Research Topics
Genomes and GenesSpecies | A PalouSummaryAffiliation: Universitat de les Illes Balears Country: Spain Publications
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Detail Information
Publications
[Nutrigenomics and obesity]A Palou
Laboratori de Biologia Molecular, Nutrició i Biotecnologia, Universitat de les Illes Balears, Palma de Mallorca
Rev Med Univ Navarra 48:36-48. 2004....
Nutrient-gene interactions in early life programming: leptin in breast milk prevents obesity later on in lifeAndreu Palou
Laboratory of Molecular Biology, Nutrition and Biotechnology Nutrigenomics, University of the Balearic Islands UIB and CIBER Fisiopatología de la Obesidad y Nutrición CIBEROBN, Palma de Mallorca, Spain
Adv Exp Med Biol 646:95-104. 2009..Recent data from our laboratory, identifying leptin as the first specific compound responsible for these beneficial effects, are reviewed and discussed...
On the role and fate of sugars in human nutrition and health. IntroductionA Palou
Molecular Biology, Nutrition and Biotechnology Nutrigenomics, University of the Balearic Islands UIB, Palma de Mallorca, Spain
Obes Rev 10:1-8. 2009....
Moderate doses of conjugated linoleic acid reduce fat gain, maintain insulin sensitivity without impairing inflammatory adipose tissue status in mice fed a high-fat dietPilar Parra
University of the Balearic Islands, Cra Valldemossa Km 7, 5, E 07122, Palma de Mallorca, Spain
Nutr Metab (Lond) 7:5. 2010..In the present study we assessed the potential beneficial effects of CLA mixture (cis-9, trans-11 and trans-10, cis-12, 50:50) in mice fed a high-fat diet...
Leptin intake during lactation prevents obesity and affects food intake and food preferences in later lifeAndreu Palou
Molecular Biology, Nutrition and Biotechnology Nutrigenomics, University of the Balearic Islands, Palma de Mallorca 07122, and CIBER de Fisiopatología de la Obesidad y Nutrición, Spain
Appetite 52:249-52. 2009..These findings open a new area of research on the use of leptin in the design of more appropriate infant formula, which is significant considering the increasing incidence of obesity and its associated medical complications...
General aspects on the assessment of functional foods in the European UnionA Palou
Laboratori de Biologia Molecular, Nutrició i Biotecnologia, Departament de Biologia Fonamental i Ciencies de la Salut, Universitat de les Illes Balears, Palma de Mallorca, Spain
Eur J Clin Nutr 57:S12-7. 2003....
Sexual dimorphism in the lasting effects of moderate caloric restriction during gestation on energy homeostasis in rats is related with fetal programming of insulin and leptin resistanceMariona Palou
Laboratory of Molecular Biology, Nutrition and Biotechnology Nutrigenomics, University of the Balearic Islands UIB and CIBER Fisiopatología de la Obesidad y Nutrición CIBEROBN, Palma de Mallorca, Spain
Nutr Metab (Lond) 7:69. 2010..We aimed to characterize the lasting effect of moderate caloric restriction during early pregnancy on offspring energy homeostasis, by focusing on the effects on food intake and body weight as well as on the insulin and leptin systems...
Integration of risk and benefit analysis-the window of benefit as a new tool?Andreu Palou
University of the Balearic Islands, Spain
Crit Rev Food Sci Nutr 49:670-80. 2009..Ultimately this should lead to an integrated risk-benefit assessment, which will allow better management and, especially, communication, to the benefit of the consumer...
Leptin intake during the suckling period improves the metabolic response of adipose tissue to a high-fat dietT Priego
Laboratory of Molecular Biology, University of the Balearic Islands, Palma de Mallorca, Spain
Int J Obes (Lond) 34:809-19. 2010..The intake of leptin during the suckling period protects against obesity and improves insulin and central leptin sensitivity in adult rats...
