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Genomes and Genes | Antoni CaminsSummaryAffiliation: Universitat de Barcelona Country: Spain Publications
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Publications
Sirtuin activators: designing molecules to extend life spanAntoni Camins
Unitat de Farmacologia i Farmacognòsia Facultat de Farmàcia, Institut de Biomedicina IBUB, Centros de Investigación Biomédica en Red de Enfermedades Neurodegenerativas CIBERNED, Universitat de Barcelona, Nucli Universitari de Pedralbes, 08028 Barcelona, Spain
Biochim Biophys Acta 1799:740-9. 2010..This review summarises current knowledge about the biological functions of SIRT1 in aging and aging-associated diseases and discusses its potential as a pharmacological target...- Aging biology: a new frontier for drug discoveryEster Verdaguer
Unitat de Farmacologia i Farmacognòsia Facultat de Farmàcia, Institut de Biomedicina IBUB, Centros de Investigación Biomédica en Red de Enfermedades Neurodegenerativas CIBERNED, Universitat de Barcelona, Nucli Universitari de Pedralbes, 08028 Barcelona, Spain 934024531 934035982
Expert Opin Drug Discov 7:217-29. 2012..Moreover, caloric restriction currently constitutes the most effective antiaging pathway. Thus, the strategy is to study drugs for aging-associated diseases, such as diabetes, that also have antiaging effects... - Activation of ataxia telangiectasia muted under experimental models and human Parkinson's diseaseAntoni Camins
Institut de Biomedicina, Centros de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Universitat de Barcelona, Spain
Cell Mol Life Sci 67:3865-82. 2010..Therefore, this study demonstrates a new link between DNA damage by MPP(+) and cell-cycle re-entry through retinoblastoma protein phosphorylation... - Inhibition of cell cycle pathway by flavopiridol promotes survival of cerebellar granule cells after an excitotoxic treatmentEster Verdaguer
Unitat de Farmacologia i Farmacognosia, Facultat de Farmacia, Universitat de Barcelona, Nucli Universitari de Pedralbes, Barcelona, Spain
J Pharmacol Exp Ther 308:609-16. 2004..Flavopiridol might thus be used as a preventive agent against neurodegenerative diseases associated with cell cycle activation... - Inhibition of ataxia telangiectasia-p53-E2F-1 pathway in neurons as a target for the prevention of neuronal apoptosisAntoni Camins
Unitat de Farmacologia i Farmacognosia, Facultat de Farmacia, Universitat de Barcelona, Nucli Universitari de Pedralbes, 08028, Barcelona, Spain
Curr Drug Metab 8:709-15. 2007..Finally, we put forward drugs that are now being studied experimentally, such as p53 inhibitors, ATM inhibitors and cyclin-dependent kinase (CDKs) inhibitors, for the treatment of neurodegenerative diseases... - The role of CDK5/P25 formation/inhibition in neurodegenerationAntoni Camins
Unitat de Farmacologia i Farmacognosia, Facultat de Farmacia, Universitat de Barcelona, E 08028 Barcelona, Spain
Drug News Perspect 19:453-60. 2006..Furthermore, the dual inhibitory effect of some of these drugs on cdk5 and GSK3beta could be beneficial... - Potential mechanisms involved in the prevention of neurodegenerative diseases by lithiumAntoni Camins
Unitat de Farmacologia i Farmacognòsia Facultat de Farmàcia, Centros de Investigación Biomédica en Red de Enfermedades Neurodegenerativas CIBERNED, Institut de Biomedicina IBUB Universitat de Barcelona, Barcelona, Spain
CNS Neurosci Ther 15:333-44. 2009.... - An overview of investigational antiapoptotic drugs with potential application for the treatment of neurodegenerative disordersAntoni Camins
Institut de Biomedicina IBUB, Facultat de Farmacia, Universitat de Barcelona, Barcelona, Spain
Expert Opin Investig Drugs 19:587-604. 2010..Given this new social scenario, there is a need to identify therapeutic strategies to delay the advance of these pathologies, for which no effective treatment is currently available... - Resveratrol and neurodegenerative diseases: activation of SIRT1 as the potential pathway towards neuroprotectionMerce Pallas
Facultat de Farmacia, Institut de Biomedicina IBUB, Centro de Investigación de Biomedicina en Red de Enfermedades Neurodegenerativas, Universitat de Barcelona, Nucli Universitari de Pedralbes, Barcelona, Spain
Curr Neurovasc Res 6:70-81. 2009..In addition, we discuss the possibility of using resveratrol in the treatment of neurodegenerative diseases... - Oxidative stress-induced DNA damage and cell cycle regulation in B65 dopaminergic cell lineJavier G Pizarro
