Research Topics
Genomes and GenesSpecies | Malcolm CollinsSummaryAffiliation: University of Cape Town Country: South Africa Publications
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Publications
Type V collagen genotype and exercise-related phenotype relationships: a novel hypothesisMalcolm Collins
UCT MRC Research Unit for Exercise Science and Sports Medicine, Department of Human Biology, Faculty of Health Sciences, University of Cape Town and the South African Medical Research Council, Newlands 7925, South Africa
Exerc Sport Sci Rev 39:191-8. 2011..We therefore hypothesize that variants in the COL5A1 gene alter fibril architecture and structure and, thereby, mechanical properties...- Genetic risk factors for musculoskeletal soft tissue injuriesMalcolm Collins
MRC UCT Research Unit for Exercise Science and Sports Medicine of the South African Medical Research Council, University of Cape Town, Cape Town, South Africa
Med Sport Sci 54:136-49. 2009..Clinicians could eventually use these models to develop personalised training programmes to reduce the risk of injury as well as to develop treatment and rehabilitation regimens for the injured individual... - The COL5A1 genotype is associated with range of motion measurementsM Collins
UCT MRC Research Unit for Exercise Science and Sports Medicine, Department of Human Biology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
Scand J Med Sci Sports 19:803-10. 2009..8% of the variance, were weight (P=0.004), age (P<0.001) and the BstUI RFLP (P=0.001). These data suggest that the COL5A1 BstUI RFLP is independently associated with lower limb ROM within the cohort investigated in this study... - The COL1A1 gene and acute soft tissue rupturesMalcolm Collins
South African Medical Research Council, Cape Town, South Africa
Br J Sports Med 44:1063-4. 2010..0001) groups. This combined analysis indicates that the TT genotype appears to be protective against acute soft tissue ruptures and should be incorporated into multifactorial models determining risk of acute soft tissue ruptures... - Dipsogenic genes associated with weight changes during Ironman TriathlonsColleen J Saunders
Medical Research Council of South Africa, MRC UCT Research Unit for Exercise Science and Sports Medicine, University of Cape Town, Newlands 7725, South Africa
Hum Mol Genet 15:2980-7. 2006..These findings suggest the involvement of the serotonergic pathways in the control of thirst and drinking behaviour and provide further evidence for the dipsogenic effect of circulating bradykinin... - Association between the 4 bp proinsulin gene insertion polymorphism (IVS-69) and body composition in black South African womenPeter Berman
Division of Chemical Pathology, UCT MRC Research Unit for Exercise Science and Sports Medicine, Department of Human Biology, University of Cape Town, Cape Town, South Africa
Obesity (Silver Spring) 17:1298-300. 2009..In conclusion, the 4 bp proinsulin gene insertion allele is associated with extreme obesity, reflected by greater fat-free soft tissue mass and fat mass, particularly SAT, in obese black South African women... - Tumor necrosis factor-alpha gene -308 G/A polymorphism modulates the relationship between dietary fat intake, serum lipids, and obesity risk in black South African womenYael T Joffe
University of Cape Town Medical Research Council Research Unit for Exercise Science and Sports Medicine, Cape Town, South Africa
J Nutr 140:901-7. 2010..The TNFA -308 G/A polymorphism modified the relationship between dietary fat intake, obesity risk, and serum lipid concentrations in black SA women... - The COL5A1 gene is associated with increased risk of anterior cruciate ligament ruptures in female participantsMichael Posthumus
Department of Human Biology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
Am J Sports Med 37:2234-40. 2009..The COL5A1 gene, which encodes for the alpha1 chain of type V collagen, has been shown to be associated with Achilles tendon injuries... - Investigation of the Sp1-binding site polymorphism within the COL1A1 gene in participants with Achilles tendon injuries and controlsMichael Posthumus
UCT MRC Research Unit for Exercise Science and Sports Medicine of the Department of Human Biology, Faculty of Health Sciences, University of Cape Town, South Africa
