M Guzman

Summary

Country: Spain

Publications

  1. ncbi Control of the cell survival/death decision by cannabinoids
    M Guzman
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, Madrid, Spain
    J Mol Med (Berl) 78:613-25. 2001
  2. ncbi JunD is involved in the antiproliferative effect of Delta9-tetrahydrocannabinol on human breast cancer cells
    M M Caffarel
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, Madrid, Spain
    Oncogene 27:5033-44. 2008
  3. ncbi Effects of extracellular ATP on hepatic fatty acid metabolism
    M Guzman
    Department of Biochemistry and Molecular Biology I, Faculty of Biology, Complutense University, Madrid, Spain
    Am J Physiol 270:G701-7. 1996
  4. ncbi The orphan G protein-coupled receptor GPR55 promotes cancer cell proliferation via ERK
    C Andradas
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, Madrid, Spain
    Oncogene 30:245-52. 2011
  5. ncbi Anti-tumoral action of cannabinoids on hepatocellular carcinoma: role of AMPK-dependent activation of autophagy
    D Vara
    Department of Biochemistry and Molecular Biology, School of Medicine, Alcala University, Madrid, Spain
    Cell Death Differ 18:1099-111. 2011
  6. ncbi Ceramide: a new second messenger of cannabinoid action
    M Guzman
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040, Madrid, Spain
    Trends Pharmacol Sci 22:19-22. 2001
  7. ncbi Effects of cannabinoids on energy metabolism
    M Guzman
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, Madrid, Spain
    Life Sci 65:657-64. 1999
  8. ncbi Stimulation of the midkine/ALK axis renders glioma cells resistant to cannabinoid antitumoral action
    M Lorente
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, Madrid, Spain
    Cell Death Differ 18:959-73. 2011
  9. ncbi Is there an astrocyte-neuron ketone body shuttle?
    M Guzman
    Dept Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040 Madrid, Spain
    Trends Endocrinol Metab 12:169-73. 2001
  10. ncbi A pilot clinical study of Delta9-tetrahydrocannabinol in patients with recurrent glioblastoma multiforme
    M Guzman
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, Madrid 28040, Spain
    Br J Cancer 95:197-203. 2006

Collaborators

  • C Sanchez
  • M Lorente
  • J Castro
  • M R Aberturas
  • M M Caffarel
  • G Velasco
  • C Andradas
  • D Vara
  • M Salazar
  • C Blazquez
  • I Diaz-Laviada
  • N Olea-Herrero
  • E Pérez-Gómez
  • C Cerutti
  • J Palacios
  • G Moreno-Bueno
  • F Mechta-Grigoriou
  • M J Geelen

Detail Information

Publications13

  1. ncbi Control of the cell survival/death decision by cannabinoids
    M Guzman
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, Madrid, Spain
    J Mol Med (Berl) 78:613-25. 2001
    ..Ongoing investigation is in search for cannabinoid-based therapeutic strategies devoid of nondesired psychotropic effects...
  2. ncbi JunD is involved in the antiproliferative effect of Delta9-tetrahydrocannabinol on human breast cancer cells
    M M Caffarel
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, Madrid, Spain
    Oncogene 27:5033-44. 2008
    ..In summary, this is the first report showing not only that cannabinoids regulate JunD but, more generally, that JunD activation reduces the proliferation of cancer cells, which points to a new target to inhibit breast cancer progression...
  3. ncbi Effects of extracellular ATP on hepatic fatty acid metabolism
    M Guzman
    Department of Biochemistry and Molecular Biology I, Faculty of Biology, Complutense University, Madrid, Spain
    Am J Physiol 270:G701-7. 1996
    ....
  4. ncbi The orphan G protein-coupled receptor GPR55 promotes cancer cell proliferation via ERK
    C Andradas
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, Madrid, Spain
    Oncogene 30:245-52. 2011
    ..These findings reveal the importance of GPR55 in human cancer, and suggest that it could constitute a new biomarker and therapeutic target in oncology...
  5. ncbi Anti-tumoral action of cannabinoids on hepatocellular carcinoma: role of AMPK-dependent activation of autophagy
    D Vara
    Department of Biochemistry and Molecular Biology, School of Medicine, Alcala University, Madrid, Spain
    Cell Death Differ 18:1099-111. 2011
    ..Moreover, cannabinoids were also able to inhibit tumor growth and ascites in an orthotopic model of HCC xenograft. Our findings may contribute to the design of new therapeutic strategies for the management of HCC...
  6. ncbi Ceramide: a new second messenger of cannabinoid action
    M Guzman
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040, Madrid, Spain
    Trends Pharmacol Sci 22:19-22. 2001
    ..Ceramide in turn mediates cannabinoid-induced apoptosis, as shown by in vitro and in vivo studies. These findings provide a new perspective on how cannabinoids act, and raise exciting physiological and therapeutic questions...
  7. ncbi Effects of cannabinoids on energy metabolism
    M Guzman
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, Madrid, Spain
    Life Sci 65:657-64. 1999
    ..Anandamide has also been shown to exert metabolic effects in hepatocytes, cells that do not express cannabinoid receptors. The biological role of cannabinoids as modulators of metabolism is as yet unclear...
  8. ncbi Stimulation of the midkine/ALK axis renders glioma cells resistant to cannabinoid antitumoral action
    M Lorente
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, Madrid, Spain
    Cell Death Differ 18:959-73. 2011
    ....
  9. ncbi Is there an astrocyte-neuron ketone body shuttle?
    M Guzman
    Dept Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040 Madrid, Spain
    Trends Endocrinol Metab 12:169-73. 2001
    ..These findings support the notion that astrocytes might supply neurons with ketone bodies in situ, and raise the possibility that astrocyte ketogenesis is a cytoprotective pathway...
  10. ncbi A pilot clinical study of Delta9-tetrahydrocannabinol in patients with recurrent glioblastoma multiforme
    M Guzman
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, Madrid 28040, Spain
    Br J Cancer 95:197-203. 2006
    ....
  11. ncbi Treatment with anabolic steroids increases the activity of the mitochondrial outer carnitine palmitoyltransferase in rat liver and fast-twitch muscle
    M Guzman
    Department of Biochemistry and Molecular Biology, Faculty of Chemistry, Complutense University, Madrid, Spain
    Biochem Pharmacol 41:833-5. 1991
    ..In addition, our results are at odds with the notion that (most of) the metabolic effects of anabolic steroids on muscle are only evident when physical training is parallely performed...
  12. ncbi Effect of nanoparticles on digitoxin uptake and pharmacologic activity in rat glomerular mesangial cell cultures
    M Guzman
    Department of Pharmacy and Pharmaceutical Technology, University of Alcala de Henares, Madrid, Spain
    Drug Deliv 7:215-22. 2000
    ..Therefore, PCL-NP improved drug uptake by the cells without altering the pharmacologic activity and toxicity of the drug. Thus, they can be a useful approach to target drugs to the kidneys or the heart...
  13. ncbi The AMP-activated protein kinase prevents ceramide synthesis de novo and apoptosis in astrocytes
    C Blazquez
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, Madrid, Spain
    FEBS Lett 489:149-53. 2001
    ..Data indicate that AMPK may protect cells from apoptosis induced by stress stimuli...