Merce Pallas

Summary

Affiliation: Universitat de Barcelona
Country: Spain

Publications

  1. ncbi Modulation of sirtuins: new targets for antiageing
    Merce Pallas
    Unitat de Farmacologia i Farmacognòsia i Institut de Biomedicina IBUB, Facultat de Farmacia, Universitat de Barcelona, Nucli Universitari de Pedralbes, E 08028 Barcelona, Spain
    Recent Pat CNS Drug Discov 3:61-9. 2008
  2. ncbi Long-term treadmill exercise induces neuroprotective molecular changes in rat brain
    S Bayod
    Unitat de Farmacologia i Farmacognòsia Facultat de Farmàcia, Universitat de Barcelona, Nucli Universitari de Pedralbes, E 08028 Barcelona, Spain
    J Appl Physiol 111:1380-90. 2011
  3. ncbi Modulation of SIRT1 expression in different neurodegenerative models and human pathologies
    M Pallas
    Unitat de Farmacologia i Farmacognosia, Facultat de Farmacia i Institut de Biomedicina IBUB, Universitat de Barcelona, Nucli Universitari de Pedralbes, Barcelona, Spain
    Neuroscience 154:1388-97. 2008
  4. ncbi Flavopiridol: an antitumor drug with potential application in the treatment of neurodegenerative diseases
    M Pallas
    Unitat de Farmacologia i Farmacognosia, Facultat de Farmacia, Universitat de Barcelona, Nucli Universitari de Pedralbes, E 08028 Barcelona, Spain
    Med Hypotheses 64:120-3. 2005
  5. ncbi Molecular and biochemical features in Alzheimer's disease
    Merce Pallas
    Unitat de Farmacologia i Farmacognosia, Facultat de Farmacia, Universitat de Barcelona, Nucli Universitari de Pedralbes, E 08028 Barcelona, Spain
    Curr Pharm Des 12:4389-408. 2006
  6. ncbi Activation of ataxia telangiectasia muted under experimental models and human Parkinson's disease
    Antoni Camins
    Institut de Biomedicina, Centros de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Universitat de Barcelona, Spain
    Cell Mol Life Sci 67:3865-82. 2010
  7. ncbi Oxidative stress-induced DNA damage and cell cycle regulation in B65 dopaminergic cell line
    Javier G Pizarro
    Unitat de Farmacologia i Farmacognosia, Institut de Biomedicina, Centro de Investigacion Biomedica en Red de Enfermedades Neurodegenerativas, Facultat de Farmacia, Universitat de Barcelona, Nucli Universitari de Pedralbes, Barcelona, Spain
    Free Radic Res 43:985-94. 2009
  8. ncbi Cell cycle activation in striatal neurons from Huntington's disease patients and rats treated with 3-nitropropionic acid
    Carme Pelegri
    Departament de Fisiologia, Facultat de Farmacia, Universitat de Barcelona, Av Joan XXIII s n, 08028 Barcelona, Spain
    Int J Dev Neurosci 26:665-71. 2008
  9. ncbi Systemic administration of 3-nitropropionic acid points out a different role for active caspase-3 in neurons and astrocytes
    Joaquim Duran-Vilaregut
    Departament de Fisiologia, Facultat de Farmacia, Universitat de Barcelona, Av Joan XXIII s n, 08028 Barcelona, Spain
    Neurochem Int 56:443-50. 2010
  10. ncbi Lithium treatment decreases activities of tau kinases in a murine model of senescence
    Marta Tajes
    Unitat de Farmacologia, Facultat de Farmácia Institut de Biomedicina Universitat de Barcelona, Nucli Universitari de Pedralbes, Barcelona, Spain
    J Neuropathol Exp Neurol 67:612-23. 2008

Collaborators

Detail Information

Publications67

  1. ncbi Modulation of sirtuins: new targets for antiageing
    Merce Pallas
    Unitat de Farmacologia i Farmacognòsia i Institut de Biomedicina IBUB, Facultat de Farmacia, Universitat de Barcelona, Nucli Universitari de Pedralbes, E 08028 Barcelona, Spain
    Recent Pat CNS Drug Discov 3:61-9. 2008
    ....
  2. ncbi Long-term treadmill exercise induces neuroprotective molecular changes in rat brain
    S Bayod
    Unitat de Farmacologia i Farmacognòsia Facultat de Farmàcia, Universitat de Barcelona, Nucli Universitari de Pedralbes, E 08028 Barcelona, Spain
    J Appl Physiol 111:1380-90. 2011
    ..These findings are consistent with other reports showing that physical exercise has positive effects on hormesis...
