Research Topics
| Sonia RamosSummaryCountry: Spain Publications
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Publications
Cancer chemoprevention and chemotherapy: dietary polyphenols and signalling pathwaysSonia Ramos
Department of Metabolism and Nutrition, Instituto del Frio, Consejo Superior de Investigaciones Cientificas CSIC, Ciudad Universitaria, Madrid, Spain
Mol Nutr Food Res 52:507-26. 2008....- Comparative effects of food-derived polyphenols on the viability and apoptosis of a human hepatoma cell line (HepG2)Sonia Ramos
Department of Metabolism and Nutrition, Instituto del Frio, Consejo Superior de Investigaciones Cientificas CSIC, Jose Antonio Novais 10, Ciudad Universitaria, 28040, Madrid, Spain
J Agric Food Chem 53:1271-80. 2005..Moreover, quercetin and fruit extracts arrested the G1 phase in the cell cycle progression prior to apoptosis. Quercetin and strawberry and plum extracts may induce apoptosis and contribute to a reduced cell viability in HepG2 cells... - Effects of dietary flavonoids on apoptotic pathways related to cancer chemopreventionSonia Ramos
Department of Metabolism and Nutrition, Instituto del Frio, Consejo Superior de Investigaciones Cientificas, 28040 Madrid, Spain
J Nutr Biochem 18:427-42. 2007.... - A diet rich in dietary fiber from cocoa improves lipid profile and reduces malondialdehyde in hypercholesterolemic ratsElena Lecumberri
Department of Metabolism and Nutrition, Instituto del Frio CSIC, Madrid, Spain
Nutrition 23:332-41. 2007..The potential hypolipidemic effect of a new cocoa product rich in dietary fiber (DF) naturally containing antioxidant polyphenols (cocoa fiber [CF]) was studied in a rat model of dietary-induced hypercholesterolemia... - Cocoa flavonoids up-regulate antioxidant enzyme activity via the ERK1/2 pathway to protect against oxidative stress-induced apoptosis in HepG2 cellsMaria Angeles Martin
Department of Metabolism and Nutrition, Instituto de Ciencia y Tecnologia de los Alimentos y Nutricion formerly Instituto del Frio, CSIC, Ciudad Universitaria, 28040 Madrid, Spain
J Nutr Biochem 21:196-205. 2010..These findings suggest that CPE is an effective inductor of GPx and GR activities via ERK activation and that this up-regulation seems to be required to attenuate t-BOOH-induced injury... - Molecular mechanisms of (-)-epicatechin and chlorogenic acid on the regulation of the apoptotic and survival/proliferation pathways in a human hepatoma cell lineAna Belen Granado Serrano
Department of Metabolism and Nutrition, Instituto del Frio, Consejo Superior de Investigaciones Cientificas, Jose Antonio Novais 10, Ciudad Universitaria, 28040 Madrid, Spain
J Agric Food Chem 55:2020-7. 2007..These data suggest that EC and CGA have no effect on apoptosis and enhance the intrinsic cellular tolerance against oxidative insults either by activating survival/proliferation pathways or by increasing antioxidant potential in HepG2... - Time-course regulation of survival pathways by epicatechin on HepG2 cellsAna Belén Granado-Serrano
Department of Metabolism and Nutrition, Instituto del Frio, Consejo Superior de Investigaciones Cientificas CSIC, Jose Antonio Novais 10, Ciudad Universitaria, 28040, Madrid, Spain
J Nutr Biochem 20:115-24. 2009.... - Selenium methylselenocysteine protects human hepatoma HepG2 cells against oxidative stress induced by tert-butyl hydroperoxideSusana Cuello
Departamento de Quimica Analitica, Facultad de Quimicas, Universidad Complutense, 28040, Madrid, Spain
Anal Bioanal Chem 389:2167-78. 2007..The results show that treatment of HepG2 cells with concentrations of Se-MeSeCys in the nanomolar to micromolar range confers a significant protection against an oxidative insult... - Protection of human HepG2 cells against oxidative stress by cocoa phenolic extractMaria Angeles Martin
Department of Metabolism and Nutrition Instituto del Frio, Consejo Superior de Investigaciones Cientificas, Jose Antonio Novais 10, 28040 Madrid, Spain