J Sci Med Sport 12:184-9. 2009..In conclusion, this study has shown that there is no association between the Sp1-binding site polymorphism within the first intron of COL1A1 and Achilles tendinopathy or Achilles tendon rupture within the population studied... - Comparison of body fatness measurements by near-infrared reactance and dual-energy X-ray absorptiometry in normal-weight and obese black and white womenCourtney L Jennings
UCT MRC Research Unit for Exercise Science and Sports Medicine, Department of Human Biology, University of Cape Town, PO Box 115, Newlands 7725, Cape Town, South Africa
Br J Nutr 103:1065-9. 2010..The results of single-site NIR as a measure of BF % should therefore be interpreted with caution, particularly in women of African descent and in those with very high levels of adiposity... - Increased running speed and previous cramps rather than dehydration or serum sodium changes predict exercise-associated muscle cramping: a prospective cohort study in 210 Ironman triathletesMartin P Schwellnus
UCT MRC Research Unit for Exercise Science and Sports Medicine, Department of Human Biology, University of Cape Town, Cape Town, South Africa
Br J Sports Med 45:650-6. 2011..Despite the high prevalence of exercise-associated muscle cramping (EAMC) in endurance athletes, the aetiology and risk factors for this condition are not fully understood... - The atypical presentation of the metabolic syndrome components in black African women: the relationship with insulin resistance and the influence of regional adipose tissue distributionCourtney L Jennings
UCT MRC Research Unit for Exercise Science and Sports Medicine, Department of Human Biology, Faculty of Health Sciences, University of Cape Town, PO Box 115, Newlands 7725, South Africa
Metabolism 58:149-57. 2009..The measurement of waist circumference, as an indicator of disease risk, should therefore be encouraged in the public health setting... - The guanine-thymine dinucleotide repeat polymorphism within the tenascin-C gene is associated with achilles tendon injuriesGaonyadiwe G Mokone
UCT MRC Research Unit for Exercise Science and Sports Medicine, University of Cape Town, PO Box 115, Newlands 7725, South Africa
Am J Sports Med 33:1016-21. 2005..The tenascin-C gene, which has been mapped to chromosome 9q32-q34, encodes for a structural component of tendons... - The COL5A1 gene, ultra-marathon running performance, and range of motionJames C Brown
Department of Human Biology, University of Cape Town, Cape Town, South Africa
Int J Sports Physiol Perform 6:485-96. 2011..The aim of this study was to investigate whether COL5A1 is associated with ultra-marathon running performance and whether this relationship could be partly explained by prerace SR ROM... - Insulin response in relation to insulin sensitivity: an appropriate beta-cell response in black South African womenJulia H Goedecke
Department of Human Biology, UCT MRC Research Unit for Exercise Science and Sports Medicine, University of Cape Town, Cape Town, South Africa
Diabetes Care 32:860-5. 2009..The purpose of this study was to characterize differences in the acute insulin response to glucose (AIR(g)) relative to insulin sensitivity (S(I)) in black and white premenopausal normoglycemic South African women matched for body fatness... - Determinants of insulin-resistant phenotypes in normal-weight and obese Black African womenCourtney L Jennings
UCT MRC Research Unit for Exercise Science and Sports Medicine, Department of Human Biology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
Obesity (Silver Spring) 16:1602-9. 2008..The aim of this study was to explore the determinants of these phenotypes in black South African (SA) women... - The interleukin-6, serotonin transporter, and monoamine oxidase A genes and endurance performance during the South African Ironman TriathlonLiesl de Milander
UCT MRC Research Unit for Exercise Science and Sports Medicine, Department of Human Biology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
Appl Physiol Nutr Metab 34:858-65. 2009..The neurogenetic basis of the central governor requires further investigation... - The bradykinin beta 2 receptor (BDKRB2) and endothelial nitric oxide synthase 3 (NOS3) genes and endurance performance during Ironman TriathlonsColleen J Saunders
