Research Topics
| C FeldmanSummaryAffiliation: University of the Witwatersrand Country: South Africa Publications
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Detail Information
Publications
Clinical relevance of antimicrobial resistance in the management of pneumococcal community-acquired pneumoniaCharles Feldman
Division of Pulmonology, Department of Medicine, Johannesburg Hospital and University of the Witwatersrand, Johannesburg, South Africa
J Lab Clin Med 143:269-83. 2004....- Prognostic scoring systems: which one is best?Charles Feldman
Division of Pulmonology, Department of Medicine, Johannesburg Hospital and University of the Witwatersrand, Johannesburg, South Africa
Curr Opin Infect Dis 20:165-9. 2007..This assessment will determine the appropriate site of care, diagnostic work-up, and choice of empiric antibiotics. A number of severity assessment tools have been developed and some of the recent findings are reviewed... - Neutrophils potentiate platinum-mediated injury to human ciliated epithelium in vitroCharles Feldman
Division of Pulmonology, Department of Medicine, University of the Witwatersrand, Johannesburg, South Africa
Inhal Toxicol 17:297-301. 2005..If such effects also occur in vivo they may play a role, at least partly, in the pathogenesis of airway disorders that may manifest in exposed workers... - Controversies in the treatment of pneumococcal community-acquired pneumoniaCharles Feldman
University of the Witwatersrand Medical School, Division of Pulmonology, Department of Medicine, Parktown, Johannesburg, South Africa
Future Microbiol 1:271-81. 2006.... - Hyaluronidase augments pneumolysin-mediated injury to human ciliated epitheliumC Feldman
Division of Pulmonology, Department of Medicine, Johannesburg Hospital and University of the Witwatersrand, 7 York Road, Parktown, 2193 Johannesburg, South Africa
Int J Infect Dis 11:11-5. 2007..The main objective of this study was to investigate the effects of pneumococcal hyaluronidase (0.1-10microg/ml), alone and in combination with pneumolysin (50 and 100ng/ml), on human ciliated epithelium... - Pneumonia associated with HIV infectionCharles Feldman
Division of Pulmonology, Department of Medicine, Johannesburg Hospital and University of the Witwatersrand, Johannesburg, South Africa
Curr Opin Infect Dis 18:165-70. 2005..Pneumonia occurs commonly in HIV-infected patients and this review highlights some of the recent findings in the epidemiology, pathogenesis, clinical features, treatment and prevention of this condition... - Bacteraemic pneumococcal pneumonia: impact of HIV on clinical presentation and outcomeCharles Feldman
Division of Pulmonology, Department of Medicine, Johannesburg Hospital, University of the Witwatersrand, Medical School, 7 York Road, Parktown 2193, Johannesburg, South Africa
J Infect 55:125-35. 2007.... - New insights into pneumococcal diseaseCharles Feldman
Division of Pulmonology, Department of Medicine, Johannesburg Hospital, University of the Witwatersrand, Johannesburg, South Africa
Respirology 14:167-79. 2009..An important advance in the prevention of pneumococcal infections has been the introduction of the pneumococcal protein conjugate vaccine... - Bacteremic pneumococcal pneumonia in HIV-seropositive and HIV-seronegative adultsC Feldman
Department of Medicine, Hillbrow Hospital, University of the Witwatersrand, Johannesburg, South Africa
Chest 116:107-14. 1999..To compare the demographic, clinical, laboratory, and microbiological data, and the hospital course and outcome of HIV-seropositive and HIV-seronegative adults with bacteremic pneumococcal pneumonia... - The effects of pneumolysin and hydrogen peroxide, alone and in combination, on human ciliated epithelium in vitroC Feldman
Division of Pulmonology, Department of Medicine, Johannesburg Hospital, University of the Witwatersrand, South Africa
