: Universitat de Lleida Country: Spain Publications
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Detail Information
Publications
Membrane phospholipids, lipoxidative damage and molecular integrity: a causal role in aging and longevityReinald Pamplona
Department of Experimental Medicine, University of Lleida IRBLleida, Lleida, Spain
Biochim Biophys Acta 1777:1249-62. 2008....- When cholesterol is not cholesterol: a note on the enzymatic determination of its concentration in model systems containing vegetable extractsMariona Jove
Institut de Recerca Biomèdica de Lleida Universitat de Lleida Parc Científic i Agroalimentari Tecnològic de Lleida, Spain
Lipids Health Dis 9:65. 2010..Experimental evidences demonstrate that vegetable derived extracts inhibit cholesterol absorption in the gastrointestinal tract. To further explore the mechanisms behind, we modeled duodenal contents with several vegetable extracts... - Advanced lipoxidation end-productsReinald Pamplona
Department of Experimental Medicine, Faculty of Medicine, University of Lleida IRBLleida, c Montserrat Roig 2, E 25008 Lleida, Spain
Chem Biol Interact 192:14-20. 2011..The consequent loss of function and structural integrity of modified biomolecules can have a wide range of downstream functional consequences and may be the cause of subsequent cellular dysfunctions and tissue damage... - An evolutionary comparative scan for longevity-related oxidative stress resistance mechanisms in homeothermsReinald Pamplona
Department of Experimental Medicine, University of Lleida IRBLleida, Lleida, 25008, Spain
Biogerontology 12:409-35. 2011..It is proposed that natural selection tends to decrease the mitochondrial ROS generation and to increase the molecular resistance to the oxidative damage in long-lived species... - Methionine restriction decreases endogenous oxidative molecular damage and increases mitochondrial biogenesis and uncoupling protein 4 in rat brainAlba Naudi
Department of Experimental Medicine, Faculty of Medicine, University of Lleida IRBLleida, c Montserrat Roig 2, Lleida, Spain
Rejuvenation Res 10:473-84. 2007..These beneficial MetR-induced changes likely derived from metabolic reprogramming at the cellular and tissue level can play a key role in the protection against aging-associated neurodegenerative disorders... - Mitochondrial dysfunction and oxidative and endoplasmic reticulum stress in argyrophilic grain diseaseEkaterina V Ilieva
Department of Experimental Medicine, University of Lleida IRBLleida, Lleida, Spain
J Neuropathol Exp Neurol 70:253-63. 2011..The findings suggest that, despite the common pathogenic trends in AD and AGD, there is molecular specificity for AGD... - Cell stress induces TDP-43 pathological changes associated with ERK1/2 dysfunction: implications in ALSVictoria Ayala
Grup de Fisiopatologia Metabòlica, Departament de Medicina Experimental, Universitat de Lleida IRBLLEIDA, Lleida, Spain
Acta Neuropathol 122:259-70. 2011..These results demonstrate that cellular stressors are key factors in neurodegeneration associated with TDP-43 and disclose the identity of ERK1/2 as novel players in the pathogenesis of ALS... - Double-edged sword behaviour of gallic acid and its interaction with peroxidases in human microvascular endothelial cell culture (HMEC-1). Antioxidant and pro-oxidant effectsJose Serrano
NUTREN Department of Experimental Medicine, University of Lleida IRBLleida, Spain
Acta Biochim Pol 57:193-8. 2010..These observations were confirmed with several oxidative stress biomarkers and the evaluation of the activation of cell survival pathways like AKT and MAPK/ERK... - Dietary protein restriction decreases oxidative protein damage, peroxidizability index, and mitochondrial complex I content in rat liverVictoria Ayala
Department of Basic Medical Sciences, Faculty of Medicine, University of Lleida, Spain
J Gerontol A Biol Sci Med Sci 62:352-60. 2007..Recent studies suggest that those benefits of PR could be caused, in turn, by the lowered methionine intake of that dietary manipulation... - Modification of the longevity-related degree of fatty acid unsaturation modulates oxidative damage to proteins and mitochondrial DNA in liver and brainReinald Pamplona
Department of Basic Medical Sciences, Faculty of Medicine, University of Lleida, Lleida 25198, Spain
Exp Gerontol 39:725-33. 2004..This is mechanistically relevant in relation to the constitutively low tissue fatty acid unsaturation of long-lived animals... - Oxidative and endoplasmic reticulum stress interplay in sporadic amyotrophic lateral sclerosisEkaterina V Ilieva
Fisiopatologia Metabòlica, IRBLLEIDA, Departament de Medicina Experimental, Facultat de Medicina, Universitat de Lleida, Lleida, Spain
Brain 130:3111-23. 2007.... - Depletion of oxidative and endoplasmic reticulum stress regulators in Pick diseaseEkaterina V Ilieva
Department of Experimental Medicine, University of Lleida, Lleida 25008, Spain
Free Radic Biol Med 48:1302-10. 2010..We suggest this was caused by complete and specific depletion of Grp78/BiP, contributing to the pathophysiology of this neurodegenerative disease... - Cellular dysfunction in diabetes as maladaptive response to mitochondrial oxidative stressAlba Naudi
Department of Experimental Medicine, Faculty of Medicine, University of Lleida IRBLleida, Spain
Exp Diabetes Res 2012:696215. 2012..Finally, we outline potential therapies for diabetes focused to the prevention of mitochondrial oxidative damage... - Aging increases Nepsilon-(carboxymethyl)lysine and caloric restriction decreases Nepsilon-(carboxyethyl)lysine and Nepsilon-(malondialdehyde)lysine in rat heart mitochondrial proteinsReinald Pamplona
Department of Basic Medical Sciences, Faculty of Medicine, Lleida University, Spain