Changes of adiposity in response to vitamin A status correlate with changes of PPAR gamma 2 expressionJ Ribot
Depertment of Fundamental Biology and Health Sciences, University of Illes Balears, Palma de Mallorca, Spain
Obes Res 9:500-9. 2001..DISCUSSION: The results emphasize the importance of retinoids as physiological regulators of adipose tissue development and function in intact animals...
Response to carbohydrate and fat refeeding in the expression of genes involved in nutrient partitioning and metabolism: striking effects on fibroblast growth factor-21 inductionJ Sanchez
University of the Balearic Islands and Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición, Palma de Mallorca 07122, Spain
Endocrinology 150:5341-50. 2009....
Differential expression of genes for uncoupling proteins 1, 2 and 3 in brown and white adipose tissue depots during rat developmentP Oliver
, Universitat de les Illes Balears, Palma de Mallorca, Spain
Cell Mol Life Sci 58:470-6. 2001..In contrast to ucp1 and ucp3, ucp2 had a peak of expression at about 2 months, and lower expression at 3 months, suggesting different regulation and probably a different role for this UCP...
Weight loss reduces expression of SREBP1c/ADD1 and PPARgamma2 in adipose tissue of obese womenJ Ribot
Departament de Biologia Fonamental i Ciencies de la Salut, Universitat de les Illes Balears, Palma de Mallorca, Spain
Pflugers Arch 441:498-505. 2001..Our results suggest a functional role for SREBP1c/ADD1 and PPARgamma2 in the control of energy metabolism in human adipose tissue...
Sequential changes in the expression of genes involved in lipid metabolism in adipose tissue and liver in response to fastingM Palou
Biologia Molecular, Nutrición y Biotecnología Nutrigenómica, Universidad de las Islas Baleares UIB, Palma de Mallorca, Spain
Pflugers Arch 456:825-36. 2008....
Dietary l-leucine supplementation of lactating rats results in a tendency to increase lean/fat ratio associated to lower orexigenic neuropeptide expression in hypothalamusN Lopez
Molecular Biology, Nutrition and Biotechnology Nutrigenomics, University of the Balearic Islands UIB and CIBER Fisiopatología de la Obesidad y Nutrición CIBEROBN, Palma de Mallorca, Spain
Peptides 31:1361-7. 2010....
Impairment of nutritional regulation of adipose triglyceride lipase expression with ageA Caimari
Laboratory of Molecular Biology, Nutrition and Biotechnology, Universitat de les Illes Balears and CIBER de Fisiopatología de la Obesidad y Nutrición, CIBEROBN, Palma de Mallorca, Spain
Int J Obes (Lond) 32:1193-200. 2008..Fasting-induced lipolysis becomes less effective with age. We have studied whether nutritional regulation of adipose triglyceride lipase (ATGL)--with an important role in lipolysis in low energy states--is affected by age...
Obesity: molecular bases of a multifactorial problemA Palou
Departament de Biologia Fonamental i Ciencies de la Salut, Bioquimica i Biologia Molecular, Universitat de les Illes Balears, Palma de Mallorca, Spain
Eur J Nutr 39:127-44. 2000....
"In vivo" glutamic acid metabolism in late pregnant ratsP Roca
, , Universitat de les Illes Balears, Valldemossa, Palma de Mallorca, Spain
Horm Metab Res 25:294-7. 1993....
The intake of physiological doses of leptin during lactation in rats prevents obesity in later lifeC Pico
Departamento de Biología Fundamental y Ciencias de la Salud, Universitat de les Illes Balears, Palma de Mallorca, Spain
Int J Obes (Lond) 31:1199-209. 2007..Breast milk contains leptin, a hormone that regulates food intake and energy expenditure, and previous studies in rats have shown that leptin orally administered during lactation exerts anorexigenic effects...
Moderate caloric restriction during gestation results in lower arcuate nucleus NPY- and alphaMSH-neurons and impairs hypothalamic response to fed/fasting conditions in weaned ratsA P Garcia
Laboratory of Molecular Biology, Nutrition and Biotechnology Nutrigenomics, University of Balearic Islands and CIBER Fisiopatología de la Obesidad y Nutrición CIBEROBN, Palma de Mallorca, Spain
Diabetes Obes Metab 12:403-13. 2010..We aimed to characterize the developmental programming effects of moderate caloric restriction during early pregnancy on factors involved in hypothalamic control of energy balance...