Unitat de Farmacologia i Farmacognosia, Institut de Biomedicina, Centro de Investigacion Biomedica en Red de Enfermedades Neurodegenerativas, Facultat de Farmacia, Universitat de Barcelona, Nucli Universitari de Pedralbes, Barcelona, Spain
Free Radic Res 43:985-94. 2009..In summary, this study describes the molecular mechanisms involved in cell cycle alterations induced by oxidative stress in B65 cells. These findings highlight the relevance of ATM in the regulation of cell cycle after oxidative stress... - Neuroprotective action of flavopiridol, a cyclin-dependent kinase inhibitor, in colchicine-induced apoptosisElvira G Jorda
, , Universitat de Barcelona, Nucli Universitari de Pedralbes, 08028 Barcelona, Spain
Neuropharmacology 45:672-83. 2003..Our data suggest a potential therapeutic use of flavopiridol in disorders of the central nervous system in which cytoskeleton alteration mediated by cdk5 activation and Par-4 expression has been demonstrated, such as Alzheimer's disease... - ATM is involved in cell-cycle control through the regulation of retinoblastoma protein phosphorylationJavier G Pizarro
Unitat de Farmacologia i Farmacognosia, Institut de Biomedicina IBUB, Centro deInvestigacion Biomedica en Red de Enfermedades Neurodegenerativas CIBERNED, Facultat de Farmacia, Universitat de Barcelona, Nucli Universitari de Pedralbes, Barcelona E 08028, Spain
J Cell Biochem 110:210-8. 2010..Collectively, our data demonstrate how a new molecular network on ATM regulates the cell cycle through the control of pRb phosphorylation. These findings support a new target of ATM... - Effects of MPP+ on the molecular pathways involved in cell cycle control in B65 neuroblastoma cellsJavier G Pizarro
Unitat de Farmacologia i Farmacognosia, Institut de Biomedicina IBUB, Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas CIBERNED, Universitat de Barcelona, Nucli Universitari de Pedralbes, 08028 Barcelona, Spain
Pharmacol Res 61:391-9. 2010..In summary, the present work characterizes the molecular changes involved in damage caused by MPP(+) in B65 cells, and highlights the effects of MPP(+) on molecules involved in the control of cell cycle progression... - Cell cycle activation in striatal neurons from Huntington's disease patients and rats treated with 3-nitropropionic acidCarme Pelegri
Departament de Fisiologia, Facultat de Farmacia, Universitat de Barcelona, Av Joan XXIII s n, 08028 Barcelona, Spain
Int J Dev Neurosci 26:665-71. 2008..These results indicate that cell cycle re-entry is activated in Huntington's disease and may contribute to the neurodegenerative process... - Inhibition of multiple pathways accounts for the antiapoptotic effects of flavopiridol on potassium withdrawal-induced apoptosis in neuronsEster Verdaguer
, , Universitat de Barcelona, Nucli Universitari de Pedralbes, E-08028 Barcelona, Spain
J Mol Neurosci 26:71-84. 2005..We propose that the antiapoptotic properties of flavopiridol are mediated through kinase pathway inhibition... - Lithium treatment decreases activities of tau kinases in a murine model of senescenceMarta Tajes
Unitat de Farmacologia, Facultat de Farmácia Institut de Biomedicina Universitat de Barcelona, Nucli Universitari de Pedralbes, Barcelona, Spain
J Neuropathol Exp Neurol 67:612-23. 2008.... - Systemic administration of 3-nitropropionic acid points out a different role for active caspase-3 in neurons and astrocytesJoaquim Duran-Vilaregut
Departament de Fisiologia, Facultat de Farmacia, Universitat de Barcelona, Av Joan XXIII s n, 08028 Barcelona, Spain
Neurochem Int 56:443-50. 2010..This indicates the presence of a caspase-mediated apoptotic process. TUNEL was not present in control animals or in the astrocytes of treated animals. Thus, the presence of active caspase-3 in astrocytes may be merely constitutive... - Neuroprotective effects of caffeine against complex I inhibition-induced apoptosis are mediated by inhibition of the Atm/p53/E2F-1 path in cerebellar granule neuronsDaniel Alvira
Unitat de Farmacologia i Farmacognosia, Facultat de Farmacia, Universitat de Barcelona, Nucli Universitari de Pedralbes, Barcelona, Spain
J Neurosci Res 85:3079-88. 2007.... - Neuroprotective effects of SB-415286 on hydrogen peroxide-induced cell death in B65 rat neuroblastoma cells and neuronsJavier G Pizarro
Unitat de Farmacologia i Farmacognòsia i Institut de Biomedicina IBUB, Facultat de Farmacia, Universitat de Barcelona, Nucli Universitari de Pedralbes, Barcelona, Spain