  3. ncbi Modulation of SIRT1 expression in different neurodegenerative models and human pathologies
    M Pallas
    Unitat de Farmacologia i Farmacognosia, Facultat de Farmacia i Institut de Biomedicina IBUB, Universitat de Barcelona, Nucli Universitari de Pedralbes, Barcelona, Spain
    Neuroscience 154:1388-97. 2008
    ..SIRT1 expression decreased dramatically in HD, but there were no significant changes in Parkinson-related illnesses. In conclusion, SIRT1 expression may be a good sensor of toxic neuronal processes...
  4. ncbi Flavopiridol: an antitumor drug with potential application in the treatment of neurodegenerative diseases
    M Pallas
    Unitat de Farmacologia i Farmacognosia, Facultat de Farmacia, Universitat de Barcelona, Nucli Universitari de Pedralbes, E 08028 Barcelona, Spain
    Med Hypotheses 64:120-3. 2005
    ..Expression of CDKs was observed in rodent models of excitotoxicity and stroke, and CDK inhibitors showed neuroprotective effects. Flavopiridol may provide significant improvement in neurodegenerative diseases in humans...
  5. ncbi Molecular and biochemical features in Alzheimer's disease
    Merce Pallas
    Unitat de Farmacologia i Farmacognosia, Facultat de Farmacia, Universitat de Barcelona, Nucli Universitari de Pedralbes, E 08028 Barcelona, Spain
    Curr Pharm Des 12:4389-408. 2006
    ..Finally, a multiple therapy with antioxidants, cell cycle inhibitors and other drugs modulating APP processing could be, in the future, a suitable strategy in order to delay Alzheimer's disease progression...
  6. ncbi Activation of ataxia telangiectasia muted under experimental models and human Parkinson's disease
    Antoni Camins
    Institut de Biomedicina, Centros de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Universitat de Barcelona, Spain
    Cell Mol Life Sci 67:3865-82. 2010
    ..Therefore, this study demonstrates a new link between DNA damage by MPP(+) and cell-cycle re-entry through retinoblastoma protein phosphorylation...
  7. ncbi Oxidative stress-induced DNA damage and cell cycle regulation in B65 dopaminergic cell line
    Javier G Pizarro
    Unitat de Farmacologia i Farmacognosia, Institut de Biomedicina, Centro de Investigacion Biomedica en Red de Enfermedades Neurodegenerativas, Facultat de Farmacia, Universitat de Barcelona, Nucli Universitari de Pedralbes, Barcelona, Spain
    Free Radic Res 43:985-94. 2009
    ..In summary, this study describes the molecular mechanisms involved in cell cycle alterations induced by oxidative stress in B65 cells. These findings highlight the relevance of ATM in the regulation of cell cycle after oxidative stress...
  8. ncbi Cell cycle activation in striatal neurons from Huntington's disease patients and rats treated with 3-nitropropionic acid
    Carme Pelegri
    Departament de Fisiologia, Facultat de Farmacia, Universitat de Barcelona, Av Joan XXIII s n, 08028 Barcelona, Spain
    Int J Dev Neurosci 26:665-71. 2008
    ..These results indicate that cell cycle re-entry is activated in Huntington's disease and may contribute to the neurodegenerative process...
  9. ncbi Systemic administration of 3-nitropropionic acid points out a different role for active caspase-3 in neurons and astrocytes
    Joaquim Duran-Vilaregut
    Departament de Fisiologia, Facultat de Farmacia, Universitat de Barcelona, Av Joan XXIII s n, 08028 Barcelona, Spain
    Neurochem Int 56:443-50. 2010
    ..This indicates the presence of a caspase-mediated apoptotic process. TUNEL was not present in control animals or in the astrocytes of treated animals. Thus, the presence of active caspase-3 in astrocytes may be merely constitutive...
  10. ncbi Lithium treatment decreases activities of tau kinases in a murine model of senescence
    Marta Tajes
    Unitat de Farmacologia, Facultat de Farmácia Institut de Biomedicina Universitat de Barcelona, Nucli Universitari de Pedralbes, Barcelona, Spain
    J Neuropathol Exp Neurol 67:612-23. 2008
    ....
  11. ncbi Neuroprotective effects of SB-415286 on hydrogen peroxide-induced cell death in B65 rat neuroblastoma cells and neurons
    Javier G Pizarro
    Unitat de Farmacologia i Farmacognòsia i Institut de Biomedicina IBUB, Facultat de Farmacia, Universitat de Barcelona, Nucli Universitari de Pedralbes, Barcelona, Spain
    Int J Dev Neurosci 26:269-76. 2008
    ..We conclude that the GSK-3 inhibitor SB-415286 has antioxidant properties, which may explain the cytoprotective effects against H(2)O(2) damage. Furthermore, inhibition of GSK-3 activity was not involved in this protective effect...
