Fourie Joubert

Summary

Affiliation: University of Pretoria
Country: South Africa

Publications

  1. ncbi A structural annotation resource for the selection of putative target proteins in the malaria parasite
    Yolandi Joubert
    Bioinformatics and Computational Biology Unit, Department of Biochemistry, University of Pretoria, Pretoria, 0002, South Africa
    Malar J 7:90. 2008
  2. ncbi De novo assembled expressed gene catalog of a fast-growing Eucalyptus tree produced by Illumina mRNA-Seq
    Eshchar Mizrachi
    Department of Genetics, Forestry and Agricultural Biotechnology Institute FABI, University of Pretoria, Pretoria, 0002, South Africa
    BMC Genomics 11:681. 2010
  3. ncbi Discovery: an interactive resource for the rational selection and comparison of putative drug target proteins in malaria
    Fourie Joubert
    Bioinformatics and Computational Biology Unit, Department of Biochemistry, University of Pretoria, Pretoria, South Africa
    Malar J 8:178. 2009
  4. ncbi Structural and mechanistic insights into the action of Plasmodium falciparum spermidine synthase
    Pieter B Burger
    Bioinformatics and Computational Biology Unit, Faculty of Natural and Agricultural Sciences, University of Pretoria, Pretoria 0002, South Africa
    Bioorg Med Chem 15:1628-37. 2007
  5. ncbi Influence of prostaglandin A2 and 2-methoxyestradiol on Bax and Bcl-2 expression levels in cervical carcinoma cells
    Annie Joubert
    Department of Physiology, University of Pretoria, Pretoria, South Africa
    Biomed Res 26:87-90. 2005
  6. ncbi Bax/Bcl-2 expression levels of 2-methoxyestradiol-exposed esophageal cancer cells
    Annie Joubert
    Department of Physiology, University of Pretoria, P O Box 2034, Pretoria 0001, South Africa
    Biomed Res 26:131-4. 2005
  7. ncbi Genome sequence of Pantoea ananatis LMG20103, the causative agent of Eucalyptus blight and dieback
    Pieter De Maayer
    Forestry and Agricultural Biotechnology Institute, University of Pretoria, Pretoria 0002, South Africa
    J Bacteriol 192:2936-7. 2010
  8. ncbi Influence of prostaglandin A2 on Bax, Bcl-2 and PCNA expression in MCF-7 cells
    Annie Joubert
    Department of Physiology, University of Pretoria, Pretoria, South Africa
    Biomed Res 27:157-62. 2006
  9. ncbi Docking, synthesis, and in vitro evaluation of antimitotic estrone analogs
    Andre Stander
    Department of Physiology, University of Pretoria, Pretoria, South Africa
    Chem Biol Drug Des 77:173-81. 2011
  10. ncbi MADIBA: a web server toolkit for biological interpretation of Plasmodium and plant gene clusters
    Philip J Law
    Bioinformatics and Computational Biology Unit, African Centre for Gene Technologies ACGT, Department of Biochemistry, Faculty of Natural and Agricultural Sciences, University of Pretoria, Pretoria, 0002, South Africa
    BMC Genomics 9:105. 2008