Respir Med 96:580-5. 2002..These actions of pneumolysin and H2O2 may contribute to the pathogenesis of respiratory tract infections caused by the pneumococcus... - Procalcitonin and C-reactive protein levels in HIV-positive subjects with tuberculosis and pneumoniaG K Schleicher
Dept of Medicine, Johannesburg Hospital and University of the Witwatersrand, Johannesburg, South Africa
Eur Respir J 25:688-92. 2005..A procalcitonin level >3 ng x mL(-1) and a C-reactive protein level >246 mg x L(-1) were both highly predictive of pneumococcal infection... - Pneumonia in the elderlyC Feldman
Department of Medicine, University of Witwatersrand, Johannesburg, South Africa
Clin Chest Med 20:563-73. 1999..Attention to nutrition and hydration, the use of pneumococcal and influenza vaccination, and a number of diverse procedures in the hospital setting may help limit the occurrence and impact of such infections... - Prognostic factors in severe community-acquired pneumonia in patients without co-morbid illnessC Feldman
Intensive Care Unit, Department of Medicine, Hillbrow Hospital and University of the Witwatersrand, 7 York Road, Parktown 2193, Johannesburg, South Africa
Respirology 6:323-30. 2001..We wished to determine the prognostic factors and the impact of initial empirical antibiotic therapy on the outcome of severe community-acquired pneumonia in patients without underlying co-morbid illness... - Dual infection with Streptococcus pneumoniae and Mycobacterium tuberculosis in HIV-seropositive patients with community acquired pneumoniaG K Schleicher
Department of Medicine, Johannesburg Hospital and University of the Witwatersrand, Sloane Park, Gauteng, South Africa
Int J Tuberc Lung Dis 7:1207-8. 2003..It is important to exclude pulmonary tuberculosis in HIV-seropositive patients with CAP who fail to respond appropriately to initial antibiotic therapy, even if another etiological pathogen has been found... - CD4 T-lymphocyte subset counts in HIV-seropositive patients during the course of community-acquired pneumonia caused by Streptococcus pneumoniaeG K Schleicher
Department of Medicine, Johannesburg Hospital and University of the Witwatersrand, Johannesburg, South Africa
Clin Microbiol Infect 10:587-9. 2004..pneumoniae, with a subsequent increase in 90% (27/30) of cases after resolution of the infection. There was no significant difference in the CD4/CD8 T-lymphocyte ratio on admission compared with 1 month later (p 0.9)... - CURB-65, PSI, and APACHE II to assess mortality risk in patients with severe sepsis and community acquired pneumonia in PROWESSGuy Richards
University of Witwatersrand, Johannesburg, South Africa
J Intensive Care Med 26:34-40. 2011.... - Therapy for pneumococcal bacteremia: monotherapy or combination therapy?Charles Feldman
Division of Pulmonology, Department of Medicine, Johannesburg Hospital and Faculty of Health Sciences, University of the Witwatersrand, 7 York Road, Parkdown, Johannesburg, South Africa
Curr Opin Infect Dis 22:137-42. 2009..This review highlights recent studies that have addressed this issue... - Vitamin E attenuates the injurious effects of bioactive phospholipids on human ciliated epithelium in vitroC Feldman
Dept of Medicine, Johannesburg Hospital and University of the Witwatersrand, South Africa
Eur Respir J 18:122-9. 2001..Vitamin E status may be a determinant of susceptibility to phospholipid-mediated airway inflammation and damage... - Prevalence of exercise-induced bronchospasm in Thokoza schoolchildrenM B N Mashalane
Department of Physiotherapy, University of the Witwatersrand, Johannesburg, South Africa
S Afr Med J 96:67-70. 2006..Asthma is a common childhood illness, with a prevalence of 1 in 10 children. Exercise-induced bronchospasm (EIB) is a common feature of asthma and is found more often in children than in adults... - Penicillin- and cephalosporin-resistant Streptococcus pneumoniae. Emerging treatment for an emerging problemK P Klugman
Department of Clinical Microbiology and Infectious Diseases, South African Institute for Medical Research, Johannesburg, South Africa