Int J Dev Neurosci 26:269-76. 2008..We conclude that the GSK-3 inhibitor SB-415286 has antioxidant properties, which may explain the cytoprotective effects against H(2)O(2) damage. Furthermore, inhibition of GSK-3 activity was not involved in this protective effect... - Neuroprotective effects of (+/-)-huprine Y on in vitro and in vivo models of excitoxicity damageAnna M Canudas
, , Universitat de Barcelona, Barcelona, Spain
Exp Neurol 180:123-30. 2003..In conclusion, (+/-)-huprine Y attenuated excitotoxic-induced lesions, both in vitro and in vivo, and further evidence is provided for the potential use of this compound in the prevention of neurodegenerative disorders... - Antiapoptotic effects of roscovitine on camptothecin-induced DNA damage in neuroblastoma cellsJavier G Pizarro
Centros de Investigación Biomédica en Red Enfermedades Neurodegenerativas, Unitat de Farmacologia i Farmacognosia, Facultat de Farmacia, Institut de Biomedicina, Universitat de Barcelona, Nucli Universitari de Pedralbes, Spain
Apoptosis 16:536-50. 2011..Our findings have a potential clinical implication, suggesting that combinatory drugs in the treatment of cancer activation should be administered with caution... - Cyclosporin A enhances colchicine-induced apoptosis in rat cerebellar granule neuronsAnna Maria Canudas
, , Universitat de Barcelona, Nucli Universitari de Pedralbes, Barcelona E-08028, Spain
Br J Pharmacol 141:661-9. 2004..5. Immunohistochemical results showed a nuclear localization of cdk5 after neurotoxic treatment, which was prevented by cdk inhibitors. Thus, we propose a new mechanism of modulation of CsA neurotoxicity mediated by cdk5... - Differences in activation of ERK1/2 and p38 kinase in Jnk3 null mice following KA treatmentLuisa de Lemos
Unitat de Farmacologia i Farmacognòsia Facultat de Farmàcia, Institut de Biomedicina IBUB, Centros de Investigación Biomédica en Red de Enfermedades Neurodegenerativas CIBERNED, Universitat de Barcelona, Barcelona, Spain
J Neurochem 114:1315-22. 2010..Therefore, the data indicate that the lack of the JNK3 protein modulates other MAPKs and these changes could also have a pivotal role in neuroprotection... - Novel huprine derivatives with inhibitory activity toward ?-amyloid aggregation and formation as disease-modifying anti-Alzheimer drug candidatesElisabet Viayna
Laboratori de Química Farmacèutica Unitat Associada al CSIC, Facultat de Farmacia, and Institut de Biomedicina IBUB, Universitat de Barcelona, Av Diagonal 643, 08028, Barcelona, Spain
ChemMedChem 5:1855-70. 2010.... - A molecular study of pathways involved in the inhibition of cell proliferation in neuroblastoma B65 cells by the GSK-3 inhibitors lithium and SB-415286Javier G Pizarro
Unitat de Farmacologia i Farmacognosia, Facultat de Farmacia, Institut de Biomedicina and Centros de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Universitat de Barcelona, Nucli Universitari de Pedralbes, Barcelona, Spain
J Cell Mol Med 13:3906-17. 2009..We conclude that inhibitors of GSK-3 induced cell-cycle arrest, mediated by the phosphorylation of cdc2 and, in the case of SB-415286, SIRT2 expression, which induced apoptosis in a caspase-independent manner... - Antiapoptotic effects of roscovitine in cerebellar granule cells deprived of serum and potassium: a cell cycle-related mechanismEster Verdaguer
, , Universitat de Barcelona, Nucli Universitari de Pedralbes, E-08028 Barcelona, Spain
Neurochem Int 44:251-61. 2004..We suggest that the antiapoptotic effects of roscovitine on CGNs are due to its anti-proliferative efficacy and to an action on the mitochondrial apoptotic mechanism... - Kainate-induced toxicity in the hippocampus: potential role of lithiumNatalia Crespo-Biel
Unitat de Farmacologia i Farmacognòsia i Institut de Biomedicina IBUB i Centro de Investigación de Biomedicina en Red de Enfermedades Neurodegenerativas CIBERNED, Facultat de Farmacia, Universitat de Barcelona, Nucli Universitari de Pedralbes, Barcelona, Spain
Bipolar Disord 12:425-36. 2010..We investigated the neuroprotective effects of lithium in an experimental neurodegeneration model gated to kainate (KA) receptor activation... - Time-course of blood-brain barrier disruption in senescence-accelerated mouse prone 8 (SAMP8) miceJaume del Valle
Departament de Fisiologia, Facultat de Farmacia, Universitat de Barcelona, Av Joan XXIII s n, 08028 Barcelona, Spain