Free Radic Res 36:47-54. 2002..The CEL and MDA-lys results support the notion that caloric restriction decreases oxidative stress-derived damage to heart mitochondrial proteins... - Inhibition of renin angiotensin system decreases renal protein oxidative damage in diabetic ratsManuel Portero-Otin
Department of Experimental Medicine, Faculty of Medicine, University of Lleida IRBLLEIDA PCiTAL Parc Científic Agroalimentari de Lleida, 25008 Lleida, Spain
Biochem Biophys Res Commun 368:528-35. 2008..These results show that RAS inhibition improves DN at several levels, independently of its effects on blood pressure and glycemic control, via mechanisms depending of renal oxidative stress... - Oxidative, glycoxidative and lipoxidative damage to rat heart mitochondrial proteins is lower after 4 months of caloric restriction than in age-matched controlsReinald Pamplona
Department of Basic Medical Sciences, Faculty of Medicine, Lleida University, Lleida 25198, Spain
Mech Ageing Dev 123:1437-46. 2002..They also suggest that these decreases are due to an increase in the capacity of the restricted mitochondria to decompose oxidatively modified proteins... - Maillard reaction versus other nonenzymatic modifications in neurodegenerative processesReinald Pamplona
Department of Experimental Medicine, School of Medicine, University of Lleida IRBLleida, Lleida 25008, Spain
Ann N Y Acad Sci 1126:315-9. 2008..In addition, these findings suggest the lack of a "gold marker of oxidative stress," and, consequently, they strengthen the need for a molecular dissection of the nonenzymatic reactions underlying neurodegenerative processes... - Membrane fatty acid unsaturation, protection against oxidative stress, and maximum life span: a homeoviscous-longevity adaptation?Reinald Pamplona
Metabolic Physiopathology Research Group, Department of Basic Medical Sciences, Faculty of Medicine, University of Lleida, Lleida 25198, Spain
Ann N Y Acad Sci 959:475-90. 2002..Here, the physiological meaning of these findings and the effects of experimental manipulations such as dietary stress, caloric restriction, and endocrine control in relation to aging and longevity are discussed... - Highly resistant macromolecular components and low rate of generation of endogenous damage: two key traits of longevityReinald Pamplona
Department of Basic Medical Sciences, Faculty of Medicine, University of Lleida, Lleida 25008, Spain
Ageing Res Rev 6:189-210. 2007..It is emphasized that both a low rate of generation of endogenous damage and an intrinsically high resistance to modification of tissue macromolecules are key traits of animal longevity... - Cell death and learning impairment in mice caused by in vitro modified pro-NGF can be related to its increased oxidative modifications in Alzheimer diseaseAnton Kichev
Department of Basic Medical Sciences, University of Lleida IRBLleida, Lleida, Spain
Am J Pathol 175:2574-85. 2009..Taken together, the data we present here offer a novel pathway of ethiopathogenesis in AD caused by advanced glycation and lipoxidation end-products modification of pro-NGF... - Dietary antioxidants interfere with Amplex Red-coupled-fluorescence assaysJose Serrano
Department of Experimental Medicine, Faculty of Medicine, University of Lleida IRBLleida, Lleida, Spain
Biochem Biophys Res Commun 388:443-9. 2009..The interference observed showed a dose-dependent manner, and a possible mechanism of interaction of dietary antioxidants with HRP in the Amplex Red-coupled-fluorescent assay is proposed... - Chemical and immunological characterization of oxidative nonenzymatic protein modifications in dialysis fluidsMaria Cristina Ruiz
Metabolic Pathophysiology Research Group, Department of Basic Medical Sciences, University of Lleida, Lleida, Spain
Perit Dial Int 23:23-32. 2003..3) These properties are directly related to GDP concentration. (4) Peritoneal dialysis fluid is able to generate glycoxidative and oxidative damage to proteins in vitro in a dwell-time dependent fashion... - Multicompartmental LC-Q-TOF-based metabonomics as an exploratory tool to identify novel pathways affected by polyphenol-rich diets in miceMariona Jove
Institut de Recerca Biomèdica de Lleida Universitat de Lleida Parc Científic i Agroalimentari Tecnològic de Lleida IRBLLEIDA UdL PCiTAL, c Montserrat Roig 2, 25008 Lleida, Spain
J Proteome Res 10:3501-12. 2011..The number of inter- and intracompartment correlations is significantly affected by diet. These analyses reveal the complexity of interorgan metabolic relationships and their sensitivity to dietary changes... - Molecular and structural antioxidant defenses against oxidative stress in animalsReinald Pamplona
Department of Experimental Medicine, University of Lleida Biomedical Research Institute of Lleida, Lleida, Spain
Am J Physiol Regul Integr Comp Physiol 301:R843-63. 2011..Moreover, the study of inheritance mechanisms of antioxidant mechanisms has clear potential to evaluate the contribution of epigenetic mechanisms to stress response phenotype variation... - Prefrontal cortex, caloric restriction and stress during aging: studies on dopamine and acetylcholine release, BDNF and working memoryAlberto Del Arco
Department of Physiology, Faculty of Medicine, Universidad Complutense, Ciudad Universitaria, S N, 28040 Madrid, Spain
Behav Brain Res 216:136-45. 2011..These results suggest that CR does not modify the function of the PFC in response to an acute stress nor the changes found as a result of the normal process of aging... - Advanced glycation end product precursors impair epidermal growth factor receptor signalingManuel Portero-Otin
Metabolic Pathophysiology Research Group, Department of Basic Medical Sciences, University of Lleida, Lleida, Spain
Diabetes 51:1535-42. 2002..These data introduce a novel mechanism for impaired cellular homeostasis in situations that lead to increased production of these reactive aldehydes, such as diabetes...