Drugs 58:1-4. 1999..The new fluoroquinolones with excellent antipneumococcal activity may be considered for use in the setting of pneumonia caused by highly resistant pneumococci and are under evaluation for the management of meningitis... - An unusual pneumococcal sequence type is the predominant cause of serotype 3 invasive disease in South AfricaKedibone M Mothibeli
Respiratory and Meningeal Pathogens Research Unit, National Institute for Communicable Diseases, Medical Research Council, University of the Witwatersrand, Johannesburg, South Africa
J Clin Microbiol 48:184-91. 2010..We have therefore identified ST458 as predominating in South Africa, but with an invasive potential similar to that of the predominant global clone ST180... - Emergence of levofloxacin-non-susceptible Streptococcus pneumoniae and treatment for multidrug-resistant tuberculosis in children in South Africa: a cohort observational surveillance studyAnne Von Gottberg
National Institute for Communicable Diseases of the National Health Laboratory Service, Johannesburg, South Africa
Lancet 371:1108-13. 2008..Our aim was to estimate the incidence of, and risk factors for, invasive pneumococcal disease caused by fluoroquinolone-resistant Streptococcus pneumoniae in children in South Africa... - An open, randomised, multi-centre study comparing the safety and efficacy of sitafloxacin and imipenem/cilastatin in the intravenous treatment of hospitalised patients with pneumoniaC Feldman
Division of Pulmonology, Department of Medicine, Medical School, University of the Witwatersrand, 7 York Road, 2193, Parktown, South Africa
Int J Antimicrob Agents 17:177-88. 2001..In conclusion, for the treatment of pneumonia, sitafloxacin was considered as safe and as tolerable as imipenem and preliminary data from this study suggest that it may have similar efficacy... - Pneumonia in the elderlyC Feldman
Department of Medicine, Division of Pulmonology, University of the Witwatersrand, Johannesburg Hospital, Johannesburg, South Africa 014
Med Clin North Am 85:1441-59. 2001..Many relatively simple procedures, including attention to nutrition, influenza and pneumococcal vaccination, and avoidance of intubation, may help limit the occurrence of such infections... - Severity of illness scoring systems in patients with bacteraemic pneumococcal pneumonia: implications for the intensive care unit careC Feldman
Division of Pulmonology, Department of Medicine, Charlotte Maxeke Johannesburg Academic Hospital and University of the Witwatersrand, Johannesburg, South Africa
Clin Microbiol Infect 15:850-7. 2009..The low PPV of the PSI rendered it not usable as a parameter for decision-making in severely-ill patients with pneumococcal bacteraemia... - Increased incidence of meningococcal disease in HIV-infected individuals associated with higher case-fatality ratios in South AfricaCheryl Cohen
National Institute for Communicable Diseases, Johannesburg, South Africa
AIDS 24:1351-60. 2010..We aimed to compare the incidence of meningococcal disease amongst HIV-infected and uninfected individuals and to evaluate whether HIV is a risk factor for mortality and bacteremia amongst patients with meningococcal disease... - Adrenocortical function in hospitalised patients with active pulmonary tuberculosis receiving a rifampicin-based regimen -- a pilot studyW D Francois Venter
Reproductive Health and HIV Research Unit, University of the Witwatersrand, Johannesburg, South Africa
S Afr Med J 96:62-6. 2006..To assess whether adrenocortical function was compromised in patients with active tuberculosis (TB) during the first 5 days of therapy with either a rifampicin-based or ciprofloxacin-based regimen... - Systems for the management of respiratory disease in primary care--an international series: South AfricaEric Bateman
Division of Pulmonology, Department of Medicine, University of Cape Town, and University of Cape Town Lung Institute, Cape Town, South Africa
