Research Topics
Genomes and Genes | Francisco J TinahonesSummaryAffiliation: Hospital Universitario Country: Spain Publications
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Publications
Green tea reduces LDL oxidability and improves vascular functionF J Tinahones
Servicio de Endocrinologia, Hospital Clinico Virgen de la Victoria de Malaga, Spain
J Am Coll Nutr 27:209-13. 2008..The aim of this study was to determine the short-to medium-term effect of a green tea extract on vascular function and lipid peroxidation as compared with placebo...- Influence of age and sex on levels of anti-oxidized LDL antibodies and anti-LDL immune complexes in the general populationFrancisco J Tinahones
Servicio de Endocrinologia y Nutricion, Carlos Haya Regional University Hospital, Malaga, Spain
J Lipid Res 46:452-7. 2005..The higher prevalence of anti-oxidized LDL (MDA-LDL) antibodies in females and young persons is in agreement with studies that found an inverse association between atherosclerosis and the level of these antibodies... - Decreased levels of uric acid after oral glucose challenge is associated with triacylglycerol levels and degree of insulin resistanceF J Tinahones
Servicio de Endocrinologia y Nutricion, Hospital Clinico Universitario Virgen de la Victoria, Málaga and CIBER Fisiopatología de la obesidad y nutrición CB06 03 Instituto de Salud Carlos III, Malaga, Spain
Br J Nutr 99:44-8. 2008..077). Levels of UA were significantly lower after the OGTT and the individuals with the greatest decrease in UA levels are those who have greater insulin resistance and higher TAG levels... - Recovery of menstrual cycle after therapy for anorexia nervosaF J Tinahones
Unidad de Trastornos del Comportamiento Alimentario, Servicio de Endocrinologia, Hospital Regional Carlos Haya, Malaga, Spain
Eat Weight Disord 10:e52-5. 2005..We therefore studied the variations in anthropometric variables in women with restrictive anorexia nervosa (AN) at the time they recovered their menstrual cycle... - PPARgamma expression after a high-fat meal is associated with plasma superoxide dismutase activity in morbidly obese personsEduardo Garcia-Fuentes
Ciber Fisiopatologia Obesidad y Nutricion, Hospital Clinico Virgen de la Victoria, Malaga, Spain
Obesity (Silver Spring) 18:952-8. 2010..733, P = 0.016). In conclusion, the decreased expression of PPARgamma in PBMC in morbidly obese persons after a high-fat meal was associated with the state of IR, the plasma SOD activity, and the changes in the concentration of FFA... - Apelin levels are increased in morbidly obese subjects with type 2 diabetes mellitusFederico Soriguer
Servicio de Endocrinologia y Nutricion, Hospital Regional Universitario Carlos Haya, Malaga, Spain
Obes Surg 19:1574-80. 2009..We measured the changes in apelin levels in morbidly obese subjects, with and without diabetes, and in the inverse situation of improvement in carbohydrate metabolism as a result of bariatric surgery... - Continuous positive airway pressure therapy reduces oxidative stress markers and blood pressure in sleep apnea-hypopnea syndrome patientsMora Murri
Laboratorio de Investigaciones Biomedicas, Fundacion IMABIS, Hospital Clinico Universitario Virgen de la Victoria, 29010, Malaga, Spain
Biol Trace Elem Res 143:1289-301. 2011..Consequently, we believe that the decrease in oxidative stress after 1 month of CPAP treatment in these patients is not contributing much to IR genesis, though it could be related to the hypertension etiology... - Oxidative stress in severely obese persons is greater in those with insulin resistanceFrancisco J Tinahones
Servicio de Endocrinologia y Nutricion, Hospital Clinico Virgen de la Victoria, Malaga, Spain
Obesity (Silver Spring) 17:240-6. 2009..However, we are unable to determine from this study whether there is first an increase in oxidative stress or in insulin resistance... - Changes in oxidative stress and insulin resistance in morbidly obese patients after bariatric surgeryMora Murri
Servicio de Endocrinologia y Nutricion, Campus Teatinos s n, Hospital Clinico Universitario Virgen de la Victoria, 29010 Malaga, Spain
Obes Surg 20:363-8. 2010.... - Changes in the serum composition of free-fatty acids during an intravenous glucose tolerance testFederico Soriguer
Servicio de Endocrinologia y Nutricion, Hospital Regional Universitario Carlos Haya, Malaga, Spain
Obesity (Silver Spring) 17:10-5. 2009..In conclusion, during an IVGTT, severely obese persons with IFG or T2DM experienced a lower fall in the FFA than the severely obese persons with NFG and the controls, becoming normal after bariatric surgery... - Effect of CPAP on oxidative stress and circulating progenitor cell levels in sleep patients with apnea-hypopnea syndromeMora Murri
