Josep Maria Haro

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..Three year data collected in the frame of the SOHO study within Spain were used to evaluate antipsychotic treatment outcomes by analyzing remission and relapse as well as the factors influencing them...

..Antipsychotic maintenance in SOHO was higher than the results of previous randomized studies...

..The results should be interpreted conservatively because of the observational, nonrandomized study design...

..The results show that description of the long-term outcome of schizophrenia cannot be summarized with just one outcome variable...

..In conclusion, treatment effectiveness and tolerability varied among antipsychotic medications in previously untreated patients with schizophrenia. The results should be interpreted conservatively given the observational study design...

..To describe patients included in the European Mania in Bipolar Longitudinal Evaluation of Medication (EMBLEM) study and to assess and clinically validate the presence of clinical subtypes of patients with acute mania...

..In conclusion, functional recovery occurred in approximately half of those who achieved remission. Impairment of work and social functioning was consistently associated with lower remission and recovery rates...

..Large observational studies may be useful in identifying variables that predict switch to depression after mania and provide data on medication use and outcomes in "real world" patients...

..To estimate the comorbidity of mental disorders with chronic physical conditions and to assess their independent and combined effects on health-related quality of life (HRQOL)...

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..Evidence suggests that schizophrenia may have a better outcome for individuals living in low- and middle-income countries compared with affluent settings...

..In conclusion, in this group of outpatients with schizophrenia, gender is a predictor of clinical response to antipsychotic treatment, but its influence is not the same for all antipsychotics...

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..This study compared the 2-year outcomes of patients with a manic/mixed episode of bipolar disorder taking olanzapine monotherapy or olanzapine in combination with other agents...

..The World Health Organization (WHO) has stated that the three leading causes of burden of disease in 2030 are projected to include HIV/AIDS, unipolar depression and ischaemic heart disease...

..Antidepressants are supposed to be withdrawn during a manic episode. The aim of this study was to analyze the characteristics of manic patients who received antidepressants during a manic phase in a large, naturalistic study...

..Factors that could be associated with adequacy of care also were explored...

..The aim of the present study is to compare suicide ideation among women in the pre-, peri-, and post-menopause using a cross-sectional household survey of non-institutionalised adults from six European countries...

..Women had a faster time to mania improvement and a higher risk of developing a depressive episode during the 12-month follow-up period...

..The prevalence of obsessive-compulsive symptom dimensions and their sociodemographic and psychopathological correlates at the population level are unknown...

..CONCLUSIONS: CBP-CNP is highly prevalent and comorbid with other physical and mental conditions. Comorbidity negatively affects individuals global functioning...

..This could cause high levels of family burden. The objective of this study is to assess the relationship between the patients' needs and other clinical and disability variables and the level of family burden...

..Until now, MSMs have not been used to compare the effects of more than two treatments...

..To evaluate the baseline characteristics and follow-up outcomes of rapid-cycling (RC) bipolar I patients in a large, prospective, observational study...

..Previous cost-utility studies, comparing selective serotonin reuptake inhibitors and tricyclic antidepressants, have used modelling techniques or have not included indirect costs in the economic analyses...

..There are few quality-of-life instruments specifically for schizophrenia; thus, the objective of our study is to adapt and validate the Satisfaction with Life Domains Scale (SLDS) by Baker and Intagliata...

..Observational studies, when properly conducted and when using adequate statistical methods, can provide valid information on the evaluation of health technologies...

..The findings from this study should be interpreted conservatively because of its non-randomized observational design...

..The results from the SOHO study indicate that differences in effectiveness and tolerability do exist between the antipsychotics...

..Antipsychotic treatment dose adjustments may influence treatment outcomes in patients with schizophrenia...

..The present findings suggest that further investigation on the mediators between clinical and social outcomes may help to design specific treatments to reduce disability...

..This important information is likely to impact on the future use of antipsychotics and will assist clinicians in refining the use of these drugs and improving the outcome of patients to whom they are prescribed...

