Lyn Marie Birkholtz

Summary

Affiliation: University of Pretoria
Country: South Africa

Publications

  1. ncbi Polyamine homoeostasis as a drug target in pathogenic protozoa: peculiarities and possibilities
    Lyn Marie Birkholtz
    Department of Biochemistry, University of Pretoria, Hatfield, South Africa
    Biochem J 438:229-44. 2011
  2. ncbi Heterologous expression of plasmodial proteins for structural studies and functional annotation
    Lyn Marie Birkholtz
    Department of Biochemistry, University of Pretoria, Pretoria, South Africa
    Malar J 7:197. 2008
  3. ncbi Novel properties of malarial S-adenosylmethionine decarboxylase as revealed by structural modelling
    Gordon A Wells
    Department of Biochemistry, School of Biological Sciences, Faculty of Natural and Agricultural Sciences, University of Pretoria, Pretoria 0002, South Africa
    J Mol Graph Model 24:307-18. 2006
  4. ncbi Plasmodium falciparum spermidine synthase inhibition results in unique perturbation-specific effects observed on transcript, protein and metabolite levels
    John V W Becker
    CSIR Biosciences, PO Box 395, Pretoria, 0001, South Africa
    BMC Genomics 11:235. 2010
  5. ncbi Biochemical characterisation and novel classification of monofunctional S-adenosylmethionine decarboxylase of Plasmodium falciparum
    Marni Williams
    Department of Biochemistry, University of Pretoria, Hatfield, South Africa
    Mol Biochem Parasitol 180:17-26. 2011
  6. ncbi Deletion mutagenesis of large areas in Plasmodium falciparum genes: a comparative study
    Marni Williams
    Department of Biochemistry, School of Biological Sciences, Faculty of Natural and Agricultural Sciences, University of Pretoria, Pretoria, South Africa
    Malar J 6:64. 2007
  7. ncbi Transcriptional responses of Plasmodium falciparum to alpha-difluoromethylornithine-induced polyamine depletion
    Katherine Clark
    Department of Biochemistry, School of Biological Sciences, Faculty of Natural and Agricultural Sciences, University of Pretoria, Pretoria 0002, South Africa
    Biol Chem 389:111-25. 2008
  8. ncbi Proteomic profiling of Plasmodium falciparum through improved, semiquantitative two-dimensional gel electrophoresis
    Salome Smit
    Department of Biochemistry, Faculty of Natural and Agricultural Sciences, University of Pretoria, Pretoria, 0002, South Africa
    J Proteome Res 9:2170-81. 2010
  9. ncbi Discovery of novel alkylated (bis)urea and (bis)thiourea polyamine analogues with potent antimalarial activities
    Bianca K Verlinden
    Department of Biochemistry, Faculty of Natural and Agricultural Sciences, University of Pretoria, PO Box x20, Pretoria, 0028, South Africa
    J Med Chem 54:6624-33. 2011
  10. ncbi Integration and mining of malaria molecular, functional and pharmacological data: how far are we from a chemogenomic knowledge space?
    Lyn Marie Birkholtz
    Department of Biochemistry and African Centre for Gene Technologies, Faculty of Natural and Agricultural Sciences, University of Pretoria, 0002, Pretoria, South Africa
    Malar J 5:110. 2006

