Juan M Falcon-Perez

Summary

Country: Spain

Publications

  1. ncbi Sub-proteome approach to the knowledge of liver
    Juan M Falcon-Perez
    Metabolomics Unit, CICbioGUNE, CIBERehd, Bizkaia Technology Park, Derio, Bizkaia, Spain
    Proteomics Clin Appl 4:407-15. 2010
  2. ncbi Zinc transporter 2 (SLC30A2) can suppress the vesicular zinc defect of adaptor protein 3-depleted fibroblasts by promoting zinc accumulation in lysosomes
    Juan M Falcon-Perez
    Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Exp Cell Res 313:1473-83. 2007
  3. ncbi Intracellular rescue of the uroporphyrinogen III synthase activity in enzymes carrying the hotspot mutation C73R
    Arola Fortian
    Structural Biology Unit, Centro de Investigacion Cooperativa en Biociencias, Derio, Vizcaya 48160, Spain
    J Biol Chem 286:13127-33. 2011
  4. ncbi Biogenesis of lysosome-related organelles complex 3 (BLOC-3): a complex containing the Hermansky-Pudlak syndrome (HPS) proteins HPS1 and HPS4
    Ramin Nazarian
    Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 100:8770-5. 2003
  5. ncbi BLOC-1, a novel complex containing the pallidin and muted proteins involved in the biogenesis of melanosomes and platelet-dense granules
    Juan M Falcon-Perez
    Department of Human Genetics, UCLA School of Medicine, Los Angeles, California 90095, USA
    J Biol Chem 277:28191-9. 2002
  6. ncbi The pallidin (Pldn) gene and the role of SNARE proteins in melanosome biogenesis
    Juan M Falcon-Perez
    Department of Human Genetics, University of California at Los Angeles UCLA School of Medicine, 90095, USA
    Pigment Cell Res 15:82-6. 2002
  7. ncbi BLOC-1 interacts with BLOC-2 and the AP-3 complex to facilitate protein trafficking on endosomes
    Santiago M Di Pietro
    Department of Human Genetics, University of California, Los Angeles, CA 90095, USA
    Mol Biol Cell 17:4027-38. 2006
  8. ncbi Distribution and dynamics of Lamp1-containing endocytic organelles in fibroblasts deficient in BLOC-3
    Juan M Falcon-Perez
    Department of Human Genetics, University of California, Los Angeles, CA 90095, USA
    J Cell Sci 118:5243-55. 2005
  9. ncbi Characterization of BLOC-2, a complex containing the Hermansky-Pudlak syndrome proteins HPS3, HPS5 and HPS6
    Santiago M Di Pietro
    Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Traffic 5:276-83. 2004
  10. ncbi Overview of extracellular microvesicles in drug metabolism
    Javier Conde-Vancells
    Metabolomics Unit, CICbioGUNE, CIBERehd, Bizkaia Technology Park, Bldg 801 A, Derio 48160, Bizkaia, Spain
    Expert Opin Drug Metab Toxicol 6:543-54. 2010

