David Comas

Summary

Affiliation: Universitat Pompeu Fabra
Country: Spain

Publications

  1. ncbi Linguistic and maternal genetic diversity are not correlated in Native Mexicans
    Karla Sandoval
    Institute of Evolutionary Biology UPF CSIC, CEXS UPF PRBB, 08003 Barcelona, Catalonia, Spain
    Hum Genet 126:521-31. 2009
  2. ncbi Alu insertion polymorphisms in the Balkans and the origins of the Aromuns
    D Comas
    Unitat de Biologia Evolutiva, Universitat Pompeu Fabra, Barcelona Department of Anthropology, University of Ulm, Germany
    Ann Hum Genet 68:120-7. 2004
  3. ncbi Admixture, migrations, and dispersals in Central Asia: evidence from maternal DNA lineages
    David Comas
    Unitat de Biologia Evolutiva, Departament de Ciències de la Salut i de la Vida, Universitat Pompeu Fabra, Barcelona 08003, Spain
    Eur J Hum Genet 12:495-504. 2004
  4. ncbi Decay of linkage disequilibrium within genes across HGDP-CEPH human samples: most population isolates do not show increased LD
    Elena Bosch
    Institut de Biologia Evolutiva UPF CSIC, Departament de Ciències Experimentals i de Salut, Universitat Pompeu Fabra, Parc de Recerca Biomedica de Barcelona, Barcelona, Spain
    BMC Genomics 10:338. 2009
  5. ncbi Genetic origin, admixture, and asymmetry in maternal and paternal human lineages in Cuba
    Isabel Mendizabal
    Unitat de Biologia Evolutiva, Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Spain
    BMC Evol Biol 8:213. 2008
  6. ncbi Association study between Alzheimer's disease and genes involved in Abeta biosynthesis, aggregation and degradation: suggestive results with BACE1
    Jordi Clarimon
    Unitat de Biologia Evolutiva, Facultat de Ciencies de la Salut i de la Vida, Universitat Pompeu Fabra, Doctor Aiguader 80, 08003 Barcelona, Spain
    J Neurol 250:956-61. 2003
  7. ncbi A genomic analysis identifies a novel component in the genetic structure of sub-Saharan African populations
    Martin Sikora
    Institut de Biologia Evolutiva UPF CSIC, CEXS UPF PRBB, Barcelona, Catalonia, Spain
    Eur J Hum Genet 19:84-8. 2011
  8. ncbi Genetic and demographic implications of the Bantu expansion: insights from human paternal lineages
    Gemma Berniell-Lee
    Institute of Evolutionary Biology, Consejo Superior de Investigaciones Cientificas UPF, CEXS UPF PRBB, Barcelona, Catalonia, Spain
    Mol Biol Evol 26:1581-9. 2009
  9. ncbi Extreme individual marker F(ST )values do not imply population-specific selection in humans: the NRG1 example
    Michelle Gardner
    Unitat de Biologia Evolutiva, Universitat Pompeu Fabra, Doctor Aiguader 88, Barcelona, 08003, Spain
    Hum Genet 121:759-62. 2007
  10. ncbi HSP70-2 (HSPA1B) is associated with noncognitive symptoms in late-onset Alzheimer's disease
    Jordi Clarimon
    Unitat de Biologia Evolutiva, Facultat de Ciencies de la Salut i de la Vida, Universitat Pompeu Fabra, Barcelona, Spain
    J Geriatr Psychiatry Neurol 16:146-50. 2003

Detail Information

Publications48

  1. ncbi Linguistic and maternal genetic diversity are not correlated in Native Mexicans
    Karla Sandoval
    Institute of Evolutionary Biology UPF CSIC, CEXS UPF PRBB, 08003 Barcelona, Catalonia, Spain
    Hum Genet 126:521-31. 2009
    ....
  2. ncbi Alu insertion polymorphisms in the Balkans and the origins of the Aromuns
    D Comas
    Unitat de Biologia Evolutiva, Universitat Pompeu Fabra, Barcelona Department of Anthropology, University of Ulm, Germany
    Ann Hum Genet 68:120-7. 2004
    ....