  12. ncbi ATM is involved in cell-cycle control through the regulation of retinoblastoma protein phosphorylation
    Javier G Pizarro
    Unitat de Farmacologia i Farmacognosia, Institut de Biomedicina IBUB, Centro deInvestigacion Biomedica en Red de Enfermedades Neurodegenerativas CIBERNED, Facultat de Farmacia, Universitat de Barcelona, Nucli Universitari de Pedralbes, Barcelona E 08028, Spain
    J Cell Biochem 110:210-8. 2010
    ..Collectively, our data demonstrate how a new molecular network on ATM regulates the cell cycle through the control of pRb phosphorylation. These findings support a new target of ATM...
  13. ncbi Effects of MPP+ on the molecular pathways involved in cell cycle control in B65 neuroblastoma cells
    Javier G Pizarro
    Unitat de Farmacologia i Farmacognosia, Institut de Biomedicina IBUB, Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas CIBERNED, Universitat de Barcelona, Nucli Universitari de Pedralbes, 08028 Barcelona, Spain
    Pharmacol Res 61:391-9. 2010
    ..In summary, the present work characterizes the molecular changes involved in damage caused by MPP(+) in B65 cells, and highlights the effects of MPP(+) on molecules involved in the control of cell cycle progression...
  14. ncbi Antiapoptotic effects of roscovitine on camptothecin-induced DNA damage in neuroblastoma cells
    Javier G Pizarro
    Centros de Investigación Biomédica en Red Enfermedades Neurodegenerativas, Unitat de Farmacologia i Farmacognosia, Facultat de Farmacia, Institut de Biomedicina, Universitat de Barcelona, Nucli Universitari de Pedralbes, Spain
    Apoptosis 16:536-50. 2011
    ..Our findings have a potential clinical implication, suggesting that combinatory drugs in the treatment of cancer activation should be administered with caution...
  15. ncbi Differences in activation of ERK1/2 and p38 kinase in Jnk3 null mice following KA treatment
    Luisa de Lemos
    Unitat de Farmacologia i Farmacognòsia Facultat de Farmàcia, Institut de Biomedicina IBUB, Centros de Investigación Biomédica en Red de Enfermedades Neurodegenerativas CIBERNED, Universitat de Barcelona, Barcelona, Spain
    J Neurochem 114:1315-22. 2010
    ..Therefore, the data indicate that the lack of the JNK3 protein modulates other MAPKs and these changes could also have a pivotal role in neuroprotection...
  16. ncbi Prosurvival role of JAK/STAT and Akt signaling pathways in MPP+-induced apoptosis in neurons
    Felix Junyent
    Institut de Biomedicina IBUB, Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas CIBERNED, Facultat de Farmacia, Universitat de Barcelona, Barcelona, Spain
    Neurochem Int 57:774-82. 2010
    ..Meanwhile Akt activation, using a PTEN inhibitor, did not play a prominent role in neuroprotection; loss of STAT3 could be a signal pathway involved in neuroprotection against the Parkinsonian neurotoxin MPP(+)...
  17. ncbi A molecular study of pathways involved in the inhibition of cell proliferation in neuroblastoma B65 cells by the GSK-3 inhibitors lithium and SB-415286
    Javier G Pizarro
    Unitat de Farmacologia i Farmacognosia, Facultat de Farmacia, Institut de Biomedicina and Centros de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Universitat de Barcelona, Nucli Universitari de Pedralbes, Barcelona, Spain
    J Cell Mol Med 13:3906-17. 2009
    ..We conclude that inhibitors of GSK-3 induced cell-cycle arrest, mediated by the phosphorylation of cdc2 and, in the case of SB-415286, SIRT2 expression, which induced apoptosis in a caspase-independent manner...
  18. ncbi Time-course of blood-brain barrier disruption in senescence-accelerated mouse prone 8 (SAMP8) mice
    Jaume del Valle
    Departament de Fisiologia, Facultat de Farmacia, Universitat de Barcelona, Av Joan XXIII s n, 08028 Barcelona, Spain
    Int J Dev Neurosci 27:47-52. 2009
    ..On the other hand, as blood-brain barrier permeability in SAMP8 mice increases with age, blood-brain barrier alterations may contribute to the cerebral pathology observed in this strain...
  19. ncbi Evaluation of potential pro-survival pathways regulated by melatonin in a murine senescence model
    Javier Gutierrez-Cuesta
    Unitat de Farmacologia i Farmacognòsia Facultat de Farmàcia, Institut de Biomedicina IBUB, Centros de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Universitat de Barcelona, Nucli Universitari de Pedralbes, Barcelona, Spain
    J Pineal Res 45:497-505. 2008
    ..Melatonin reduced all these changes. We conclude that melatonin improves pro-survival signals and reduces pro-death signals in age-related impairments of neural processes...
  20. ncbi Content and traffic of taurine in hippocampal reactive astrocytes
    Felix Junyent
    Unitat de Farmacologia i Farmacognòsia Facultat de Farmàcia, Institut de Biomedicina IBUB, Centros de Investigación Biomédica en Red de Enfermedades Neurodegenerativas CIBERNED, Universitat de Barcelona, Spain
    Hippocampus 21:185-97. 2011
    ..All data obtained indicate that astrocytes could play a key role in taurine level changes induced by neuronal damage. More studies are, therefore, needed to clarify the role taurine has in relation to neuronal death and repair...
