Research Topics
| Ramon EstruchSummaryCountry: Spain Publications
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Publications
Effects of a Mediterranean-style diet on cardiovascular risk factors: a randomized trialRamon Estruch
Institut d Investigacions Biomèdiques August Pi Sunyer, Municipal Institut for Medical Research, University of Barcelona, and Catalan Institute of Health, Barcelona, Spain
Ann Intern Med 145:1-11. 2006..The Mediterranean diet has been shown to have beneficial effects on cardiovascular risk factors...- Anti-inflammatory effects of the Mediterranean diet: the experience of the PREDIMED studyRamon Estruch
Department of Internal Medicine, Hospital Clinic, IDIBAPS, University of Barcelona, Spain
Proc Nutr Soc 69:333-40. 2010..These results support the recommendation of the Med-Diet as a useful tool against CVD... - Moderate consumption of red wine, but not gin, decreases erythrocyte superoxide dismutase activity: a randomised cross-over trialR Estruch
Department of Internal Medicine, Hospital Clinic, IDIBAPS, University of Barcelona, Barcelona, Spain
Nutr Metab Cardiovasc Dis 21:46-53. 2011.... - Effects of dietary fibre intake on risk factors for cardiovascular disease in subjects at high riskR Estruch
Department of Internal Medicine, Hospital Clinic, Institut d Investigacions Biomèdiques August Pi Sunyer, Barcelona, Spain
J Epidemiol Community Health 63:582-8. 2009..Thus, the effects of changes in dietary fibre intake on cardiovascular risk factors were assessed over 3 months in free-living high-risk subjects... - Effect of cocoa powder on the modulation of inflammatory biomarkers in patients at high risk of cardiovascular diseaseMaria Monagas
Department of Internal Medicine, Hospital Clinic, Institut d Investigacio Biomedica August Pi i Sunyer, University of Barcelona, Barcelona, Spain
Am J Clin Nutr 90:1144-50. 2009..Because atherosclerosis is considered a low-grade inflammatory disease, some feeding trials have analyzed the effects of cocoa (an important source of flavonoids) on inflammatory biomarkers, but the results have been controversial... - Inhibition of circulating immune cell activation: a molecular antiinflammatory effect of the Mediterranean dietMari Pau Mena
Department of Internal Medicine, Institut d Investigacions Biomediques August Pi i Sunyer, Instituto de Salud Carlos III, Spain
Am J Clin Nutr 89:248-56. 2009..Adherence to the Mediterranean diet (Med-Diet) is associated with a reduced risk of cardiovascular disease (CVD). However, the molecular mechanisms involved are not fully understood... - Down-regulation of adhesion molecules and other inflammatory biomarkers after moderate wine consumption in healthy women: a randomized trialEmilio Sacanella
Department of Internal Medicine, Hospital Clinic, Hospital Clinic, University of Barcelona, Barcelona, Spain
Am J Clin Nutr 86:1463-9. 2007..The mechanism for this beneficial effect might be reduced inflammatory responses, as suggested by prospective studies and small clinical trials in men. No studies have evaluated the antiinflammatory effects of wine in women... - The effects of milk as a food matrix for polyphenols on the excretion profile of cocoa (-)-epicatechin metabolites in healthy human subjectsElena Roura
Department of Nutrition and Food Science CeRTA, University of Barcelona, Av Joan XXIII s n, Barcelona 08028, Spain
Br J Nutr 100:846-51. 2008..Thus, more studies are needed to evaluate the effect of these different metabolite profiles on the body... - Hypertensive status and lipoprotein oxidation in an elderly population at high cardiovascular riskMonica Guxens
Cardiovascular Risk and Nutrition Research Unit, Institut Municipal d Investigacio Medica, Barcelona, Spain
Am J Hypertens 22:68-73. 2009..Our aim was to assess the relationship between the degree of in vivo low-density lipoprotein (oxLDL) oxidation and the hypertensive status in a elderly population at high cardiovascular risk... - Inflammatory markers of atherosclerosis are decreased after moderate consumption of cava (sparkling wine) in men with low cardiovascular riskMónica Vázquez Agell
Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Barcelona 08036, Spain
J Nutr 137:2279-84. 2007..05). In conclusion, both cava and gin showed antiinflammatory properties; however, cava had a greater protective effect, probably due its polyphenol content... - Differential effects of polyphenols and alcohol of red wine on the expression of adhesion molecules and inflammatory cytokines related to atherosclerosis: a randomized clinical trialGemma Chiva-Blanch
Department of Internal Medicine, Hospital Clinic, Institut d Investigacio Biomedica August Pi i Sunyer, Barcelona, Spain
Am J Clin Nutr 95:326-34. 2012..Few clinical studies have focused on the alcohol-independent cardiovascular effects of the phenolic compounds of red wine (RW)... - Effect of Mediterranean diet on the expression of pro-atherogenic genes in a population at high cardiovascular riskVicenta Llorente-Cortes
