Research Topics
Species | Hoosen CoovadiaSummaryAffiliation: University of KwaZulu-Natal Country: South Africa Publications
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Detail Information
Publications
Preliminary outcomes of a paediatric highly active antiretroviral therapy cohort from KwaZulu-Natal, South AfricaAnand Reddi
Sinikithemba HIV AIDS Clinic, McCord Hospital, Durban, South Africa
BMC Pediatr 7:13. 2007..Few studies address the use of paediatric highly active antiretroviral therapy (HAART) in Africa...
Preserving breastfeeding practice through the HIV pandemicH M Coovadia
Centre for HIV AIDS Networking, University of KwaZulu Natal, Durban, South Africa
Trop Med Int Health 12:1116-33. 2007..This review provides recent key findings and opinions around making breastfeeding safer for HIV-positive women, and argues for preservation of breastfeeding, as opposed to complete avoidance of breastfeeding for all HIV-positive women...
HIV, infant feeding, and survival: old wine in new bottles, but brimming with promiseHoosen M Coovadia
Nelson Mandela School of Medicine, University of Kwazulu/Natal, 719 Umbilo Road, Congella 4013, South Africa
AIDS 21:1837-40. 2007
Breastfeeding to prevent HIV transmission in infants: balancing pros and consHoosen Coovadia
Doris Duke Medical Research Institute, South Africa
Curr Opin Infect Dis 21:11-5. 2008..We assesses breastfeeding is a rational and viable option for HIV-infected women in poor environments...
Science and society: the HIV epidemic and South African political responsesHoosen Coovadia
Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa
Adv Exp Med Biol 609:16-28. 2008
From Alma-Ata to Agincourt: primary health care in AIDSHoosen Coovadia
University of KwaZulu-Natal, Durban, KwaZulu-Natal 4013, South Africa
Lancet 372:866-8. 2008
Current issues in prevention of mother-to-child transmission of HIV-1Hoosen Coovadia
Doris Duke Medical Research Institute, Nelson Mandela School of Medicine, University of KwaZulu Natal, 719 Umbilo Road, Congella, South Africa 4013, South Africa
Curr Opin HIV AIDS 4:319-24. 2009..To review new evidence in prevention of mother-to-child-transmission of HIV-1, which establishes, in principle, the feasibility of greatly improved effectiveness in developing countries...
Impact of HLA in mother and child on disease progression of pediatric human immunodeficiency virus type 1 infectionChristina F Thobakgale
HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu Natal, Durban, South Africa
J Virol 83:10234-44. 2009....
Human immunodeficiency virus-specific CD8+ T-cell activity is detectable from birth in the majority of in utero-infected infantsChristina F Thobakgale
HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu Natal, Durban, South Africa
J Virol 81:12775-84. 2007..Moreover, the detection of virus-specific CD8+ T-cell responses in the first days of life in most in utero-infected infants is encouraging for HIV vaccine interventions in infants...
Women's morbidity and mortality in the first 2 years after delivery according to HIV statusAnna Coutsoudis
Department of Paediatrics and Child Health, University of KwaZulu Natal, Durban, South Africa
AIDS 24:2859-66. 2010..Better knowledge of the impact of HIV status on morbidity and mortality patterns of women after delivery is important to improve clinical and policy recommendations...
Short communication: CD4 counts of HIV-infected pregnant women and their infected children--implications for PMTCT and treatment programmesAnkie Lebon
Africa Centre for Health and Population Studies, University of KwaZulu Natal, South Africa
Trop Med Int Health 12:1472-4. 2007..The antenatal-postnatal divide needs to be bridged with respect to the follow-up of both HIV-infected women and their exposed infants...
CD8+ T-cell responses to different HIV proteins have discordant associations with viral loadPhotini Kiepiela
HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu Natal, Durban 4013, South Africa
Nat Med 13:46-53. 2007..These population-based data, suggesting the existence of both effective immune responses and responses lacking demonstrable biological impact in chronic HIV infection, are of relevance to HIV vaccine design and evaluation...
Breastfeeding, HIV status and weights in South African children: a comparison of HIV-exposed and unexposed childrenDeven Patel
Africa Centre for Health and Population Studies, University of KwaZulu Natal, Mtubatuba, KwaZulu Natal 3935, South Africa
AIDS 24:437-45. 2010..To examine growth of children by maternal and infant HIV status allowing for infant feeding mode...