  21. ncbi Kainate-induced toxicity in the hippocampus: potential role of lithium
    Natalia Crespo-Biel
    Unitat de Farmacologia i Farmacognòsia i Institut de Biomedicina IBUB i Centro de Investigación de Biomedicina en Red de Enfermedades Neurodegenerativas CIBERNED, Facultat de Farmacia, Universitat de Barcelona, Nucli Universitari de Pedralbes, Barcelona, Spain
    Bipolar Disord 12:425-36. 2010
    ..We investigated the neuroprotective effects of lithium in an experimental neurodegeneration model gated to kainate (KA) receptor activation...
  22. ncbi Early amyloid accumulation in the hippocampus of SAMP8 mice
    Jaume del Valle
    Departament de Fisiologia, Facultat de Farmacia, Universitat de Barcelona, Barcelona, Spain
    J Alzheimers Dis 19:1303-15. 2010
    ..The demonstration that SAMP8 mice present with amyloid deposits in their hippocampus makes this animal model a useful tool to understand the mechanisms involved in Abeta deposition in AD...
  23. ncbi Inhibition of CDKs: a strategy for preventing kainic acid-induced apoptosis in neurons
    E Verdaguer
    Unitat de Farmacologia i Farmacognosia, Facultat de Farmacia, Universitat de Barcelona, Barcelona, Spain
    Ann N Y Acad Sci 1010:671-4. 2003
    ..We concluded that CDK activation is involved, at least, in part, in the pro-apoptotic effects of kainic acid...
  24. ncbi Study of the pathways involved in apoptosis induced by PI3K inhibition in cerebellar granule neurons
    Aurelio Vazquez De la Torre
    Unitat de Farmacologia i Farmacognosia, Facultat de Farmacia, Centros de Investigación Biomédica en Red Enfermedades Neurodegenerativas CIBERNED, Institut de Biomedicina, Universitat de Barcelona, Nucli Universitari de Pedralbes, 08028 Barcelona, Spain
    Neurochem Int 59:159-67. 2011
    ....
  25. ncbi Characterization of amyloid-? granules in the hippocampus of SAMP8 mice
    Gemma Manich
    Departament de Fisiologia, Facultat de Farmacia, Universitat de Barcelona, Barcelona, Spain
    J Alzheimers Dis 25:535-46. 2011
    ..As the components identified in A? granules are characteristic of the aggregates present in some neurodegenerative diseases, the SAMP8 model seems to be appropriate for the study of the processes involved in these pathologies...
  26. ncbi Neuroprotective effects of caffeine against complex I inhibition-induced apoptosis are mediated by inhibition of the Atm/p53/E2F-1 path in cerebellar granule neurons
    Daniel Alvira
    Unitat de Farmacologia i Farmacognosia, Facultat de Farmacia, Universitat de Barcelona, Nucli Universitari de Pedralbes, Barcelona, Spain
    J Neurosci Res 85:3079-88. 2007
    ....
  27. ncbi Tau hyperphosphorylation and axonal damage induced by N,N-diethyldithiocarbamate (DEDTC) treatment along late postnatal development is followed by a rescue during adulthood
    Juana Utrera
    Departament de Biologia Cellular, Facultat Biologia, Universitat Barcelona, Barcelona, Spain
    J Neurosci Res 88:1083-93. 2010
    ..All these data support the idea that the axonal damage induced by DEDTC treatment along postnatal development is followed by an axonal rescue during adulthood...
  28. ncbi Potential mechanisms involved in the prevention of neurodegenerative diseases by lithium
    Antoni Camins
    Unitat de Farmacologia i Farmacognòsia Facultat de Farmàcia, Centros de Investigación Biomédica en Red de Enfermedades Neurodegenerativas CIBERNED, Institut de Biomedicina IBUB Universitat de Barcelona, Barcelona, Spain
    CNS Neurosci Ther 15:333-44. 2009
    ....
  29. ncbi Gene expression profile in JNK3 null mice: a novel specific activation of the PI3K/AKT pathway
    Felix Junyent
    Unitat de Farmacologia i Farmacognosia, Facultat de Farmacia, Institut de Biomedicina IBUB, Centros de Investigación Biomédica en Red de Enfermedades Neurodegenerativas CIBERNED, Universitat de Barcelona, Barcelona, Spain
    J Neurochem 117:244-52. 2011
    ..Therefore, our results indicate that the activation of PI3K/AKT pathway in hippocampus because of the increase in pik3cb transcription and that this mechanism is specifically related to the lack of Jnk3...
