Research Topics
| Martin Peter GrobuschSummaryAffiliation: University of the Witwatersrand Country: South Africa Publications
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Detail Information
Publications
Intermittent preventive therapy for malaria: progress and future directionsMartin P Grobusch
Infectious Diseases Unit, Division of Clinical Microbiology and Infectious Diseases, National Health Laboratory Service and University of Witwatersrand, Johannesburg, South Africa
Curr Opin Infect Dis 20:613-20. 2007..This review summarizes recent evidence regarding the efficacy of intermittent preventive treatment with focus on infancy (IPTi) and the rationale behind such a control strategy...- Severe malaria in a splenectomised Gabonese womanMartin P Grobusch
Medical Research Unit, Albert Schweitzer Hospital, Lambarene, Gabon
Wien Klin Wochenschr 115:63-5. 2003..Regarding the optimal drug regimen for treating malaria in splenectomized patients, a combination of an aminoquinoline with an artemisinin derivative might be the optimal choice... - Molecular surveillance of mutations in the cytochrome b gene of Plasmodium falciparum in Gabon and EthiopiaTamirat Gebru
Department of Medical Laboratory Technology, Faculty of Health Sciences, Haramaya University, Haramaya, Ethiopia
Malar J 5:112. 2006..Molecular modelling showed that amino acid mutations are clustered around a putative atovaquone-binding site resulting in a reduced binding affinity of atovaquone for plasmodial cytochrome b, thus resulting in drug resistance... - Is flow cytometry better in counting malaria pigment-containing leukocytes compared to microscopy?Thomas Hanscheid
Medical Research Unit, Hopital Albert Schweitzer, Lambarene, Gabon
Malar J 8:255. 2009..Detection of malaria pigment (or haemozoin; Hz)-containing leukocytes may have prognostic relevance in malaria; however, studies reported conflicting results, with microscopic counts suggestive of being inaccurate and imprecise... - Artesunate--amodiaquine combination therapy for falciparum malaria in young Gabonese childrenSunny Oyakhirome
Medical Research Unit, Albert Schweitzer Hospital, Lambarene, Gabon
Malar J 6:29. 2007..Effectiveness data on this combination in young children is scarce... - Malaria incidence in Limpopo Province, South Africa, 1998-2007Annette A M Gerritsen
Department of Public Health, University of Venda, Private Bag X5050, Thohoyandou, 0950, Limpopo Province, South Africa
Malar J 7:162. 2008..The aim of this descriptive study is to give an overview of the malaria incidence and mortality in Limpopo Province for the seasons 1998-1999 to 2006-2007 and to detect trends over time and place... - Therapeutic and prophylactic effect of intermittent preventive anti-malarial treatment in infants (IPTi) from Ghana and GabonJurgen May
Research Group Infectious Disease Epidemiology, Bernhard Nocht Institute for Tropical Medicine, Bernhard Nocht Strasse 74, D 20359 Hamburg, Germany
Malar J 7:198. 2008..The exact mechanism by which the protective effect is mediated needs to be defined. This study aimed to investigate therapeutic, prophylactic, and possible exceeding effects of SP-based IPTi in two clinical trials... - Full blood count and haemozoin-containing leukocytes in children with malaria: diagnostic value and association with disease severityThomas Hanscheid
Medical Research Unit, Albert Schweitzer Hospital, Lambarene, Gabon
Malar J 7:109. 2008..Diligent and correct laboratory diagnosis and up-front identification of risk factors for progression to severe disease are the basis for optimal management of malaria... - Socio-economic status is inversely related to bed net use in GabonJulia N Goesch
Medical Research Unit, Albert Schweitzer Hospital, Lambarene, Gabon
Malar J 7:60. 2008..The goal of this study was to investigate the influence of socio-economic factors on the use of bed nets by mothers in Gabon... - Community response to intermittent preventive treatment of malaria in infants (IPTi) delivered through the expanded programme of immunization in five African settingsMarjolein Gysels
Centre for International Health Research CRESIB, University of Barcelona, Spain
Malar J 8:191. 2009.... - Early rectal artesunate administration: a life-saver in remote areas?Martin P Grobusch
Infectious Diseases Unit, Division of Clinical Microbiology and Infectious Diseases, National Health Laboratory Service and School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
Future Microbiol 4:397-400. 2009..With some questions remaining, this strategy appears to be an important, probably highly cost-effective additional tool urgently needed to help reducing the burden of disease... - Intermittent preventive treatment against malaria in infants in Gabon--a randomized, double-blind, placebo-controlled trialMartin P Grobusch