Int J Dev Neurosci 27:47-52. 2009..On the other hand, as blood-brain barrier permeability in SAMP8 mice increases with age, blood-brain barrier alterations may contribute to the cerebral pathology observed in this strain... - p21(WAF1/Cip1) is not involved in kainic acid-induced apoptosis in murine cerebellar granule cellsEster Verdaguer
Unitat de Farmacologia i Farmacognosia, Facultat de Farmacia, Universitat de Barcelona, Nucli Universitari de Pedralbes, E 08028 Barcelona, Spain
Brain Res 1030:297-302. 2004..Data suggest that p21(WAF/Cip) was unable to modulate KA-induced apoptosis in murine CGNs... - Early amyloid accumulation in the hippocampus of SAMP8 miceJaume del Valle
Departament de Fisiologia, Facultat de Farmacia, Universitat de Barcelona, Barcelona, Spain
J Alzheimers Dis 19:1303-15. 2010..The demonstration that SAMP8 mice present with amyloid deposits in their hippocampus makes this animal model a useful tool to understand the mechanisms involved in Abeta deposition in AD... - Study of the pathways involved in apoptosis induced by PI3K inhibition in cerebellar granule neuronsAurelio Vazquez De la Torre
Unitat de Farmacologia i Farmacognosia, Facultat de Farmacia, Centros de Investigación Biomédica en Red Enfermedades Neurodegenerativas CIBERNED, Institut de Biomedicina, Universitat de Barcelona, Nucli Universitari de Pedralbes, 08028 Barcelona, Spain
Neurochem Int 59:159-67. 2011.... - Inhibition of CDKs: a strategy for preventing kainic acid-induced apoptosis in neuronsE Verdaguer
Unitat de Farmacologia i Farmacognosia, Facultat de Farmacia, Universitat de Barcelona, Barcelona, Spain
Ann N Y Acad Sci 1010:671-4. 2003..We concluded that CDK activation is involved, at least, in part, in the pro-apoptotic effects of kainic acid... - Evaluation of potential pro-survival pathways regulated by melatonin in a murine senescence modelJavier Gutierrez-Cuesta
Unitat de Farmacologia i Farmacognòsia Facultat de Farmàcia, Institut de Biomedicina IBUB, Centros de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Universitat de Barcelona, Nucli Universitari de Pedralbes, Barcelona, Spain
J Pineal Res 45:497-505. 2008..Melatonin reduced all these changes. We conclude that melatonin improves pro-survival signals and reduces pro-death signals in age-related impairments of neural processes... - Prosurvival role of JAK/STAT and Akt signaling pathways in MPP+-induced apoptosis in neuronsFelix Junyent
Institut de Biomedicina IBUB, Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas CIBERNED, Facultat de Farmacia, Universitat de Barcelona, Barcelona, Spain
Neurochem Int 57:774-82. 2010..Meanwhile Akt activation, using a PTEN inhibitor, did not play a prominent role in neuroprotection; loss of STAT3 could be a signal pathway involved in neuroprotection against the Parkinsonian neurotoxin MPP(+)... - DNA low-density array analysis of colchicine neurotoxicity in rat cerebellar granular neuronsMarc Yeste-Velasco
Facultat de Farmacia, Universitat de Barcelona, Nucli Universitari de Pedralbes, 08028 Barcelona, Spain
Neurotoxicology 29:309-17. 2008..Present data may help to a better understanding of the molecular mechanisms involved in cytoskeletal degradation-induced apoptosis in neurons... - Tau hyperphosphorylation and axonal damage induced by N,N-diethyldithiocarbamate (DEDTC) treatment along late postnatal development is followed by a rescue during adulthoodJuana Utrera
Departament de Biologia Cellular, Facultat Biologia, Universitat Barcelona, Barcelona, Spain
J Neurosci Res 88:1083-93. 2010..All these data support the idea that the axonal damage induced by DEDTC treatment along postnatal development is followed by an axonal rescue during adulthood... - Content and traffic of taurine in hippocampal reactive astrocytesFelix Junyent
Unitat de Farmacologia i Farmacognòsia Facultat de Farmàcia, Institut de Biomedicina IBUB, Centros de Investigación Biomédica en Red de Enfermedades Neurodegenerativas CIBERNED, Universitat de Barcelona, Spain
Hippocampus 21:185-97. 2011..All data obtained indicate that astrocytes could play a key role in taurine level changes induced by neuronal damage. More studies are, therefore, needed to clarify the role taurine has in relation to neuronal death and repair... - Kainic acid-induced neuronal cell death in cerebellar granule cells is not prevented by caspase inhibitorsEster Verdaguer
, , Universitat de Barcelona, Nucli Universitari de Pedralbes, E-08028 Barcelona, Spain