  30. ncbi Inhibition of ataxia telangiectasia-p53-E2F-1 pathway in neurons as a target for the prevention of neuronal apoptosis
    Antoni Camins
    Unitat de Farmacologia i Farmacognosia, Facultat de Farmacia, Universitat de Barcelona, Nucli Universitari de Pedralbes, 08028, Barcelona, Spain
    Curr Drug Metab 8:709-15. 2007
    ..Finally, we put forward drugs that are now being studied experimentally, such as p53 inhibitors, ATM inhibitors and cyclin-dependent kinase (CDKs) inhibitors, for the treatment of neurodegenerative diseases...
  31. ncbi p21(WAF1/Cip1) is not involved in kainic acid-induced apoptosis in murine cerebellar granule cells
    Ester Verdaguer
    Unitat de Farmacologia i Farmacognosia, Facultat de Farmacia, Universitat de Barcelona, Nucli Universitari de Pedralbes, E 08028 Barcelona, Spain
    Brain Res 1030:297-302. 2004
    ..Data suggest that p21(WAF/Cip) was unable to modulate KA-induced apoptosis in murine CGNs...
  32. ncbi GSK-3 beta inhibition and prevention of mitochondrial apoptosis inducing factor release are not involved in the antioxidant properties of SB-415286
    Marc Yeste-Velasco
    Unitat de Farmacologia i Farmacognòsia and Institut de Biomedicina IBUB, Facultat de Farmacia, Universitat de Barcelona, Nucli Universitari de Pedralbes, 08028 Barcelona, Spain
    Eur J Pharmacol 588:239-43. 2008
    ..However, these antioxidant properties are independent of GSK-3 beta inhibition and prevention of mitochondrial AIF release...
  33. ncbi Sirtuin activators: designing molecules to extend life span
    Antoni Camins
    Unitat de Farmacologia i Farmacognòsia Facultat de Farmàcia, Institut de Biomedicina IBUB, Centros de Investigación Biomédica en Red de Enfermedades Neurodegenerativas CIBERNED, Universitat de Barcelona, Nucli Universitari de Pedralbes, 08028 Barcelona, Spain
    Biochim Biophys Acta 1799:740-9. 2010
    ..This review summarises current knowledge about the biological functions of SIRT1 in aging and aging-associated diseases and discusses its potential as a pharmacological target...
  34. ncbi An overview of investigational antiapoptotic drugs with potential application for the treatment of neurodegenerative disorders
    Antoni Camins
    Institut de Biomedicina IBUB, Facultat de Farmacia, Universitat de Barcelona, Barcelona, Spain
    Expert Opin Investig Drugs 19:587-604. 2010
    ..Given this new social scenario, there is a need to identify therapeutic strategies to delay the advance of these pathologies, for which no effective treatment is currently available...
  35. ncbi DNA low-density array analysis of colchicine neurotoxicity in rat cerebellar granular neurons
    Marc Yeste-Velasco
    Facultat de Farmacia, Universitat de Barcelona, Nucli Universitari de Pedralbes, 08028 Barcelona, Spain
    Neurotoxicology 29:309-17. 2008
    ..Present data may help to a better understanding of the molecular mechanisms involved in cytoskeletal degradation-induced apoptosis in neurons...
  36. ncbi Resveratrol inhibits proliferation and promotes apoptosis of neuroblastoma cells: role of sirtuin 1
    Javier G Pizarro
    Institut de Biomedicina IBUB, Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas CIBERNED, Facultat de Farmacia, Universitat de Barcelona, Barcelona, Spain
    Neurochem Res 36:187-94. 2011
    ..Our results show that a decrease in SIRT1 content, caused by exposure to resveratrol, does not appear to be involved in cell-cycle arrest or activation of apoptosis...
  37. ncbi Anti-aging properties of melatonin in an in vitro murine senescence model: involvement of the sirtuin 1 pathway
    M Tajes
    Unitat de Farmacologia i Farmacognòsia Facultat de Farmàcia, Institut de Biomedicina IBUB, Centros de Investigación Biomédica en Red de Enfermedades Neurodegenerativas CIBERNED, Universitat de Barcelona, Nucli Universitari de Pedralbes, Barcelona, Spain
    J Pineal Res 47:228-37. 2009
    ..Globally, these results add weight to the findings of previous reports, indicating a new role for melatonin in improving cell function gated to an increased neuroprotective role for the sirtuin 1 pathway...
  38. ncbi Resveratrol and neurodegenerative diseases: activation of SIRT1 as the potential pathway towards neuroprotection
    Merce Pallas
    Facultat de Farmacia, Institut de Biomedicina IBUB, Centro de Investigación de Biomedicina en Red de Enfermedades Neurodegenerativas, Universitat de Barcelona, Nucli Universitari de Pedralbes, Barcelona, Spain
    Curr Neurovasc Res 6:70-81. 2009
    ..In addition, we discuss the possibility of using resveratrol in the treatment of neurodegenerative diseases...
