Research Topics
Genomes and Genes
Species | Oscar MarinSummaryCountry: Spain Publications
| Collaborators
|
Detail Information
Publications
Interneuron dysfunction in psychiatric disordersOscar Marin
Instituto de Neurociencias, Consejo Superior de Investigaciones Científicas y Universidad Miguel Hernández, 03550 Sant Joan d Alacant, Spain
Nat Rev Neurosci 13:107-20. 2012..These insights are leading to a better understanding of the causes of schizophrenia, autism and intellectual disabilities, and may contribute to the development of more-effective therapeutic interventions...- [Origin of cortical interneurons: basic concepts and clinical implications]O Marin
Division of Neurobiología del Desarrollo, Instituto de Neurociencias, CSIC, Universidad Miguel Hernandez, San Juan de Alicate, Alicate, Espana
Rev Neurol 35:743-51. 2002..Aims. In this review I have summarized our current knowledge of the factors that control the specification of cortical interneurons, as well as the mechanisms that direct their migration to the cortex... - Cell migration in the forebrainOscar Marin
Unidad de Neurobiologia del Desarrollo, Instituto de Neurociencias, Consejo Superior de Investigaciones Cientificas Universidad Miguel Hernandez, 03550 San Juan de Alicante, Spain
Annu Rev Neurosci 26:441-83. 2003.... - Neurons in motion: same principles for different shapes?Oscar Marin
Instituto de Neurociencias de Alicante, CSIC and Universidad Miguel Hernandez, 03550 Sant Joan d Alacant, Spain
Trends Neurosci 29:655-61. 2006..According to this idea, the same basic molecular mechanisms found in other cell types, such as fibroblasts, might have been adapted to the special morphological needs of migrating neurons in different regions of the developing brain... - Guiding neuronal cell migrationsOscar Marin
Instituto de Neurociencias, Consejo Superior de Investigaciones Científicas and Universidad Miguel Hernández, Sant Joan d Alacant 03550, Spain
Cold Spring Harb Perspect Biol 2:a001834. 2010..Perhaps more surprisingly, the cellular mechanisms underlying the response of the leading process of migrating cells to guidance cues might be different to those involved in growth cone steering, at least for some neuronal populations... - The embryonic preoptic area is a novel source of cortical GABAergic interneuronsDiego M Gelman
Instituto de Neurociencias de Alicante, Consejo Superior de Investigaciones Científicas and Universidad Miguel Hernández, 03550 Sant Joan d Alacant, Spain
J Neurosci 29:9380-9. 2009.... - Origin and molecular specification of globus pallidus neuronsSandrina Nóbrega-Pereira
Instituto de Neurociencias, Consejo Superior de Investigaciones Científicas y Universidad Miguel Hernández, Sant Joan d Alacant, Spain
J Neurosci 30:2824-34. 2010.... - Tangential neuronal migration controls axon guidance: a role for neuregulin-1 in thalamocortical axon navigationGuillermina López-Bendito
Instituto de Neurociencias de Alicante, CSIC and Universidad Miguel Hernandez, 03550 Sant Joan d Alacant, Spain
Cell 125:127-42. 2006..These results show that neuronal tangential migration constitutes a novel mechanism to control the timely arrangement of guidance cues required for axonal tract formation in the mammalian brain... - Chemokine signaling controls intracortical migration and final distribution of GABAergic interneuronsGuillermina López-Bendito
Instituto de Neurociencias de Alicante, Consejo Superior de Investigaciones Científicas and Universidad Miguel Hernández, 03550 Sant Joan d Alacant, Spain
J Neurosci 28:1613-24. 2008.... - Control of cortical GABA circuitry development by Nrg1 and ErbB4 signallingPietro Fazzari
Instituto de Neurociencias, Consejo Superior de Investigaciones Científicas and Universidad Miguel Hernández, 03550 Sant Joan d Alacant, Spain
Nature 464:1376-80. 2010.... - Meninges control tangential migration of hem-derived Cajal-Retzius cells via CXCL12/CXCR4 signalingVictor Borrell
Instituto de Neurociencias de Alicante, Consejo Superior de Investigaciones Científicas and Universidad Miguel Hernández, 03550 Sant Joan d Alacant, Spain
Nat Neurosci 9:1284-93. 2006..Thus, the meningeal membranes are fundamental in the development of Cajal-Retzius cells and, hence, in the normal development of the cerebral cortex... - Robo1 and Robo2 cooperate to control the guidance of major axonal tracts in the mammalian forebrainGuillermina López-Bendito
Instituto de Neurociencias de Alicante, Consejo Superior de Investigaciones Científicas and Universidad Miguel Hernández, 03550 Sant Joan d Alacant, Spain
J Neurosci 27:3395-407. 2007..Our results demonstrate that Robo1 and Robo2 mostly cooperate to mediate the function of Slit proteins in guiding the major forebrain projections... - Postmitotic Nkx2-1 controls the migration of telencephalic interneurons by direct repression of guidance receptorsSandrina Nóbrega-Pereira
Instituto de Neurociencias de Alicante, CSIC and Universidad Miguel Hernandez, 03550 Sant Joan d Alacant, Spain
Neuron 59:733-45. 2008..Our results demonstrate a role for the cell-fate determinant Nkx2-1 in regulating neuronal migration by direct transcriptional regulation of guidance receptors in postmitotic cells... - Biased selection of leading process branches mediates chemotaxis during tangential neuronal migrationFrancisco J Martini