Servicio de Hematologia, Hospital Clinico Universitario Virgen de la Victoria, Malaga, Spain
Respir Care 56:1830-6. 2011..The sleep apnea-hypopnea syndrome is associated with elevated oxidative stress, which is associated with reduced levels and functional impairment of progenitor cells... - The obese healthy paradox: is inflammation the answer?Nuria Barbarroja
Hospital Virgen de la Victoria, Malaga, CIBER Fisiopatologia de la Obesidad y Nutricion, Instituto de Salud Carlos III, Spain
Biochem J 430:141-9. 2010.... - The -1131T>C SNP of the APOA5 gene modulates response to fenofibrate treatment in patients with the metabolic syndrome: a postprandial studyFernando Cardona
Servicio de Endocrinologia y Nutricion, Hospital Virgen de la Victoria, Malaga, Malaga, Spain
Atherosclerosis 206:148-52. 2009..We hypothesised that variability in the promoter of the APOA5 gene may affect the individual response to fibrate therapy, in both the fasting and postprandial states... - Improved carbohydrate metabolism after bariatric surgery raises antioxidized LDL antibody levels in morbidly obese patientsLourdes Garrido-Sanchez
CIBER Fisiopatologia de la Obesidad y Nutricion CB06 03, ISCIII, Malaga, Spain
Diabetes Care 31:2258-64. 2008..We measured the changes in anti-oxLDL antibody levels in the inverse situation of improvement in carbohydrate metabolism... - Oxidative stress and metabolic changes after continuous positive airway pressure treatment according to previous metabolic disorders in sleep apnea-hypopnea syndrome patientsMora Murri
Servicio de Endocrinologia y Nutricion, Hospital Clinico Universitario Virgen de la Victoria, Malaga, Spain
Transl Res 154:111-21. 2009..Moreover, the blood pressure decreased after CPAP treatment, particularly in the obese, nondyslipidemic, and hypertensive patients. No significant change in IR was found in any of the SAHS patients after CPAP treatment... - The retinoic acid receptor-related orphan nuclear receptor ?1 (ROR?1): a novel player determinant of insulin sensitivity in morbid obesityFrancisco J Tinahones
Laboratorio de Investigación Biomédica, Servicio de Endocrinologia Nutricion, Hospital Virgen de la Victoria Fundacion IMABIS, Malaga, Spain
Obesity (Silver Spring) 20:488-97. 2012..Measurement of ROR?1 and PPAR?2 in adipose tissue might be useful for evaluating the outcomes of various clinical interventions for obesity-related diabetes type II... - Decrease in FASN expression in adipose tissue of hypertensive individualsMaría D Mayas
Servicio de Endocrinologia y Nutricion, Hospital Clínico Universitario Virgen de Victoria de Málaga y CIBEROBN CB06 03 010, Instituto de Salud Carlos III, Madrid, Spain
Am J Hypertens 22:1258-62. 2009..Due to the fact that there is no literature that relates FASN and ACC expression with hypertension, we investigate how FASN and ACC expression in adipose tissue is related to hypertension... - Why not use the HbA1c as a criterion of dysglycemia in the new definition of the metabolic syndrome? Impact of the new criteria in the prevalence of the metabolic syndrome in a Mediterranean urban population from Southern Europe (IMAP study. MultidiscipliM Rosa Bernal-Lopez
Biomedical Research Laboratory, Endocrinology Department, Hospital Virgen de la Victoria, Malaga, Spain
Diabetes Res Clin Pract 93:e57-60. 2011..We studied 2006 adults without cardiovascular disease or diabetes. The use of the new criteria and the HbA1c resulted in an increase in the population prevalence of MS... - Response to a urate-lowering diet according to polymorphisms in the apolipoprotein AI-CIII-AIV clusterFernando Cardona
Endocrinology and Nutrition Service, Hospital Civil, Carlos Haya University Hospital, Malaga, Spain
J Rheumatol 32:903-5. 2005..We assessed the influence of polymorphisms in the apolipoprotein AI-CIII-AIV cluster on the response to a urate-lowering diet in patients with hyperuricemia... - Pro12Ala sequence variant of the PPARG gene is associated with postprandial hypertriglyceridemia in non-E3/E3 patients with the metabolic syndromeFernando Cardona
Servicio de Endocrinología y Nutrición Hospital Clínico Virgen de la Victoria de Málaga, Malaga, Spain
Clin Chem 52:1920-5. 2006..Variations in these genes may affect postprandial hypertriglyceridemia in the context of the metabolic syndrome... - Anti-oxidized low-density lipoprotein antibody levels are associated with the development of type 2 diabetes mellitusL Garrido-Sanchez
Endocrinology and Nutrition Service, Virgen de la Victoria Clinical Hospital, Malaga, Spain