  39. ncbi Activation of Akt by lithium: pro-survival pathways in aging
    Marta Tajes
    Unitat de Farmacologia i Farmacognòsia Facultat de Farmàcia, Institut de Biomedicina, Centros de Investigación Biomédica en Red de Enfermedades Neurodegenerativas CIBERNED, Universitat de Barcelona, Nucli Universitari de Pedralbes, Barcelona, Spain
    Mech Ageing Dev 130:253-61. 2009
    ..These results demonstrate the effectiveness of lithium in preventing age-related neural loss and the potential therapeutic applications of lithium in treatment/prevention of neurological disease...
  40. ncbi The p38(MAPK) signaling pathway regulates neuronal apoptosis through the phosphorylation of the retinoblastoma protein
    Marc Yeste-Velasco
    Unitat de Farmacologia i Farmacognosia, Facultat de Farmacia, Institut de Biomedicina IBUB, Centros de Investigación Biomédica en Red de Enfermedades Neurodegenerativas CIBERNED, Universitat de Barcelona, Avinguda Diagonal 643, 08028 Barcelona, Spain
    Neurochem Int 54:99-105. 2009
    ..In conclusion, these results suggest that p38MAPK converged with the cell cycle in S/K deprivation-induced apoptosis through pRb phosphorylation...
  41. ncbi GSK3? inhibition is involved in the neuroprotective effects of cyclin-dependent kinase inhibitors in neurons
    Aurelio Vazquez de la Torre
    Unitat de Farmacologia i Farmacognosia, Facultat de Farmacia, Centros de Investigación Biomédica en Red Enfermedades Neurodegenerativas CIBERNED, Institut de Biomedicina IBUB, Universitat de Barcelona, Nucli Universitari de Pedralbes, 08028 Barcelona, Spain
    Pharmacol Res 65:66-73. 2012
    ..Therefore, our data identify GSK3? as a crucial mediator of CGN apoptosis induced by PI3K inhibition and indicate that the antiapoptotic effects of CDKs are mediated by the inhibition of this pharmacological target...
  42. ncbi A new method for determining blood-brain barrier integrity based on intracardiac perfusion of an Evans Blue-Hoechst cocktail
    Jaume del Valle
    Departament de Fisiologia, Facultat de Farmacia, Universitat de Barcelona, Av Joan XXIII s n, Barcelona, Spain
    J Neurosci Methods 174:42-9. 2008
    ..Thus, immunohistochemistry has been used here to determine the nature of intense EB fluorescent cells that appear in the perilesional rim, which were identified here as neuronal cells...
  43. ncbi Blood-brain barrier disruption in the striatum of rats treated with 3-nitropropionic acid
    Joaquim Duran-Vilaregut
    Departament de Fisiologia, Facultat de Farmacia, Universitat de Barcelona, Av Joan XXIII s n, 08028 Barcelona, Spain
    Neurotoxicology 30:136-43. 2009
    ..We conclude that the BBB is severely affected in the 3-NPA rat model of HD and that disruption of this barrier is a crucial event during the development of this disease...
  44. ncbi The role of CDK5/P25 formation/inhibition in neurodegeneration
    Antoni Camins
    Unitat de Farmacologia i Farmacognosia, Facultat de Farmacia, Universitat de Barcelona, E 08028 Barcelona, Spain
    Drug News Perspect 19:453-60. 2006
    ..Furthermore, the dual inhibitory effect of some of these drugs on cdk5 and GSK3beta could be beneficial...
  45. ncbi Cerebral amyloid angiopathy, blood-brain barrier disruption and amyloid accumulation in SAMP8 mice
    Jaume del Valle
    Departament de Fisiologia, Facultat de Farmacia, Barcelona, Spain
    Neurodegener Dis 8:421-9. 2011
    ..Finally, we can conclude that vascular amyloid deposition seems to induce BBB alterations, but BBB disruption may also be due to other factors...
  46. ncbi Dysfunction of astrocytes in senescence-accelerated mice SAMP8 reduces their neuroprotective capacity
    Silvia García-Matas
    Department of Pharmacology and Toxicology, Institut d Investigacions Biomediques de Barcelona, CSIC IDIBAPS, Barcelona, Spain
    Aging Cell 7:630-40. 2008
    ..In addition, our study supports the contention that astrocytes play a key role in neurodegeneration during the aging process...
  47. ncbi Calpains as a target for therapy of neurodegenerative diseases: putative role of lithium
    Antoni Camins
    Institut de Biomedicina, Centros de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Universitat de Barcelona Nucli Universitari de Pedralbes, Barcelona, Spain
    Curr Drug Metab 10:433-47. 2009
    ....
  48. ncbi The antiproliferative activity of melatonin in B65 rat dopaminergic neuroblastoma cells is related to the downregulation of cell cycle-related genes
    Javier G Pizarro
    Unitat de Farmacologia i Farmacognosia, Facultat de Farmacia, Universitat de Barcelona, Nucli Universitari de Pedralbes, Barcelona, Spain
    J Pineal Res 45:8-16. 2008
    ....