..This study aimed to describe the adequacy of treatment for Anxiety and Depressive disorders in Spain, how this differs between providers (primary versus specialised care) and which factors are associated with appropriate care...

..To present the 6-month outcomes associated with antipsychotic treatment of patients participating in the Schizophrenia Outpatient Health Outcomes (SOHO) study...

..The role of observational studies in the assessment of the effectiveness of antipsychotic agents is reviewed, and the rationale, design and recruitment issues surrounding the SOHO study are presented...

..The analysis of these differences should facilitate the monitoring of ongoing mental health reform initiatives in Europe and provide new research hypotheses...

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..In a multiple regression model, needs were weakly associated with the clinical variables and quality of life. Needs assessment is complementary to clinical evaluation in schizophrenia...

..The results also show that the risk of rehospitalization depends on the previous tenures in the community...

..Prescription of PSD is associated with clinical and non-clinical factors. Purpose. To describe the patterns of PSD prescribing over a 12-month period and to determine the factors associated with this in a PC population...

..We hypothesized that SP4 levels may be altered in the brain of bipolar disorder (BD) subjects and regulated by neuronal activity and drug treatment...

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..To study the relevance of gender on social functioning in schizophrenia...

..To analyse the association between symptom dimensions in schizophrenia and number and type of met and unmet needs...

..We assessed the prevalence of perceived stigma among persons with mental disorders and chronic physical conditions in an international study...

..This paper aims to show the validity and reliability of the Spanish version of the Family Burden Interview Schedule (FBIS) designed to assess objective and subjective family burden for people with schizophrenia...

..Comorbidity among mental disorders in the general population is common, affecting more than the 50 % of individuals with a lifetime mental disorder. In Spain, there are no data describing it or its associated risk factors...

..The aims of the present study were to investigate the prevalence and correlates of suicidal ideas and attempts in the general population of Europe...

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..The results should be interpreted conservatively due to the observational study design...

..The results should be interpreted conservatively due to the observational design of SOHO...

..The objective of this study was to describe clinical and work functional outcomes associated with 6-month open-label olanzapine treatment for bipolar I disorder...

..Patients who switched to olanzapine experienced a higher weight gain. In conclusion, among patients switching antipsychotic medication, those who switched to olanzapine had better long-term outcomes...

..We describe mental health care in 17 countries participating in the WHO world mental health (WMH) survey initiative and examine unmet needs for treatment...

..Symptomatic remission is an achievable goal of treatment in patients with schizophrenia...

..To examine factors associated with the use of antidepressants (AD) and benzodiazepines (BZD) in 6 European countries...

..Knowledge of moderators of symptom improvement over time in acute mania improves predictability of individual patient outcomes. This study attempted to identify such moderators of the rate of symptom improvement...

..To determine the cost utility of treating schizophrenic patients with olanzapine compared with other antipsychotics in a naturalistic outpatient setting...

..Differential treatment course and outcome after 12 weeks of treatment were examined for three distinct classes of patients with acute mania in bipolar disorder...

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..This observational study was conducted across Europe to assess health outcomes in men with erectile dysfunction (ED) who took tadalafil, sildenafil citrate (sildenafil), or vardenafil HCl (vardenafil) for 6 mo...

..Consistency across emotional disorders and cultures would suggest that relatively universal mechanisms underlie the association...

..Suicide is a public health problem and it is increasing in Spain. The objective of this study is to analyze the prevalence and risk factors of suicide related outcomes (ideation, plan and attempt) using data from the ESEMeD-Spain project...

..The association of mental disorders with back/neck pain showed a consistent pattern across both developed and developing countries...

..The validity of the CIDI is likely to be under-estimated in these comparisons due to the fact that the reliability of the SCID diagnoses, which is presumably less than perfect, sets a ceiling on maximum CIDI-SCID concordance...

..Structural barriers exist to this reallocation. Careful consideration needs to be given to the value of treating some mild cases, especially those at risk for progressing to more serious disorders...

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