Oxygen as a neonatal health hazard: call for détente in clinical practiceAugusto Sola
Mid Atlantic Neonatology Associates and Morristown Memorial Hospital, Morristown, NJ, USA
Acta Paediatr 96:801-12. 2007
..Neonatal exposure to pure O2, even if brief, or to pulse oximetry >95% when breathing supplemental O2 must be avoided as much as possible...
- An evident view of evidence-based practice in perinatal medicine: absence of evidence is not evidence of absence
Augusto Sola
MANA and Atlantic Neonatal Research Institute, Division of Neonatology, Atlantic Health System, Morristown, NJ, USA
J Pediatr (Rio J) 83:395-414. 2007
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- [Oral sildenafil in neonatal medicine: ''tested in adults also used in neonates'']
A Sola
Mid Atlantic Neonatology Associates, Morristown Memorial Hospital, Morristown, NJ, USA
An Pediatr (Barc) 66:167-76. 2007
- Animal models of neonatal stroke and response to erythropoietin and cardiotrophin-1
Augusto Sola
Division of Neonatology, MANA and Atlantic Neonatal Research Institute, Morristown, NJ 07960, USA
Int J Dev Neurosci 26:27-35. 2008
..In addition, we review and report potential neuroprotective strategies specific to neonatal stroke, with a focus on erythropoietin and cardiotrophin-1 because of their potential role in protection as well as repair...
- Oxygen for the preterm newborn: one infant at a time
Augusto Sola
Mid Atlantic Neonatology Associates and Atlantic Neonatal Research Institute, Atlantic Health System, 100 Madison Ave, Morristown, NJ 07960
Pediatrics 121:1257. 2008
- Oxygen in neonatal anesthesia: friend or foe?
Augusto Sola
Mid Atlantic Neonatology Associates and Atlantic Neonatal Research Institute, Morristown, NJ 07960, USA
Curr Opin Anaesthesiol 21:332-9. 2008
..Nevertheless, the only known cause for hyperoxemia is the excess and unnecessary administration of oxygen by healthcare providers. To avoid hyperoxemia is an important objective during neonatal anesthesia...
- Clinical practices in neonatal oxygenation: where have we failed? What can we do?
A Sola
Mid Atlantic Neonatology Associates and Atlantic Neonatal Research Institute, Atlantic Health System, Morristown, NJ 07960, USA
J Perinatol 28:S28-34. 2008
..Therapies that prove to be outdated or even dangerous must be eliminated while further research and confirmation of the best practices are determined. Freedom to choose can come at a price...
- Caspase inhibition by cardiotrophin-1 prevents neuronal death in vivo and in vitro
Hui Peng
Atlantic Neonatal Research Institute, MidAtlantic Neonatology Associates, and Atlantic Health, Morristown, New Jersey, USA
J Neurosci Res 88:1041-51. 2010
..This is the first suggestion that CT-1 prevents neuronal injury in the developing central nervous system possibly through mediating multiple signal pathways, inhibiting activation of C-8 and C-3...
- Fructose-1,6-biphosphate prevents excitotoxic neuronal cell death in the neonatal mouse brain
Marta Rogido
Division of Neonatology, Emory University, Atlanta, GA, USA
Brain Res Dev Brain Res 140:287-97. 2003
..This data extends the neuroprotective profile of FBP in neonatal brain injury and identifies gray matter lesions involving N-methyl-D-aspartate receptors as a major target for this promising drug...
- Can changes in clinical practice decrease the incidence of severe retinopathy of prematurity in very low birth weight infants?
Lily C Chow
Division of Neonatology, Department of Pediatrics, Cedars-Sinai Medical Center and UCLA School of Medicine, Los Angeles, California, USA
Pediatrics 111:339-45. 2003
..Although several confounders cannot be excluded, it is likely that differences in these clinical practices may be, at least in part, responsible for the documented intercenter variability in rates of ROP...
- Different doses of dopamine have heterogeneous effects on cerebral hemodynamics and dopamine receptors in young rabbits as measured with near infrared spectroscopy
Mariana C Baserga
Department of Pediatrics, Children's Hospital of Orange County, Orange, CA, USA
Biol Neonate 87:229-35. 2005
..We therefore speculate that dopamine has an effect on the cerebrovasculature that could be mediated by factors other than changes in the basal ganglia dopamine receptors...
