Research Topics
| WILLEM ALBERT HANEKOMSummaryAffiliation: University of Cape Town Country: South Africa Publications
Research Grants
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Detail Information
Publications
Tuberculosis research updateW A Hanekom
South African Tuberculosis Vaccine Initiative, University of Cape Town, Cape Town, South Africa
Trop Med Int Health 15:981-9. 2010..In this brief review, we provide a focused update on these four key areas of TB research...- Predominance of interleukin-22 over interleukin-17 at the site of disease in human tuberculosisKerryn Matthews
Clinical Infectious Diseases Research Initiative, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Observatory 7925, South Africa Department of Medicine, Faculty of Health Sciences, University of Cape Town, Observatory 7925, South Africa
Tuberculosis (Edinb) 91:587-93. 2011..We propose that our findings support a role for IL-22 in TB-induced pathology or the resulting repair process... - Novel application of Ki67 to quantify antigen-specific in vitro lymphoproliferationAndreia Soares
South African Tuberculosis Vaccine Initiative, Institute of Infectious Diseases and Molecular Medicine and School of Child and Adolescent Health, University of Cape Town, Cape Town, South Africa
J Immunol Methods 362:43-50. 2010..Overall our data suggest that intracellular Ki67 expression provides a specific, quantitative and reproducible measure of antigen-specific T cell proliferation in vitro... - Evaluation of the quality of informed consent in a vaccine field trial in a developing country settingDeon Minnies
South African Tuberculosis Vaccine Initiative, Institute of Infectious Diseases and Molecular Medicine and School of Child and Adolescent Health, University of Cape Town, Cape Town, South Africa
BMC Med Ethics 9:15. 2008..The aim of the study was to evaluate the quality of consent in the case control study, and to identify factors that may influence the quality of consent. Cross-sectional study conducted over a 4 month period... - Transcriptional profiling of mycobacterial antigen-induced responses in infants vaccinated with BCG at birthHelen A Fletcher
South African Tuberculosis Vaccine Initiative, Institute of Infectious Diseases and Molecular Medicine, and School of Child and Adolescent Health, University of Cape Town, South Africa
BMC Med Genomics 2:10. 2009..CONCLUSION: Our results suggest that a combination of suppressed and up-regulated genes may be key in determining development of protective immunity to TB induced by vaccination with BCG... - Immunological protection against tuberculosisWillem A Hanekom
South African Tuberculosis Vaccine Initiative, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town
S Afr Med J 97:973-7. 2007 - CD4 and CD8 T-cell responses to mycobacterial antigens in African childrenNontobeko G Tena-Coki
Institute of Infectious Diseases and Molecular Medicine, South African Tuberculosis Vaccine Initiative, and School of Child and Adolescent Health, University of Cape Town, Cape Town, South Africa
Am J Respir Crit Care Med 182:120-9. 2010..Furthermore, more efficacious TB vaccines are needed for children with immunodeficiencies such as HIV infection, who are at highest risk of disease... - HIV-1 infection impairs the bronchoalveolar T-cell response to mycobacteriaBarbara Kalsdorf
Clinical Infectious Diseases Research Initiative, University of Cape Town, Observatory, South Africa
Am J Respir Crit Care Med 180:1262-70. 2009..Immune responses in the lung are important to restrict the growth of M. tuberculosis to prevent the development of disease... - Significantly skewed memory CD8+ T cell subsets in HIV-1 infected infants during the first year of lifeNazma Mansoor
South African Tuberculosis Vaccine Initiative, Institute of Infectious Diseases and Molecular Medicine and School of Child and Adolescent Health, University of Cape Town, Anzio Road, Observatory, 7925, South Africa
Clin Immunol 130:280-9. 2009..We concluded that the proportion of naive, memory, effector and senescent CD8(+) T cells during the first year of life is significantly altered by HIV-1 infection... - Comparison of T-SPOT.TB assay and tuberculin skin test for the evaluation of young children at high risk for tuberculosis in a community settingMark P Nicol
School of Child and Adolescent Health, University of Cape Town, Cape Town, South Africa
Pediatrics 123:38-43. 2009..TB; Oxford Immunotec, Oxford, United Kingdom) and the tuberculin skin test for the detection of tuberculosis infection in very young children being evaluated for active tuberculosis in a rural community setting... - Safety and immunogenicity of a new tuberculosis vaccine, MVA85A, in healthy adults in South AfricaTony Hawkridge