MRC UCT Research Unit for Exercise Science and Sports Medicine of the Medical Research Council of South Africa, University of Cape Town, South Africa
Hum Mol Genet 15:979-87. 2006..6% of the variance in the overall race time for the triathlon. In conclusion, both the NOS3 and BDKRB2 genes are associated with the actual performance during the Ironman Triathlons... - The association between the COL12A1 gene and anterior cruciate ligament rupturesMichael Posthumus
UCT MRC Research Unit for Exercise Science and Sports Medicine, Department of Human Biology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
Br J Sports Med 44:1160-5. 2010..Type XII collagen, similarly to types I and V collagen, is a structural component of the ligament fibril and is encoded by a single gene, COL12A1... - The COL5A1 gene: a novel marker of endurance running performanceMichael Posthumus
UCT MRC Research Unit for Exercise Science and Sports Medicine of the Department of Human Biology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
Med Sci Sports Exerc 43:584-9. 2011..Type V collagen is a quantitatively minor fibrillar collagen, which is believed to regulate fibrillogenesis within tendons and other connective tissue... - Sequence variants within the 3'-UTR of the COL5A1 gene alters mRNA stability: implications for musculoskeletal soft tissue injuriesMary Jessica Laguette
UCT MRC Research Unit for Exercise Science and Sports Medicine, Department of Human Biology, University of Cape Town, Cape Town, South Africa
Matrix Biol 30:338-45. 2011..These results have important implications for our understanding of the molecular basis of musculoskeletal soft tissue injuries and other exercise-related phenotypes... - Skeletal muscle monocarboxylate transporter content is not different between black and white runnersYolande X R Harley
Department of Human Biology, University of Cape Town, UCT MRC Research Unit for Exercise Science Sports Medicine, PO Box 115, Newlands, Cape Town 7725, South Africa
Eur J Appl Physiol 105:623-32. 2009..88, P < 0.001), but MCT1 content did not. Although whole homogenate MCT content was not different between the groups, more research is required to explain the lower plasma lactate concentrations in black runners... - Factors associated with a self-reported history of exercise-associated muscle cramps in ironman triathletes: a case-control studyGavin Shang
UCT MRC Research Unit for Exercise Science and Sports Medicine, Department of Human Biology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
Clin J Sport Med 21:204-10. 2011..The exact cause of and risk factors for EAMC are still being investigated. The main objective of this study was to investigate factors that are associated with a self-reported history of EAMC in Ironman triathletes... - The -308 G/A polymorphism of the tumour necrosis factor-? gene modifies the association between saturated fat intake and serum total cholesterol levels in white South African womenYael T Joffe
UCT MRC Research Unit for Exercise Science and Sports Medicine, Department of Human Biology, University of Cape Town, Newlands, Cape Town, South Africa
Genes Nutr 6:353-9. 2011..The TNFA -308 G/A polymorphism appears to modify the relationship between dietary fat intake and serum total cholesterol concentrations in white SA women... - Are splanchnic hemodynamics related to the development of gastrointestinal symptoms in ironman triathletes? A prospective cohort studyHelen Wright
UCT MRC Research Unit for Exercise Science and Sports Medicine, Department of Human Biology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
Clin J Sport Med 21:337-43. 2011..To determine if prerace to postrace changes in superior mesenteric artery (SMA) and coeliac artery hemodynamics were related to the development of gastrointestinal (GI) symptoms during a triathlon... - A pathway-based approach investigating the genes encoding interleukin-1?, interleukin-6 and the interleukin-1 receptor antagonist provides new insight into the genetic susceptibility of Achilles tendinopathyAlison V September
UCT MRC Unit for Exercise Science and Sports Medicine, Department of Human Biology, University of Cape Town, Cape Town, South Africa
