Research Topics
Genomes and Genes
| Mayte CoirasSummaryAffiliation: Instituto de Salud Carlos III Country: Spain Publications
| Collaborators
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Detail Information
Publications
Simultaneous detection of influenza A, B, and C viruses, respiratory syncytial virus, and adenoviruses in clinical samples by multiplex reverse transcription nested-PCR assayM T Coiras
Laboratorio de Virus Respiratorios, Servicio de Virologia, Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain
J Med Virol 69:132-44. 2003..Accurately amplifying RNA from influenza and RSV prototype strains and DNA from all adenovirus serotypes demonstrates the use of this method for both laboratory routine diagnosis and surveillance of all these viruses...
Simultaneous detection of fourteen respiratory viruses in clinical specimens by two multiplex reverse transcription nested-PCR assaysM T Coiras
Laboratorio de Virus Respiratorios, Servicio de Virologia, Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Madrid, Spain
J Med Virol 72:484-95. 2004....
Caspase-3-mediated cleavage of p65/RelA results in a carboxy-terminal fragment that inhibits IkappaBalpha and enhances HIV-1 replication in human T lymphocytesMayte Coiras
AIDS Immunopathology Unit, National Center of Microbiology, Instituto de Salud Carlos III, 28220 Majadahonda, Madrid, Spain
Retrovirology 5:109. 2008....
Understanding HIV-1 latency provides clues for the eradication of long-term reservoirsMayte Coiras
AIDS Immunopathology Unit, National Centre of Microbiology, Instituto de Salud Carlos III, 28220 Majadahonda, Madrid, Spain
Nat Rev Microbiol 7:798-812. 2009....
HIV-1 latency and eradication of long-term viral reservoirsMayte Coiras
AIDS Immunopathology Unit, Instituto de Salud Carlos III, Madrid, Spain
Discov Med 9:185-91. 2010..Further understanding of the mechanisms underlying HIV-1 latency is of primary importance to develop new strategies that ensure the complete destruction of reservoirs and, therefore, the eradication of the infection...
Basal shuttle of NF-kappaB/I kappaB alpha in resting T lymphocytes regulates HIV-1 LTR dependent expressionMayte Coiras
AIDS Immunopathology Unit, National Center of Microbiology, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain
Retrovirology 4:56. 2007..On the other hand, basal NF-kappaB activity detected in resting CD4+ T lymphocytes was related to low level HIV replication in these cells...
Protein kinase Ctheta is a specific target for inhibition of the HIV type 1 replication in CD4+ T lymphocytesMaría Rosa López-Huertas
AIDS Immunopathology Unit, National Center of Microbiology, Instituto de Salud Carlos III, 28220 Majadahonda, Madrid, Spain
J Biol Chem 286:27363-77. 2011....
Dual role of host cell factors in HIV-1 replication: restriction and enhancement of the viral cycleMayte Coiras
AIDS Immunopathology Unit, National Centre of Microbiology, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain
AIDS Rev 12:103-12. 2010..The increasing knowledge of viral protein interactions with host cell factors will be essential for the discovery of new targets that could be used to design new therapeutic strategies...
[Immunopathogenesis of HIV infection]Jose Alcami
Unidad de Inmunopatologia del Sida, Instituto de Salud Carlos III, Majadahonda, Madrid, Espana
Enferm Infecc Microbiol Clin 29:216-26. 2011..In this article, the mechanisms of immune suppression, the evolution of immune response throughout the infection and the mechanisms of viral escape are analysed...
Mechanisms of RNA interference in the HIV-1-host cell interplayMaría Sánchez-Del Cojo
AIDS Immunopathology Unit, Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain
AIDS Rev 13:149-60. 2011..This strategy, combined with current antiretroviral therapy, could be valuable in controlling HIV-1 replication in infected cells...
Application of proteomics technology for analyzing the interactions between host cells and intracellular infectious agentsMayte Coiras
Unidad de Inmunopatologia del Sida, Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain
Proteomics 8:852-73. 2008..A review on the most relevant proteomic applications used in the study of host-pathogen interactions is presented...
Oligonucleotide microarray design for detection and serotyping of human respiratory adenoviruses by using a virtual amplicon retrieval softwareGuillermo Lopez-Campos
Medical Bioinformatics Unit, National Center of Microbiology, Instituto de Salud Carlos III, Ctra Majadahonda Pozuelo, Km 2, 28220 Majadahonda, Madrid, Spain
J Virol Methods 145:127-36. 2007..This new technology was applied for the simultaneous detection and serotyping of acute respiratory disease-causing adenoviruses in laboratory and clinical samples with efficiency and accuracy...
Modifications in the human T cell proteome induced by intracellular HIV-1 Tat protein expressionMayte Coiras
AIDS Immunopathology Unit, National Centre of Microbiology, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain
Proteomics 6:S63-73. 2006..In conclusion, in addition to its role in viral mRNA elongation, the proteomic approach has provided insight into the way that Tat modifies host cell gene expression...
Oligonucleotide array for simultaneous detection of respiratory viruses using a reverse-line blot hybridization assayM T Coiras
AIDS Immunopathology Unit, National Centre for Microbiology, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain
J Med Virol 76:256-64. 2005..The feasibility and accuracy of the RT-PCR-RLB assay for detecting respiratory viruses proves that such approach could be a first stage to develop a microarray assay for routine diagnosis of infectious diseases...
Rapid molecular analysis of the haemagglutinin gene of human influenza A H3N2 viruses isolated in spain from 1996 to 2000M T Coiras
Servicio de Virologia, Centro Nacional de Microbiologia (CNM, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain
Arch Virol 146:2133-47. 2001..This rapid, simple and variant-specific procedure could, therefore, be used to rapidly screen clinical specimens prior to more detailed antigenic and genetic analyses...
Synthesis of recombinant human parainfluenza virus 1 and 3 nucleocapsid proteins in yeast Saccharomyces cerevisiaeMindaugas Juozapaitis
Institute of Biotechnology, V A Graiciuno 8, Vilnius LT 02241, Lithuania
Virus Res 133:178-86. 2008..When used as coating antigens in an indirect ELISA, the recombinant N proteins reacted with sera of patients infected with HPIV1 or 3. Serological assays to detect HPIV-specific antibodies could be designed on this basis...
