Research Topics
| Julian SevillaSummaryCountry: Spain Publications
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Publications
Transient donor cell-derived myelodysplastic syndrome with monosomy 7 after unrelated cord blood transplantationJulian Sevilla
Oncohematología pediátrica Hospital Universitario Niño Jesús, Madrid, Spain
Eur J Haematol 77:259-63. 2006..Moreover, the clinical follow-up of this patient, recommends a more conservative treatment for this clonal disease early developed after transplantation...- Fatal hepatic failure secondary to acute herpes simplex virus infectionJulian Sevilla
Oncohematología Pediátrica, Hospital Nino Jesus, Madrid, Spain
J Pediatr Hematol Oncol 26:686-8. 2004..Typical signs and symptoms in patients at risk, when there is no other obvious cause of fulminant hepatitis, should lead to early empirical treatment with acyclovir... - Peripheral blood progenitor cell collection adverse events for childhood allogeneic donors: variables related to the collection and safety profileJulian Sevilla
Servicio de Transfusión, Hospital Infantil Universitario Nino Jesus, Avd Menéndez Pelayo 65, Madrid, Spain
Br J Haematol 144:909-16. 2009..The donor/recipient body weight ratio predicted the outcome of collection in a single large volume leukapheresis. Donors with body weight ratio >or=0.75 had 4.69 times higher likelihood to reach the minimum target cell dose... - Early acute myeloblastic leukemia treatment for childhood myelodysplastic syndrome with t(3;5) (NPM/MLF1)Julian Sevilla
Oncohematología pediátrica Hospital Niño Jesús, Madrid, Spain
J Pediatr Hematol Oncol 29:839-40. 2007..He is alive and well 4 years after the end of treatment. This unusual MDS needs further studies to better understand the disease... - Risks and methods for peripheral blood progenitor cell collection in small childrenJulian Sevilla
Hospital Infantil Universitario Nino Jesus, Avd Menéndez Pelayo 65, Madrid 28009, Spain
Transfus Apher Sci 31:221-31. 2004..Anyway, taking all these complications together, they are not higher than those adverse events or toxicities reported after general anesthesia and bone marrow harvesting... - [Acute leukemia in patients with Down syndrome]S Fernandez-Plaza
Sección de Oncohematología, Servicio de Pediatria, Hospital Universitario Nino Jesus, Madrid, Spain
An Pediatr (Barc) 61:515-9. 2004..The main cause of morbidity and mortality in children with Down syndrome are complications related to chemotherapy, leading to numerous modifications in treatment protocols... - Severe systemic autoimmune disease associated with Epstein-Barr virus infectionJulian Sevilla
Pediatric Oncohematology, Hospital Nino Jesus, Menendez Pelayo 65, Madrid 28009, Spain
J Pediatr Hematol Oncol 26:831-3. 2004..Despite immunosuppressive treatment and ultimately liver transplantation, this patient could not overcome her clinical condition and died. The etiopathogenesis of this complex disease and the association with EBV infection is discussed... - Hematopoietic transplantation for bone marrow failure syndromes and thalassemiaJ Sevilla
Department of Pediatric Oncohematology, Hospital Infantil Universitario Nino Jesus, Madrid, Spain
Bone Marrow Transplant 35:S17-21. 2005..In the previous years, donors other than HLA-identical siblings have been increasingly used in patients not responding to conventional measures, but this approach needs to be evaluated in larger studies... - PBSC collection in extremely low weight infants: a single-center experienceJ Sevilla
Hospital Infantil Universitario Nino Jesus, Madrid, Spain
Cytotherapy 9:356-61. 2007..We have conducted a prospective study to analyze the incidence of adverse events during PBPC collection in the smallest children (< or = 10 kg)... - Graft manipulation and reduced-intensity conditioning for allogeneic hematopoietic stem cell transplantation from mismatched unrelated and mismatched/haploidentical related donors in pediatric leukemia patientsMarta Gonzalez-Vicent
Department of Pediatrics, Division of Pediatric Hematology Oncology and Hematopoietic Stem Cell Transplantation and Cell Therapy Unit, Niño Jesus Children Hospital, Madrid, Spain
J Pediatr Hematol Oncol 32:e85-90. 2010..In conclusion, using graft engineering procedures after RIC for hematopoietic stem cell transplantation offers a high probability of engraftment, fast immune recovery, and very low mortality even with mismatched donors... - Intentional induction of mixed haematopoietic chimerism as platform for cellular therapy after HLA-matched allogeneic stem cell transplantation in childhood leukaemia patientsAntonio Perez
Division of Paediatric Hematology Oncology, Haematopoietic Stem Cell transplantation Unit and Cellular Therapy, Hospital Nino Jesus, Madrid, Spain