Collaborators

Detail Information

Publications12

  1. ncbi Polyamine homoeostasis as a drug target in pathogenic protozoa: peculiarities and possibilities
    Lyn Marie Birkholtz
    Department of Biochemistry, University of Pretoria, Hatfield, South Africa
    Biochem J 438:229-44. 2011
    ..Particularly interesting features within polyamine metabolism in these parasites are highlighted for their potential in selective therapeutic strategies...
  2. ncbi Heterologous expression of plasmodial proteins for structural studies and functional annotation
    Lyn Marie Birkholtz
    Department of Biochemistry, University of Pretoria, Pretoria, South Africa
    Malar J 7:197. 2008
    ..Here the status quo of heterologous production of plasmodial proteins is presented, constraints are highlighted and alternative strategies and hosts for functional expression and annotation of plasmodial proteins are reviewed...
  3. ncbi Novel properties of malarial S-adenosylmethionine decarboxylase as revealed by structural modelling
    Gordon A Wells
    Department of Biochemistry, School of Biological Sciences, Faculty of Natural and Agricultural Sciences, University of Pretoria, Pretoria 0002, South Africa
    J Mol Graph Model 24:307-18. 2006
    ..These novel features of malarial AdoMetDC suggest possibilities for the discovery of parasite-specific inhibitors...
  4. ncbi Plasmodium falciparum spermidine synthase inhibition results in unique perturbation-specific effects observed on transcript, protein and metabolite levels
    John V W Becker
    CSIR Biosciences, PO Box 395, Pretoria, 0001, South Africa
    BMC Genomics 11:235. 2010
    ..falciparum spermidine synthase (PfSpdSyn) were examined on a morphological, transcriptomic, proteomic and metabolic level...
  5. ncbi Biochemical characterisation and novel classification of monofunctional S-adenosylmethionine decarboxylase of Plasmodium falciparum
    Marni Williams
    Department of Biochemistry, University of Pretoria, Hatfield, South Africa
    Mol Biochem Parasitol 180:17-26. 2011
    ..Furthermore, based on the results obtained in this study we propose a new AdoMetDC subclass for plasmodial AdoMetDCs...
  6. ncbi Deletion mutagenesis of large areas in Plasmodium falciparum genes: a comparative study
    Marni Williams
    Department of Biochemistry, School of Biological Sciences, Faculty of Natural and Agricultural Sciences, University of Pretoria, Pretoria, South Africa
    Malar J 6:64. 2007
    ..A comparative study of five widely used PCR-based mutagenesis methods identified a modified inverse PCR method as particularly suitable for the deletion of large areas (>100 bp) in malaria parasite genes...
  7. ncbi Transcriptional responses of Plasmodium falciparum to alpha-difluoromethylornithine-induced polyamine depletion
    Katherine Clark
    Department of Biochemistry, School of Biological Sciences, Faculty of Natural and Agricultural Sciences, University of Pretoria, Pretoria 0002, South Africa
    Biol Chem 389:111-25. 2008
    ..The data presented provide input into the role of the polyamines in the cellular biology of P. falciparum and contribute towards the validation of polyamine biosynthesis as an antimalarial target...
  8. ncbi Proteomic profiling of Plasmodium falciparum through improved, semiquantitative two-dimensional gel electrophoresis
    Salome Smit
    Department of Biochemistry, Faculty of Natural and Agricultural Sciences, University of Pretoria, Pretoria, 0002, South Africa
    J Proteome Res 9:2170-81. 2010
    ....
  9. ncbi Discovery of novel alkylated (bis)urea and (bis)thiourea polyamine analogues with potent antimalarial activities
    Bianca K Verlinden
    Department of Biochemistry, Faculty of Natural and Agricultural Sciences, University of Pretoria, PO Box x20, Pretoria, 0028, South Africa
    J Med Chem 54:6624-33. 2011
    ....
  10. ncbi Integration and mining of malaria molecular, functional and pharmacological data: how far are we from a chemogenomic knowledge space?
    Lyn Marie Birkholtz
    Department of Biochemistry and African Centre for Gene Technologies, Faculty of Natural and Agricultural Sciences, University of Pretoria, 0002, Pretoria, South Africa
    Malar J 5:110. 2006
    ..Recent progress towards a grid-enabled chemogenomic knowledge space is discussed...
  11. ncbi Co-inhibition of Plasmodium falciparum S-adenosylmethionine decarboxylase/ornithine decarboxylase reveals perturbation-specific compensatory mechanisms by transcriptome, proteome, and metabolome analyses
    Anna C van Brummelen
    Department of Biochemistry, University of Pretoria, Pretoria, Gauteng 0002, South Africa
    J Biol Chem 284:4635-46. 2009
    ..In contrast with previous reports, the results provide evidence that P. falciparum responds to alleviate the detrimental effects of polyamine depletion via regulation of its transcriptome and subsequently the proteome and metabolome...
  12. ncbi Structural and mechanistic insights into the action of Plasmodium falciparum spermidine synthase
    Pieter B Burger
    Bioinformatics and Computational Biology Unit, Faculty of Natural and Agricultural Sciences, University of Pretoria, Pretoria 0002, South Africa
    Bioorg Med Chem 15:1628-37. 2007
    ....