Br J Pharmacol 135:1297-307. 2002..5. The calpain inhibitor ALLN had no effect on KA or colchicine-induced neurotoxicity. 6. Our findings indicate that colchicine-induced apoptosis in CGCs is mediated by caspase-3 activation, unlike KA-induced apoptosis... - Kainic acid-induced apoptosis in cerebellar granule neurons: an attempt at cell cycle re-entryEster Verdaguer
, , Universitat de Barcelona, Nucli Universitari de Pedralbes, E-08028 Barcelona, Spain
Neuroreport 13:413-6. 2002..Western blot analysis showed that KA induced an increase in the expression of Cdk2, cyclin E and E2F-1. It is proposed that, in post-mitotic cells like CGNs, re-entry cell cycle could be responsible for the apoptotic effect of KA... - The p38(MAPK) signaling pathway regulates neuronal apoptosis through the phosphorylation of the retinoblastoma proteinMarc Yeste-Velasco
Unitat de Farmacologia i Farmacognosia, Facultat de Farmacia, Institut de Biomedicina IBUB, Centros de Investigación Biomédica en Red de Enfermedades Neurodegenerativas CIBERNED, Universitat de Barcelona, Avinguda Diagonal 643, 08028 Barcelona, Spain
Neurochem Int 54:99-105. 2009..In conclusion, these results suggest that p38MAPK converged with the cell cycle in S/K deprivation-induced apoptosis through pRb phosphorylation... - Characterization of amyloid-? granules in the hippocampus of SAMP8 miceGemma Manich
Departament de Fisiologia, Facultat de Farmacia, Universitat de Barcelona, Barcelona, Spain
J Alzheimers Dis 25:535-46. 2011..As the components identified in A? granules are characteristic of the aggregates present in some neurodegenerative diseases, the SAMP8 model seems to be appropriate for the study of the processes involved in these pathologies... - Neuronal apoptosis in the striatum of rats treated with 3-nitropropionic acid is not triggered by cell-cycle re-entryJoaquim Duran-Vilaregut
Departament de Fisiologia, Facultat de Farmacia, Universitat de Barcelona, Av Joan XXIII s n, E 08028 Barcelona, Spain
Neurotoxicology 32:734-41. 2011.... - GSK-3 beta inhibition and prevention of mitochondrial apoptosis inducing factor release are not involved in the antioxidant properties of SB-415286Marc Yeste-Velasco
Unitat de Farmacologia i Farmacognòsia and Institut de Biomedicina IBUB, Facultat de Farmacia, Universitat de Barcelona, Nucli Universitari de Pedralbes, 08028 Barcelona, Spain
Eur J Pharmacol 588:239-43. 2008..However, these antioxidant properties are independent of GSK-3 beta inhibition and prevention of mitochondrial AIF release... - Gene expression profile in JNK3 null mice: a novel specific activation of the PI3K/AKT pathwayFelix Junyent
Unitat de Farmacologia i Farmacognosia, Facultat de Farmacia, Institut de Biomedicina IBUB, Centros de Investigación Biomédica en Red de Enfermedades Neurodegenerativas CIBERNED, Universitat de Barcelona, Barcelona, Spain
J Neurochem 117:244-52. 2011..Therefore, our results indicate that the activation of PI3K/AKT pathway in hippocampus because of the increase in pik3cb transcription and that this mechanism is specifically related to the lack of Jnk3... - Activation of Akt by lithium: pro-survival pathways in agingMarta Tajes
Unitat de Farmacologia i Farmacognòsia Facultat de Farmàcia, Institut de Biomedicina, Centros de Investigación Biomédica en Red de Enfermedades Neurodegenerativas CIBERNED, Universitat de Barcelona, Nucli Universitari de Pedralbes, Barcelona, Spain
Mech Ageing Dev 130:253-61. 2009..These results demonstrate the effectiveness of lithium in preventing age-related neural loss and the potential therapeutic applications of lithium in treatment/prevention of neurological disease... - Inhibition of the cdk5/p25 fragment formation may explain the antiapoptotic effects of melatonin in an experimental model of Parkinson's diseaseDaniel Alvira
, Facultat de Farmacia, Universitat de Barcelona, Nucli Universitari de Pedralbes, Barcelona, Spain
J Pineal Res 40:251-8. 2006..Moreover, these data suggest that the calpain/cdk5 signaling cascade has a potential role in the MPP+ -mediated apoptotic process in CGNs... - Antiapoptotic drugs: a therapautic strategy for the prevention of neurodegenerative diseasesFrancesc X Sureda
Unitat de Farmacologia, Centros de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Facultat de Medicina i Ciencies de la Salut, Universitat Rovira i Virgili, Reus, Tarragona, Spain