Uncoupling proteins: gender dependence and their relation to body weight controlA M Rodriguez
Departament de Biologia Fonamental i Ciencies de la Salut, Ed Guillem Colom, Laboratori de Biologia Molecular, Nutrició i Biotecnologia, Universitat de les Illes Balears, Palma de Mallorca, Spain
Int J Obes Relat Metab Disord 28:500-2. 2004....
Slc27a2 expression in peripheral blood mononuclear cells as a molecular marker for overweight developmentA Caimari
Laboratory of Molecular Biology, Nutrition and Biotechnology, Universitat de les Illes Balears and CIBER de Fisiopatología de la Obesidad y Nutrición CIBEROBN, Palma de Mallorca, Spain
Int J Obes (Lond) 34:831-9. 2010..Obesity is becoming the most common health problem of the 21st century, being dietary intake an important determinant of this pathology and numerous chronic health conditions...
Retinol-binding protein 4 and nicotinamide phosphoribosyltransferase/visfatin in rat obesity modelsJ Mercader
Laboratory of Molecular Biology, Nutrition and Biotechnology, Universitat de les Illes Balears, Palma de Mallorca, Spain
Horm Metab Res 40:467-72. 2008..Hence, increases in RBP4 or Nampt/visfatin do not accompany obesity and insulin resistance in the models examined...
Body weight and tissue composition in rats made obese by a cafeteria diet. Effect of 24 hours starvationM Gianotti
Departamento de Biologia i Ciencias de la Slut (Laboratori de Bioquimica, Universitat de les Illes Balears, Fac. de Ciencies, Spain
Horm Metab Res 20:208-12. 1988..The overall cafeteria fed versus chow fed rat differences in the effects of a 24 hour starvation, were minor but less liver glycogen and much more skeletal muscle lipids were mobilized in the cafeteria fed rats than in controls...
Effect of selective beta-adrenoceptor stimulation on UCP synthesis in primary cultures of brown adipocytesP Puigserver
Dept de Biologia Fonamental i Ciències de la Salut, Universitat de les Illes Balears, Palma de Mallorca, Spain
Mol Cell Endocrinol 117:7-16. 1996..However, all three beta AR subtypes do not become fully functional until cultured cells become confluent...
Vitamin A and the regulation of fat reservesM L Bonet
Laboratori de Biologia Molecular, , , Universitat de les Illes Balears, Cra. Valldemossa Km 7.5, 07071 Palma de Mallorca, Spain
Cell Mol Life Sci 60:1311-21. 2003..Moreover, vitamin A status can influence the development and function of adipose tissues in whole animals, with a low vitamin A status favouring increased fat deposition...
Ontogenesis of leptin expression in different adipose tissue depots in the ratP Oliver
, Universitat de les Illes Balears, Palma de Mallorca, Spain
Pflugers Arch 442:383-90. 2001....
Protective effects of leptin during the suckling period against later obesity may be associated with changes in promoter methylation of the hypothalamic pro-opiomelanocortin geneM Palou
Laboratory of Molecular Biology, Nutrition and Biotechnology Nutrigenomics, University of the Balearic Islands, Carretera Valldemossa Km 7 5, Palma de Mallorca 07122, Spain
Br J Nutr 106:769-78. 2011....
Uncoupling proteins: gender-dependence and their relation to body weight controlA M Rodriguez
Laboratori de Biologia Molecular, Nutrició i Biotecnologia, Departament de Biologia Fonamental i Ciencies de la Salut, Universitat de les Illes Balears, Palma de Mallorca, Spain
Int J Obes Relat Metab Disord 28:327-9. 2004....
Resistin as a putative modulator of insulin action in the daily feeding/fasting rhythmP Oliver
Laboratory of Molecular Biology, Nutrition and Biotechnology, Department of Fundamental Biology and Health Sciences, University of the Balearic Islands, Cra Valldemossa Km 7 5, 07122, Palma de Mallorca, Spain
Pflugers Arch 452:260-7. 2006....
