Research Topics
| Mario David CorderoSummaryAffiliation: Universidad Pablo de Olavide Country: Spain Publications
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Detail Information
Publications
[Low levels of serotonin in serum correlates with severity of fibromyalgia]Mario David Cordero
Centro Andaluz de Biologia del Desarrollo CABD, Universidad Pablo de Olavide CSIC y Centro de Investigación Biomédica en Red de Enfermedades Raras CIBERER, ISCIII, Sevilla, Espana
Med Clin (Barc) 135:644-6. 2010..The aim of the present study was to assess the correlation levels between low levels of serotonin and severity of symptoms in FM...
Coenzyme Q?? in salivary cells correlate with blood cells in Fibromyalgia: improvement in clinical and biochemical parameter after oral treatmentMario D Cordero
Centro Andaluz de Biologia del Desarrollo, Universidad Pablo de Olavide CSIC Junta de Andalucía, ISCIII, Sevilla, Spain
Clin Biochem 45:509-11. 2012..We have determined Coenzyme Q(10) (CoQ(10)) levels in salivary cells (SCs) and mononuclear blood cells (BMCs) from Fibromyalgia (FM), and we study the influence of oral CoQ(10) supplementation on cells levels and clinical symptoms...
Clinical symptoms in fibromyalgia are better associated to lipid peroxidation levels in blood mononuclear cells rather than in plasmaMario D Cordero
Centro Andaluz de Biologia del Desarrollo, Universidad Pablo de Olavide CSIC and Centro de Investigación Biomédica en Red de Enfermedades Raras, ISCIII, Sevilla, Spain
PLoS ONE 6:e26915. 2011..We examined lipid peroxidation (LPO) in blood mononuclear cells (BMCs) and plasma, as a marker of oxidative damage, and its association to clinical symptoms in Fibromyalgia (FM) patients...
Coenzyme Q(10): a novel therapeutic approach for Fibromyalgia? case series with 5 patientsMario D Cordero
Centro Andaluz de Biologia del Desarrollo CABD, Universidad Pablo de Olavide CSIC, Sevilla, Spain
Mitochondrion 11:623-5. 2011..Determination of deficiency and consequent supplementation in FM may result in clinical improvement. Further analysis involving more scientifically rigorous methodology will be required to confirm this observation...
Mitochondrial dysfunction in skin biopsies and blood mononuclear cells from two cases of fibromyalgia patientsMario D Cordero
Centro Andaluz de Biologia del Desarrollo, CABD, Universidad Pablo de Olavide CSIC and Centro de Investigación Biomédica en Red de Enfermedades Raras, CIBERER, ISCIII, Sevilla, Spain
Clin Biochem 43:1174-6. 2010..The aim of this study was to analyze CoQ(10) levels, mitochondrial dysfunction, and oxidative stress in plasma, blood mononuclear cells, and skin biopsies from FM patients...
Mitochondrial dysfunction and mitophagy activation in blood mononuclear cells of fibromyalgia patients: implications in the pathogenesis of the diseaseMario D Cordero
Centro Andaluz de Biologia del Desarrollo CABD, Universidad Pablo de Olavide CSIC, Ctra, de Utrera, km, 1, ISCIII, Sevilla 41013, Spain
Arthritis Res Ther 12:R17. 2010..Furthermore, the role of mitochondria in the redox imbalance reported in fibromyalgia also is controversial. We undertook this study to investigate the role of mitochondrial dysfunction, oxidative stress, and mitophagy in fibromyalgia...
Acute oxidant damage promoted on cancer cells by amitriptyline in comparison with some common chemotherapeutic drugsMario David Cordero
Departamento Citología e Histología Normal y Patológica, Facultad de Medicina, Universidad de Sevilla, Sevilla, Spain
Anticancer Drugs 21:932-44. 2010..In conclusion, based on the capacity of generating ROS and inhibiting antioxidants in tumor cells, amitriptyline emerges as a promising new drug to be tested for anticancer therapy...
[Mitochondrial dysfunction in fibromyalgia and its implication in the pathogenesis of disease]Mario David Cordero
Centro Andaluz de Biologia del Desarrollo, Universidad Pablo de Olavide CSIC y Centro de Investigación Biomédica en Red de Enfermedades Raras, Instituto Carlos III, Sevilla, Espana
Med Clin (Barc) 136:252-6. 2011....
Mitochondrial dysfunction promoted by Porphyromonas gingivalis lipopolysaccharide as a possible link between cardiovascular disease and periodontitisPedro Bullon
Department of Periodontology, Dental School, University of Sevilla, Sevilla, Spain
Free Radic Biol Med 50:1336-43. 2011..In conclusion, mitochondrial dysfunction could represent a possible link to understanding the interrelationships between two prominent inflammatory diseases: periodontitis and CVD...
The apoptotic microtubule network preserves plasma membrane integrity during the execution phase of apoptosisJosé A Sánchez-Alcázar
Centro Andaluz de Biologia del Desarrollo, Universidad Pablo de Olavide CSIC, Carretera de Utrera Km 1, Sevilla, 41013, Spain
Apoptosis 12:1195-208. 2007..We propose that apoptotic microtubule network is required to maintain plasma membrane integrity during the execution phase of apoptosis...
Coenzyme Q deficiency triggers mitochondria degradation by mitophagyAngeles Rodriguez-Hernandez
Centro Andaluz de Biologia del Desarrollo CABD, and Centro de Investigación Biomédica en Red Enfermedades Raras, Instituto de Salud Carlos III, Universidad Pablo de Olavide Consejo Superior de Investigaciones Científicas, Sevilla, Spain
Autophagy 5:19-32. 2009....
Coenzyme Q10 and alpha-tocopherol protect against amitriptyline toxicityMario D Cordero
Centro Andaluz de Biología de Desarrollo CABD, Universidad Pablo de Olavide CSIC, and Centro de Investigación Biomédica en Red de Enfermedades Raras CIBERER, ISCIII, Sevilla, Spain
Toxicol Appl Pharmacol 235:329-37. 2009..Amitriptyline significantly increased embryonic cell death and apoptosis rate, and both antioxidants provided a significant protection against amitriptyline embryotoxicity...
Missense mutation of the COQ2 gene causes defects of bioenergetics and de novo pyrimidine synthesisJosé M López-Martín
Centro Andaluz de Biologia del Desarrollo, Universidad Pablo de Olavide CSIC, 41013 Sevilla, Spain
Hum Mol Genet 16:1091-7. 2007..Moreover, we demonstrate that CoQ(10) deficiency in addition to the bioenergetics defect also impairs de novo pyrimidine synthesis, which may contribute to the pathogenesis of the disease...
