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Genomes and Genes | J MoscatSummaryCountry: Spain Publications
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Publications
NF-kappaB activation by protein kinase C isoforms and B-cell functionJorge Moscat
Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas Universidad Autonoma de Madrid, Canto Blanco, Spain
EMBO Rep 4:31-6. 2003..These studies have also given rise to a number of important questions that must be answered with further experimentation to establish accurately the signalling pathways that regulate B-cell function through NF-kappaB...- PKCzeta at the crossroad of NF-kappaB and Jak1/Stat6 signaling pathwaysJ Moscat
Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma de Madrid, Cantoblanco, 28049 Madrid, Spain
Cell Death Differ 13:702-11. 2006.... - Par-4 keeps the atypical PKCs at bayJorge Moscat
, , Universidad Autonoma de Madrid, Canto Blanco, 28049 Madrid, Spain
Cell Cycle 2:71-2. 2003 - The atypical protein kinase Cs. Functional specificity mediated by specific protein adaptersJ Moscat
Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma de Madrid, Universidad Autonoma, Canto Blanco, Spain
EMBO Rep 1:399-403. 2000.... - The atypical PKC-interacting protein p62 channels NF-kappaB activation by the IL-1-TRAF6 pathwayL Sanz
Laboratorio Glaxo Wellcome CSIC de Biología Molecular y Celular, Centro de Biología Molecular Severo Ochoa Consejo Superior de Investigaciones Científicas Universidad Autónoma de Madrid, Universidad Autonoma, Canto Blanco, 28049 Madrid, Spain
EMBO J 19:1576-86. 2000..Together, these results indicate that p62 is an important intermediary not only in TNFalpha but also in IL-1 signaling to NF-kappaB through the specific adapters RIP and TRAF6... - Protein kinase C zeta isoform is critical for kappa B-dependent promoter activation by sphingomyelinaseJ Lozano
, Canto Blanco, Madrid, Spain
J Biol Chem 269:19200-2. 1994..In keeping with this notion, we also demonstrate here that zeta PKC is activated in vitro by ceramide and in vivo by treatment of NIH-3T3 fibroblasts with SMase... - Activation of IkappaB kinase beta by protein kinase C isoformsM J Lallena
Laboratorio Glaxo Wellcome CSIC de Biología Molecular y Celular, Centro de Biología Molecular Severo Ochoa Consejo Superior de Investigaciones Científicas Universidad Autónoma de Madrid, Universidad Autonoma, 28049 Madrid, Spain
Mol Cell Biol 19:2180-8. 1999..Collectively, these results demonstrate a critical role for the PKC isoforms in the NF-kappaB pathway at the level of IKKbeta activation and IkappaB degradation... - MEK5, a new target of the atypical protein kinase C isoforms in mitogenic signalingM T Diaz-Meco
Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas Universidad Autonoma de Madrid, Universidad Autonoma, 28049 Madrid, Spain
Mol Cell Biol 21:1218-27. 2001..From all these results, we conclude that MEK5 is a critical target of the aPKCs during mitogenic signaling... - The downregulation of the pro-apoptotic protein Par-4 is critical for Ras-induced survival and tumor progressionM Barradas
, , , Canto Blanco, Madrid, Spain
EMBO J 18:6362-9. 1999..This indicates that the downregulation of Par-4 by oncogenic Ras is a critical event in tumor progression... - Localization of atypical protein kinase C isoforms into lysosome-targeted endosomes through interaction with p62P Sanchez
Centro de Biología Molecular Severo Ochoa Consejo Superior de Investigaciones Científicas Universidad Autónoma de Madrid, Universidad Autonoma, Canto Blanco, Spain
Mol Cell Biol 18:3069-80. 1998..This is particularly relevant in light of the role played by the aPKCs in mitogenic cell signaling events... - Lambda-interacting protein, a novel protein that specifically interacts with the zinc finger domain of the atypical protein kinase C isotype lambda/iota and stimulates its kinase activity in vitro and in vivoM T Diaz-Meco
Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas Universidad Autonoma de Madrid, Universidad Autonoma, Spain
Mol Cell Biol 16:105-14. 1996.... - DaPKC-dependent phosphorylation of Crumbs is required for epithelial cell polarity in DrosophilaSol Sotillos
Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas and Univerisidad Autonoma de Madrid, Cantoblanco, 28049 Madrid, Spain