J Agric Food Chem 56:7765-72. 2008..These results show that treatment of HepG2 in culture with CPE (within the physiological range of concentrations) confers a significant protection against oxidation to the cells... - Hydroxytyrosol induces antioxidant/detoxificant enzymes and Nrf2 translocation via extracellular regulated kinases and phosphatidylinositol-3-kinase/protein kinase B pathways in HepG2 cellsMaria Angeles Martin
Instituto del Frio ICTAN, Consejo Superior de Investigaciones Cientificas, 28040, Madrid, Spain
Mol Nutr Food Res 54:956-66. 2010.... - Quercetin modulates Nrf2 and glutathione-related defenses in HepG2 cells: Involvement of p38Ana Belén Granado-Serrano
Department of Metabolism and Nutrition, Institute of Food Science, Technology and Nutrition ICTAN Former Instituto del Frío, Consejo Superior de Investigaciones Cientificas CSIC, Jose Antonio Novais 10, Ciudad Universitaria, Madrid, Spain
Chem Biol Interact 195:154-64. 2012..In conclusion, p38-MAPK is involved in the mechanisms of the cell response to quercetin through the modulation of Nrf2 and glutathione-related enzymes in HepG2 cells... - Quercetin modulates NF-kappa B and AP-1/JNK pathways to induce cell death in human hepatoma cellsAna Belén Granado-Serrano
Instituto del Frio Instituto de Ciencia y Tecnologia de Alimentos y Nutricion, Madrid, Spain
Nutr Cancer 62:390-401. 2010.... - Hypolipidemic effect in cholesterol-fed rats of a soluble fiber-rich product obtained from cocoa husksSonia Ramos
Department of Metabolism and Nutrition, Instituto del Frio, Spanish Council for Scientific Research CSIC, C Jose Antonio Novais 10, 28040 Madrid, Spain
J Agric Food Chem 56:6985-93. 2008..The SCFP also decreased triglyceride levels to values lower than those in the group fed the cholesterol-free diet. These results put forward the potential application of the SCFP as a dietary supplement or functional food ingredient... - Comparative effects of dietary flavanols on antioxidant defences and their response to oxidant-induced stress on Caco2 cellsIldefonso Rodríguez-Ramiro
Department of Metabolism and Nutrition, Instituto del Frio ICTAN, CSIC, Ciudad Universitaria, Madrid, Spain
Eur J Nutr 50:313-22. 2011..The objective was to evaluate the antioxidant response of colon-derived Caco2 cells to dietary flavanols... - Time-course regulation of quercetin on cell survival/proliferation pathways in human hepatoma cellsAna Belén Granado-Serrano
Department of Metabolism and Nutrition, Instituto del Frio, Consejo Superior de Investigaciones Cientificas CSIC, Jose Antonio Novais 10, Ciudad Universitaria, Madrid, Spain
Mol Nutr Food Res 52:457-64. 2008.... - Dietary flavanols exert different effects on antioxidant defenses and apoptosis/proliferation in Caco-2 and SW480 colon cancer cellsSonia Ramos
Department of Metabolism and Nutrition, Instituto de Ciencia y Tecnología de Alimentos y Nutrición ICTAN, Former Instituto del Frío, Consejo Superior de Investigaciones Cientificas CSIC, Jose Antonio Novais 10, Ciudad Universitaria, 28040 Madrid, Spain
Toxicol In Vitro 25:1771-81. 2011..Thus, ECG induced apoptosis in SW480 cells and contributed to the cytotoxic effect, whereas ECG enhanced the antioxidant potential in Caco-2 cells. PB2 activated cell proliferation and survival/proliferation pathways in SW480 cells... - Cocoa-rich diet prevents azoxymethane-induced colonic preneoplastic lesions in rats by restraining oxidative stress and cell proliferation and inducing apoptosisIldefonso Rodríguez-Ramiro
Instituto de Ciencia y Tecnología de Alimentos y Nutrición ICTAN CSIC, Madrid, Spain
Mol Nutr Food Res 55:1895-9. 2011..Our findings provide the first in vivo evidence that a cocoa-rich diet may inhibit the early stage of colon carcinogenesis probably by preventing oxidative stress and cell proliferation and by inducing apoptosis... - A diet rich in cocoa attenuates N-nitrosodiethylamine-induced liver injury in ratsAna Belén Granado-Serrano
