Research Topics
| Eulalia MartiSummaryAffiliation: Center for Genomic Regulation Country: Spain Publications
| Collaborators
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Detail Information
Publications
Dyrk1A expression pattern supports specific roles of this kinase in the adult central nervous systemEulalia Marti
Program in Genes and Disease, Centre de Regulacio Genomica CRG, Passeig Maritim 37 49, 08003, Barcelona, Spain
Brain Res 964:250-63. 2003....
A myriad of miRNA variants in control and Huntington's disease brain regions detected by massively parallel sequencingEulalia Marti
Genetic Causes of Disease Group, Genes and Disease Program, Centre for Genomic Regulation CRG, Centro de Investigación Biomédica en Red en Epidemiología y Salud Pública CIBERESP, Molecular and Cellular Neurobiotechnology, Institute of Bioengineering of Catalonia and Department of Cell Biology, University of Barcelona, Barcelona, Catalonia, Spain
Nucleic Acids Res 38:7219-35. 2010..Our results show that miRNA variability is a ubiquitous phenomenon in the adult human brain, which may influence gene expression in physiological and pathological conditions...
RCAN1 (DSCR1) increases neuronal susceptibility to oxidative stress: a potential pathogenic process in neurodegenerationSilvia Porta
Genes and Disease Program, Center for Genomic Regulation CRG UPF, Biomedical Research Park Building, E 08003 Barcelona, Catalonia, Spain
Hum Mol Genet 16:1039-50. 2007....
MicroRNA profiling of Parkinson's disease brains identifies early downregulation of miR-34b/c which modulate mitochondrial functionElena Miñones-Moyano
Genetic Causes of Disease Group, Genes and Disease Program, Centre for Genomic Regulation, Barcelona, Catalonia, Spain
Hum Mol Genet 20:3067-78. 2011..A better understanding of the cellular pathways controlling and/or controlled by miR-34b/c should allow identification of targets for development of therapeutic approaches...
A pathogenic mechanism in Huntington's disease involves small CAG-repeated RNAs with neurotoxic activityMónica Bañez-Coronel
Genes and Disease Programme, Centre for Genomic Regulation and Universitat Pompeu Fabra, Barcelona, Catalonia, Spain
PLoS Genet 8:e1002481. 2012..The identification of the specific cellular processes affected by sCAGs may provide insights into the pathogenic mechanisms underlying HD, offering opportunities to develop new therapeutic approaches...
Dyrk1A haploinsufficiency affects viability and causes developmental delay and abnormal brain morphology in miceVassiliki Fotaki
Medical and Molecular Genetics Center, Institut de Recerca Oncologica, 08907 L Hospitalet de Llobregat, Barcelona, Spain
Mol Cell Biol 22:6636-47. 2002..These data provide evidence about the nonredundant, vital role of Dyrk1A and suggest a conserved mode of action that determines normal growth and brain size in both mice and flies...
Overexpression of miR-128 specifically inhibits the truncated isoform of NTRK3 and upregulates BCL2 in SH-SY5Y neuroblastoma cellsMonica Guidi
Center for Genomic Regulation, Genes and Disease Program, Dr, Aiguader 88, 08003 Barcelona, Spain
BMC Mol Biol 11:95. 2010..Here, we provide evidence that the two isoforms of NTRK3 are targeted by different sets of microRNAs, small non-coding RNAs that play an important regulatory role in the nervous system...
A non-biased framework for the annotation and classification of the non-miRNA small RNA transcriptomeLorena Pantano
Genetic Causes of Disease, Genes and Disease Programme, Centre for Genomic Regulation CRG and UPF, Barcelona, Spain
Bioinformatics 27:3202-3. 2011..We were able to detect all known classes of sRNAs described to date using SeqCluster with different sRNA datasets...
SeqBuster, a bioinformatic tool for the processing and analysis of small RNAs datasets, reveals ubiquitous miRNA modifications in human embryonic cellsLorena Pantano
Genetic Causes of Disease Group, Genes and Disease Program, Centre for Genomic Regulation, Pompeu Fabra University, Barcelona, Catalonia, Spain
Nucleic Acids Res 38:e34. 2010..The exhaustive description of the isomiRs provided by SeqBuster could help to identify miRNA-variants that are relevant in physiological and pathological processes. SeqBuster is available at http://estivill_lab.crg.es/seqbuster...
Transgenic mice overexpressing the full-length neurotrophin receptor TrkC exhibit increased catecholaminergic neuron density in specific brain areas and increased anxiety-like behavior and panic reactionMara Dierssen
Genes and Disease Program, Genomic Regulation Center CRG UPF, Barcelona, Biomedical Research Park, E 08003 Barcelona, Catalonia, Spain
Neurobiol Dis 24:403-18. 2006..Our results demonstrate that the elevated NT3-TrkC tone via overexpression of TrkC in the brain may constitute a molecular mechanism for the expression of anxiety and anxiety...
Three-dimensional structure and survival of newly formed blood vessels after focal cerebral ischemiaJerzy Krupinski
Department of Neurology, Hospital Universitario de Bellvitge, Barcelona, Spain
Neuroreport 14:1171-6. 2003..This normal growth pattern might be essential in future therapies involving induction of vascularization and neuroprotection to enhance long-term survival of the penumbra...