J Cell Biol 166:549-57. 2004..These results provide a mechanistic framework for the functional interaction between the Par-3-Par-6-aPKC and Crumbs-Sdt-Patj complexes based in the posttranslational modification of Crb by DaPKC... - Crosstalk between PKCzeta and the IL4/Stat6 pathway during T-cell-mediated hepatitisAngeles Duran
Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma de Madrid, Madrid, Spain
EMBO J 23:4595-605. 2004..In contrast, Par-4-/- mice have increased sensitivity to ConA-induced liver damage and IL-4 signaling. This unveils a novel and critical involvement of PKCzeta in the IL-4/Stat6 signaling pathway in vitro and in vivo... - Control of T helper 2 cell function and allergic airway inflammation by PKCzetaPilar Martin
Centro de Biología Molecular Severo Ochoa and Departamento de Inmunologia y Oncologia Centro Nacional de Biotecnología, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma de Madrid, Cantoblanco, 28049 Madrid, Spain
Proc Natl Acad Sci U S A 102:9866-71. 2005..Moreover, PKCzeta-/- mice display dramatic inhibition of ovalbumin-induced allergic airway disease, strongly suggesting that PKCzeta can be a therapeutic target in asthma... - The signaling adapter p62 is an important mediator of T helper 2 cell function and allergic airway inflammationPilar Martin
Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma de Madrid, Cantoblanco, Madrid, Spain
EMBO J 25:3524-33. 2006.... - Par-4 inhibits Akt and suppresses Ras-induced lung tumorigenesisJayashree Joshi
Department of Cancer and Cell Biology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
EMBO J 27:2181-93. 2008.... - The atypical PKC-interacting protein p62 is an important mediator of RANK-activated osteoclastogenesisAngeles Duran
Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma, Canto Blanco, 28049 Madrid, Spain
Dev Cell 6:303-9. 2004..These observations demonstrate that p62 is an important mediator during osteoclastogenesis and induced bone remodeling... - Akt regulation and lung cancer: a novel role and mechanism of action for the tumor suppressor Par-4Maria T Diaz-Meco
Department of Cancer and Cell Biology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA
Cell Cycle 7:2817-20. 2008.... - Essential role of RelA Ser311 phosphorylation by zetaPKC in NF-kappaB transcriptional activationAngeles Duran
Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma de Madrid, Canto Blanco, 28049 Madrid, Spain
EMBO J 22:3910-8. 2003..These results demonstrate the mechanism whereby zetaPKC regulates NF-kappaB activation in vivo... - Genetic inactivation of Par4 results in hyperactivation of NF-kappaB and impairment of JNK and p38Isabel Garcia-Cao
Department of Immunology and Oncology, Centro Nacional de Biotecnologia, Universidad Autonoma de Madrid, Canto Blanco, 28049 Madrid, Spain
EMBO Rep 4:307-12. 2003..Higher levels of an anti-apoptotic JNK-inhibitor protein, X-chromosome-linked inhibitor of apoptosis, in Par4(-/-) EFs might explain the inhibition of JNK activation in these cells... - Role of zeta PKC in B-cell signaling and functionPilar Martin
Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas Universidad Autonoma de Madrid, Canto Blanco, E 28049 Madrid, Spain
EMBO J 21:4049-57. 2002..Furthermore, zeta PKC-/- mice are unable to mount an optimal T-cell-dependent immune response. Collectively, these results genetically establish a critical role for zeta PKC in B-cell function in vitro and in vivo... - The Drosophila atypical protein kinase C-ref(2)p complex constitutes a conserved module for signaling in the toll pathwayAntonia Avila
Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma, Canto Blanco, 28049 Madrid, Spain
Mol Cell Biol 22:8787-95. 2002..Collectively, these results demonstrate the conservation of the p62-aPKC complex for the control of innate immunity signal transduction in Drosophila melanogaster... - Essential role of sequestosome 1/p62 in regulating accumulation of Lys63-ubiquitinated proteinsMarie W Wooten
Department of Biological Sciences, Program in Cell and Molecular Biosciences, Auburn University, Auburn, Alabama 36849, USA