Br J Haematol 140:340-3. 2008..Median time (range) to neutrophil and platelet engraftment was 13 (11-15) and 12 d (8-13) respectively. Probability of relapse and disease-free survival was 23 +/- 9% and 72 +/- 6% respectively (median follow-up of 15 months)... - High-dose busulfan and melphalan as conditioning regimen for autologous peripheral blood progenitor cell transplantation in high-risk ewing sarcoma patients: a long-term follow-up single-center studyMiguel A Diaz
Department of Pediatrics, Division of Pediatric Hematology Oncology and Hematopoietic Stem Cell Transplantation and Cell Therapy Unit, Hospital Infantil Universitario Nino Jesus, Madrid, Spain
Pediatr Hematol Oncol 27:272-82. 2010..Patients with localized disease at diagnosis and those with good response to treatment before or after transplant would benefit most... - Allogeneic hematopoietic transplantation using haploidentical donor vs. unrelated cord blood donor in pediatric patients: a single-center retrospective studyMarta Gonzalez-Vicent
Stem Cell Transplant Unit, Hospital Nino Jesus, Madrid, Spain
Eur J Haematol 87:46-53. 2011..05). In conclusion, haploidentical transplants are a good and promising alternative option for patients with childhood leukemia who lack an human leukocyte antigen-matched donor (sibling or unrelated donor)... - KIR-HLA receptor-ligand mismatch associated with a graft-versus-tumor effect in haploidentical stem cell transplantation for pediatric metastatic solid tumorsAntonio Perez-Martinez
Department of Pediatric Hematology and Oncology, Hospital Nino Jesus, Universidad Autonoma de Madrid, Madrid, Spain
Pediatr Blood Cancer 53:120-4. 2009..Our results showed that beneficial antitumor effects could be observed in the presence of inhibitory KIR-HLA mismatch. These preliminary results suggest a possible association between disease control and NK cell alloreactivity... - Allogeneic cord blood transplantation in children with hematological malignancies: a long-term follow-up single-center studyMiguel A Diaz
Department of Pediatrics, Division of Pediatric Hematology Oncology and Hematopoietic Stem Cell Transplantation and Cell Therapy Unit, Hospital Infantil Universitario Nino Jesus, Madrid, Spain
Pediatr Hematol Oncol 26:165-74. 2009..The cord blood unit for transplantation in pediatric patients with hematological malignancies should be chosen based on cell dose, especially a CD34(+) cell dose... - Analysis of clinical outcome and survival in pediatric patients undergoing extracorporeal photopheresis for the treatment of steroid-refractory GVHDMarta Gonzalez Vicent
Stem Cell Transplant Unit, Pediatric Hematology Oncology Section, Hospital Nino Jesus, Madrid, Spain
J Pediatr Hematol Oncol 32:589-93. 2010..Clinical response favorably impacts on long-term survival and seems to be associated with peripheral blood lymphocyte subset changes generating peripheral tolerance... - Peripheral blood progenitor cell collection in low-weight childrenJulian Sevilla
Hospital Infantil Universitario Nino Jesus, Madrid, 28009 Spain
J Hematother Stem Cell Res 11:633-42. 2002..Pediatric donors may be used for allogeneic transplantation with no higher incidence of complications. PBPC collection even in the smallest children is a safe and efficient procedure when performed by experienced apheresis teams... - Pulmonary glial heterotopia in a child diagnosed with fanconi anemia and epilepsyLaura Alonso
Hemato Oncología Pediátrica y Trasplante hematopoyético, Hospital Infantil Universitario Nino Jesus, Madrid, Spain
J Pediatr Hematol Oncol 33:462-4. 2011..Pulmonary glial heterotopia is rare and its pathogenesis is still obscure as for Fanconi anemia (FA)... - Intrathecal liposomal cytarabine in children under 4 years with malignant brain tumorsAlvaro Lassaletta
Pediatric Oncology Department, Universitary Children s Hospital Niño Jesus, Madrid, Spain
J Neurooncol 95:65-9. 2009..This study demonstrates the feasibility of using intrathecal liposomal cytarabine in children under 4 years of age with malignant brain tumors... - Early onset of acute immune-mediated lung injury in a child undergoing allogeneic peripheral blood transplantationJulian Sevilla
Department of Pediatrics, Division of Hematology Oncology, Hospital Nino Jesus, Madrid, Spain
Am J Hematol 69:56-8. 2002..Immune-mediated lung injury, as defined by animal models, should be considered in patients with severe signs of systemic aGVHD while excluding other known etiologies of pulmonary disease... - Priming of Hematopoietic Progenitor Cells by Plerixafor and Filgrastim in Children With Previous Failure of Mobilization With Chemotherapy and/or Cytokine TreatmentJulian Sevilla
Hospital Infantil Universitario Nino Jesus, Avd Menéndez Pelayo 65, Madrid, Spain Pediatric Unit, Fondazione IRCCS Istituto Nazionale Tumori Hematology Department of Oncology, San Raffaele Scientific Institute, Milano Division of Rheumatology, Department of Pediatric Medicine, Bambino Gesu Children s Hospital, Rome, Italy Hospital Quirón, Madrid, Spain