Curr Pharm Des 17:230-45. 2011..This research contributes to the development of new methods in the field of apoptosis inhibitors that could provide the future tools for the treatment of Alzheimer's and Parkinson's disease, as well as other neurodegenerative diseases... - Resveratrol inhibits proliferation and promotes apoptosis of neuroblastoma cells: role of sirtuin 1Javier G Pizarro
Institut de Biomedicina IBUB, Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas CIBERNED, Facultat de Farmacia, Universitat de Barcelona, Barcelona, Spain
Neurochem Res 36:187-94. 2011..Our results show that a decrease in SIRT1 content, caused by exposure to resveratrol, does not appear to be involved in cell-cycle arrest or activation of apoptosis... - From aging to Alzheimer's disease: unveiling "the switch" with the senescence-accelerated mouse model (SAMP8)Merce Pallas
Unitat de Farmacologia, Facultat de Farmàcia Institut de Biomedicina Universitat de Barcelona IBUB, Nucli Universitari de Pedralbes, Barcelona, Spain
J Alzheimers Dis 15:615-24. 2008..Here, the neurochemical, neuropathological, and behavioral alterations, characterized in SAMP8 mice are critically reviewed and discussed in relation to the potential use of this mouse model in the study of AD pathogenesis... - Chronic administration of melatonin reduces cerebral injury biomarkers in SAMP8Javier Gutierrez-Cuesta
Unitat de Farmacologia i Farmacognosia, Facultat de Farmàcia and Institut de Biomedicina, Universitat de Barcelona, Nucli Universitari de Pedralbes, Barcelona, Spain
J Pineal Res 42:394-402. 2007..Moreover, these data suggest that the cdk5/GSKbeta signaling cascade has a potential role as a target for neurodegenerative diseases related to aging... - Calpains as a target for therapy of neurodegenerative diseases: putative role of lithiumAntoni Camins
Institut de Biomedicina, Centros de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Universitat de Barcelona Nucli Universitari de Pedralbes, Barcelona, Spain
Curr Drug Metab 10:433-47. 2009.... - GSK3? inhibition is involved in the neuroprotective effects of cyclin-dependent kinase inhibitors in neuronsAurelio Vazquez de la Torre
Unitat de Farmacologia i Farmacognosia, Facultat de Farmacia, Centros de Investigación Biomédica en Red Enfermedades Neurodegenerativas CIBERNED, Institut de Biomedicina IBUB, Universitat de Barcelona, Nucli Universitari de Pedralbes, 08028 Barcelona, Spain
Pharmacol Res 65:66-73. 2012..Therefore, our data identify GSK3? as a crucial mediator of CGN apoptosis induced by PI3K inhibition and indicate that the antiapoptotic effects of CDKs are mediated by the inhibition of this pharmacological target... - Cerebral amyloid angiopathy, blood-brain barrier disruption and amyloid accumulation in SAMP8 miceJaume del Valle
Departament de Fisiologia, Facultat de Farmacia, Barcelona, Spain
Neurodegener Dis 8:421-9. 2011..Finally, we can conclude that vascular amyloid deposition seems to induce BBB alterations, but BBB disruption may also be due to other factors... - New oxapolycyclic cage amines with NMDA receptor antagonist and trypanocidal activitiesMaría D Duque
Laboratori de Química Farmacèutica, Unitat Associada al CSIC, Facultat de Farmacia, and Institute of Biomedicine, Universitat de Barcelona, Av Diagonal, 643, Barcelona E 08028, Spain
Bioorg Med Chem 18:46-57. 2010..Several of them display very similar activity to memantine as NMDA receptor antagonists. Several derivatives showed a significant level of trypanocidal activity... - The antiproliferative activity of melatonin in B65 rat dopaminergic neuroblastoma cells is related to the downregulation of cell cycle-related genesJavier G Pizarro
Unitat de Farmacologia i Farmacognosia, Facultat de Farmacia, Universitat de Barcelona, Nucli Universitari de Pedralbes, Barcelona, Spain
J Pineal Res 45:8-16. 2008.... - 3-Nitropropionic acid activates calpain/cdk5 pathway in rat striatumNatalia Crespo Biel
Unitat de Farmacologia i Farmacognosia, Facultat de Farmacia, Universitat de Barcelona, Nucli Universitari de Pedralbes, E 08028 Barcelona, Spain
Neurosci Lett 421:77-81. 2007..We suggest that calpain/cdk5 activation could also be a common pathway activated in other neurodegenerative diseases, which is liable to be targeted... - Blood-brain barrier disruption in the striatum of rats treated with 3-nitropropionic acidJoaquim Duran-Vilaregut
Departament de Fisiologia, Facultat de Farmacia, Universitat de Barcelona, Av Joan XXIII s n, 08028 Barcelona, Spain