Collaborators

Detail Information

Publications15

  1. ncbi A structural annotation resource for the selection of putative target proteins in the malaria parasite
    Yolandi Joubert
    Bioinformatics and Computational Biology Unit, Department of Biochemistry, University of Pretoria, Pretoria, 0002, South Africa
    Malar J 7:90. 2008
    ..falciparum proteins. Additionally, the annotation of a range of structural features facilitates the identification of suitable targets for experimental and computational studies...
  2. ncbi De novo assembled expressed gene catalog of a fast-growing Eucalyptus tree produced by Illumina mRNA-Seq
    Eshchar Mizrachi
    Department of Genetics, Forestry and Agricultural Biotechnology Institute FABI, University of Pretoria, Pretoria, 0002, South Africa
    BMC Genomics 11:681. 2010
    ....
  3. ncbi Discovery: an interactive resource for the rational selection and comparison of putative drug target proteins in malaria
    Fourie Joubert
    Bioinformatics and Computational Biology Unit, Department of Biochemistry, University of Pretoria, Pretoria, South Africa
    Malar J 8:178. 2009
    ..The Discovery system provides data mining functionality on extensive annotations of five malaria species together with the human and mosquito hosts, enabling the selection of new targets based on multiple protein and ligand properties...
  4. ncbi Structural and mechanistic insights into the action of Plasmodium falciparum spermidine synthase
    Pieter B Burger
    Bioinformatics and Computational Biology Unit, Faculty of Natural and Agricultural Sciences, University of Pretoria, Pretoria 0002, South Africa
    Bioorg Med Chem 15:1628-37. 2007
    ....
  5. ncbi Influence of prostaglandin A2 and 2-methoxyestradiol on Bax and Bcl-2 expression levels in cervical carcinoma cells
    Annie Joubert
    Department of Physiology, University of Pretoria, Pretoria, South Africa
    Biomed Res 26:87-90. 2005
    ..Further investigation of the function and regulation of the Bcl-2 family will allow researchers to consider potential pathways of apoptosis signaling mechanisms for diseases where apoptosis can potentially be controlled...
  6. ncbi Bax/Bcl-2 expression levels of 2-methoxyestradiol-exposed esophageal cancer cells
    Annie Joubert
    Department of Physiology, University of Pretoria, P O Box 2034, Pretoria 0001, South Africa
    Biomed Res 26:131-4. 2005
    ....
  7. ncbi Genome sequence of Pantoea ananatis LMG20103, the causative agent of Eucalyptus blight and dieback
    Pieter De Maayer
    Forestry and Agricultural Biotechnology Institute, University of Pretoria, Pretoria 0002, South Africa
    J Bacteriol 192:2936-7. 2010
    ..Here, we report the genome sequence of P. ananatis LMG20103 isolated from diseased Eucalyptus in South Africa...
  8. ncbi Influence of prostaglandin A2 on Bax, Bcl-2 and PCNA expression in MCF-7 cells
    Annie Joubert
    Department of Physiology, University of Pretoria, Pretoria, South Africa
    Biomed Res 27:157-62. 2006
    ..7. The present study suggests that an accumulation in the S phase, a decrease in expression levels of PCNA, as well as an altered ratio in favor of Bax, could lead to the induction of apoptosis in these cells...
  9. ncbi Docking, synthesis, and in vitro evaluation of antimitotic estrone analogs
    Andre Stander
    Department of Physiology, University of Pretoria, Pretoria, South Africa
    Chem Biol Drug Des 77:173-81. 2011
    ....
  10. ncbi MADIBA: a web server toolkit for biological interpretation of Plasmodium and plant gene clusters
    Philip J Law
    Bioinformatics and Computational Biology Unit, African Centre for Gene Technologies ACGT, Department of Biochemistry, Faculty of Natural and Agricultural Sciences, University of Pretoria, Pretoria, 0002, South Africa
    BMC Genomics 9:105. 2008
    ..While many algorithms and software have been developed for analysing gene expression, the extraction of relevant information from experimental data is still a substantial challenge, requiring significant time and skill...
  11. ncbi Integration and mining of malaria molecular, functional and pharmacological data: how far are we from a chemogenomic knowledge space?
    Lyn Marie Birkholtz
    Department of Biochemistry and African Centre for Gene Technologies, Faculty of Natural and Agricultural Sciences, University of Pretoria, 0002, Pretoria, South Africa
    Malar J 5:110. 2006
    ..Recent progress towards a grid-enabled chemogenomic knowledge space is discussed...
  12. ncbi Elucidation of sulfadoxine resistance with structural models of the bifunctional Plasmodium falciparum dihydropterin pyrophosphokinase-dihydropteroate synthase
    Tjaart A P de Beer
    Bioinformatics and Computational Biology Unit, Department of Biochemistry, Faculty of Natural and Agricultural Sciences, University of Pretoria, South Africa
    Bioorg Med Chem 14:4433-43. 2006
    ..coli. The informative nature of these models opens up avenues for structure-based drug design approaches toward the development of alternative and more effective inhibitors of P. falciparum PPPK-DHPS...
  13. ncbi Novel properties of malarial S-adenosylmethionine decarboxylase as revealed by structural modelling
    Gordon A Wells
    Department of Biochemistry, School of Biological Sciences, Faculty of Natural and Agricultural Sciences, University of Pretoria, Pretoria 0002, South Africa
    J Mol Graph Model 24:307-18. 2006
    ..These novel features of malarial AdoMetDC suggest possibilities for the discovery of parasite-specific inhibitors...
  14. ncbi The genome of the heartwater agent Ehrlichia ruminantium contains multiple tandem repeats of actively variable copy number
    Nicola E Collins
    Department of Veterinary Tropical Diseases, Faculty of Veterinary Science, University of Pretoria, Private Bag X04, Onderstepoort 0110, South Africa
    Proc Natl Acad Sci U S A 102:838-43. 2005
    ..Rather then being the result of the reductive evolution seen in other intracellular bacteria, these pseudogenes appear to be the product of ongoing sequence duplication events...
  15. ncbi Parasite-specific inserts in the bifunctional S-adenosylmethionine decarboxylase/ornithine decarboxylase of Plasmodium falciparum modulate catalytic activities and domain interactions
    Lyn-Marie Birkholtz
    Department of Biochemistry, School of Biological Sciences, Faculty of Natural and Agricultural Sciences, University of Pretoria, Pretoria, 0002, South Africa
    Biochem J 377:439-48. 2004
    ..Interference with essential protein-protein interactions mediated by parasite-specific regions therefore appears to be a viable strategy to aid the design of selective inhibitors of polyamine metabolism of P. falciparum...