Instituto de Neurociencias de Alicante, Consejo Superior de Investigaciones Científicas and Universidad Miguel Hernández, 03550 Sant Joan d Alacant, Spain
Development 136:41-50. 2009..These results reveal a novel guidance mechanism during neuronal migration that might be extensively used in brain development... - Delineation of multiple subpallial progenitor domains by the combinatorial expression of transcriptional codesNuria Flames
Instituto de Neurociencias de Alicante, Consejo Superior de Investigaciones Científicas and Universidad Miguel Hernández, 03550 Sant Joan d Alacant, Spain
J Neurosci 27:9682-95. 2007..Furthermore, the results of microtransplantation experiments in vivo corroborate that anatomically defined regions of the mouse subpallium, such as the medial ganglionic eminence, can be subdivided into functionally distinct domains... - Layer acquisition by cortical GABAergic interneurons is independent of Reelin signalingRamón Pla
Instituto de Neurociencias de Alicante, Consejo Superior de Investigaciones Científicas and Universidad Miguel Hernández, 03550 Sant Joan d Alacant, Spain
J Neurosci 26:6924-34. 2006.... - Focal adhesion kinase modulates radial glia-dependent neuronal migration through connexin-26Manuel Valiente
Instituto de Neurociencias, Consejo Superior de Investigaciones Científicas and Universidad Miguel Hernández, 03550 Sant Joan d Alacant, Spain
J Neurosci 31:11678-91. 2011..These results indicate that FAK plays a fundamental role in the dynamic regulation of Gap-mediated adhesions during glial-guided neuronal migration in the mouse... - Cxcr7 controls neuronal migration by regulating chemokine responsivenessJuan Antonio Sánchez-Alcañiz
Instituto de Neurociencias, Consejo Superior Universidad Miguel Hernández, Sant Joan d Alacant 03550, Spain
Neuron 69:77-90. 2011..This demonstrates that a chemokine receptor modulates the function of another chemokine receptor by controlling the amount of protein that is made available for signaling at the cell surface... - A wide diversity of cortical GABAergic interneurons derives from the embryonic preoptic areaDiego Gelman
Instituto de Neurociencias, Consejo Superior de Investigaciones Científicas and Universidad Miguel Hernández, Sant Joan d Alacant 03550, Spain, Instituto de Investigaciones en Ingenieria Genetica y Biologia Molecular, Consejo Nacional de Investigaciones Cientificas y Tecnicas, Buenos Aires, Argentina, and Institut Jacques Monod, CNRS UMR 7592, Universite Paris Diderot, Sorbonne Paris Cité, 75013 Paris, France
J Neurosci 31:16570-80. 2011..Together with earlier findings, our results also suggest that the POA generates nearly 10% of the GABAergic interneurons in the cerebral cortex of the mouse... - Transcriptional control of neuronal migration in the developing mouse brainSandrina Nóbrega-Pereira
Instituto de Neurociencias de Alicante, Consejo Superior de Investigaciones Cientificas, and Universidad Miguel Hernandez, Sant Joan d Alacant, Spain
Cereb Cortex 19:i107-13. 2009..In this review, we will describe recent progress made in understanding the contribution of transcription factors in controlling neuronal migration in the developing mouse brain, with a special focus on the developing telencephalon... - Neuregulin signaling, cortical circuitry development and schizophreniaBeatriz Rico
Instituto de Neurociencias, Consejo Superior de Investigaciones Científicas and Universidad Miguel Hernández, 03550 Sant Joan d Alacant, Spain
Curr Opin Genet Dev 21:262-70. 2011..We will also discuss how this basic knowledge may help us to understand the etiology of schizophrenia, and eventually lead to the development of novel therapies for treating the disorder... - Generation of interneuron diversity in the mouse cerebral cortexDiego M Gelman
Instituto de Neurociencias, Consejo Superior de Investigaciones Científicas and Universidad Miguel Hernández, 03550 Sant Joan d Alacant, Spain
Eur J Neurosci 31:2136-41. 2010..In this review, we summarize recent progress on this process, progress which holds the promise of providing a rational framework for their classification, as well as means to understand their role in cortical processing... - Short- and long-range attraction of cortical GABAergic interneurons by neuregulin-1Nuria Flames
Instituto de Neurociencias de Alicante, Consejo Superior de Investigaciones Científicas and Universidad Miguel Hernández, 03550 San Joan d Alacant, Spain
Neuron 44:251-61. 2004..These observations provide evidence that Neuregulin-1 and its ErbB4 receptor directly control neuronal migration in the nervous system... - Neuronal migration mechanisms in development and diseaseManuel Valiente
Instituto de Neurociencias, Consejo Superior de Investigaciones Científicas and Universidad Miguel Hernández, 03550 Sant Joan d Alacant, Spain
Curr Opin Neurobiol 20:68-78. 2010..We will also review how this basic knowledge is contributing to a better understanding of the etiology and pathophysiology of multiple neurological syndromes in which neuronal migration is disrupted...