J Pediatr Hematol Oncol 34:146-50. 2012..Plerixafor, therefore seems to be safe and effective for peripheral blood progenitor cell mobilization in children. Adverse events were comparable with those described with filgrastim alone... - Chemotherapy-related secondary acute myeloid leukemia in patients diagnosed with osteosarcomaM Carmen Escudero
Department of Pediatric Oncology, , , Madrid, Spain
J Pediatr Hematol Oncol 26:454-6. 2004..The authors also discuss the data regarding cisplatin-associated SAL. Different molecular and pathogenic agents may be implicated in the development of second malignant neoplasms in long-term survivors of osteosarcomas... - Primary gastrointestinal aspergillosis after autologous peripheral blood progenitor cell transplantation: an unusual presentation of invasive aspergillosisM Gonzalez-Vicent
Stem Cell Transplant Unit, Niño Jesús Children s Hospital, Madrid, Spain
Transpl Infect Dis 10:193-6. 2008..He had no evidence of pulmonary, sinus, or central nervous system infection. The patient died of septic shock after emergency surgery... - Granulocyte colony-stimulating factor alone at 12 microg/kg twice a day for 4 days for peripheral blood progenitor cell priming in pediatric patientsJ Sevilla
, Madrid, Spain
Bone Marrow Transplant 30:417-20. 2002..6%) after a single large volume leukapheresis. In conclusion, this mobilization schedule allows safe and efficient collection of the minimum target CD34(+) cell dose in most pediatric patients by only one procedure... - Predicting factors for admission to an intensive care unit and clinical outcome in pediatric patients receiving hematopoietic stem cell transplantationMiguel Angel Diaz
Department of Pediatrics, Division of Pediatric Hematology Oncology, BMT Unit, Niño Jesús Children s Hospital, Menendez Pelayo 65, 28009 Madrid, Spain
Haematologica 87:292-8. 2002..Few studies have been reported analyzing this issue in a pediatric population and most focused on risk factors predicting survival following PICU admission... - Large volume leukapheresis in small children: safety profile and variables affecting peripheral blood progenitor cell collectionJ Sevilla
, Madrid, Spain
Bone Marrow Transplant 31:263-7. 2003..0001). In all, 77% of patients achieved the target CD34(+) cell dose of 2 x 10(6)/kg in their first apheresis. Recruitment was seen in 72% of the procedures, and this was related to the total blood volume processed (P=0.0005)... - Lentiviral-mediated genetic correction of hematopoietic and mesenchymal progenitor cells from Fanconi anemia patientsAriana Jacome
División de Hematopoyesis y Terapia Génica, Centro de Investigaciones Energeticas, Medioambientales y Tecnologicas, Madrid, Spain
Mol Ther 17:1083-92. 2009..We propose a new approach for the gene therapy of FA based on the rapid transduction of unselected hematopoietic grafts with lentiviral vectors (LVs)... - Autologous peripheral blood stem cell transplant in patients previously diagnosed with invasive aspergillosisJ Sevilla
Banco de Sangre, Hospital Nino Jesus, Madrid, Spain
Ann Hematol 80:456-9. 2001.... - Engraftment syndrome in children undergoing autologous peripheral blood progenitor cell transplantationL Madero
Department of Pediatric Hematology and Oncology, , Madrid, Spain
Bone Marrow Transplant 30:355-8. 2002..In summary, we have found ES to be the most important cause of morbidity and mortality in children undergoing autologous PBPCT... - Acute autoimmune hemolytic anemia following unrelated cord blood transplantation as an early manifestation of chronic graft-versus-host diseaseJ Sevilla
Bone Marrow Transplantation Unit, , Madrid, Spain
Bone Marrow Transplant 28:89-92. 2001..This abnormal reconstitution is also the basis of cGVHD. We suggest that aggressive immunosuppressive treatment with intensive measures against infection could give a better prognosis to such patients... - Secondary acute myeloid leukemia and myelodysplasia after autologous peripheral blood progenitor cell transplantationJ Sevilla
Banco de Sangre, Hospital Nino Jesus, Av Menéndez Pelayo 65, Madrid 28009, Spain
Ann Hematol 81:11-5. 2002.... - A comprehensive strategy for the subtyping of patients with Fanconi anaemia: conclusions from the Spanish Fanconi Anemia Research NetworkJosé Antonio Casado
Spanish Fanconi Anemia Research Network and Centre for Biomedical Research on Rare Diseases CIBERER, Madrid, Spain
J Med Genet 44:241-9. 2007..Identifying the complementation group in patients with Fanconi anaemia constitutes a direct procedure to confirm the diagnosis of the disease and is required for the recruitment of these patients in gene therapy trials... - Hematopoietic stem cell transplantation using umbilical cord blood progenitors: review of current clinical resultsA I Benito
Hematology/Oncology Department and Bone Marrow Transplantation Unit, , Autonomous University, Madrid, Spain
Bone Marrow Transplant 33:675-90. 2004..A concise review of the clinical results achieved after related and unrelated CBT is presented and discussed...