  49. ncbi From aging to Alzheimer's disease: unveiling "the switch" with the senescence-accelerated mouse model (SAMP8)
    Merce Pallas
    Unitat de Farmacologia, Facultat de Farmàcia Institut de Biomedicina Universitat de Barcelona IBUB, Nucli Universitari de Pedralbes, Barcelona, Spain
    J Alzheimers Dis 15:615-24. 2008
    ..Here, the neurochemical, neuropathological, and behavioral alterations, characterized in SAMP8 mice are critically reviewed and discussed in relation to the potential use of this mouse model in the study of AD pathogenesis...
  50. ncbi Synthesis, uptake and release of taurine in astrocytes treated with 8-Br-cAMP
    Felix Junyent
    Unitat de Farmacologia i Farmacognòsia Facultat de Farmàcia, Institut de Biomedicina, Centros de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Universitat de Barcelona, Avda Diagnol 643, 08028 Barcelona, Spain
    Neurosci Lett 467:199-202. 2009
    ..The data indicate that taurine synthesis and traffic kinetics vary according to the differentiation state of the astrocytes. Thus, our results highlight the importance of astrocytes in modulating taurine levels in the brain...
  51. ncbi Increased permeability of blood-brain barrier on the hippocampus of a murine model of senescence
    Carme Pelegri
    Departament de Fisiologia, Facultat de Farmacia, Universitat de Barcelona, Av Joan XXIII s n, 08028 Barcelona, Spain
    Mech Ageing Dev 128:522-8. 2007
    ..We have found significantly higher levels of IgG extravasation in the hippocampus of 12-month-old SAMP8 mice compared to SAMR1 mice, indicating an increased permeability of BBB in aged senescence-accelerated mice...
  52. ncbi Chronic administration of melatonin reduces cerebral injury biomarkers in SAMP8
    Javier Gutierrez-Cuesta
    Unitat de Farmacologia i Farmacognosia, Facultat de Farmàcia and Institut de Biomedicina, Universitat de Barcelona, Nucli Universitari de Pedralbes, Barcelona, Spain
    J Pineal Res 42:394-402. 2007
    ..Moreover, these data suggest that the cdk5/GSKbeta signaling cascade has a potential role as a target for neurodegenerative diseases related to aging...
  53. ncbi Hyperphosphorylation of microtubule-associated protein tau in senescence-accelerated mouse (SAM)
    Anna M Canudas
    Unitat de Farmacologia i Farmacognosia, Facultat de Farmacia, Universitat de Barcelona, Nucli Universitari de Pedralbes, E 08028 Barcelona, Spain
    Mech Ageing Dev 126:1300-4. 2005
    ..In conclusion, tau hyperphosphorylation occurs in SAMP-8 (early senescent) mice, indicating a link between aging and tau modifications in this murine model...
  54. ncbi Aging biology: a new frontier for drug discovery
    Ester Verdaguer
    Unitat de Farmacologia i Farmacognòsia Facultat de Farmàcia, Institut de Biomedicina IBUB, Centros de Investigación Biomédica en Red de Enfermedades Neurodegenerativas CIBERNED, Universitat de Barcelona, Nucli Universitari de Pedralbes, 08028 Barcelona, Spain 934024531 934035982
    Expert Opin Drug Discov 7:217-29. 2012
    ..Moreover, caloric restriction currently constitutes the most effective antiaging pathway. Thus, the strategy is to study drugs for aging-associated diseases, such as diabetes, that also have antiaging effects...
  55. ncbi Neuronal apoptosis in the striatum of rats treated with 3-nitropropionic acid is not triggered by cell-cycle re-entry
    Joaquim Duran-Vilaregut
    Departament de Fisiologia, Facultat de Farmacia, Universitat de Barcelona, Av Joan XXIII s n, E 08028 Barcelona, Spain
    Neurotoxicology 32:734-41. 2011
    ....
  56. ncbi Activation of the calpain/cdk5/p25 pathway in the girus cinguli in Parkinson's disease
    Daniel Alvira
    Unitat de Farmacologia i Farmacognosia, Facultat de Farmacia, Universitat de Barcelona, Nucli Universitari de Pedralbes, 08028 Barcelona, Spain
    Parkinsonism Relat Disord 14:309-13. 2008
    ..Our results implicate the cdk5/p25 pathway and re-entry into the cell cycle in the process of neuronal loss in patients with PD...
  57. ncbi Hypertriglyceridemia and hepatic steatosis in senescence-accelerated mouse associate to changes in lipid-related gene expression
    Laia Vilà
    Department of Pharmacology and Therapeutic Chemistry, University of Barcelona, Barcelona, Spain
    J Gerontol A Biol Sci Med Sci 62:1219-27. 2007
    ..Triglyceride accretion and a deficit in hepatic fatty acid oxidation, features of the aging process in mammals, associate to a deficit in hepatic FXR activity in the SAM-P8 mice...