Collaborators

Detail Information

Publications13

  1. ncbi Sub-proteome approach to the knowledge of liver
    Juan M Falcon-Perez
    Metabolomics Unit, CICbioGUNE, CIBERehd, Bizkaia Technology Park, Derio, Bizkaia, Spain
    Proteomics Clin Appl 4:407-15. 2010
    ....
  2. ncbi Zinc transporter 2 (SLC30A2) can suppress the vesicular zinc defect of adaptor protein 3-depleted fibroblasts by promoting zinc accumulation in lysosomes
    Juan M Falcon-Perez
    Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Exp Cell Res 313:1473-83. 2007
    ....
  3. ncbi Intracellular rescue of the uroporphyrinogen III synthase activity in enzymes carrying the hotspot mutation C73R
    Arola Fortian
    Structural Biology Unit, Centro de Investigacion Cooperativa en Biociencias, Derio, Vizcaya 48160, Spain
    J Biol Chem 286:13127-33. 2011
    ..The intracellularly recovered C73R-UROIIIS protein shows enzymatic activity, paving the way for a new line of therapeutic intervention in CEP patients...
  4. ncbi Biogenesis of lysosome-related organelles complex 3 (BLOC-3): a complex containing the Hermansky-Pudlak syndrome (HPS) proteins HPS1 and HPS4
    Ramin Nazarian
    Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 100:8770-5. 2003
    ....
  5. ncbi BLOC-1, a novel complex containing the pallidin and muted proteins involved in the biogenesis of melanosomes and platelet-dense granules
    Juan M Falcon-Perez
    Department of Human Genetics, UCLA School of Medicine, Los Angeles, California 90095, USA
    J Biol Chem 277:28191-9. 2002
    ..We propose that BLOC-1 mediates the biogenesis of lysosome-related organelles by a mechanism that may involve self-assembly and interaction with the actin cytoskeleton...
  6. ncbi The pallidin (Pldn) gene and the role of SNARE proteins in melanosome biogenesis
    Juan M Falcon-Perez
    Department of Human Genetics, University of California at Los Angeles UCLA School of Medicine, 90095, USA
    Pigment Cell Res 15:82-6. 2002
    ..As SNARE proteins mediate fusion of intracellular membranes, pallidin may play a role in membrane fusion events required for melanosome biogenesis...
  7. ncbi BLOC-1 interacts with BLOC-2 and the AP-3 complex to facilitate protein trafficking on endosomes
    Santiago M Di Pietro
    Department of Human Genetics, University of California, Los Angeles, CA 90095, USA
    Mol Biol Cell 17:4027-38. 2006
    ..These findings support the idea that BLOC-1 and -2 represent hitherto unknown components of the endosomal protein trafficking machinery...
  8. ncbi Distribution and dynamics of Lamp1-containing endocytic organelles in fibroblasts deficient in BLOC-3
    Juan M Falcon-Perez
    Department of Human Genetics, University of California, Los Angeles, CA 90095, USA
    J Cell Sci 118:5243-55. 2005
    ..These results suggest that BLOC-3 function is required, directly or indirectly, for optimal attachment of late endocytic organelles to microtubule-dependent motors...
  9. ncbi Characterization of BLOC-2, a complex containing the Hermansky-Pudlak syndrome proteins HPS3, HPS5 and HPS6
    Santiago M Di Pietro
    Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Traffic 5:276-83. 2004
    ..Our results suggest a common biological basis underlying the pathogenesis of HPS-3, -5 and -6 disease...
  10. ncbi Overview of extracellular microvesicles in drug metabolism
    Javier Conde-Vancells
    Metabolomics Unit, CICbioGUNE, CIBERehd, Bizkaia Technology Park, Bldg 801 A, Derio 48160, Bizkaia, Spain
    Expert Opin Drug Metab Toxicol 6:543-54. 2010
    ....
  11. ncbi Structural, thermodynamic, and mechanistical studies in uroporphyrinogen III synthase: molecular basis of congenital erythropoietic porphyria
    Arola Fortian
    CIC bioGUNE, Bizkaia Technology Park, Derio, Spain
    Adv Protein Chem Struct Biol 83:43-74. 2011
    ..The stabilization of the protein in vivo is discussed in the context of a new line of intervention to complement existing treatments such as bone marrow transplantation and gene therapy...
  12. ncbi Characterization and comprehensive proteome profiling of exosomes secreted by hepatocytes
    Javier Conde-Vancells
    Metabolomics Unit, CICbioGUNE, CIBERehd, Bizkaia Technology Park, Derio, 48160, Bizkaia, Spain
    J Proteome Res 7:5157-66. 2008
    ..Furthermore, we demonstrated that exosomal membrane proteins can constitute an interesting tool to express nonexosomal proteins into exosomes with therapeutic purposes...
  13. ncbi The Drosophila pigmentation gene pink (p) encodes a homologue of human Hermansky-Pudlak syndrome 5 (HPS5)
    Juan M Falcon-Perez
    Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Traffic 8:154-68. 2007
    ..The phenotype of pink mutants was exacerbated by mutations in AP-3 subunits or in the orthologs of VPS33A and Rab38. These results validate D. melanogaster as a genetic model to study the function of the BLOCs...