  3. ncbi Admixture, migrations, and dispersals in Central Asia: evidence from maternal DNA lineages
    David Comas
    Unitat de Biologia Evolutiva, Departament de Ciències de la Salut i de la Vida, Universitat Pompeu Fabra, Barcelona 08003, Spain
    Eur J Hum Genet 12:495-504. 2004
    ....
  4. ncbi Decay of linkage disequilibrium within genes across HGDP-CEPH human samples: most population isolates do not show increased LD
    Elena Bosch
    Institut de Biologia Evolutiva UPF CSIC, Departament de Ciències Experimentals i de Salut, Universitat Pompeu Fabra, Parc de Recerca Biomedica de Barcelona, Barcelona, Spain
    BMC Genomics 10:338. 2009
    ..Within each gene region and population we use r2 between all possible single nucleotide polymorphism (SNP) pairs as a measure of linkage disequilibrium and focus on the proportion of SNP pairs with r2 greater than 0.8...
  5. ncbi Genetic origin, admixture, and asymmetry in maternal and paternal human lineages in Cuba
    Isabel Mendizabal
    Unitat de Biologia Evolutiva, Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Spain
    BMC Evol Biol 8:213. 2008
    ....
  6. ncbi Association study between Alzheimer's disease and genes involved in Abeta biosynthesis, aggregation and degradation: suggestive results with BACE1
    Jordi Clarimon
    Unitat de Biologia Evolutiva, Facultat de Ciencies de la Salut i de la Vida, Universitat Pompeu Fabra, Doctor Aiguader 80, 08003 Barcelona, Spain
    J Neurol 250:956-61. 2003
    ....
  7. ncbi A genomic analysis identifies a novel component in the genetic structure of sub-Saharan African populations
    Martin Sikora
    Institut de Biologia Evolutiva UPF CSIC, CEXS UPF PRBB, Barcelona, Catalonia, Spain
    Eur J Hum Genet 19:84-8. 2011
    ..Finally, we find a strong differentiation of the southeastern Bantu population from Mozambique, which suggests an assimilation of a pre-Bantu substrate by Bantu speakers in the region...
  8. ncbi Genetic and demographic implications of the Bantu expansion: insights from human paternal lineages
    Gemma Berniell-Lee
    Institute of Evolutionary Biology, Consejo Superior de Investigaciones Cientificas UPF, CEXS UPF PRBB, Barcelona, Catalonia, Spain
    Mol Biol Evol 26:1581-9. 2009
    ..We also find the intriguing presence of paternal lineages belonging to Eurasian haplogroup R1b1*, which might represent footprints of demographic expansions in central Africa not directly related to the Bantu expansion...
  9. ncbi Extreme individual marker F(ST )values do not imply population-specific selection in humans: the NRG1 example
    Michelle Gardner
    Unitat de Biologia Evolutiva, Universitat Pompeu Fabra, Doctor Aiguader 88, Barcelona, 08003, Spain
    Hum Genet 121:759-62. 2007
    ..In the present study we show evidence that high F(ST) values may not necessarily imply the action of selection, in particular positive selection, neither globally nor regionally, using the example of the NRG1 gene...
  10. ncbi HSP70-2 (HSPA1B) is associated with noncognitive symptoms in late-onset Alzheimer's disease
    Jordi Clarimon
    Unitat de Biologia Evolutiva, Facultat de Ciencies de la Salut i de la Vida, Universitat Pompeu Fabra, Barcelona, Spain
    J Geriatr Psychiatry Neurol 16:146-50. 2003
    ..These results indicate a possible association between the A2 allele and an overexpression of noncognitive symptoms in AD...
  11. ncbi Admixture and sexual bias in the population settlement of La Réunion Island (Indian Ocean)
    Gemma Berniell-Lee
    Unitat de Biologia Evolutiva, Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra, 08003 Barcelona, Spain
    Am J Phys Anthropol 136:100-7. 2008
    ..The absence of genetic diversity within these two major components of the mtDNA gene pool suggests these populations may have witnessed strong founder effects during the colonization process...