Br J Sports Med 45:1040-7. 2011..Achilles tendinopathy (AT) is a multifactorial condition for which genetic risk factors have been identified. A pathway-based approach was used to investigate genes within the inflammatory pathway... - Tendon and ligament injuries: the genetic componentAlison V September
UCT MRC Research Unit for Exercise Science and Sports Medicine, Department of Human Biology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
Br J Sports Med 41:241-6; discussion 246. 2007..In future, specific genotypes associated with increased risk of injury to specific tendons and ligaments can prevent these injuries by identifying individuals at higher risk... - Mind and muscle: the cognitive-affective neuroscience of exerciseDan J Stein
Department of Mental Health and Psychiatry, University of Cape Town, South Africa
CNS Spectr 12:19-22. 2007..The hypothesis that Homo sapiens evolved as a specialist endurance runner provides an intriguing context against which to research the proximal mechanisms relevant to a cognitive-affective neuroscience of exercise... - Skeletal muscle telomere length in healthy, experienced, endurance runnersDale E Rae
UCT MRC Research Unit for Exercise Science and Sports Medicine, Department of Human Biology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
Eur J Appl Physiol 109:323-30. 2010..035). Therefore, since exposure to endurance running may influence minimum TRF length, and by implication, the proliferative potential of the satellite cells, chronic endurance running may be seen as a stressor to skeletal muscle... - A comparison of two treatment protocols in the management of exercise-associated postural hypotension: a randomised clinical trialCameron Anley
UCT MRC Research Unit for Exercise Science and Sports Medicine, Department of Human Biology, Faculty of Health Sciences, University of Cape Town, South Africa
Br J Sports Med 45:1113-8. 2011..To investigate which of two commonly used treatment protocols for exercise-associated postural hypotension (EAPH) resulted in earlier discharge from the medical facility... - Maintenance of plasma volume and serum sodium concentration despite body weight loss in ironman triathletesTamara Hew-Butler
University of Capetown Medical Research Council Research Unit for Exercise Science and Sports Medicine, Department of Human Biology, University of Cape Town, Cape Town, South Africa
Clin J Sport Med 17:116-22. 2007..To examine the relationship between body weight, plasma volume, and serum sodium concentration ([Na]) during prolonged endurance exercise... - The COL5A1 Gene, Ultra-Marathon Running Performance, and Range of MotionJames C Brown
UCT MRC Research Unit for Exercise Science and Sports Medicine, Department of Human Biology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
Int J Sports Physiol Perform 6:485-96. 2011..The aim of this study was to investigate whether COL5A1 is associated with ultra-marathon running performance and whether this relationship could be partly explained by prerace SR ROM... - Dysnatremia predicts a delayed recovery in collapsed ultramarathon runnersTamara Hew-Butler
Department of Human Biology, University of Cape Town, South Africa
Clin J Sport Med 17:289-96. 2007.... - Weight changes, sodium levels, and performance in the South African Ironman TriathlonKaren Sharwood
UCT MRC Research Unit for Exercise Science and Sports Medicine, Department of Human Biology, Faculty of Health Sciences, University of Cape Town and Sports Science Institute of South Africa, South Africa
Clin J Sport Med 12:391-9. 2002..To establish relationships between body weight changes and serum sodium during and after an Ironman Triathlon, and postrace fluid status and rectal temperature, including the incidence of hyponatremia... - Athletes with exercise-associated fatigue have abnormally short muscle DNA telomeresMalcolm Collins
Department of Human Biology, University of Cape Town, South Africa
Med Sci Sports Exerc 35:1524-8. 2003.... - The intrinsic risk factors for ACL ruptures: an evidence-based reviewMichael Posthumus
UCT MRC Research Unit for Exercise Science and Sports Medicine, University of Cape Town, Cape Town, South Africa