Cardiovascular Research Center, CSIC ICCC, Hospital Sant Pau, Barcelona, Spain
Atherosclerosis 208:442-50. 2010..Dietary intervention can thus actively modulate the expression of pro-atherothrombotic genes even in a high-risk population... - Targeted metabolic profiling of phenolics in urine and plasma after regular consumption of cocoa by liquid chromatography-tandem mass spectrometryMireia Urpi-Sarda
Nutrition and Food Science Department, XaRTA, INSA, Pharmacy Faculty, University of Barcelona, 08028 Barcelona, Spain
J Chromatogr A 1216:7258-67. 2009..The results found herein indicate that 5-(3',4'-dihydroxyphenyl)-gamma-valerolactone and hydroxyphenylacetic acids could be good biomarkers of the regular consumption of cocoa and therefore, of flavanol-rich foods... - Milk does not affect the bioavailability of cocoa powder flavonoid in healthy humanElena Roura
Department of Nutrition and Food Science CeRTA, University of Barcelona, Barcelona, Spain
Ann Nutr Metab 51:493-8. 2007..The food matrix is one the factors than can affect their bioavailability, but previous studies have concluded rather contradictory results about the effect of milk on the bioavailability of polyphenols... - Evaluation of myocyte proliferation in alcoholic cardiomyopathy: telomerase enzyme activity (TERT) compared with Ki-67 expressionMeritxell Lluis
Alcohol Research Unit, Department of Internal Medicine, Institut d Investigació August Pi i Sunyer, Hospital Clinic, University of Barcelona, Villarroel 170, 08036 Barcelona, Spain
Alcohol Alcohol 46:534-41. 2011..We evaluated myocyte proliferation response in the heart of chronic alcoholic donors with telomerase activity (telomerase reverse transcriptase (TERT)) compared with Ki-67 nuclear expression... - Serum sterol responses to increasing plant sterol intake from natural foods in the Mediterranean dietVeronica Escurriol
Lipid Clinic, Endocrinology and Nutrition Service, Institut d Investigacions Biomèdiques Ausgust Pi Sunyer IDIBAPS, Hospital Clinic, Barcelona, Spain
Eur J Nutr 48:373-82. 2009..Phytosterols in natural foods are thought to inhibit cholesterol absorption. The Mediterranean diet is rich in phytosterol-containing plant foods... - Resveratrol metabolites in urine as a biomarker of wine intake in free-living subjects: The PREDIMED StudyRaul Zamora-Ros
Nutrition and Food Science Department XaRTA, INSA, Pharmacy School, University of Barcelona, 08028 Barcelona, Spain
Free Radic Biol Med 46:1562-6. 2009..This biomarker would provide an additional tool for investigating more precisely the relationship between wine consumption and health benefits... - Effect of a traditional Mediterranean diet on lipoprotein oxidation: a randomized controlled trialMontserrat Fito
Lipids and Cardiovascular Epidemiology Unit, Institut Municipal d Investigacio Medica, IMIM Hospital del Mar, Barcelona, Spain
Arch Intern Med 167:1195-203. 2007..Despite the richness in antioxidants of the Mediterranean diet, to our knowledge, no randomized controlled trials have assessed its effect on in vivo lipoprotein oxidation... - Rapid Folin-Ciocalteu method using microtiter 96-well plate cartridges for solid phase extraction to assess urinary total phenolic compounds, as a biomarker of total polyphenols intakeAlexander Medina-Remón
Nutrition and Food Science Department, XaRTA, INSA Pharmacy School, University of Barcelona, Av Joan XXIII s n, 08028 Barcelona, Spain
Anal Chim Acta 634:54-60. 2009..The method is fast and simple and it allows analysis of a large number of samples at the same time... - Total polyphenol intake estimated by a modified Folin-Ciocalteu assay of urineElena Roura
Department of Nutrition, , IDIBAPS, University of Barcelona, Barcelona, Spain
Clin Chem 52:749-52. 2006.... - Effects of alcohol withdrawal on 24 hour ambulatory blood pressure among alcohol-dependent patientsRamon Estruch
Alcohol Unit, Department of Internal Medicine, Hospital Clinic, University of Barcelona, Institut de Investigacions Biomediques August Pi i Sunyer, Spain
Alcohol Clin Exp Res 27:2002-8. 2003..We embarked on a study to determine whether different subgroups of alcohol-dependent patients may be identified in relation to the effect of alcohol on BP... - Effect of milk on the urinary excretion of microbial phenolic acids after cocoa powder consumption in humansMireia Urpi-Sarda
Nutrition and Food Science Department, XaRTA, INSA, Pharmacy Faculty, University of Barcelona, Barcelona, Spain
J Agric Food Chem 58:4706-11. 2010..In conclusion, milk partially affects the formation of microbial phenolic acids derived from the colonic degradation of procyanidins and other compounds present in cocoa powder... - Determination of resveratrol and piceid in beer matrices by solid-phase extraction and liquid chromatography-tandem mass spectrometryGemma Chiva-Blanch
Nutrition and Food Science Department, XaRTA, INSA, Pharmacy Faculty, University of Barcelona, Av Joan XXIII s n, 08028 Barcelona, Spain
