Lorenzo Melchor

Summary

Country: Spain

Publications

  1. ncbi An integrative hypothesis about the origin and development of sporadic and familial breast cancer subtypes
    Lorenzo Melchor
    Human Genetics Group, Human Cancer Genetics Programme, Spanish National Cancer Centre CNIO, Madrid E 28029, Spain
    Carcinogenesis 29:1475-82. 2008
  2. ncbi Estrogen receptor status could modulate the genomic pattern in familial and sporadic breast cancer
    Lorenzo Melchor
    Human Genetics Group, Human Cancer Genetics Program, Spanish National Cancer Center CNIO, Madrid, Spain
    Clin Cancer Res 13:7305-13. 2007
  3. ncbi Genomic analysis of the 8p11-12 amplicon in familial breast cancer
    Lorenzo Melchor
    Human Genetics Group, Human Cancer Genetics Program, Spanish National Cancer Center CNIO, Madrid, Spain
    Int J Cancer 120:714-7. 2007
  4. ncbi Comprehensive characterization of the DNA amplification at 13q34 in human breast cancer reveals TFDP1 and CUL4A as likely candidate target genes
    Lorenzo Melchor
    Human Genetics Group, Human Cancer Genetics Program, Spanish National Cancer Research Center CNIO, Madrid, E 28029, Spain
    Breast Cancer Res 11:R86. 2009
  5. ncbi A predictor based on the somatic genomic changes of the BRCA1/BRCA2 breast cancer tumors identifies the non-BRCA1/BRCA2 tumors with BRCA1 promoter hypermethylation
    Sara Alvarez
    Human Genetics Department, Molecular Pathology Programme, Spanish National Cancer Centre, c o Melchor Fernandez Almagro, 28029 Madrid, Spain
    Clin Cancer Res 11:1146-53. 2005
  6. ncbi About the origin and development of hereditary conventional renal cell carcinoma in a four-generation t(3;8)(p14.1;q24.23) family
    Laura Valle
    Department of Human Genetics, Spanish National Cancer Centre, Madrid, Spain
    Eur J Hum Genet 13:570-8. 2005
  7. ncbi The accumulation of specific amplifications characterizes two different genomic pathways of evolution of familial breast tumors
    Lorenzo Melchor
    Human Genetics Group, Human Cancer Genetics Programme, Spanish National Cancer Center, Madrid, Spain
    Clin Cancer Res 11:8577-84. 2005
  8. ncbi Immunohistochemical classification of non-BRCA1/2 tumors identifies different groups that demonstrate the heterogeneity of BRCAX families
    Emiliano Honrado
    Department of Human Genetics, Spanish National Cancer Centre, Melchor Fernandez Almagro 3, Madrid, Spain
    Mod Pathol 20:1298-306. 2007

Detail Information

Publications9

  1. ncbi An integrative hypothesis about the origin and development of sporadic and familial breast cancer subtypes
    Lorenzo Melchor
    Human Genetics Group, Human Cancer Genetics Programme, Spanish National Cancer Centre CNIO, Madrid E 28029, Spain
    Carcinogenesis 29:1475-82. 2008
    ....
  2. ncbi Estrogen receptor status could modulate the genomic pattern in familial and sporadic breast cancer
    Lorenzo Melchor
    Human Genetics Group, Human Cancer Genetics Program, Spanish National Cancer Center CNIO, Madrid, Spain
    Clin Cancer Res 13:7305-13. 2007
    ....
  3. ncbi Genomic analysis of the 8p11-12 amplicon in familial breast cancer
    Lorenzo Melchor
    Human Genetics Group, Human Cancer Genetics Program, Spanish National Cancer Center CNIO, Madrid, Spain
    Int J Cancer 120:714-7. 2007
    ..Finally, we found correlation between the 8p11-12 amplification and proliferation (Ki-67) and cyclin E expression, which further proves in familial tumors the poor prognosis association previously reported in sporadic breast cancer...
  4. ncbi Comprehensive characterization of the DNA amplification at 13q34 in human breast cancer reveals TFDP1 and CUL4A as likely candidate target genes
    Lorenzo Melchor
    Human Genetics Group, Human Cancer Genetics Program, Spanish National Cancer Research Center CNIO, Madrid, E 28029, Spain
    Breast Cancer Res 11:R86. 2009
    ..These genomic aberrations may drive carcinogenesis through the upregulation of proto-oncogenes. We have characterized DNA amplification at the human chromosomal region 13q34 in breast cancer...
  5. ncbi A predictor based on the somatic genomic changes of the BRCA1/BRCA2 breast cancer tumors identifies the non-BRCA1/BRCA2 tumors with BRCA1 promoter hypermethylation
    Sara Alvarez
    Human Genetics Department, Molecular Pathology Programme, Spanish National Cancer Centre, c o Melchor Fernandez Almagro, 28029 Madrid, Spain
    Clin Cancer Res 11:1146-53. 2005
    ..This fact suggests that somatic BRCA1 inactivation could modify the profile of tumor progression in most of the BRCAX cases...
  6. ncbi About the origin and development of hereditary conventional renal cell carcinoma in a four-generation t(3;8)(p14.1;q24.23) family
    Laura Valle
    Department of Human Genetics, Spanish National Cancer Centre, Madrid, Spain
    Eur J Hum Genet 13:570-8. 2005
    ..We have not found new candidate regions along 3p by using a 1-Mb resolution array-based CGH. (4) The tumorigenesis mechanism of a second gastric tumor developed in the probandus is different from that of CRCC...
  7. ncbi The accumulation of specific amplifications characterizes two different genomic pathways of evolution of familial breast tumors
    Lorenzo Melchor
    Human Genetics Group, Human Cancer Genetics Programme, Spanish National Cancer Center, Madrid, Spain
    Clin Cancer Res 11:8577-84. 2005
    ..CONCLUSION: In summary, our data suggest the existence of two different patterns of evolution, probably common to familial and sporadic breast tumors...
  8. ncbi Immunohistochemical classification of non-BRCA1/2 tumors identifies different groups that demonstrate the heterogeneity of BRCAX families
    Emiliano Honrado
    Department of Human Genetics, Spanish National Cancer Centre, Melchor Fernandez Almagro 3, Madrid, Spain
    Mod Pathol 20:1298-306. 2007
    ..In addition we have defined a subset of them that have somatic inactivation of the BRCA1 gene...