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Species | Pilar CaroSummaryAffiliation: Universidad Complutense Country: Spain Publications
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Publications
Effect of 40% restriction of dietary amino acids (except methionine) on mitochondrial oxidative stress and biogenesis, AIF and SIRT1 in rat liverPilar Caro
Departamento de Fisiología Animal II, Universidad Complutense, Madrid, Spain
Biogerontology 10:579-92. 2009..They also show for the first time that restriction of dietary amino acids different from methionine decreases mitochondrial protein oxidative modification and AIF, and increases SIRT1, in rat liver...- Forty percent methionine restriction decreases mitochondrial oxygen radical production and leak at complex I during forward electron flow and lowers oxidative damage to proteins and mitochondrial DNA in rat kidney and brain mitochondriaPilar Caro
Department of Animal Physiology II, Complutense University of Madrid, Madrid, Spain
Rejuvenation Res 12:421-34. 2009..We conclude that methionine is the only dietary factor responsible for the decrease in mitochondrial ROS production and oxidative stress, and likely for part of the longevity extension effect, occurring in DR... - Effect of methionine dietary supplementation on mitochondrial oxygen radical generation and oxidative DNA damage in rat liver and heartJose Gomez
Department of Animal Physiology II, Faculty of Biological Sciences, Complutense University, Madrid, Spain
J Bioenerg Biomembr 41:309-21. 2009..These results show that methionine supplementation in the diet specifically increases mitochondrial ROS production and mitochondrial DNA oxidative damage in rat liver mitochondria offering a plausible mechanism for its hepatotoxicity... - Methionine restriction decreases mitochondrial oxygen radical generation and leak as well as oxidative damage to mitochondrial DNA and proteinsAlberto Sanz
Department of Animal Physiology-II, Complutense University, Madrid, Spain
FASEB J 20:1064-73. 2006.... - Forty percent and eighty percent methionine restriction decrease mitochondrial ROS generation and oxidative stress in rat liverPilar Caro
Departamento de Fisiología Animal II, Facultad de Ciencias Biologicas, Complutense University, c Jose Antonio Novais 2, Madrid 28040, Spain
Biogerontology 9:183-96. 2008..The results show that 40% isocaloric MetR is enough to decrease ROS production and oxidative stress in rat liver. This suggests that the lowered intake of methionine is responsible for the decrease in oxidative stress observed in DR... - Effect of every other day feeding on mitochondrial free radical production and oxidative stress in mouse liverPilar Caro
Department of Animal Physiology II, Complutense University, Madrid, Spain
Rejuvenation Res 11:621-9. 2008..These results support the possibility that EOD DR increases maximum life span at least in part through decreases in mitochondrial oxidative stress which are independent from insulin/IGF-1-like signaling... - Effect of lipid restriction on mitochondrial free radical production and oxidative DNA damageAlberto Sanz
Department of Animal Physiology II, Faculty of Biological Sciences, Complutense University, Madrid, Spain
Ann N Y Acad Sci 1067:200-9. 2006..These results deny a role for lipids and reinforce the possible role of dietary proteins as being responsible for the decrease in mitochondrial ROS production and DNA damage in caloric restriction... - Testing the vicious cycle theory of mitochondrial ROS production: effects of H2O2 and cumene hydroperoxide treatment on heart mitochondriaAlberto Sanz
Department of Animal Physiology-II, Faculty of Biology, Complutense University, Madrid, 28040, Spain
J Bioenerg Biomembr 38:121-7. 2006.... - Protein restriction without strong caloric restriction decreases mitochondrial oxygen radical production and oxidative DNA damage in rat liverAlberto Sanz
Department of Animal Physiology-II, Faculty of Biological Sciences, Complutense University, Madrid, 28040, Spain
J Bioenerg Biomembr 36:545-52. 2004..Interestingly, these tissue oxidative stress-linked parameters can be lowered by restricting only the intake of dietary protein, probably a more feasible option than caloric restriction for adult humans...