  12. ncbi SNPlexing the human Y-chromosome: a single-assay system for major haplogroup screening
    Gemma Berniell Lee
    Unitat de Biologia Evolutiva, Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Spain
    Electrophoresis 28:3201-6. 2007
    ....
  13. ncbi Similarity in recombination rate estimates highly correlates with genetic differentiation in humans
    Hafid Laayouni
    IBE, Institute of Evolutionary Biology UPF CSIC, CEXS UPF PRBB, Barcelona, Catalonia, Spain
    PLoS ONE 6:e17913. 2011
    ..This result indicates a rapid pace of evolution of recombination, within the time span of differentiation of modern humans...
  14. ncbi Worldwide genetic variation in dopamine and serotonin pathway genes: implications for association studies
    Michelle Gardner
    Unitat de Biologia Evolutiva, Universitat Pompeu Fabra, Doctor Aiguader, Barcelona, Spain
    Am J Med Genet B Neuropsychiatr Genet 147:1070-5. 2008
    ..A list of tagSNPs per gene and continental region is proposed providing a guide for future association studies with these genes...
  15. ncbi SNP analysis to results (SNPator): a web-based environment oriented to statistical genomics analyses upon SNP data
    Carlos Morcillo-Suarez
    Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona Biomedical Research Park PRBB, Barcelona, Spain
    Bioinformatics 24:1643-4. 2008
    ..Many different quality control and analysis procedures can be performed either by using built-in SNPator algorithms or by calling standard genetic software. AVAILABILITY: Access is granted from the SNPator webpage http://www.snpator.org...
  16. ncbi Baseline brain perfusion and the serotonin transporter promoter polymorphism
    Roberto Viviani
    Department of Psychiatry and Psychotherapy III, University of Ulm, Germany
    Biol Psychiatry 67:317-22. 2010
    ..We reassess the findings of an increased baseline perfusion in the amygdala and ventral prefrontal areas in healthy carriers of the risk genotype in a much larger sample than in previous studies...
  17. ncbi Reconstructing the Indian origin and dispersal of the European Roma: a maternal genetic perspective
    Isabel Mendizabal
    Institute of Evolutionary Biology CSIC UPF, CEXS UPF PRBB, Barcelona, Spain
    PLoS ONE 6:e15988. 2011
    ....
  18. ncbi Family-based association study of neuregulin-1 gene and psychosis in a Spanish sample
    Araceli Rosa
    Unitat de Biologia Evolutiva, Facultat de Ciencies de la Salut i de la Vida, Universitat Pompeu Fabra, Doctor Aiguader 88, 08003 Barcelona, Catalonia, Spain
    Am J Med Genet B Neuropsychiatr Genet 144:954-7. 2007
    ....
  19. ncbi A new method to reconstruct recombination events at a genomic scale
    Marta Mele
    IBE, Institute of Evolutionary Biology UPF CSIC, CEXS UPF PRBB, Barcelona, Catalonia, Spain
    PLoS Comput Biol 6:e1001010. 2010
    ....
  20. ncbi Why names
    Francesc Calafell
    Unitat de Biologia Evolutiva, Universitat Pompeu Fabra, 08003 Barcelona, Catalonia, Spain
    Genome Res 12:219-21. 2002
  21. ncbi Joint analysis of candidate genes related to Alzheimer's disease in a Spanish population
    Jordi Clarimon
    Unitat de Biologia Evolutiva, Facultat de Ciencies de la Salut i de la Vida, Universitat Pompeu Fabra, Barcelona, Spain
    Psychiatr Genet 13:85-90. 2003
    ..Most of these studies have examined only one or two polymorphisms in a defined population, which provides a lack of a general view of the Alzheimer's disease genetic component...
  22. ncbi Extreme population differences across Neuregulin 1 gene, with implications for association studies
    M Gardner
    Unitat de Biologia Evolutiva, Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra, Doctor Aiguader 80, 08003 Barcelona, Catalonia, Spain
    Mol Psychiatry 11:66-75. 2006
    ..We have given recommendations for taking this into account in future association studies since this diversity could give rise to erroneous results...