Medical Research Unit, Albert Schweitzer Hospital, Lambarene, Gabon
J Infect Dis 196:1595-602. 2007..Intermittent preventive treatment aims to maximize the protective effects of malaria chemoprophylaxis while minimizing the deleterious effects... - No rebound of morbidity following intermittent preventive sulfadoxine-pyrimethamine treatment of malaria in infants in GabonMartin P Grobusch
Medical Research Unit, Albert Schweitzer Hospital, Lambarene, Gabon
J Infect Dis 200:1658-61. 2009..These results do not appear to support the concept of a rebound effect after intermittent preventive sulfadoxine-pyrimethamine treatment of malaria in infants. Clinical trials registration. NCT00167843... - Drug-resistant and extensively drug-resistant tuberculosis in southern AfricaMartin Peter Grobusch
Division of Infectious Diseases, Department of Medicine, Faculty of Health Sciences, University of Witwatersrand, Johannesburg, South Africa
Curr Opin Pulm Med 16:180-5. 2010..Drug-resistant tuberculosis (TB) is of increasing global concern. One of the hardest hit regions is southern Africa. This study focuses on a concise update on recently published developments in the field... - Clinical and parasitological characteristics of puerperal malariaMichael Ramharter
Medical Research Unit, Albert Schweitzer Hospital, Lambarene, Gabon, Germany
J Infect Dis 191:1005-9. 2005..Recent findings indicate that this increased risk might persist beyond delivery, but the underlying mechanisms for this change in risk are poorly understood... - 5-day nonobserved artesunate monotherapy for treating uncomplicated Falciparum malaria in young Gabonese childrenNorbert G Schwarz
Medical Research Unit, , Gabon
Am J Trop Med Hyg 73:705-9. 2005..Artesunate was well tolerated, and no severe adverse events were reported... - Effectiveness of quinine monotherapy for the treatment of Plasmodium falciparum infection in pregnant women in Lambaréné, GabonAyola A Adegnika
Medical Research Unit, Albert Schweitzer Hospital, Lambarene, Gabon
Am J Trop Med Hyg 73:263-6. 2005..We conclude that a 7-day course of quinine has a poor effectiveness and that alternative treatment regimens for malaria in pregnant women should be assessed... - Malaria and asymptomatic parasitaemia in Gabonese infants under the age of 3 monthsPeter M C Klein Klouwenberg
Medical Research Unit, Albert Schweitzer Hospital, B.P. 118, , Gabon
Acta Trop 95:81-5. 2005..The malaria incidence density was 1.1/1000 person-months or 0.1% of observations. Our findings underpin the notion that the incidence of malaria and parasitaemia in infants below the age of 3 months is very low... - Placental malaria increases malaria risk in the first 30 months of lifeNorbert G Schwarz
Medical Research Unit, Albert Schweitzer Hospital, Lambarene, Gabon, South Africa
Clin Infect Dis 47:1017-25. 2008..An additional consequence may be increased risk of malaria in early life, although the epidemiological evidence of this consequence is limited... - High prevalence of asymptomatic Plasmodium falciparum infection in Gabonese adultsMatthias P Dal-Bianco
Medical Research Unit, Albert Schweitzer Hospital, Lambarene, Gabon
Am J Trop Med Hyg 77:939-42. 2007..falciparum. Most positive cases were only detected by the stevor-PCR. Asymptomatic P. falciparum parasitemia in adults living in a malaria-endemic country is frequent... - Automated detection of haemozoin-containing monocytes for the diagnosis of malaria in microscopically negative cases during pregnancyThomas Hanscheid
Medical Research Unit, Albert Schweitzer Hospital, Lambarene, Gabon
Acta Trop 109:245-6. 2009..In a subset of 37 Cell-Dyn positive but microscopy negative samples, PCR detected five positive cases. This methodology may serve as an adjunct rapid diagnostic tool for malaria during pregnancy, even in microscopically negative cases... - WHO 2006 child growth standards: implications for the prevalence of stunting and underweight-for-age in a birth cohort of Gabonese children in comparison to the Centers for Disease Control and Prevention 2000 growth charts and the National Center for HealNorbert G Schwarz
Medical Research Unit, Albert Schweitzer Hospital, Lambarene, Gabon
Public Health Nutr 11:714-9. 2008.... - Lamivudine-induced red cell aplasiaMelanie Anne A John
Infectious Diseases Unit, Division of Clinical Microbiology and Infectious Diseases, National Health Laboratory Service and School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