South African Tuberculosis Vaccine Initiative, Institute of Infectious Diseases and Molecular Medicine, and School of Child and Adolescent Health, University of Cape Town, Observatory, South Africa
J Infect Dis 198:544-52. 2008..We investigated the safety and immunogenicity of MVA85A in mycobacteria-exposed--but Mycobacterium tuberculosis-uninfected--healthy adults from a region of South Africa where TB is endemic... - Distinct, specific IL-17- and IL-22-producing CD4+ T cell subsets contribute to the human anti-mycobacterial immune responseThomas J Scriba
South African Tuberculosis Vaccine Initiative, Observatory, South Africa
J Immunol 180:1962-70. 2008..IL-17- and IL-22-producing CD4(+) T cells may play important roles in the human immune response to mycobacteria... - The impact of a change in bacille Calmette-Guérin vaccine policy on tuberculosis incidence in children in Cape Town, South AfricaHassan Mahomed
South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa
Pediatr Infect Dis J 25:1167-72. 2006.... - Specific T cell frequency and cytokine expression profile do not correlate with protection against tuberculosis after bacillus Calmette-Guérin vaccination of newbornsBenjamin M N Kagina
South African Tuberculosis Vaccine Initiative, Institute of Infectious Diseases and Molecular Medicine and School of Child and Adolescent Health, University of Cape Town, Cape Town, South Africa
Am J Respir Crit Care Med 182:1073-9. 2010..Immunogenicity of new tuberculosis (TB) vaccines is commonly assessed by measuring the frequency and cytokine expression profile of T cells... - The immune response to BCG vaccination of newbornsWillem A Hanekom
SATVI, Institute of Infectious Diseases and Molecular Medicine, UCT Health Sciences Faculty, Wernher and Beit S2 01, Anzio Road, Observatory, 7925 Cape Town, South
Ann N Y Acad Sci 1062:69-78. 2005..Tests will, therefore, be made to determine whether CD8 or regulatory CD4 T-cell responses, as well as "outlier" cytokine responses, are associated with vaccination-induced protection against tuberculosis... - Quantitative and functional differences between peripheral blood myeloid dendritic cells from patients with pleural and parenchymal lung tuberculosisMarc Mendelson
Laboratory of Mycobcterial Immunity and Pathogenesis, Public Health Research Institute, International Center for Public Health, Newark, New Jersey 07103 3535, USA
Clin Vaccine Immunol 13:1299-306. 2006..Our findings suggest important differences in innate immunity between patients with different forms of active TB, and this may contribute to the differences in natural history observed between the two groups... - Dissection of regenerating T-Cell responses against tuberculosis in HIV-infected adults sensitized by Mycobacterium tuberculosisKatalin A Wilkinson
Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Room S3 13, Wernher and Beit Building South, Observatory 7925, Republic of South Africa
Am J Respir Crit Care Med 180:674-83. 2009..Therefore a novel approach to gain insight into protection against tuberculosis is to analyze the T cells that expand in people sensitized by Mycobacterium tuberculosis (MTB) during cART... - Modified vaccinia Ankara-expressing Ag85A, a novel tuberculosis vaccine, is safe in adolescents and children, and induces polyfunctional CD4+ T cellsThomas J Scriba
South African Tuberculosis Vaccine Initiative, Institute of Infectious Diseases and Molecular Medicine, and School of Child and Adolescent Health, University of Cape Town, Observatory, South Africa
Eur J Immunol 40:279-90. 2010..This includes induction of novel Th1-cell populations that have not been previously described in humans... - Bacillus Calmette-Guérin vaccination of human newborns induces T cells with complex cytokine and phenotypic profilesAndreia P Soares
South African TB Institute of Infectious Diseases and Molecular Medicine and School of Child and Adolescent Health, Vaccine Initiative, University of Cape Town, Cape Town, South Africa
J Immunol 180:3569-77. 2008..Measuring IFN-gamma production alone underestimates the magnitude and complexity of the host cytokine response to BCG vaccination and may not be an optimal readout in studies of BCG and novel tuberculosis vaccination... - Delaying BCG vaccination from birth to 10 weeks of age may result in an enhanced memory CD4 T cell responseBenjamin M N Kagina
South African Tuberculosis Vaccine Initiative SATVI, Institute of Infectious Diseases and Molecular Medicine and School of Child and Adolescent Health, University of Cape Town, Cape Town, South Africa
Vaccine 27:5488-95. 2009..The neonatal immune system is immature. Our hypothesis was that delaying BCG vaccination from birth to 10 weeks of age would enhance the vaccine-induced immune response... - HIV-1 infection in infants severely impairs the immune response induced by Bacille Calmette-Guérin vaccineNazma Mansoor