Department of Metabolism and Nutrition, Instituto del Frio ICTAN, Consejo Superior de Investigaciones Cientificas, 28040 Madrid, Spain
Food Chem Toxicol 47:2499-506. 2009..However, cocoa administration did not abrogate the DEN-induced body weight loss and the increased levels of hepatic-specific enzymes and LDH. These results suggested that cocoa-rich diet attenuates the DEN-induced liver injury... - Molecular mechanisms of methylmercury-induced cell death in human HepG2 cellsSusana Cuello
Departamento de Quimica Analitica, Facultad de Quimicas, Universidad Complutense, Madrid, Spain
Food Chem Toxicol 48:1405-11. 2010.... - Determination of malondialdehyde (MDA) by high-performance liquid chromatography in serum and liver as a biomarker for oxidative stress. Application to a rat model for hypercholesterolemia and evaluation of the effect of diets rich in phenolic antioxidantRaquel Mateos
, , Ciudad Universitaria, E-28040-Madrid, Spain
J Chromatogr B Analyt Technol Biomed Life Sci 827:76-82. 2005..These results point out the beneficial effects of phenolic antioxidants from fruits in preventing oxidative damage in vivo... - Epicatechin induces NF-kappaB, activator protein-1 (AP-1) and nuclear transcription factor erythroid 2p45-related factor-2 (Nrf2) via phosphatidylinositol-3-kinase/protein kinase B (PI3K/AKT) and extracellular regulated kinase (ERK) signalling in HepG2 ceAna Belén Granado-Serrano
Department of Metabolism and Nutrition, Instituto del Frio ICTAN, Consejo Superior de Investigaciones Cientificas CSIC, Jose Antonio Novais 10, 28040 Madrid, Spain
Br J Nutr 103:168-79. 2010..These data suggest that the epicatechin-induced survival effect occurs by the induction of redox-sensitive transcription factors through a tight regulation of survival and proliferation pathways... - Olive oil hydroxytyrosol reduces toxicity evoked by acrylamide in human Caco-2 cells by preventing oxidative stressIldefonso Rodríguez-Ramiro
Department of Metabolism and Nutrition, ICTAN, Consejo Superior de Investigaciones Cientificas CSIC, Madrid, Spain
Toxicology 288:43-8. 2011.... - Biscuit melanoidins of different molecular masses protect human HepG2 cells against oxidative stressMaria Angeles Martin
Consejo Superior de Investigaciones Cientificas, Instituto del Frio ICTAN, Jose Antonio Novais 10, Madrid, Spain
J Agric Food Chem 57:7250-8. 2009..The results show that treatment of HepG2 cells with concentrations of biscuit melanoidins within the expected physiological range confers on the cells a significant protection against an oxidative challenge... - Procyanidin B2 and a cocoa polyphenolic extract inhibit acrylamide-induced apoptosis in human Caco-2 cells by preventing oxidative stress and activation of JNK pathwayIldefonso Rodríguez-Ramiro
Department of Metabolism and Nutrition, Instituto del Frio ICTAN, Consejo Superior de Investigaciones Cientificas, Jose Antonio Novais 10, Ciudad Universitaria, 28040 Madrid, Spain
J Nutr Biochem 22:1186-94. 2011..Interestingly, natural dietary antioxidant such as PB2 and CPE were able to suppress AA toxicity by improving the redox status of Caco-2 cells and by blocking the apoptotic pathway activated by AA... - Interaction between malnutrition and ovarian hormones on the systemic IGF-I axisLuis Goya
Institute of Biochemistry, CSIC-Universidad Complutense, Madrid, Spain
Eur J Endocrinol 147:417-24. 2002..CONCLUSION: These results indicate that the presence of circulating ovarian hormones significantly affects the response of the IGF system to undernutrition... - Genomic organization and expression profile of the small GTPases of the RhoBTB family in human and mouseSonia Ramos
Institut fur Biochemie I, Medizinische Fakultat, University of Cologne, Joseph Stelzmann Strasse 52, D 50931 Cologne, Germany
Gene 298:147-57. 2002..All three genes were also detected in fetal tissues, and in a number of cell lines RHOBTB3 predominates. RHOBTB genes are upregulated in some cancer cell lines, suggesting that these proteins might participate in tumorigenesis...