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Genomes and Genes | Balbino AlarconSummaryCountry: Spain Publications
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Publications
Initiation of TCR signaling: regulation within CD3 dimersBalbino Alarcon
Centro de Biologia Molecular Severo Ochoa, CSIC Universidad Autonoma de Madrid, Madrid, Spain
Immunol Rev 191:38-46. 2003..How the presence of TCR in clusters influences TCR avidity and propagation of TCR signals is something that has yet to be investigated...- The immunological synapse: a cause or consequence of T-cell receptor triggering?Balbino Alarcon
Centro de Biologia Molecular Severo Ochoa, CSIC UAM, Madrid, Spain
Immunology 133:420-5. 2011..Here, we shall review the historical evolution of the role of the cSMAC in T-cell activation, finally discussing our most recent data indicating that the cSMAC serves to internalize exhausted TCRs by phagocytosis... - Two receptors, two kinases, and T cell lineage determinationBalbino Alarcon
Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma de Madrid, Cantoblanco, Madrid 28049, Spain
Sci Signal 3:pe11. 2010..This finding, together with the known importance of Lck in the determination of CD4(+) and CD8(+) lineages, enables us to propose that a balance between the activation of these two kinases by the TCR determines lineage decisions... - MTOC translocation modulates IS formation and controls sustained T cell signalingNoa B Martín-Cófreces
Servicio de Inmunologia, Hospital de la Princesa, Universidad Autonoma de Madrid, 28006 Madrid, Spain
J Cell Biol 182:951-62. 2008..Together, these data reveal MTOC translocation as an important mechanism underlying IS formation and sustained T cell signaling... - T cell receptor internalization from the immunological synapse is mediated by TC21 and RhoG GTPase-dependent phagocytosisNuria Martínez-Martín
Centro de Biologia Molecular Severo Ochoa, CSIC UAM, 28049 Madrid, Spain
Immunity 35:208-22. 2011..Therefore, TC21 and RhoG dependence underlie the existence of a common phagocytic mechanism that drives TCR internalization from the IS together with its peptide-MHC ligand... - T cell receptor engagement triggers its CD3epsilon and CD3zeta subunits to adopt a compact, locked conformationRuth M Risueno
Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma de Madrid, Madrid, Spain
PLoS ONE 3:e1747. 2008..These results are consistent with a model in which transduction of the conformational change induced upon TCR triggering promotes condensation and shielding of the CD3 cytoplasmic tails... - Increased sensitivity of antigen-experienced T cells through the enrichment of oligomeric T cell receptor complexesRashmi Kumar
Departamento de Biología Celular e Inmunología, Centro Biología Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma de Madrid, 28049 Madrid, Spain
Immunity 35:375-87. 2011..Thus, we propose that an "avidity maturation" mechanism underlies T cell antigenic memory... - Activation outcomes induced in naïve CD8 T-cells by macrophages primed via "phagocytic" and nonphagocytic pathwaysIsabel María Olazabal
Servicio de Inmunologia, Hospital de la Princesa, Universidad Autonoma de Madrid, 28006 Madrid, Spain
Mol Biol Cell 19:701-10. 2008..These results suggest that the pathway used for antigen uptake may modulate the antigen density presented on MHC-I, resulting in different signals induced in naïve CD8 T-cells, leading either to CD8 T-cell activation or anergy... - Conformational modelRuth M Risueno
Centro de Biologia Molecular Severo Ochoa, CSIC Universidad Autonoma de Madrid, Cantoblanco, Madrid 28049, Spain
Adv Exp Med Biol 640:103-12. 2008.... - Coexistence of multivalent and monovalent TCRs explains high sensitivity and wide range of responseWolfgang W A Schamel
Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma de Madrid, Madrid 28049, Spain
J Exp Med 202:493-503. 2005..Thus, besides resolving TCR stoichiometry, these data can explain how T cells respond to a wide range of MHCp concentrations while maintaining high sensitivity... - Cooperativity between T cell receptor complexes revealed by conformational mutants of CD3epsilonNuria Martínez-Martín
Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma de Madrid, Cantoblanco, Madrid 28049, Spain
Sci Signal 2:ra43. 2009..These results emphasize the importance of the conformational change in CD3epsilon for the activation of T cells and suggest the existence of unforeseen cooperativity between TCR complexes... - Essential function for the GTPase TC21 in homeostatic antigen receptor signalingPilar Delgado
Centro de Biologia Molecular Severo Ochoa, Universidad Autonoma de Madrid, Cantoblanco, Spain
Nat Immunol 10:880-8. 2009..Consequently, we propose TC21 directly links antigen receptors to PI(3)K-mediated survival pathways... - H-ras and N-ras are dispensable for T-cell development and activation but critical for protective Th1 immunitySalvador Iborra
Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas, Departamento de Biologia Molecular, Universidad Autonoma de Madrid, Cantoblanco, Madrid, Spain
Blood 117:5102-11. 2011..Furthermore, we demonstrate for the first time that H-ras and N-ras act as critical controllers of Th1 responses, mostly by transmitting TCR signals for Th1 priming of CD4? T cells... - Expression of a modified form of CD4 results in the release of an anti-HIV factor derived from the Env sequenceIrene Zaldivar
Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas Universidad Autonoma de Madrid, Spain
J Immunol 183:1188-96. 2009..The presence of EDAF improves the therapeutic potential of the CD4epsilon15 gene and it opens new possibilities for antiviral treatment and vaccine development... - Overlapping functions of human CD3delta and mouse CD3gamma in alphabeta T-cell development revealed in a humanized CD3gamma-mouseEdgar Fernández-Malavé
Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma de Madrid, Cantoblanco, 28049 Madrid, Spain
Blood 108:3420-7. 2006..Taken together, these data demonstrate that CD3delta and CD3gamma play a different role in humans and mice in pre-TCR and TCR function during alphabeta T-cell development... - Role of Fyn in the rearrangement of tubulin cytoskeleton induced through TCRNoa B Martín-Cófreces
Servicio de Inmunologia, Hospital de la Princesa, Universidad Autonoma de Madrid, Spain
J Immunol 176:4201-7. 2006..In addition, Fyn deficiency significantly affects the MTOC relocation mediated by agonist peptide stimulation. These results reveal Fyn to be a key regulator of tubulin cytoskeleton reorganization in T cells... - Recruitment of Nck by CD3 epsilon reveals a ligand-induced conformational change essential for T cell receptor signaling and synapse formationDiana Gil
Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma de Madrid, Cantoblanco, Madrid 20849, Spain
Cell 109:901-12. 2002..Finally, by interfering with Nck-CD3 epsilon association in vivo, we demonstrate that TCR-CD3 recruitment of Nck is critical for maturation of the immune synapse and for T cell activation... - An orderly inactivation of intracellular retention signals controls surface expression of the T cell antigen receptorPilar Delgado
, , , Madrid 28049, Spain
J Exp Med 201:555-66. 2005..We propose that the stepwise assembly of the TCR complex guarantees that all assembly intermediates have at least one functional ER retention signal and that only a full signaling-competent TCR complex is expressed on the cell surface...