Effect of high-fat diet feeding on leptin receptor expression in white adipose tissue in rats: depot- and sex-related differential responseT Priego
Laboratory of Molecular Biology, Nutrition and Biotechnology Nutrigenomics, University of the Balearic Islands UIB and CIBER Fisiopatología de la Obesidad y Nutrición CIBEROBN, 07122, Palma de Mallorca, Spain
Genes Nutr 4:151-6. 2009....
[New challenges in basic and applied nutrition]A Palou
, , Universitat de les Illes Balears, Palma de Mallorca
Rev Med Univ Navarra 50:62-70. 2006..g. nutrigenomics) are emerging and new trends towards a more conscious, better informed, consumer are foreseen that will allow an appropriate reaction to these new challenges in the medium and long term...
Opposite actions of testosterone and progesterone on UCP1 mRNA expression in cultured brown adipocytesA M Rodriguez
Departament de Biologia Fonamental i Ciencies de la Salut, Laboratori de Biologia Molecular, Nutrició i Biotecnologia, Universitat de les Illes Balears, Cra Valldemossa, km 7 5, Palma de Mallorca 07071, Spain
Cell Mol Life Sci 59:1714-23. 2002....
Diet-induced obesity affects expression of adiponutrin/PNPLA3 and adipose triglyceride lipase, two members of the same familyP Oliver
Laboratory of Molecular Biology, Nutrition and Biotechnology, Universitat de les Illes Balears and CIBER de Fisiopatología de la Obesidad y Nutrición CIBEROBN, Palma de Mallorca, Spain
Int J Obes (Lond) 36:225-32. 2012..These results reinforce the importance of a proper expression and regulation of both proteins for body weight maintenance and their role in energy metabolism...
Up-regulation of muscle uncoupling protein 3 gene expression in mice following high fat diet, dietary vitamin A supplementation and acute retinoic acid-treatmentF Felipe
Laboratori de Biologia Molecular, , , Universitat de les Illes Balears, Palma de Mallorca, Spain
Int J Obes Relat Metab Disord 27:60-9. 2003..CONCLUSION: The results provide evidence of a stimulatory effect of retinoids on muscle UCP3 expression in vivo, and a differential retinoid-regulation of the UCP3 gene in muscle and BAT...
Carboxypeptidase E and thrombospondin-1 are differently expressed in subcutaneous and visceral fat of obese subjectsJ M Ramis
Department of Fundamental Biology and Health Sciences, University of the Balearic Islands, Palma de Mallorca, Spain
Cell Mol Life Sci 59:1960-71. 2002..The involvement of CPE and THBS1 in obesity allows us to suggest that the physiological processes controlled by these genes contribute to depot and gender-related differences in the metabolic complications of obesity...
The glutamine 27 glutamic acid polymorphism of the beta2-adrenoceptor gene is associated with abdominal obesity and greater risk of impaired glucose tolerance in men but not in women: a population-based study in SpainJ L Gonzalez Sanchez
Departamento de Medicina Interna II, Hospital Universitario Clinico San Carlos, Madrid, Spain
Clin Endocrinol (Oxf) 59:476-81. 2003....
[Genetic polymorphisms and new perspectives in the prevention and treatment of obesity]A Palou
Departamento de Biología Fundamental y Ciencias de la Salud, Universidad de las Islas Baleares, Espana
Nutr Hosp 17:23-33. 2002....
Understanding and preventing childhood obesity and related disorders--IDEFICS: a European multilevel epidemiological approachW Ahrens
Division of Epidemiological Methods and Etiologic Research, Bremen Institute for Prevention Research and Social Medicine BIPS, University of Bremen, Linzer Strasse 10, D 28359 Bremen, Germany
Nutr Metab Cardiovasc Dis 16:302-8. 2006..We will propose knowledge-based guidelines on dietary and lifestyle activities for health promotion and disease prevention in children for health professionals, stakeholders and consumers...
