Research Topics
| Marina GordalizaSummaryAffiliation: Universidad de Salamanca Country: Spain Publications
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Detail Information
Publications
Cytotoxic terpene quinones from marine spongesMarina Gordaliza
Department of Pharmaceutical Chemistry, Pharmacy Faculty, Salamanca University, Campus Miguel de Unamuno, Salamanca, Spain
Mar Drugs 8:2849-70. 2010..The present review summarizes the structure and cytotoxicity of natural terpenequinones/hydroquinones and their bioactive analogues and derivatives...- Synthetic strategies to terpene quinones/hydroquinonesMarina Gordaliza
Farmacy Faculty and Institute of Science and Technology Studies, Campus Miguel de Unamuno, Salamanca University, 37007 Salamanca, Spain
Mar Drugs 10:358-402. 2012..A review dealing with different strategies for obtaining bioactive terpenyl quinones/hydroquinones is presented. The different synthetic approches for the preparation of the most relevant quinones/hydroquinones are described... - Terpenyl-purines from the seaMarina Gordaliza
Department of Pharmaceutical Chemistry, Pharmacy Faculty, Salamanca University, Campus Miguel de Unamuno, Salamanca, Spain
Mar Drugs 7:833-49. 2009..This review summarizes the sources of isolation, chemistry and bioactivity of marine alkylpurines and their bioactive derivatives... - Natural products as leads to anticancer drugsM Gordaliza
Departamento de Quimica Farmaceutica, Facultad de Farmacia, Universidad de Salamanca, Salamanca, Spain
Clin Transl Oncol 9:767-76. 2007..Combinatorial biosynthesis is also applied for the modification of natural microbial products. Likewise, advances in genomics and the advent of biotechnology have improved both the discovery and production of new natural compounds... - Podophyllotoxin: distribution, sources, applications and new cytotoxic derivativesM Gordaliza
Departamento de Quimica Farmaceutica, Facultad de Farmacia, Universidad de Salamanca, 37007 Salamanca, Spain
Toxicon 44:441-59. 2004..Most of the compounds maintained their cytotoxicity at the microM level. Distribution, biosynthesis, production, biotechnology, applications and synthesis have also been reviewed... - Synthesis and cytotoxicity of new heterocyclic terpenylnaphthoquinonesJosé M Miguel Del Corral
Departamento de Quimica Farmaceutica, Facultad de Farmacia, Universidad de Salamanca, E 37007 Salamanca, Spain
Bioorg Med Chem 14:2816-27. 2006..The compounds synthesized have been evaluated against neoplastic cell lines. The extension of the polycyclic system clearly decreased the cytotoxic potency of the 2-substituted terpenylnaphthoquinones... - Synthesis and cytotoxic evaluation of C-9 oxidized podophyllotoxin derivativesMa Angeles Castro
Departamento de Quimica Farmaceutica, Facultad de Farmacia, Campus Miguel de Unamuno, Universidad de Salamanca, 37007 Salamanca, Spain
Bioorg Med Chem 15:1670-8. 2007.... - Synthesis and cytotoxicity of new aminoterpenylquinonesJosé M Miguel Del Corral
Departamento de Quimica Farmaceutica, Facultad de Farmacia, Universidad de Salamanca, E 37007 Salamanca, Spain
Bioorg Med Chem 13:631-44. 2005..Of particular interest is substitution by arylamino, specifically p-oxyarylamino, groups, which considerably enhance their bioactivity and selectivity... - Synthesis, cytotoxicity and antiviral activity of podophyllotoxin analogues modified in the E-ringM Angeles Castro
Departamento de Quimica Farmaceutica, Facultad de Farmacia, Universidad de Salamanca, 37007 Salamanca, Spain
Eur J Med Chem 38:899-911. 2003..Most of the compounds maintained their cytotoxicity at the muM level and some of them showed antiherpetic activity... - Synthesis and cytotoxicity of podophyllotoxin analogues modified in the A ringAngeles Castro
Departamento de Quimica Farmaceutica, Facultad de Farmacia, Universidad de Salamanca, 37007 Salamanca, Spain
Eur J Med Chem 38:65-74. 2003..Most of them maintained their cytotoxicity at the microM level... - Synthesis and biological evaluation of new selective cytotoxic cyclolignans derived from podophyllotoxinMaria Angeles Castro
Departamento de Quimica Farmaceutica, Facultad de Farmacia, Universidad de Salamanca, E 37007 Salamanca, Spain
J Med Chem 47:1214-22. 2004.... - Cytotoxic cyclolignans related to podophyllotoxinM Gordaliza
Departamento de Quimica Farmaceutica, Facultad de Farmacia, Campus Miguel de Unamuno, Universidad de Salamanca, Spain
Farmaco 56:297-304. 2001..Several cyclolignans related to podophyllotoxin have been prepared and evaluated for their cytotoxic activities on four neoplastic cell lines (P-388, A-549, HT-29 and MEL-28); some of them have antiviral and immunosuppressive activities... - New selective cytotoxic diterpenylquinones and diterpenylhydroquinonesJ M Miguel del Corral
Departamento de Quimica Farmaceutica, Facultad de Farmacia, Universidad de Salamanca, E 37007 Salamanca, Spain
J Med Chem 44:1257-67. 2001..The results showed an important selectivity toward renal cancer lines, identifying these compounds as a very promising group of antineoplastics... - Synthesis and antineoplastic activity of cyclolignan aldehydesM Gordaliza
Departamento de Quimica Farmaceutica, Facultad de Farmacia, Universidad de Salamanca, E 37007, Salamanca, Spain
Eur J Med Chem 35:691-8. 2000..All of them lacked the lactone ring but maintained their cytotoxicity at, or under, the microM level... - Synthesis and biological evaluation of cytotoxic 6(7)-alkyl-2-hydroxy-1, 4-naphthoquinonesJosé M Miguel Del Corral
Departamento de Quimica Farmaceutica, Facultad de Farmacia, Universidad de Salamanca, E 37007 Salamanca, Spain
Arch Pharm (Weinheim) 335:427-37. 2002..The compounds thus prepared were evaluated for their cytotoxic activity against several neoplastic cultured cell lines and some of them showed IC50 values below the microM level...