Prim Care Respir J 18:69-75. 2009.... - Neisseria meningitidis intermediately resistant to penicillin and causing invasive disease in South Africa in 2001 to 2005Mignon du Plessis
National Institute for Communicable Diseases of the National Health Laboratory Service, University of the Witwatersrand, Johannesburg, South Africa
J Clin Microbiol 46:3208-14. 2008..This is the first report describing the prevalence and molecular epidemiology of Pen(i) meningococcal isolates from sub-Saharan Africa... - Prevalence of anti-mycolic acid antibodies in patients with pulmonary tuberculosis co-infected with HIVGunther K Schleicher
Department of Medicine, University of the Witwatersrand, Johannesburg Hospital, South Africa
Clin Chem Lab Med 40:882-7. 2002.... - Docosahexaenoic acid and eicosapentaenoic acid antagonize the proinflammatory interactions of pneumolysin with human neutrophilsRiana Cockeran
Medical Research Council for Inflammation and Immunity, Department of Immunology, Faculty of Health Sciences, University of Pretoria, P O Box 2034, Pretoria 0001, South Africa
Infect Immun 72:4327-9. 2004..25 to 5 microg/ml). These agents may have potential in attenuating the proinflammatory properties of this pneumococcal toxin... - Effects of platinum and palladium ions on the production and reactivity of neutrophil-derived reactive oxygen speciesAnnette J Theron
Medical Research Council Unit for Inflammation and Immunity, Department of Immunology, School of Medicine, University of Pretoria, Pretoria 0001, South Africa
Free Radic Biol Med 36:1408-17. 2004.... - Global strategies to prevent bacterial pneumonia in adults with HIV diseaseDaniel R Feikin
Respiratory Diseases Branch, Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA
Lancet Infect Dis 4:445-55. 2004..Although not yet fully evaluated in Africa, based on experience in industrialised nations, use of HAART in Africa may have substantial potential to prevent bacterial pneumonia... - Pneumolysin potentiates oxidative inactivation of alpha-1-proteinase inhibitor by activated human neutrophilsRiana Cockeran
MRC Unit for Inflammation and Immunity, Department of Immunology, Faculty of Health Sciences, University of Pretoria and Tshwane Academic Division of the National Health Laboratory Services, PO Box 2034, Pretoria 0001, South Africa
Respir Med 98:865-71. 2004..These pro-proteolytic interactions of pneumolysin with chemoattractant-activated neutrophils may contribute to the invasiveness of the pneumococcus... - Pneumolysin activates the synthesis and release of interleukin-8 by human neutrophils in vitroRiana Cockeran
Medical Research Council Unit for Inflammation and Immunity, Department of Immunology, Institute of Pathology, University of Pretoria, South Africa
J Infect Dis 186:562-5. 2002..These interactions between the toxin and neutrophils may contribute to the exaggerated pulmonary inflammatory responses caused by pneumolysin-producing strains of the pneumococcus... - The role of pneumolysin in the pathogenesis of Streptococcus pneumoniae infectionRiana Cockeran
Medical Research Council Unit for Inflammation and Immunity, Department of Immunology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa
Curr Opin Infect Dis 15:235-9. 2002..Pneumolysin-based vaccine strategies, although in the early stages of development and evaluation, show promise in reducing the severity of pneumococcal disease... - Pneumolysin as a vaccine and drug target in the prevention and treatment of invasive pneumococcal diseaseRiana Cockeran
Department of Immunology, Faculty of Health Sciences, University of Pretoria and Tshwane Academic Division of the National Health Laboratory Service, Pretoria, South Africa
Arch Immunol Ther Exp (Warsz) 53:189-98. 2005.... - An international prospective study of pneumococcal bacteremia: correlation with in vitro resistance, antibiotics administered, and clinical outcomeVictor L Yu
Division of Infectious Disease, University of Pittsburgh, PA, USA