Failure of standard antimicrobial therapy in children aged 3-59 months with mild or asymptomatic HIV infection and severe pneumoniaPrakash Jeena
Department of Paediatrics and Child Health, King Edward Hospital, University of KwaZulu Natal, Durban, South Africa
Bull World Health Organ 84:269-75. 2006....
Impact of HIV-1 infection in South AfricaK Pillay
Department of Paediatrics and Child Health, University of Natal, Private Bag 7, Congella, Durban 4013, South Africa
Arch Dis Child 85:50-1. 2001..This impact may be alleviated by appropriate primary and secondary level health care...
Prevention of transmission of HIV-1 from mothers to infants in AfricaHoosen Coovadia
Centre for HIV and AIDS Networking, University of KwaZulu-Natal, Nelson R Mandela School of Medicine, Doris Duke Medical Research Institute, Congella, Durban, South Africa
Adv Exp Med Biol 582:201-20. 2006
Safety and efficacy of zinc supplementation for children with HIV-1 infection in South Africa: a randomised double-blind placebo-controlled trialRaziya Bobat
Department of Paediatrics and Child Health, Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa
Lancet 366:1862-7. 2005..In view of the reductions in diarrhoea and pneumonia morbidity, zinc supplementation should be used as adjunct therapy for children with HIV-1 infection...
Lymphadenopathy, pneumonia, and HIV--a common trio, an uncommon outcomeA Mosam
Department of Dermatology, Africa Centre for Health and Population Studies, Nelson R Mandela School of Medicine, University of KwaZulu Natal, South Africa
Lancet 365:266. 2005
Morbidity in children born to women infected with human immunodeficiency virus in South Africa: does mode of feeding matter?A Coutsoudis
Department of Paediatrics and Child Health, Nelson R Mandela School of Medicine, University of Natal, Congella, South Africa
Acta Paediatr 92:890-5. 2003..To examine infant morbidity risks associated with refraining from breastfeeding where it is used in an attempt to prevent mother-to-child transmission (MTCT) of human immunodeficiency virus (HIV)...
Routinely available cotrimoxazole prophylaxis and occurrence of respiratory and diarrhoeal morbidity in infants born to HIV-infected mothers in South AfricaA Coutsoudis
Department of Paediatrics and Child Health, University of KwaZulu Natal, Durban, South Africa
S Afr Med J 95:339-45. 2005..To examine the influence of cotrimoxazole (CTM) prophylaxis on incidence of lower respiratory tract infections (LRTIs) and diarrhoea...
Lymph node biopsies in HIV-infected and non-infected children with persistent lung diseaseP M Jeena
Department of Paediatrics and Child Health, Faculty of Medicine, University of Natal, Congella, South Africa
Int J Tuberc Lung Dis 4:139-46. 2000..Lymphadenopathy is a frequent associated clinical finding among these children. We evaluated the usefulness of excision lymph node biopsies in determining an aetiological diagnosis in HIV-infected and non-infected children with PLD...
Increasing incidence of Kaposi's sarcoma in black South Africans in KwaZulu-Natal, South Africa (1983-2006)A Mosam
Department of Dermatology, Nelson R Mandela School of Medicine, University of KwaZulu Natal
Int J STD AIDS 20:553-6. 2009..These data reinforce the need for comprehensive national access to and roll-out of antiretroviral drugs, given their success in prevention and treatment of KS in first-world settings...
Characteristics of HIV-1-associated Kaposi's sarcoma among women and men in South AfricaA Mosam
Department of Dermatology, Nelson R Mandela School of Medicine, University of KwaZulu Natal, Durban, South Africa
Int J STD AIDS 19:400-5. 2008..7 vs. 43.3%). In conclusion, HIV-associated KS in South Africans has an equal female-to-male ratio. Females are younger and have more severe disease than males...
Free formula milk for infants of HIV-infected women: blessing or curse?A Coutsoudis
Department of Paediatrics and Child Health, University of Natal, Congella, South Africa
Health Policy Plan 17:154-60. 2002....