  23. ncbi Insights into the demographic history of African Pygmies from complete mitochondrial genomes
    Chiara Batini
    Institut de Biologia Evolutiva CSIC UPF, Department de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Spain
    Mol Biol Evol 28:1099-110. 2011
    ....
  24. ncbi Determination of haploid DNA sequences in humans: application to the glucocerebrosidase pseudogene
    Rosa Martinez-Arias
    Unitat de Biologia Evolutiva, Facultat de Ciencies de la Salut i de la Vida, Universitat Pompeu Fabra, Doctor Aiguader 80, 08003 Barcelona, Spain
    DNA Seq 13:9-13. 2002
    ..The manner to combine the used techniques makes this approach a novelty. Haploid sequences from diploid organisms are obtained in a less time consuming and more accurate manner than in other used procedures...
  25. ncbi Paternal and maternal lineages in the Balkans show a homogeneous landscape over linguistic barriers, except for the isolated Aromuns
    E Bosch
    Unitat de Biologia Evolutiva, Universitat Pompeu Fabra, Barcelona, Spain
    Ann Hum Genet 70:459-87. 2006
    ..The homogeneity of Balkan populations prevented testing for the origin of the Aromuns, although a significant Roman contribution can be ruled out...
  26. ncbi High-resolution analysis of human Y-chromosome variation shows a sharp discontinuity and limited gene flow between northwestern Africa and the Iberian Peninsula
    E Bosch
    Unitat de Biologia Evolutiva, , Universitat Pompeu Fabra, 08003 Barcelona, Spain
    Am J Hum Genet 68:1019-29. 2001
    ..The high-resolution analysis of the Y chromosome allows us to separate successive migratory components and to precisely quantify each historical layer...
  27. ncbi Haplotype tagging efficiency in worldwide populations in CTLA4 gene
    A Ramírez-Soriano
    Unitat de Biologia Evolutiva, Departament de Ciencies Experimentals i de la Salut, Facultat de Ciencies de la Salut i de la Vida, Universitat Pompeu Fabra, Barcelona, Catalonia 08003, Spain
    Genes Immun 6:646-57. 2005
    ..A continent-specific set of haplotype tagging SNPs has been designed to be used for future association studies. These are portable among populations, although their efficiency might vary depending on the population haplotype spectrum...
  28. ncbi The genetics of the pre-Roman Iberian Peninsula: a mtDNA study of ancient Iberians
    M L Sampietro
    Unitat de Biologia Evolutiva, , Universitat Pompeu Fabra, Barcelona, Spain
    Ann Hum Genet 69:535-48. 2005
    ..Moreover, the Iberians were not especially closely related to the Etruscans, which points to considerable genetic heterogeneity in Pre-Roman Western Europe...
  29. ncbi Joining the pillars of Hercules: mtDNA sequences show multidirectional gene flow in the western Mediterranean
    S Plaza
    Unitat de Biologia Evolutiva, Universitat Pompeu Fabra, Doctor Aiguader 80, 08003 Barcelona, Spain
    Ann Hum Genet 67:312-28. 2003
    ..Comparison of mtDNA data with autosomal markers and Y-chromosome lineages, analysed in the same populations, shows a congruent pattern, although female-mediated gene flow seems to have been more intense than male-mediated gene flow...
  30. ncbi Structure of linkage disequilibrium in humans: genome factors and population stratification
    J Bertranpetit
    Unitat de Biologia Evolutiva, Universitat Pompeu Fabra, 08003 Barcelona, Catalonia, Spain
    Cold Spring Harb Symp Quant Biol 68:79-88. 2003
  31. ncbi Sequence variability of a human pseudogene
    R Martinez-Arias
    Unitat de Biologia Evolutiva, Universitat Pompeu Fabra, 08003 Barcelona, Spain
    Genome Res 11:1071-85. 2001
    ..In a deeper timeframe, phylogenetic analysis showed that the duplication event that created psGBA could be dated at approximately 27 million years ago, in agreement with previous estimates...