J Med Microbiol 57:1032-5. 2008.... - Short report: evaluation of a simple and inexpensive photometric device for the measurement of hemoglobinSteffen Borrmann
Medical Research Unit, Albert Schweitzer Hospital, BP 118, Lambarene, Gabon
Am J Trop Med Hyg 71:691-2. 2004..1 g/dL for the comparison of QBC with CellDyn measurements. We conclude that the poor agreement of the DHT with the CellDyn does not permit the use of the DHT for critical hemoglobin measurements, particularly in transfusion services... - History and perspectives of medical research at the Albert Schweitzer Hospital in Lambaréné, GabonMichael Ramharter
Medical Research Unit, Albert Schweitzer Hospital, Lambarene, Gabon
Wien Klin Wochenschr 119:8-12. 2007..A training program in clinical research in tropical diseases for African scientists has been set up recently... - Reasons for non-adherence to vaccination at mother and child care clinics (MCCs) in Lambaréné, GabonNorbert G Schwarz
Medical Research Unit, Albert Schweitzer Hospital, Lambarene, Gabon
Vaccine 27:5371-5. 2009.... - Shared breastfeeding in central AfricaMichael Ramharter
Medical Research Unit, Albert Schweitzer Hospital, , Gabon, Germany
AIDS 18:1847-9. 2004..Shared breastfeeding is increasing the exposure to potentially infectious individuals and has therefore to be considered in breastfeeding recommendations... - Screening for mutations related to atovaquone/proguanil resistance in treatment failures and other imported isolates of Plasmodium falciparum in EuropeOle Wichmann
Institute of Tropical Medicine, Charite, Humboldt University, Berlin, Germany
J Infect Dis 190:1541-6. 2004..However, little is known about the prevalence of codon-268 mutations and their quantitative association with treatment failure... - Efficacy of amodiaquine in uncomplicated falciparum malaria in Nigeria in an area with high-level resistance to chloroquine and sulphadoxine/pyrimethamineJens Graupner
, Max Euweplein 40, 1001, EA, Amsterdam, The Netherlands
Parasitol Res 96:162-5. 2005..The number of patients with adverse events (mainly pruritus and nausea) was few. This study shows that amodiaquine is effective, safe and affordable in an area with high resistance to chloroquine... - Molecular surveillance of mutations in dihydrofolate reductase and dihydropteroate synthase genes of Plasmodium falciparum in EthiopiaTamirat Gebru-Woldearegai
Faculty of Medicine, Department of Microbiology, Immunology and Parasitology, Addis Ababa University Addis Ababa, Ethiopia
Am J Trop Med Hyg 73:1131-4. 2005..All isolates carried mutations G437 and E540 in the DHPS gene. Two isolates (1.61%) had additional mutations at codon 581 (A581)... - Is quartan malaria safely prevented by mefloquine prophylaxis?Martin P Grobusch
Institute of Tropical Medicine, Department of Parasitology, , Germany
J Travel Med 11:125-6. 2004 - Molecular surveillance of the antifolate-resistant mutation I164L in imported African isolates of Plasmodium falciparum in Europe: sentinel data from TropNetEuropOle Wichmann
Institute of Tropical Medicine, Charite, Humboldt University, Berlin, Germany
Malar J 2:17. 2003..The objective of this study was to assess the prevalence of this mutation in African isolates of Plasmodium falciparum that have been imported into Europe through travellers... - Haemozoin: from melatonin pigment to drug target, diagnostic tool, and immune modulatorThomas Hanscheid
Institute of Molecular Medicine, Lisbon Medical College, Lisbon, Portugal
Lancet Infect Dis 7:675-85. 2007..Finally, haemozoin has a substantial effect on the immune system. Further research is needed to clarify these aspects, many of which are important in clinical practice... - Falciparum malaria and Tangier diseaseMartin P Grobusch
Int J Infect Dis 7:74-5. 2003 - Comparison of three antigen detection tests for diagnosis and follow-up of falciparum malaria in travellers returning to Berlin, GermanyMartin P Grobusch
Department of Parasitology, Institute of Tropical Medicine, Eberhard Karls University, Wilhelmstrasse 27, 72074 Tuebingen, Germany
Parasitol Res 89:354-7. 2003..We therefore conclude that a combination of both antigens might be the best option for creating a reliable RDT for the diagnosis of falciparum malaria... - Molecular surveillance of drug resistance through imported isolates of Plasmodium falciparum in EuropeTomas Jelinek
Department of Infectious Diseases and Tropical Medicine, University of Munich, Leopoldstr, 5, 80802 Munich, Germany
Malar J 1:11. 2002..The screening results were used to map the prevalence of mutations and, thus, levels of potential drug resistance in endemic areas world-wide...