Impact of HIV-1 status on the radiological presentation and clinical outcome of children with WHO defined community-acquired severe pneumoniaP M Jeena
Department of Paediatrics and Child Health, University of KwaZulu Natal, Congella, Durban, South Africa
Arch Dis Child 92:976-9. 2007..We compared the radiological features and outcome of WHO defined severe pneumonia among HIV infected and exposed uninfected children randomised to receive penicillin or oral amoxicillin in Durban, South Africa...
The health and health system of South Africa: historical roots of current public health challengesHoosen Coovadia
Nelson Mandela School of Medicine, University of KwaZulu Natal, Durban, South Africa
Lancet 374:817-34. 2009..The HIV epidemic has contributed to and accelerated these challenges. All of these factors need to be addressed by the new government if health is to be improved and the Millennium Development Goals achieved in South Africa...
A multicenter randomized controlled trial of nevirapine versus a combination of zidovudine and lamivudine to reduce intrapartum and early postpartum mother-to-child transmission of human immunodeficiency virus type 1Dhayendre Moodley
Department of Obstetrics and Gynaecology, Paediatrics and Child Health, Nelson R Mandela School of Medicine, University of Natal, KwaZulu Natal, Congella 4013, South Africa
J Infect Dis 187:725-35. 2003..3%; Zdv/3TC group, 26.3%) and respiratory for infants (Nvp group, 16.1%; Zdv/3TC group, 17.0%). This study further confirms the efficacy and safety of short-course ARV regimens in reducing MTCT rates in developing countries...
Infant feeding counselling for HIV-infected and uninfected women: appropriateness of choice and practiceR M Bland
Africa Centre for Health and Population Studies, University of KwaZulu Natal, South Africa
Bull World Health Organ 85:289-96. 2007..To examine infant feeding intentions of HIV-infected and uninfected women and the appropriateness of their choices according to their home resources; and to determine their adherence to their intentions in the first postnatal week...
Method of feeding and transmission of HIV-1 from mothers to children by 15 months of age: prospective cohort study from Durban, South AfricaA Coutsoudis
Department of Paediatrics and Child Health, University of Natal, Congella, South Africa
AIDS 15:379-87. 2001..To determine the risk of HIV transmission by infant feeding modality...
Impact of HIV-1 co-infection on presentation and hospital-related mortality in children with culture proven pulmonary tuberculosis in Durban, South AfricaP M Jeena
Department of Paediatrics and Child Health, Nelson R Mandela School of Medicine, University of Natal, Congella, South Africa
Int J Tuberc Lung Dis 6:672-8. 2002..Most studies from developing countries have included subjects in whom the diagnosis of TB is suspected but not proven. We therefore compare the findings in HIV-infected and non-HIV-infected children with culture-proven TB...
Differential immunogenicity of HIV-1 clade C proteins in eliciting CD8+ and CD4+ cell responsesDanni Ramduth
HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu Natal, Durban, South Africa
J Infect Dis 192:1588-96. 2005..The relative immunogenicity of human immunodeficiency virus type 1 (HIV-1) proteins for CD8+ and CD4+ cell responses has not been defined...
Molecular characteristics of human immunodeficiency virus type 1 subtype C viruses from KwaZulu-Natal, South Africa: implications for vaccine and antiretroviral control strategiesM Gordon
HIV-1 Molecular Virology and Bioinformatics Laboratories, Africa Centre for Health and Population Studies and the Nelson R. Mandela School of Medicine, University of Natal, Congella 4013, Durban, South Africa
J Virol 77:2587-99. 2003..This work forms a baseline for future studies aimed at understanding the impact of genetic diversity on vaccine efficacy and on natural susceptibility to antiretroviral drugs...
Challenges in the provision of ICU services to HIV infected children in resource poor settings: a South African case studyP M Jeena
Nelson R Mandela School of Medicine, University of Natal, Durban, South Africa
J Med Ethics 31:226-30. 2005....
HIV in pregnancy: strategies for managementH M Coovadia
Department of Paediatrics and Child Health, University of Natal, Congella, 4013, South Africa
Semin Neonatol 5:181-8. 2000..Strategies suitable and inappropriate for developing countries, and operational difficulties, are discussed...