  32. ncbi Correlation between genetic and geographic structure in Europe
    Oscar Lao
    Department of Forensic Molecular Biology, Erasmus University Medical Center Rotterdam, 3000 CA Rotterdam, The Netherlands
    Curr Biol 18:1241-8. 2008
    ..By including the widely used CEPH from Utah (CEU) samples into our analysis, we could show that these individuals represent northern and western Europeans reasonably well, thereby confirming their assumed regional ancestry...
  33. ncbi A global perspective on genetic variation at the ADH genes reveals unusual patterns of linkage disequilibrium and diversity
    Michael V Osier
    Department of Genetics, Yale University School of Medicine, New Haven, CT 06520, USA
    Am J Hum Genet 71:84-99. 2002
    ..It seems unlikely that this haplotype, which is rare or unobserved in other populations, reached such high frequency because of random genetic drift alone...
  34. ncbi Phylogeography of the human mitochondrial L1c haplogroup: genetic signatures of the prehistory of Central Africa
    Chiara Batini
    Dipartimento di Biologia Animale e dell Uomo, Universita La Sapienza, Roma, Italy
    Mol Phylogenet Evol 43:635-44. 2007
    ....
  35. ncbi Independent introduction of two lactase-persistence alleles into human populations reflects different history of adaptation to milk culture
    Nabil Sabri Enattah
    Department of Molecular Medicine, National Public Health Institute, Biomedicum Helsinki, 00251 Helsinki, Finland
    Am J Hum Genet 82:57-72. 2008
    ..These results support the convergent evolution of the LP in diverse populations, most probably reflecting different histories of adaptation to milk culture...
  36. ncbi Brief communication: mtDNA variation in North Cameroon: lack of Asian lineages and implications for back migration from Asia to sub-Saharan Africa
    Valentina Coia
    Department of Animal and Human Biology, University La Sapienza, 00185 Rome, Italy
    Am J Phys Anthropol 128:678-81. 2005
    ....
  37. ncbi Y-chromosomal diversity in Lebanon is structured by recent historical events
    Pierre A Zalloua
    The Lebanese American University, Chouran, Beirut 1102 2801, Lebanon
    Am J Hum Genet 82:873-82. 2008
    ....
  38. ncbi The dawn of human matrilineal diversity
    Doron M Behar
    Molecular Medicine Laboratory, Rambam Health Care Campus, Haifa 31096, Israel
    Am J Hum Genet 82:1130-40. 2008
    ..This process was further accelerated during the recent Bantu expansions. Our results suggest that the early settlement of humans in Africa was already matrilineally structured and involved small, separately evolving isolated populations...
  39. ncbi Northwest Siberian Khanty and Mansi in the junction of West and East Eurasian gene pools as revealed by uniparental markers
    Ville N Pimenoff
    Department of Forensic Medicine, Laboratory of Forensic Biology, University of Helsinki, Helsinki, Finland
    Eur J Hum Genet 16:1254-64. 2008
    ..This admixture indicates that the Khanty and Mansi populations have resided in the contact zone of genetically distinguishable eastern and western Eurasia...
  40. ncbi Maternal traces of deep common ancestry and asymmetric gene flow between Pygmy hunter-gatherers and Bantu-speaking farmers
    Lluis Quintana-Murci
    Human Evolutionary Genetics Unit, Centre National de la Recherche Scientifique URA3012, Institut Pasteur, 75015 Paris, France
    Proc Natl Acad Sci U S A 105:1596-601. 2008
    ....
  41. ncbi Evidence of still-ongoing convergence evolution of the lactase persistence T-13910 alleles in humans
    Nabil Sabri Enattah
    Department of Molecular Medicine, National Public Health Institute, Helsinki, Finland
    Am J Hum Genet 81:615-25. 2007
    ....
  42. ncbi The Genographic Project public participation mitochondrial DNA database
    Doron M Behar
    PLoS Genet 3:e104. 2007
    ..We make available to the scientific community and general public two new resources: a periodically updated database comprising all data donated by participants, and the nearest neighbor haplogroup prediction tool...