Research Topics
Species | Beatriz MaestroSummaryCountry: Spain Publications
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Publications
Novel approaches to fight Streptococcus pneumoniaeBeatriz Maestro
Instituto de Biologia Molecular y Celular, Universidad Miguel Hernandez, Av Universidad, s n 03202 Elche Alicante, Spain
Recent Pat Antiinfect Drug Discov 2:188-96. 2007..In this article we present the main relevant characteristics of this pathogen and review the most recent methods that have been patented for the prevention, diagnostic and treatment of the pneumococcal diseases...
Inhibition of pneumococcal choline-binding proteins and cell growth by esters of bicyclic aminesBeatriz Maestro
Instituto de Biologia Molecular y Celular, Universidad Miguel Hernandez, Elche, Spain
FEBS J 274:364-76. 2007..These results may open up the possibility of the development of bicyclic amines as new antimicrobials for use against pneumococcal pathologies...
Rational stabilization of the C-LytA affinity tag by protein engineeringVíctor M Hernández-Rocamora
Instituto de Biologia Molecular y Celular, Universidad Miguel Hernandez, Avda Universidad s n, Elche 03202, Spain
Protein Eng Des Sel 21:709-20. 2008..Therefore, C-LytAm7 behaves as an improved affinity tag and supports the engineering of surface salt bridges as an effective approach for protein stabilization...
Extensive unfolding of the C-LytA choline-binding module by submicellar concentrations of sodium dodecyl sulphateBeatriz Maestro
Instituto de Biologia Molecular y Celular, Universidad Miguel Hernandez, Av Universidad, s n 03202 Elche, Alicante, Spain
FEBS Lett 581:375-81. 2007..A model for the unfolding of C-LytA by SDS is presented and compared to a previous denaturation scheme by guanidine hydrochloride...
Recognition of peptidoglycan and ?-lactam antibiotics by the extracellular domain of the Ser/Thr protein kinase StkP from Streptococcus pneumoniaeBeatriz Maestro
Instituto de Biologia Molecular y Celular, Universidad Miguel Hernandez, Elche, Spain
FEBS Lett 585:357-63. 2011....
Characterization of Snail nuclear import pathways as representatives of C2H2 zinc finger transcription factorsJosé Manuel Mingot
Instituto de Neurociencias, CSIC UMH, Avda Ramon y Cajal s n, San Juan de Alicante, Spain
J Cell Sci 122:1452-60. 2009..Importantly, the identified basic residues are also conserved in other families of C(2)H(2) transcription factors whose nuclear localization requires the zinc finger region...
Affinity partitioning of proteins tagged with choline-binding modules in aqueous two-phase systemsBeatriz Maestro
Instituto de Biologia Molecular y Celular, Universidad Miguel Hernandez, Avda Universidad s n, 03202 Elche Alicante, Spain
J Chromatogr A 1208:189-96. 2008..The described procedure is simple, scalable and reproducible, and has been successfully applied to the purification of four diverse proteins, resulting in high yields and purity...
Accumulation of partly folded states in the equilibrium unfolding of the pneumococcal choline-binding module C-LytABeatriz Maestro
, , Av. Universidad, s/n, E-03202 Elche, Alicante, Spain
Biochem J 387:479-88. 2005..Thermal denaturation of C-LytA suggests the accumulation of at least the I1 species. These results might pave the way for an effective improvement of its biotechnological applications by protein engineering...
Modulation of pPS10 host range by plasmid-encoded RepA initiator proteinBeatriz Maestro
, , , Madrid, Spain
J Bacteriol 185:1367-75. 2003..We propose possible explanations for the host range effect of the different repA mutants, including the enhancement of limiting interactions of RepA with specific host replication factors such as DnaA...
Modulation of pPS10 host range by DnaABeatriz Maestro
Departamento de Microbiologia Molecular, Centro de Investigaciones Biologicas, Consejo Superior de Investigaciones Cientificas, Madrid, Spain
Mol Microbiol 46:223-34. 2002..coli and provides support for the hypothesis that interactions between RepA and DnaA modulate the establishment of pPS10 in that bacteria and probably in other species...