South African Tuberculosis Vaccine Initiative, Institute of Infectious Diseases and Molecular Medicine and School of Child and Adolescent Health, University of Cape Town, Cape Town, South Africa
J Infect Dis 199:982-90. 2009..Information regarding the immunogenicity of BCG is imperative for the risk/benefit assessment of BCG vaccination in HIV-infected infants; however, no such data exist... - The novel tuberculosis vaccine, AERAS-402, induces robust and polyfunctional CD4+ and CD8+ T cells in adultsBrian Abel
South African Tuberculosis Vaccine Initiative, Institute of Infectious Diseases and Molecular Medicine and School of Child and Adolescent Health, University of Cape Town, UCT Health Sciences, Anzio Road, Observatory 7925, Cape Town, South Africa
Am J Respir Crit Care Med 181:1407-17. 2010..AERAS-402 is a novel tuberculosis vaccine designed to boost immunity primed by bacillus Calmette-Guérin (BCG), the only licensed vaccine... - Adjunctive thalidomide therapy for childhood tuberculous meningitis: results of a randomized studyJohan F Schoeman
Department of Pediatrics and Child Health, Tygerberg Children s Hospital, Faculty of Health Sciences, University of Stellenbosch, Tygerberg, South Africa
J Child Neurol 19:250-7. 2004..8 versus mean IQ control group 67.5; P = .16). These results do not support the use of adjunctive high-dose thalidomide therapy in the treatment of tuberculous meningitis... - Mycobacterium tuberculosis inhibits maturation of human monocyte-derived dendritic cells in vitroWillem A Hanekom
Department of Pediatrics, Division of Infectious Disease and Immunology, University of Miami School of Medicine, 1550 NW 10th Avenue, Suite 211 D4 4, Miami, FL 33136, USA
J Infect Dis 188:257-66. 2003..This mechanism, which has been described elsewhere for various viruses and for the virulent mycobacterium M. leprae, may be a novel mechanism that this pathogen uses to evade the host's immune response... - Bacillus Calmette Guerin vaccination of human newborns induces a specific, functional CD8+ T cell responseRose Ann Murray
Public Health Research Institute, Newark, NJ 07103, USA
J Immunol 177:5647-51. 2006..Incubation of whole blood with M. tuberculosis also caused CD8+ T cell IFN-gamma expression. We conclude that BCG induces a robust CD8+ T cell response, which may contribute to vaccination-induced protection against tuberculosis... - Novel application of a whole blood intracellular cytokine detection assay to quantitate specific T-cell frequency in field studiesWillem A Hanekom
Department of Pediatrics, University of Miami School of Medicine, Miami, FL 33101, USA
J Immunol Methods 291:185-95. 2004..The assay proved sensitive and specific for detecting mycobacteria-specific immunity 10 weeks after Bacillus Calmette-Guerin (BCG) vaccination of newborns from a rural field site... - A whole blood assay to assess peripheral blood dendritic cell function in response to Toll-like receptor stimulationJames A Ida
Miller School of Medicine, University of Miami, USA
J Immunol Methods 310:86-99. 2006..The major impact of cryopreservation on some DC responses further strengthens the case for a rapid method that uses fresh blood... - The effect of bacille Calmette-Guérin vaccine strain and route of administration on induced immune responses in vaccinated infantsVirginia Davids
South African Tuberculosis Vaccine Initiative (SATVI, Institute of Infectious Disease and Molecular Medicine, Cape Town
J Infect Dis 193:531-6. 2006..Thus, BCG strain and route of neonatal vaccination confer different levels of immune activation, which may affect the efficacy of the vaccine... - Thalidomide and a thalidomide analogue drug costimulate virus-specific CD8+ T cells in vitroPatrick A J Haslett
The Rockefeller University, New York, New York, USA
J Infect Dis 187:946-55. 2003..This stimulatory effect was directed at CD8(+) T cells, and not DCs. These results suggest an application for thalidomide and the thalidomide analogue as a novel immune-adjuvant therapy in chronic viral infections... - Epstein-Barr nuclear antigen 1-specific CD4(+) Th1 cells kill Burkitt's lymphoma cellsCasper Paludan
Laboratory of Cellular Physiology and Immunology, The Rockefeller University, New York, NY 10021, USA
J Immunol 169:1593-603. 2002..Therefore, adaptive immunity can be directed against Burkitt's lymphoma, and perhaps this role for CD4(+) Th1 cells extends to other tumors that escape MHC class I presentation...
Research Grants
- Protective immunity induced by newborn BCG vaccinationWillem Hanekom; Fiscal Year: 2009..We will characterize this response in newborns vaccinated with BCG. We will compare the antibody response between BCG-vaccinated infants who are protected against TB, and those not protected. ..
- Host determinants of protection against tuberculosis in adolescentsWILLEM ALBERT HANEKOM; Fiscal Year: 2011....