Research Topics
Species | J VillarSummaryAffiliation: Canary Islands Country: Spain Publications
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Detail Information
Publications
From ventilator-induced lung injury to physician-induced lung injury: why the reluctance to use small tidal volumes?J Villar
Hospital Universitario N.S. de Candelaria, Tenerife, Canary Islands, Spain
Acta Anaesthesiol Scand 48:267-71. 2004- Heat shock proteins and ventilator-induced lung injuryJesus Villar
Research Institute, Hospital Universitario N S de Candelaria, and Department of Microbiology, University of La Laguna, Tenerife, Canary Islands, Spain
Curr Opin Crit Care 9:9-14. 2003..Several studies support the hypothesis that HSPs are cytoprotective In addition, recent investigations have demonstrated that HSP70 is released into the systemic circulation and is involved in the activation of innate immunity... - Ventilator or physician-induced lung injury?J Villar
Research Institute, Hospital Universitario N S of Candelaria, Tenerife, Canary Islands, Spain
Minerva Anestesiol 71:255-8. 2005.... - The use of positive end-expiratory pressure in the management of the acute respiratory distress syndromeJ Villar
Research Institute, Hospital Universitario N S de Candelaria, Tenerife, Canary Islands, Spain
Minerva Anestesiol 71:265-72. 2005.... - A high positive end-expiratory pressure, low tidal volume ventilatory strategy improves outcome in persistent acute respiratory distress syndrome: a randomized, controlled trialJesus Villar
Canarian Institute for Biomedical Research, Tomas Morales 6 1, 35003 Las Palmas de Gran Canaria, Canary Islands, Spain
Crit Care Med 34:1311-8. 2006.... - Low vs high positive end-expiratory pressure in the ventilatory management of acute lung injuryJ Villar
Division of Organ Dysfunction Research Instituto Canario de Investigación Biomédica ICIB, Las Palmas de Gran Canaria and Santa Cruz de Tenerife, Canary Islands, Spain
Minerva Anestesiol 72:357-62. 2006..In this article I will review the basic mechanisms of PEEP and the current knowledge of the effects of PEEP on the evolution and outcome of ALI/ARDS... - Bench-to-bedside review: understanding genetic predisposition to sepsisJesus Villar
Division Critical Care Research, Research Institute, Hospital Universitario NS de Candelaria, Tenerife, Canary Islands, Spain
Crit Care 8:180-9. 2004..We envision a time in the near future when genotyping will be include in the standard evaluation of critically ill patients and will help to prioritize a therapeutic option... - Angiotensin-converting enzyme insertion/deletion polymorphism is not associated with susceptibility and outcome in sepsis and acute respiratory distress syndromeJesus Villar
Multidisciplinary Organ Dysfunction Evaluation Research Network MODERN, Research Unit, Hospital Universitario Dr Negrin, Barranco de la Ballena, Las Palmas de Gran Canaria, Canary Islands, Spain
Intensive Care Med 34:488-95. 2008..We hypothesized that the I/D polymorphism also confers susceptibility to sepsis and is a predisposing factor for morbidity and mortality of patients with severe sepsis... - Current definitions of acute lung injury and the acute respiratory distress syndrome do not reflect their true severity and outcomeJ Villar
Research Institute, Hospital de la Candelaria, Tenerife, Canary Islands, Spain
Intensive Care Med 25:930-5. 1999..However, this definition may not reflect the true prevalence, severity and prognosis of these syndromes... - Genetic susceptibility to respiratory diseasesJ Villar
Research Institute, Hospital N S de Candelaria, Carretera del Rosario, S N, 38010 Santa Cruz de Tenerife, Canary Islands, Spain
Minerva Anestesiol 67:193-7. 2001..The author reviews some of these complex interactions suggesting that even the inflammatory response during lung injury can be influenced by genetic polymorphisms... - A CXCL2 tandem repeat promoter polymorphism is associated with susceptibility to severe sepsis in the Spanish populationC Flores
Research Institute Research Center associated to Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Cientificas, Madrid, Spain, Hospital Universitario NS de Candelaria, Tenerife, Spain
Genes Immun 7:141-9. 2006..22-4.03; P=0.008) and after a genomic control adjustment (P=0.017). Although replicate studies and functional assays are needed, these results suggest that CXCL2 gene variants may contribute to the development of severe sepsis... - Effects of induced hypothermia in patients with septic adult respiratory distress syndromeJ Villar
Intensive Care Unit, Hospital del Pino, Las Palmas, Canary Islands, Spain
Resuscitation 26:183-92. 1993..30 +/- 6%, P < 0.05). CONCLUSIONS: This study suggests that hypothermia was effective in improving oxygenation and survival in patients with severe ARDS associated with sepsis, even though VO2 was unchanged... - Critical care medicine in the 21st century: from CPR to PCRJ Villar
Research Institute, Hospital de la Candelaria, Tenerife, Canary Islands, Spain
Crit Care 5:125-30. 2001..Two historical paradigms, the cardiopulmonary resuscitation and polymerase chain reaction, summarize how critical care medicine began, and how it could mature in the years to come... - Molecular intensive care medicineJ Villar
Research Institute, Hospital de la Candelaria, Tenerife, Canary Islands, Spain
Intensive Care Med 25:652-61. 1999....