Clin Infect Dis 37:230-7. 2003..beta-Lactam antibiotics should still be useful for treatment of pneumococcal infections that do not involve cerebrospinal fluid, regardless of in vitro susceptibility, as determined by current NCCLS breakpoints... - Emergence of extensive drug resistance (XDR) among Gram-negative bacilli in South Africa looms nearerAdrian Brink
Department of Clinical Microbiology, Ampath National Laboratory Services, Milpark Hospital, Johannesburg
S Afr Med J 98:586, 588, 590 passim. 2008 - HIV immune reconstitution syndrome in sub-Saharan AfricaDavid M Murdoch
AIDS 22:1689-90. 2008 - Gender as a risk factor for both antibiotic resistance and infection with pediatric serogroups/serotypes, in HIV-infected and -uninfected adults with pneumococcal bacteremiaKimberly A Buie
Department of International Health, Rollins School of Public Health, Emory University, Atlanta, Georgia 30322, USA
J Infect Dis 189:1996-2000. 2004..25-2.36]) than were men. Thus, conjugate pneumococcal vaccination of children may reduce, in particular, both antibiotic resistance and the burden of conjugate vaccine serotype pneumococcal disease in young, HIV-infected women... - Molecular basis and clonal nature of increasing pneumococcal macrolide resistance in South Africa, 2000-2005Nicole Wolter
Respiratory and Meningeal Pathogens Research Unit, National Institute for Communicable Diseases, Medical Research Council and University of the Witwatersrand, Sandringham, South Africa
Int J Antimicrob Agents 32:62-7. 2008..Routine use of the 7-valent pneumococcal conjugate vaccine (PCV-7) could reduce the burden of macrolide-resistant pneumococcal disease in South Africa... - Combination antibiotic therapy lowers mortality among severely ill patients with pneumococcal bacteremiaLarry M Baddour
Mayo Clinic, Rochester, NY, USA
Am J Respir Crit Care Med 170:440-4. 2004..Combination antibiotic therapy improved survival among critically ill patients with bacteremic pneumococcal illness... - Characteristics and outcomes of adult patients lost to follow-up at an antiretroviral treatment clinic in johannesburg, South AfricaRishikesh P Dalal
Washington University School of Medicine, St Louis, MO, USA
J Acquir Immune Defic Syndr 47:101-7. 2008..A significant proportion of those initiating antiretroviral treatment (ART) for HIV infection are lost to follow-up. Causes for discontinuing ART follow-up in resource-limited settings are not well understood... - Pneumolysin in the immunopathogenesis and treatment of pneumococcal diseaseRiana Cockeran
University of Pretoria, Pretoria, South Africa
Expert Rev Anti Infect Ther 1:231-9. 2003.... - HIV and pneumococcal diseaseKeith P Klugman
Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, Georgia 30322, USA
Curr Opin Infect Dis 20:11-5. 2007..To describe the impact of highly active antiretroviral therapy on the burden of pneumococcal disease and advances in our understanding of the impact of HIV on this disease... - Altered PBP 2A and its role in the development of penicillin, cefotaxime, and ceftriaxone resistance in a clinical isolate of Streptococcus pneumoniaeAnthony M Smith
MRC NICD WITS Respiratory and Meningeal Pathogens Research Unit, National Institute for Communicable Diseases, P O Box 1038, Johannesburg 2000, South Africa
Antimicrob Agents Chemother 49:2002-7. 2005..In all likelihood, these events produced a strain which evolved into a fitter and more virulent type, isolate 3, that resulted in an aggravated pneumococcal infection and ultimately in the patient's death... - Incidence and risk factors for the immune reconstitution inflammatory syndrome in HIV patients in South Africa: a prospective studyDavid M Murdoch
Division of Pulmonary and Critical Care Medicine, Duke University Medical Center, Durham, North Carolina NC 27710, USA
AIDS 22:601-10. 2008..To determine the incidence, clinical manifestations, risk factors and outcome of immune reconstitution inflammatory syndrome (IRIS) in South Africa...