Secretory leukocyte protease inhibitor in vaginal fluids and perinatal human immunodeficiency virus type 1 transmissionK Pillay
Department of Paediatrics and Child Health, Nelson R Mandela School of Medicine, University of Natal, Private Bag 7, Congella, 4013, Republic of South Africa
J Infect Dis 183:653-6. 2001..174 virions/mL; P=.09). Increased concentrations of selected innate mucosal immune factors, such as SLPI, seem to be associated with reduced rates of perinatal HIV-1 transmission and may contribute to natural antiretroviral defense...
A health and nutritional profile of rural school children in KwaZulu-Natal, South AfricaC C Jinabhai
Department of Community Health, School of Family and Public Health Medicine, University of Natal, Private Bag 7, Congella 4013, Durban, South Africa
Ann Trop Paediatr 21:50-8. 2001..Micronutrient supplementation and de-worming provide opportunities for school-based health promotion and primary health care interventions, and might produce significant health and educational benefits...
Rapid testing may not improve uptake of HIV testing and same day results in a rural South African community: a cohort study of 12,000 womenNtombizodumo B Mkwanazi
Africa Centre for Health and Population Studies, University of KwaZulu Natal, Durban, South Africa
PLoS ONE 3:e3501. 2008..We report on the acceptability of HIV counselling and testing, and uptake of results, before and after the introduction of rapid testing in this area...
Messages about dual contraception in areas of high HIV prevalence are not heededN Ngubane
Africa Centre for Health and Population Studies, University of KwaZulu Natal, Durban
S Afr Med J 98:209-12. 2008..It is critical for HIV-negative women to prevent seroconversion and HIV transmission to their infants during pregnancy and breastfeeding...
Admission patterns and outcomes in a paediatric intensive care unit in South Africa over a 25-year period (1971-1995)P M Jeena
Department of Paediatrics and Child Health, Faculty of Medicine, University of Natal, Congella, South Africa
Intensive Care Med 25:88-94. 1999....
Tuberculous meningitis and co-infection with HIVJ M Topley
Department of Paediatrics, University of Natal, Durban, South Africa
Ann Trop Paediatr 18:261-6. 1998..Co-existing HIV encephalopathy and diminished immune competence undoubtedly contributed to the more severe clinical and neuro-radiological features...
Colloquium report: improving the health of school age children in an era of HIV/AIDS in Durban, South AfricaJ D Kvalsvig
Child, Youth and Family, Human Sciences Research Council, Durban, South Africa
J Trop Pediatr 50:251-4. 2004..In the discussions that followed four critical issues emerged: intersectoral collaboration, accountability, retraining middle management, and a more comprehensive strategy to support pupils and teachers infected and affected by HIV/AIDS...
Epidemiology of helminth infections: implications for parasite control programmes, a South African perspectiveC C Jinabhai
Department of Community Health, Nelson R Mandela School of Medicine, University of Natal, Congella, South Africa
Public Health Nutr 4:1211-9. 2001..To assess the South African government's parasite control policy...
Safety of the intradermal Copenhagen 1331 BCG vaccine in neonates in Durban, South AfricaP M Jeena
Department of Paediatrics and Child Health, Faculty of Medicine, University of Natal, Private Bag X7, Congella, 4013, KwaZulu Natal, South Africa
Bull World Health Organ 79:337-43. 2001..To evaluate the safety of the intradermal Copenhagen BCG vaccine in neonates at different levels of delivery and neonatal units of the Durban Functional Region and surrounding regions...
HIV/AIDS in children: a disaster in the makingH M Coovadia
Nelson Mandela School of Medicine, Congella 4013, Natal, South Africa
Lancet 372:271-3. 2008
Lack of efficacy of the standard potency Edmonston-Zagreb live, attenuated measles vaccine in African infantsP Kiepiela
Department of Paediatrics and Child Health, Faculty of Medicine, University of Natal, Durban, South Africa
Bull World Health Organ 69:221-7. 1991....
The impact of human immunodeficency virus 1 on largyngeal airway obstruction in childrenP M Jeena
Department of Paediatrics and Child Health, Nelson Mandela School of Medicine, University of Natal, Durban, South Africa
Arch Dis Child 87:212-4. 2002..6% v 31.3%), while oropharyngeal/laryngeal candidiasis (26.3%), tuberculosis (15.8%), and benign lymphoid hyperplasia (15.8%) were commonly seen in the HIV infected group...