J Biol Chem 283:6783-9. 2008..Thus, p62 has a bifunctional role in regulation of an E3 ubiquitin-protein ligase, TRAF6, and a DUB, CYLD, to balance the turnover of Lys63-polyubiquitinated proteins such as TrkA... - Genetic inactivation of p62 leads to accumulation of hyperphosphorylated tau and neurodegenerationJ Ramesh Babu
Department of Biological Sciences, Program in Cellular and Molecular Biosciences, Auburn University, Auburn, Alabama 36849, USA
J Neurochem 106:107-20. 2008..Thus, these findings provide new insight into manifestation of sporadic Alzheimer disease and the impact of obesity... - The signaling adaptor p62 is an important NF-kappaB mediator in tumorigenesisAngeles Duran
Department of Molecular Oncogenesis, Genome Research Institute, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
Cancer Cell 13:343-54. 2008.... - Polarized subcellular localization of Jak/STAT components is required for efficient signalingSol Sotillos
CABD CSIC, Universidad Pablo de Olavide, 41013 Sevilla, Spain
Curr Biol 18:624-9. 2008..Our results also suggest that receptor polarization in the ectoderm cell membrane restricts the cell's response to ligands provided by neighboring cells... - OPR, PC and AID: all in the PB1 familyChris P Ponting
Trends Biochem Sci 27:10. 2002 - Signal integration and diversification through the p62 scaffold proteinJorge Moscat
Department of Genome Science, Genome Research Institute, University of Cincinnati, 2180 E Galbraith Road, Cincinnati, OH 45237, USA
Trends Biochem Sci 32:95-100. 2007..The availability of mice in which p62 has been genetically inactivated is providing new insight into the mechanism and function of p62 at a whole-organism level... - The atypical PKC scaffold protein P62 is a novel target for anti-inflammatory and anti-cancer therapiesJorge Moscat
, , Canto Blanco, 28049 Madrid, Spain
Adv Enzyme Regul 42:173-9. 2002 - Mature-onset obesity and insulin resistance in mice deficient in the signaling adapter p62Angelina Rodriguez
Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma de Madrid, Cantoblanco, 28049 Madrid, Spain
Cell Metab 3:211-22. 2006..We propose that p62 normally antagonizes basal ERK activity and adipocyte differentiation and that its loss leads to the hyperactivation of ERK that favors adipogenesis and obesity... - The p62 scaffold regulates nerve growth factor-induced NF-kappaB activation by influencing TRAF6 polyubiquitinationMarie W Wooten
Department of Biological Sciences, Program in Cell and Molecular Biosciences, Auburn University, Alabama 36849, USA
J Biol Chem 280:35625-9. 2005..These results provide evidence for a mechanism whereby p62 serves to regulate the NF-kappaB pathway... - Tumour-suppression activity of the proapoptotic regulator Par4Isabel Garcia-Cao
Spanish National Cancer Center CNIO, 3 Melchor Fernandez Almagro Street, Madrid 28029, Spain
EMBO Rep 6:577-83. 2005..These data show that Par4 has an important role in tumour suppression, with a particular relevance in the endometrium and prostate... - Regulation of heterogenous nuclear ribonucleoprotein A1 transport by phosphorylation in cells stressed by osmotic shockEric Allemand
Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA
Proc Natl Acad Sci U S A 102:3605-10. 2005..Furthermore, F-peptide phosphorylation modulates the interaction of hnRNP A1 with transportin Trn1. Our findings suggest that the phosphorylation of F-peptide by cell-signaling pathways regulates the rate of hnRNP A1 nuclear import... - The death receptor antagonist FAIM promotes neurite outgrowth by a mechanism that depends on ERK and NF-kapp B signalingCarme Sole
Group Cell Signalling and Apoptosis, Department of Basic Medical Sciences, Universitat de Lleida, 25008 Lleida, Spain
J Cell Biol 167:479-92. 2004..These results reveal a new function of FAIM in promoting neurite outgrowth by a mechanism involving activation of the Ras-ERK pathway and NF-kappa B... - Regulation of mature T lymphocyte proliferation and differentiation by Par-4Maria Jose Lafuente
Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma de Madrid, Canto Blanco, 28049 Madrid, Spain
EMBO J 22:4689-98. 2003..This is compelling evidence that Par-4 is a novel modulator of the immune response through its ability to impact aPKC activity, which translates into lower JNK signaling...