Neurotoxicology 30:136-43. 2009..We conclude that the BBB is severely affected in the 3-NPA rat model of HD and that disruption of this barrier is a crucial event during the development of this disease... - A new method for determining blood-brain barrier integrity based on intracardiac perfusion of an Evans Blue-Hoechst cocktailJaume del Valle
Departament de Fisiologia, Facultat de Farmacia, Universitat de Barcelona, Av Joan XXIII s n, Barcelona, Spain
J Neurosci Methods 174:42-9. 2008..Thus, immunohistochemistry has been used here to determine the nature of intense EB fluorescent cells that appear in the perilesional rim, which were identified here as neuronal cells... - Dysfunction of astrocytes in senescence-accelerated mice SAMP8 reduces their neuroprotective capacitySilvia García-Matas
Department of Pharmacology and Toxicology, Institut d Investigacions Biomediques de Barcelona, CSIC IDIBAPS, Barcelona, Spain
Aging Cell 7:630-40. 2008..In addition, our study supports the contention that astrocytes play a key role in neurodegeneration during the aging process... - Increased permeability of blood-brain barrier on the hippocampus of a murine model of senescenceCarme Pelegri
Departament de Fisiologia, Facultat de Farmacia, Universitat de Barcelona, Av Joan XXIII s n, 08028 Barcelona, Spain
Mech Ageing Dev 128:522-8. 2007..We have found significantly higher levels of IgG extravasation in the hippocampus of 12-month-old SAMP8 mice compared to SAMR1 mice, indicating an increased permeability of BBB in aged senescence-accelerated mice... - Hyperphosphorylation of microtubule-associated protein tau in senescence-accelerated mouse (SAM)Anna M Canudas
Unitat de Farmacologia i Farmacognosia, Facultat de Farmacia, Universitat de Barcelona, Nucli Universitari de Pedralbes, E 08028 Barcelona, Spain
Mech Ageing Dev 126:1300-4. 2005..In conclusion, tau hyperphosphorylation occurs in SAMP-8 (early senescent) mice, indicating a link between aging and tau modifications in this murine model... - Modulation of sirtuins: new targets for antiageingMerce Pallas
Unitat de Farmacologia i Farmacognòsia i Institut de Biomedicina IBUB, Facultat de Farmacia, Universitat de Barcelona, Nucli Universitari de Pedralbes, E 08028 Barcelona, Spain
Recent Pat CNS Drug Discov 3:61-9. 2008.... - Synthesis, uptake and release of taurine in astrocytes treated with 8-Br-cAMPFelix Junyent
Unitat de Farmacologia i Farmacognòsia Facultat de Farmàcia, Institut de Biomedicina, Centros de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Universitat de Barcelona, Avda Diagnol 643, 08028 Barcelona, Spain
Neurosci Lett 467:199-202. 2009..The data indicate that taurine synthesis and traffic kinetics vary according to the differentiation state of the astrocytes. Thus, our results highlight the importance of astrocytes in modulating taurine levels in the brain... - Involvement of calpain activation in neurodegenerative processesAntoni Camins
, , Nucli Universitari de Pedralbes, Barcelona, Spain
CNS Drug Rev 12:135-48. 2006..The inhibition of calpain activation has recently emerged as a potential therapeutic target for the treatment of neurodegenerative diseases... - Carnosine prevents methamphetamine-induced gliosis but not dopamine terminal loss in ratsDavid Pubill
, , Universitat de Barcelona, Avgda. Diagonal 643, 08028 Barcelona, Spain
Eur J Pharmacol 448:165-8. 2002..Therefore, carnosine inhibits only some of the consequences of methamphetamine neurotoxicity, where reactive oxygen species play an important role... - Molecular and biochemical features in Alzheimer's diseaseMerce Pallas
Unitat de Farmacologia i Farmacognosia, Facultat de Farmacia, Universitat de Barcelona, Nucli Universitari de Pedralbes, E 08028 Barcelona, Spain
Curr Pharm Des 12:4389-408. 2006..Finally, a multiple therapy with antioxidants, cell cycle inhibitors and other drugs modulating APP processing could be, in the future, a suitable strategy in order to delay Alzheimer's disease progression... - Novel donepezil-based inhibitors of acetyl- and butyrylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregationPelayo Camps
Laboratori de Química Farmacèutica Unitat Associada al CSIC, Facultat de Farmacia, Barcelona, Spain
J Med Chem 51:3588-98. 2008..Moreover, six out of the eight hybrids of the series, particularly those bearing an indane moiety, exhibit a significant A beta antiaggregating activity, which makes them promising anti-Alzheimer drug candidates... - Evaluation of neuronal cell death by laser scanning cytometryEster Verdaguer