Phys Sportsmed 39:62-73. 2011..These data should be used to establish multifactorial risk factor models designed to identify individuals at high risk of sustaining an ACL injury... - Increased running speed and pre-race muscle damage as risk factors for exercise-associated muscle cramps in a 56 km ultra-marathon: a prospective cohort studyMartin P Schwellnus
Research Unit for Exercise Science and Sports Medicine, Department of Human Biology, Faculty of Health Sciences, University of Cape Town, South Africa
Br J Sports Med 45:1132-6. 2011..Despite the high prevalence of exercise-associated muscle cramping (EAMC) in endurance runners, the aetiology and risk factors for this condition are not fully understood... - The science of sex verification and athletic performanceRoss Tucker
UCT MRC Research Unit for Exercise Science and Sports Medicine of the Department of Human Biology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
Int J Sports Physiol Perform 5:127-39. 2010..This review will therefore provide the historical context of the debate and aim to discuss relevant physiological and performance aspects of the sex verification process... - Muscle cramping in athletes--risk factors, clinical assessment, and managementMartin P Schwellnus
UCT MRC Research Unit for Exercise Science and Sports Medicine, Department of Human Biology, University of Cape Town, 3rd Floor, Sports Science Institute of South Africa, Boundary Road, Newlands, Cape Town 7700, South Africa
Clin Sports Med 27:183-94, ix-x. 2008..The diagnosis of EAMC is made clinically, and the most effective immediate management of EAMC is rest and passive stretching. The key to the prevention of EAMC is to reduce the risk of developing premature muscle fatigue... - The association of interleukin-18 genotype and serum levels with metabolic risk factors for cardiovascular diseaseJuliet Evans
UCT MRC Research Unit for Exercise Science and Sports Medicine, Department of Human Biology, Faculty of Health Sciences, University of Cape Town, PO Box 115, Newlands, 7725 Cape Town, South Africa
Eur J Endocrinol 157:633-40. 2007..This study investigated the association between the circulating IL-18 levels and the -137 G/C polymorphism within the IL-18 gene with metabolic risk factors for CVD in normal-weight and obese black South African women... - The interaction of aging and 10 years of racing on ultraendurance running performanceDale E Rae
Dept. of Human Biology, University of Cape Town, Newlands, South Africa
J Aging Phys Act 13:210-22. 2005..In conclusion, these data suggest that although these runners showed similar patterns of change in race speed over a 10-year period, the extent of change in performance was greater in younger than in older runners... - The ACE gene and endurance performance during the South African Ironman TriathlonsMalcolm Collins
UCT MRC Research Unit for Exercise Science and Sports Medicine, Department of Human Biology, University of Cape Town, Cape Town, South Africa
Med Sci Sports Exerc 36:1314-20. 2004..The aim of this study was to determine whether the ID polymorphism is associated with the performance of the fastest finishers of the South African Ironman Triathlons... - Exercise and CaMK activation both increase the binding of MEF2A to the Glut4 promoter in skeletal muscle in vivoJames A H Smith
UCT MRC Research Unit for Exercise Science and Sports Medicine, Department of Human Biology, University of Cape Town, P O Box 115, Newlands 7725, South Africa
Am J Physiol Endocrinol Metab 292:E413-20. 2007..These results confirm that exercise increases the binding of MEF2A to the Glut4 promoter in vivo and provides evidence that CaMK signaling is involved in this interaction... - Variants within the COL5A1 gene are associated with Achilles tendinopathy in two populationsA V September
MRC UCT Research Unit for Exercise Science and Sports Medicine, University of Cape Town, Newlands 7725, South Africa
Br J Sports Med 43:357-65. 2009.... - Genetic risk factors for anterior cruciate ligament ruptures: COL1A1 gene variantM Posthumus
UCT MRC Research Unit for Exercise Science and Sports Medicine, Newlands 7725, Cape Town, South Africa
Br J Sports Med 43:352-6. 2009..Recently, the gene encoding for the alpha1 chain of type I collagen (COL1A1) has been shown to be associated with cruciate ligament ruptures and shoulder dislocations...