Research Topics
| Karen I BarnesSummaryAffiliation: University of Cape Town Country: South Africa Publications
| Collaborators
|
Detail Information
Publications
Effects of amodiaquine and artesunate on sulphadoxine-pyrimethamine pharmacokinetic parameters in children under five in MaliMamadou M Tekete
Molecular Epidemiology and Drug Resistance Unit, Malaria Research and Training Centre, Department of Epidemiology of Parasitic Diseases, Faculty of Medicine, Pharmacy and Dentistry, University of Bamako, P, O, Box 1805, Bamako, Mali
Malar J 10:275. 2011..Yet, limited data is available on pharmacokinetic interactions between these drugs...- The rationale and plan for creating a World Antimalarial Resistance Network (WARN)Carol Hopkins Sibley
Malar J 6:118. 2007..WARN will serve as a public resource to guide antimalarial drug treatment and prevention policies and to help confirm and characterize the new emergence of new resistance to antimalarial drugs and to contain its spread... - Impact of the large-scale deployment of artemether/lumefantrine on the malaria disease burden in Africa: case studies of South Africa, Zambia and EthiopiaKaren I Barnes
Division of Clinical Pharmacology, Department of Medicine, University of Cape Town Faculty of Health Sciences, Anzio Road, Observatory, 7925, South Africa
Malar J 8:S8. 2009..Artemisinin-based combination therapy has made a substantial contribution to reducing the burden of malaria in sub-Saharan Africa... - Antimalarial dosing regimens and drug resistanceKaren I Barnes
Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa
Trends Parasitol 24:127-34. 2008..There is an urgent need for studies to optimise antimalarial dosage regimens in infants, young children and pregnant women, both to improve cure rates and to prolong the useful therapeutic lives of antimalarial drugs... - World Antimalarial Resistance Network (WARN) IV: clinical pharmacologyKaren I Barnes
Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa
Malar J 6:122. 2007.... - Interaction between artemether-lumefantrine and nevirapine-based antiretroviral therapy in HIV-1-infected patientsT Kredo
Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa
Antimicrob Agents Chemother 55:5616-23. 2011..The mechanism of the lumefantrine interaction remains to be elucidated. Studies investigating the interaction of nevirapine and artemether-lumefantrine in HIV-infected patients with malaria are urgently needed... - Association between the pharmacokinetics and in vivo therapeutic efficacy of sulfadoxine-pyrimethamine in Malawian childrenFraction K Dzinjalamala
University of Cape Town, Division of Clinical Pharmacology, K50 Old Main Building, Groote Schuur Hospital, Cape Town 7925, South Africa
Antimicrob Agents Chemother 49:3601-6. 2005..falciparum should be interpreted with caution and needs further validation... - Increased gametocytemia after treatment: an early parasitological indicator of emerging sulfadoxine-pyrimethamine resistance in falciparum malariaKaren I Barnes
Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa
J Infect Dis 197:1605-13. 2008..Although malaria treatment aims primarily to eliminate the asexual blood stages that cause illness, reducing the carriage of gametocytes is critical for limiting malaria transmission and the spread of resistance... - Efficacy of sulphadoxine-pyrimethamine with or without artesunate for the treatment of uncomplicated Plasmodium falciparum malaria in southern Mozambique: a randomized controlled trialElizabeth N Allen
Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, South Africa
Malar J 8:141. 2009..An artemisinin-based combination therapy, artesunate (AS) plus sulphadoxine-pyrimethamine (SP), was compared to SP monotherapy to provide evidence of further treatment options in southern Mozambique... - Malaria pharmacovigilance in Africa: lessons from a pilot project in Mpumalanga Province, South AfricaUshma Mehta
Division of Clinical Pharmacology, University of Cape Town, Cape Town, South Africa
Drug Saf 30:899-910. 2007.... - Nonlinear mixed effects modeling of gametocyte carriage in patients with uncomplicated malariaGreg B Distiller
Department of Statistical Sciences, University of Cape Town, Cape Town, South Africa
Malar J 9:60. 2010..The objective of this research was to directly model observed gametocyte densities over time, during the primary infection... - Should countries implementing an artemisinin-based combination malaria treatment policy also introduce rapid diagnostic tests?Charlotte M Zikusooka
Health Economics Unit, Department of Public Health and Family Medicine, University of Cape Town, Anzio Road, Observatory, 7925 Cape Town, South Africa
Malar J 7:176. 2008..This motivates for this assessment of the cost-effectiveness of routine use of rapid diagnostic tests (RDTs) as an integral part of deploying artemisinin-based combination therapies (ACTs)... - Sulfadoxine-pyrimethamine pharmacokinetics in malaria: pediatric dosing implicationsKaren I Barnes
Division of Clinical Pharmacology and Department of Statistical Sciences, University of Cape Town, Cape Town, South Africa
Clin Pharmacol Ther 80:582-96. 2006..Despite decades of widespread use, there are few data to inform dose recommendations... - Population biology and antimalarial resistance: The transmission of antimalarial drug resistance in Plasmodium falciparumKaren I Barnes
Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town 7925, South Africa
Acta Trop 94:230-40. 2005..Artemisinin-based combination therapies are the only antimalarials currently available which rapidly reduce both asexual and gametocyte stages of the P. falciparum lifecycle... - Effect of artemether-lumefantrine policy and improved vector control on malaria burden in KwaZulu-Natal, South AfricaKaren I Barnes
Division of Clinical Pharmacology, University of Cape Town, Cape Town, South Africa
PLoS Med 2:e330. 2005..Malaria is diagnosed definitively and treatment is provided free of charge in reasonably accessible public-sector health-care facilities... - Pharmacokinetics and tolerability of artesunate and amodiaquine alone and in combination in healthy volunteersCatherine Orrell
Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Anzio Road, Observatory, Cape Town, 7925, South Africa
Eur J Clin Pharmacol 64:683-90. 2008..As no pharmacokinetic data on this combination have been published to date, we investigated its pharmacokinetic interactions and tolerability in healthy volunteers in Africa... - Artemisinin-based combination therapy reduces expenditure on malaria treatment in KwaZulu Natal, South AfricaCharlotte Muheki
Health Sciences Faculty, University of Cape Town, South Africa
Trop Med Int Health 9:959-66. 2004..However, the relevance of these findings requires careful consideration in countries with currently effective treatment policies and higher intensity malaria transmission... - Blood folate concentrations and in vivo sulfadoxine-pyrimethamine failure in Malawian children with uncomplicated Plasmodium falciparum malariaFraction K Dzinjalamala
Division of Pharmacology, University of Cape Town, Cape Town, South Africa
Am J Trop Med Hyg 72:267-72. 2005.... - Adverse drug reactions in adult medical inpatients in a South African hospital serving a community with a high HIV/AIDS prevalence: prospective observational studyUshma Mehta
Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Observatory 7925, South Africa
Br J Clin Pharmacol 65:396-406. 2008..ADRs in HIV-infected patients were less likely to be preventable... - Antimalarial treatment with artemisinin combination therapy in AfricaGrace Malenga
BMJ 331:706-7. 2005 - Measuring resistance to malariaKaren I Barnes
S Afr Med J 94:36-7. 2004 - Comment on: Audiometric changes associated with the treatment of uncomplicated falciparum malaria with co-artemetherUshma Mehta
Trans R Soc Trop Med Hyg 99:313-4; author reply 314-5. 2005 - Differential effect of regional drug pressure on dihydrofolate reductase and dihydropteroate synthetase mutations in southern MozambiqueJaishree Raman
Malaria Lead Programme, Medical Research Council, Durban, KwaZulu Natal, South Africa
Am J Trop Med Hyg 78:256-61. 2008..Our results show that drug pressure can exert its influence at a regional level rather than merely at a national level... - The pharmacokinetics of intravenous artesunate in adults with severe falciparum malariaPaul N Newton
Faculty of Tropical Medicine, Mahidol University, 420/6 Rajvithi Rd, Bangkok 10400, Thailand
Eur J Clin Pharmacol 62:1003-9. 2006..CONCLUSION: The large inter-individual variability (10 fold) in DHA Cmax and AUC in patients with potentially lethal, severe malaria, suggests that 2.4 mg/kg should be the minimum daily dose in severe malaria... - A network to monitor antimalarial drug resistance: a plan for moving forwardCarol Hopkins Sibley
Department of Genome Sciences, University of Washington, Seattle, WA, USA
Trends Parasitol 24:43-8. 2008.... - World Antimalarial Resistance Network I: clinical efficacy of antimalarial drugsRic N Price
International Health Program, Menzies School of Health Research and Charles Darwin University, Darwin, Northern Territory, Australia
Malar J 6:119. 2007..This resource will help guide rational drug policies that optimize antimalarial drug use, in the hope that the emergence and spread of resistance to new drugs can be, if not prevented, at least delayed... - Rolling back malaria in AfricaKaren I Barnes
S Afr Med J 97:36-7. 2007 - Seven years of regional malaria control collaboration--Mozambique, South Africa, and SwazilandBrian L Sharp
Malaria Research Programme, Medical Research Council, Durban, South Africa
Am J Trop Med Hyg 76:42-7. 2007..The success of the program in reducing malaria transmission throughout the target area provides a strong argument for investment in regional malaria control... - Population pharmacokinetics of artesunate and dihydroartemisinin following intra-rectal dosing of artesunate in malaria patientsJulie A Simpson
Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, The University of Melbourne, Melbourne, Australia
PLoS Med 3:e444. 2006..We studied the population pharmacokinetics of intra-rectal artesunate and the relationship with parasitological responses in patients with moderately severe falciparum malaria... - WHO, the Global Fund, and medical malpractice in malaria treatmentAmir Attaran
Royal Institute of International Affairs, London, UK
Lancet 363:237-40. 2004 - The World Bank: false financial and statistical accounts and medical malpractice in malaria treatmentAmir Attaran
Institute of Population Health and Faculty of Law, University of Ottawa, Ottawa, Ontario, K1N 6N5, Canada
Lancet 368:247-52. 2006