J Chromatogr A 1218:698-705. 2011..Overall, beer is one of the products with the lowest levels of total resveratrol (?g/L), and despite its high consumption it should not be considered as a representative source of resveratrol... - Dihydroxylated phenolic acids derived from microbial metabolism reduce lipopolysaccharide-stimulated cytokine secretion by human peripheral blood mononuclear cellsMaria Monagas
Department of Internal Medicine, Institut d Investigacio Biomedica August Pi i Sunyer IDIBAPS, Hospital Clinic, Universitat de Barcelona, 08036 Barcelona, Spain
Br J Nutr 102:201-6. 2009.... - Different effects of red wine and gin consumption on inflammatory biomarkers of atherosclerosis: a prospective randomized crossover trial. Effects of wine on inflammatory markersRamon Estruch
Department of Internal Medicine, Hospital Clinic, , University of Barcelona, Barcelona, Spain
Atherosclerosis 175:117-23. 2004..CONCLUSIONS: Both wine and gin showed anti-inflammatory effects by reducing plasma fibrinogen and IL-1alpha levels. However, wine had the additional effect of decreasing hs-CRP, as well as monocyte and endothelial adhesion molecules... - Up-regulation of myocardial L-type Ca2+ channel in chronic alcoholic subjects without cardiomyopathyFrancesc Fatjó
Department of Internal Medicine, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Barcelona, Spain
Alcohol Clin Exp Res 31:1099-105. 2007..This study was designed to evaluate the density and function of myocardial L-type Ca(2+) channel receptors in organ donors with chronic alcoholism and controls... - Determinants of the omega-3 index in a Mediterranean population at increased risk for CHDAleix Sala-Vila
Lipid Clinic, Endocrinology and Nutrition Service, Institut d Investigacions Biomèdiques August Pi Sunyer, Unitat de Lípids, Hospital Clinic, Villarroel 170, 08036 Barcelona, Spain
Br J Nutr 106:425-31. 2011..Nevertheless, the high omega-3 index could at least partially explain the paradox of low rates of fatal CHD in Spain despite a high background prevalence of cardiovascular risk factors... - Influence of nutritional status on alcoholic myopathyJosé M Nicolás
Department of Internal Medicine, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Spain
Am J Clin Nutr 78:326-33. 2003..Muscle weakness and structural changes in striated skeletal muscle are common in persons with chronic alcoholism... - Human urine: epicatechin metabolites and antioxidant activity after cocoa beverage intakeElena Roura
Department of Nutrition and Food Science, University of Barcelona, Barcelona, Spain
Free Radic Res 41:943-9. 2007..Significance of TAC increase was found in urine samples excreted during 0-6 and 6-12 h (66.6 and 72.67%, respectively, with respect to the 0 h)... - Molecular and cellular events in alcohol-induced muscle diseaseJoaquim Fernández-Solà
Alcohol Unit, Hospital Clinic, University of Barcelona, Spain
Alcohol Clin Exp Res 31:1953-62. 2007..Finally, ethanol induces skeletal muscle apoptosis and increases both pro- and antiapoptotic regulatory mechanisms... - Increased myostatin activity and decreased myocyte proliferation in chronic alcoholic cardiomyopathyJoaquim Fernández-Solà
Alcohol Research Unit, Hospital Clinic, Institut d Investigació August Pi i Sunyer, Department of Medicine, University of Barcelona, Barcelona, Spain
Alcohol Clin Exp Res 35:1220-9. 2011..Myostatin is upregulated after cardiac damage and by alcohol consumption thereby decreasing myocyte renewal. We assess the potential role of alcohol in inducing myocyte apoptosis as well as in inhibiting myocyte proliferation... - High blood pressure, alcohol and cardiovascular riskRamon Estruch
Department of Medicine, Hospital Clinic, , University of Barcelona, Barcelona, Spain
J Hypertens 23:226-9. 2005 - Rapid liquid chromatography tandem mass spectrometry assay to quantify plasma (-)-epicatechin metabolites after ingestion of a standard portion of cocoa beverage in humansElena Roura
Department of Nutrition and Food Science-CeRTA, University of Barcelona, Spain
J Agric Food Chem 53:6190-4. 2005..7 +/- 198.3 nmol/L at 2 h after consumption of a cocoa beverage containing 54.4 mg of (-)-Ec... - Muscle antioxidant status in chronic alcoholismJoaquim Fernández-Solà
Department of Medicine, Hospital Clinic, IDIBAPS, University of Barcelona, Spain
Alcohol Clin Exp Res 26:1858-62. 2002..Its pathogenesis is multi-factorial, only partially clarified, and antioxidant imbalance has been suggested to influence its development, being a type II glucolytic, fast-twitch fiber subset more sensitive to this effect... - HPLC-tandem mass spectrometric method to characterize resveratrol metabolism in humansMireia Urpi Sarda
Nutrition and Food Science Department, CeRTA, Pharmacy School, University of Barcelona, Barcelona, Spain
Clin Chem 53:292-9. 2007..We sought to develop a method for nutritional analysis of resveratrol, a phenolic compound with purported health-promoting properties, and to determine all resveratrol metabolites...