Effects of the human immunodeficiency virus on tuberculosis in childrenP M Jeena
Department of Paediatrics and Child Health, Faculty of Medicine, University of Natal, Congella, South Africa
Tuber Lung Dis 77:437-43. 1996..In children however, unlike in adults, very little has been documented about the interaction between the two diseases...
Central role of reverting mutations in HLA associations with human immunodeficiency virus set pointPhilippa C Matthews
Department of Paediatrics, Peter Medawar Building for Pathogen Research, United Kingdom
J Virol 82:8548-59. 2008..The significance of these results is in highlighting the rationale for an HIV vaccine that can induce these broad responses...
HLA class I-driven evolution of human immunodeficiency virus type 1 subtype c proteome: immune escape and viral loadChristine M Rousseau
Department of Microbiology, University of Washington, 1959 NE Pacific Street, Box 358070, Seattle, WA 98195 8070, USA
J Virol 82:6434-46. 2008....
Role of traditional birth attendants in preventing perinatal transmission of HIVMarc Bulterys
Epidemiology Branch, Division of HIV/AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
BMJ 324:222-4. 2002
Is there a difference in the efficacy of peripartum antiretroviral regimens in reducing mother-to-child transmission of HIV in Africa?Valeriane Leroy
INSERM U 593, Institut d Epidémiologie, Santé Publique et Développement ISPED, Universite Victor Segalen Bordeaux 2, Bordeaux, France
AIDS 19:1865-75. 2005....
Top stories of 2004. Perinatal transmission interventions: the benefits come with resistanceHoosen Coovadia
AIDS Clin Care 17:2. 2005
Mortality of infected and uninfected infants born to HIV-infected mothers in Africa: a pooled analysisMarie Louise Newell
Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, London WC1N 1EH, UK
Lancet 364:1236-43. 2004..With individual data from seven randomised mother-to-child transmission (MTCT) intervention trials, we estimate mortality in African children born to HIV-infected mothers and analyse selected risk factors...
Antiretroviral agents--how best to protect infants from HIV and save their mothers from AIDSHoosen Coovadia
N Engl J Med 351:289-92. 2004
The versatile lymphocyte countHoosen Coovadia
Lancet 363:574. 2004
Breast-milk shedding of drug-resistant HIV-1 subtype C in women exposed to single-dose nevirapineEsther J Lee
Center for AIDS Research, Division of Infectious Disease, Stanford University School of Medicine, Stanford, CA 94305, USA
J Infect Dis 192:1260-4. 2005..In 20 paired BM and plasma samples, 65% of BM and 50% of plasma RT sequences had NNRTI-resistance mutations, with divergent mutation patterns...
Use of antiretroviral drugs to prevent HIV-1 transmission through breast-feeding: from animal studies to randomized clinical trialsPhilippe Gaillard
World Health Organization, Reproductive Health and Research, Geneva, Switzerland
J Acquir Immune Defic Syndr 35:178-87. 2004..Laboratory studies nested within several of these trials will provide a better understanding of the pathogenesis of postnatal HIV transmission and its potential prevention using antiretroviral drugs...
The evidence for using conjugate vaccines to protect HIV-infected children against pneumococcal diseaseSandra J Bliss
Division of Infectious Diseases, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
Lancet Infect Dis 8:67-80. 2008..PCV should be considered as an important intervention for improving the lives of HIV-infected children...
Vertical HIV transmission in South Africa: translating research into policy and practiceSalim Abdool Karim
University of Natal, 4041, South Africa
Lancet 359:992-3. 2002
Broad and Gag-biased HIV-1 epitope repertoires are associated with lower viral loadsMorgane Rolland
Department of Microbiology, University of Washington School of Medicine, Seattle, Washington, USA
PLoS ONE 3:e1424. 2008..e., the intrinsic ability to present fewer, more or specific viral epitopes, could affect clinical markers of disease progression...
Roundtable. Revisiting the role of single-dose nevirapine for preventing perinatal HIV transmissionHoosen Coovadia
AIDS Clin Care 17:61-4. 2005