Eur J Clin Invest 38:615-21. 2008..We undertook a prospective study to determine the predictive capacity of anti-oxidized LDL antibodies for the onset of type 2 diabetes mellitus (T2DM)... - Increased levels of anti-oxidized low-density lipoprotein antibodies are associated with reduced levels of cholesterol in the general populationF J Tinahones
Metabolic Unit, Endocrinology Service, Carlos Haya Regional Hospital, Malaga, Spain
Metabolism 51:429-31. 2002.... - Obesity short-circuits stemness gene network in human adipose multipotent stem cellsMar Roldan
Fundacion Instituto Mediterráneo para el Avance de la Biotecnología y la Investigación Sanitaria IMABIS, Malaga, Spain
FASEB J 25:4111-26. 2011..Altogether, our data show that obesity causes a general short circuit in the stemness gene network of hO-MSCs... - Modulation of human monocyte CD36 by type 2 diabetes mellitus and other atherosclerotic risk factorsRosa M Bernal-Lopez
Endocrinology Department, Biomedical Research Laboratory, Hospital Virgen de la Victoria, Malaga, Spain
Eur J Clin Invest 41:854-62. 2011.... - Thin healthy women have a similar low bone mass to women with anorexia nervosaD Fernàndez-Garcia
Servicio de Endocrinologia y Nutricion, Hospital Virgen de la Victoria, Malaga, Spain
Br J Nutr 102:709-14. 2009..57; P = 0.04). We concluded that patients with AN had similar BMD to healthy thin women. Anthropometric parameters could contribute more significantly than oestrogen deficiency in the achievement of peak bone mass in AN patients... - Assessment of cellular and plasma oxidative stress in SAHS patients before and after continuous positive airway pressure treatmentM Murri
Servicio de Endocrinologia y Nutricion, Hospital Clinico Universitario Virgen de la Victoria, 29010 Malaga, Spain
Clin Lab 56:397-406. 2010..The purpose of this study was to find out if both, cellular or plasma oxidative stress evaluations, are good estimators to assess oxidative stress in SAHS patients before and after one month's CPAP treatment... - Association of biological markers of activity of systemic lupus erythematosus with levels of anti-oxidized low-density lipoprotein antibodiesJ M Gomez-Zumaquero
Endocrinology and Nutrition Service, Carlos Haya University Hospital, Malaga, Spain
Rheumatology (Oxford) 43:510-3. 2004.... - Prevalence of obesity in south-east Spain and its relation with social and health factorsF Soriguer
Endocrinology and Nutrition Service, Hospital Universitario Carlos Haya, Malaga, Spain
Eur J Epidemiol 19:33-40. 2004..An increased level of general education in the population may well contribute decisively to a reduction in the prevalence of obesity... - The apolipoprotein E genotype predicts postprandial hypertriglyceridemia in patients with the metabolic syndromeF Cardona
Servicio de Endocrinologia y Nutricion, Hospital Regional Universitario Carlos Haya, 29009 Malaga, Spain
J Clin Endocrinol Metab 90:2972-5. 2005..5 (confidence interval, 1.04-39.31; P = 0.02). This study shows that patients with the metabolic syndrome who do not have the E3/3 genotype have a greater risk of hyperuricemia and postprandial hypertriglyceridemia after a fat overload... - PPARgamma2 protects against obesity by means of a mechanism that mediates insulin resistanceM Macias-Gonzalez
CIBER Fisiopatología Obesidad y Nutrición CB06 03, ISC III, Malaga, Spain
Eur J Clin Invest 39:972-9. 2009..We investigated whether the PPARgamma2 mRNA expression levels are associated with IR in morbid obesity in adipose and muscle tissues... - Dietary palmitic acid influences LDL-mediated lymphocyte proliferation differently to other mono- and polyunsaturated fatty acids in ratsF J Tinahones
Endocrinology and Nutrition Service, Carlos Haya Hospital Complex, Malaga, Spain
Diabetes Nutr Metab 17:250-8. 2004.... - Similar increase in oxidative stress after fat overload in persons with baseline hypertriglyceridemia with or without the metabolic syndromeF Cardona
Servicio de Endocrinologia y Nutricion, Hospital Clínico Universitario Virgen de Victoria, 29009 Malaga and CIBER Fisiopatología Obesidad y Nutrición CB06 03 Instituto de Salud Carlos III, Spain
Clin Biochem 41:701-5. 2008..We compared the levels of biomarkers of oxidative stress before and after a fat overload in three groups... - PPARgamma mRNA expression is reduced in peripheral blood mononuclear cells after fat overload in patients with metabolic syndromeManuel Macias-Gonzalez
CIBER Fisiopatologia de la Obesidad y Nutricion, CB06 03, Instituto de Salud Carlos III, Madrid 28029, Spain
J Nutr 138:903-7. 2008..These data provide evidence that the Ala12 sequence variant is associated with a worse metabolic profile than Pro12. This is related to differences in the expression of PPARgamma and to oxidative imbalance after fat overload...