  58. ncbi Inhibition of cell cycle pathway by flavopiridol promotes survival of cerebellar granule cells after an excitotoxic treatment
    Ester Verdaguer
    Unitat de Farmacologia i Farmacognosia, Facultat de Farmacia, Universitat de Barcelona, Nucli Universitari de Pedralbes, Barcelona, Spain
    J Pharmacol Exp Ther 308:609-16. 2004
    ..Flavopiridol might thus be used as a preventive agent against neurodegenerative diseases associated with cell cycle activation...
  59. ncbi Novel huprine derivatives with inhibitory activity toward ?-amyloid aggregation and formation as disease-modifying anti-Alzheimer drug candidates
    Elisabet Viayna
    Laboratori de Química Farmacèutica Unitat Associada al CSIC, Facultat de Farmacia, and Institut de Biomedicina IBUB, Universitat de Barcelona, Av Diagonal 643, 08028, Barcelona, Spain
    ChemMedChem 5:1855-70. 2010
    ....
  60. ncbi Synthesis and pharmacological evaluation of several ring-contracted amantadine analogs
    Pelayo Camps
    Laboratori de Química Farmacèutica Unitat Associada al CSIC, Facultat de Farmacia, and Institute of Biomedicine IBUB, Universitat de Barcelona, Av Diagonal, 643, Barcelona E 08028, Spain
    Bioorg Med Chem 16:9925-36. 2008
    ..A rimantadine analogue displayed significant trypanocidal activity. Moreover, to further characterize the pharmacology of these compounds, their effects on dopamine uptake were also assessed...
  61. ncbi Novel donepezil-based inhibitors of acetyl- and butyrylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation
    Pelayo Camps
    Laboratori de Química Farmacèutica Unitat Associada al CSIC, Facultat de Farmacia, Barcelona, Spain
    J Med Chem 51:3588-98. 2008
    ..Moreover, six out of the eight hybrids of the series, particularly those bearing an indane moiety, exhibit a significant A beta antiaggregating activity, which makes them promising anti-Alzheimer drug candidates...
  62. ncbi Neurons from senescence-accelerated SAMP8 mice are protected against frailty by the sirtuin 1 promoting agents melatonin and resveratrol
    Rosa Cristofol
    Institut d Investigacions Biomediques de Barcelona, CSIC, IDIBAPS, Barcelona, Spain
    J Pineal Res 52:271-81. 2012
    ..This supports the therapeutic use of sirtuin 1-enhancing agents against age-related nerve cell dysfunction and brain frailty...
  63. ncbi 3-Nitropropionic acid activates calpain/cdk5 pathway in rat striatum
    Natalia Crespo Biel
    Unitat de Farmacologia i Farmacognosia, Facultat de Farmacia, Universitat de Barcelona, Nucli Universitari de Pedralbes, E 08028 Barcelona, Spain
    Neurosci Lett 421:77-81. 2007
    ..We suggest that calpain/cdk5 activation could also be a common pathway activated in other neurodegenerative diseases, which is liable to be targeted...
  64. ncbi Retinol-binding protein 4 and peroxisome proliferator-activated receptor-? in steatotic liver transplantation
    Arani Casillas-Ramirez
    Institut d Investigacions Biomediques August Pi i Sunyer, Barcelona, Spain
    J Pharmacol Exp Ther 338:143-53. 2011
    ..RBP4 treatment and PC, through RBP4 induction, reduced PPAR? levels in steatotic liver grafts, thus protecting them from the PPAR? detrimental effects...
  65. ncbi Neurophysiological and epigenetic effects of physical exercise on the aging process
    Perla Kaliman
    Instituto de Investigaciones Biomedicas August Pi i Sunyer, Barcelona, Spain
    Ageing Res Rev 10:475-86. 2011
    ....
  66. ncbi Free radical production induced by methamphetamine in rat striatal synaptosomes
    David Pubill
    Unitat de Farmacologia i Farmacognosia, Facultat de Farmacia, Nucli Universitari de Pedralbes, Universitat de Barcelona, 08028 Barcelona, Spain
    Toxicol Appl Pharmacol 204:57-68. 2005
    ..This would lead to DAT inhibition and NOS and PKC activation, initiating oxidation of cytosolic DA...
  67. ncbi Activation of ERK and Akt signaling in focal cerebral ischemia: modulation by TGF-alpha and involvement of NMDA receptor
    Bibiana Friguls
    Departament de Farmacologia i Toxicologia, Institut d Investigacions Biomediques de Barcelona, CSIC IDIBAPS, Facultat de Farmacia, Universitat de Barcelona, Barcelona, Spain
    Neurobiol Dis 11:443-56. 2002
    ..This study illustrates that neuroprotection results from a fine balance between death and survival signaling pathways...