, , Universitat de Barcelona, Nucli Universitari de Pedralbes, E-08028, Barcelona, Spain
Brain Res Brain Res Protoc 9:41-8. 2002..The protocol presented here, provides a fast and sensitive assay for the analysis of neuronal viability using LSC, and can be used to study new neuroprotective drugs in neuronal cell cultures... - Activation of the calpain/cdk5/p25 pathway in the girus cinguli in Parkinson's diseaseDaniel Alvira
Unitat de Farmacologia i Farmacognosia, Facultat de Farmacia, Universitat de Barcelona, Nucli Universitari de Pedralbes, 08028 Barcelona, Spain
Parkinsonism Relat Disord 14:309-13. 2008..Our results implicate the cdk5/p25 pathway and re-entry into the cell cycle in the process of neuronal loss in patients with PD... - Hypertriglyceridemia and hepatic steatosis in senescence-accelerated mouse associate to changes in lipid-related gene expressionLaia Vilà
Department of Pharmacology and Therapeutic Chemistry, University of Barcelona, Barcelona, Spain
J Gerontol A Biol Sci Med Sci 62:1219-27. 2007..Triglyceride accretion and a deficit in hepatic fatty acid oxidation, features of the aging process in mammals, associate to a deficit in hepatic FXR activity in the SAM-P8 mice... - Implication of the transcription factor E2F-1 in the modulation of neuronal apoptosisEster Verdaguer
Departament de Farmacologia i Toxicologia, IIBB CSIC, IDIBAPS, Rossello 161, Planta 6, 08036 Barcelona, Spain
Biomed Pharmacother 61:390-9. 2007.... - Changes in oxidative stress parameters and neurodegeneration markers in the brain of the senescence-accelerated mice SAMP-8Francesc X Sureda
Unitat de Farmacologia, Facultat de Medicina i Ciencies de la Salut, Universitat Rovira i Virgili, C St Llorenç 21, E 43201 Reus, Tarragona, Spain
Exp Gerontol 41:360-7. 2006.... - Inhibition of the cdk5/MEF2 pathway is involved in the antiapoptotic properties of calpain inhibitors in cerebellar neuronsEster Verdaguer
, , , 16-18, 04107 Leipzig, Germany
Br J Pharmacol 145:1103-11. 2005..Calpain inhibitors may attenuate S/K withdrawal-induced apoptosis and may provide a potential therapeutic target for drug treatment in a neurodegenerative process... - Neuroprotection associated with alternative splicing of NMDA receptors in rat cortical neuronsBeate Jaekel
Rudolf-Boehm-Institute of Pharmacology and Toxicology, University of Leipzig, , D-04107 Leipzig, Germany
Br J Pharmacol 147:622-33. 2006..Accordingly, alternative splicing could be an endogenous mechanism to counteract cellular damage due to overactivation of excitatory NRs and may be associated with an impairment of necrotic mechanisms... - Peroxisome proliferator-activated receptor alpha down-regulation is associated with enhanced ceramide levels in age-associated cardiac hypertrophyRicardo Rodríguez-Calvo
Pharmacology Unit, Department of Pharmacology and Therapeutic Chemistry, and IBUB, Faculty of Pharmacy, University of Barcelona, Spain
J Gerontol A Biol Sci Med Sci 62:1326-36. 2007..05). These findings suggest that NF-kappaB activation in SAM-P8 heart prevents PPARalpha from binding to its response elements leading to changes in gene expression that may lead to ceramide accumulation in the aged heart... - Carbonyl stress and NMDA receptor activation contribute to methylglyoxal neurotoxicitySusana Garcia de Arriba
Rudolf-Boehm Institute Pharmacology and Toxicology, University of Leipzig, Germany
Free Radic Biol Med 40:779-90. 2006..In conclusion, carbonyl scavengers as well as NMDA receptor antagonists may represent effective therapeutic tools to reduce the risk of pathophysiological changes associated with carbonyl stress in neurodegenerative diseases... - Different capacities of various NMDA receptor antagonists to prevent ischemia-induced neurodegeneration in human cultured NT2 neuronsSusana Garcia de Arriba
Rudolf-Boehm-Institute of Pharmacology and Toxicology, University of Leipzig, Leipzig, Germany
Neurochem Int 49:466-74. 2006..Accordingly, glycine antagonists might not represent an optimal therapeutic strategy for preventing ischemic neuronal damage in contrast to NMDA receptor antagonists like memantine... - Flow cytometric determination of cytoplasmic oxidants and mitochondrial membrane potential in neuronal cellsFrancesc X Sureda
Pharmacology Unit, Universitat Rovira i Virgili, 43201 Reus, Tarragona, Spain
Methods Enzymol 352:71-9. 2002