- Oxygen and oxygenation in the delivery room
Augusto Sola
J Pediatr 148:564-5. 2006
- Oral sildenafil in infants with persistent pulmonary hypertension of the newborn: a pilot randomized blinded study
Hernando Baquero
Division of Neonatology, Universidad del Norte, Barranquilla, Colombia
Pediatrics 117:1077-83. 2006
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- Mild intermittent hypoxia does not induce stress responses in the neonatal rat brain
Valerie Boss
Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322, USA
Biol Neonate 88:313-20. 2005
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- Cardiotrophin-1 protects cortical neuronal cells against free radical-induced injuries in vitro
Tong Chun Wen
Division of Neonatal Perinatal Medicine, Department of Pediatrics, Emory University School of Medicine, 2015 Uppergate Drive, Atlanta, GA 30322, USA
Neurosci Lett 387:38-42. 2005
..These results indicate that CT-1 is neuroprotective in an in vitro model of cerebral ischemia. This study indicates that further evaluation of CT-1 in acute brain injury should be investigated in vivo...
- [Recommendations for Retinopathy of Prematurity screening in at-risk populations]
Celia Lomuto
Arch Argent Pediatr 106:71-6. 2008
- Pulse oxygen saturation levels and arterial oxygen tension values in newborns receiving oxygen therapy in the neonatal intensive care unit: is 85% to 93% an acceptable range?
Armando Castillo
Division of Neonatal Perinatal Medicine, Emory University, Atlanta, Georgia, USA
Pediatrics 121:882-9. 2008
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- Turn off the lights and the oxygen, when not needed: phototherapy and oxidative stress in the neonate
Augusto Sola
J Pediatr (Rio J) 83:293-6. 2007
- Iron, oxidant injury, and practice choices in preterm infants
Augusto Sola
J Pediatr 152:295-6; author reply 296. 2008
- Corticosteroids in perinatal medicine: how to improve outcomes without affecting the developing brain?
Olivier Baud
NICU and Neonatal Medicine, INSERM U676, Robert Debré Children s Hospital, 48 Bd Serurier, Paris, France
Semin Fetal Neonatal Med 12:273-9. 2007
..Treatment with other steroids should be restricted to the context of randomized controlled trials...
- Cerebrovascular response in small preterm infants during routine nursery gavage feedings
Mariana C Baserga
Department of Pediatrics and Anesthesia, University of California-San Francisco, San Francisco, CA, USA
Biol Neonate 83:12-8. 2003
..Towards the end of the study, during the postfeeding period, cytochrome AA(3) oxygenase and oxygenated hemoglobin increased in 60%, while reduced hemoglobin decreased in 78% of the infants...
- Permanent focal cerebral ischemia activates erythropoietin receptor in the neonatal rat brain
Tong Chun Wen
Division of Neonatal Perinatal Medicine, Department of Pediatrics, Emory University School of Medicine, 1462 Clifton Road, Atlanta, GA 30322, USA
Neurosci Lett 355:165-8. 2004
..Therefore, these results suggest that EpoR is activated in the ischemic areas of neonatal rats and plays an important role in brain injury during development...
- A reproducible experimental model of focal cerebral ischemia in the neonatal rat
Tong-Chun Wen
Department of Pediatrics, Division of Neonatal-Perinatal Medicine, Emory University School of Medicine, 2040 Ridgewood Drive, Atlanta, GA 30322, USA
Brain Res Brain Res Protoc 13:76-83. 2004
..The present model opens the way for advanced pathophysiological studies of FCI in neonates...
- A case of Adams-Oliver syndrome with associated brain and pulmonary involvement: further evidence of vascular pathology?
Anthony Joseph Piazza
Division of Neonatal Perinatal Medicine, Department of Pediatrics, Emory University School of Medicine Atlanta, Georgia 30303, USA
Am J Med Genet A 130:172-5. 2004
..Evaluation for pulmonary hypertension and CNS anomalies in patients suspected to have AOS, can help identify those who are at risk for acute morbidities and associated developmental delays...
- Erythropoietin after focal cerebral ischemia activates the Janus kinase-signal transducer and activator of transcription signaling pathway and improves brain injury in postnatal day 7 rats
Augusto Sola
Division of Neonatal-Perinatal Medicine, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia 30322, USA
Pediatr Res 57:481-7. 2005
..In conclusion, Epo given after FCI in neonatal rats provides significant neuroprotection, mediated possibly by activation of the Janus kinase-signal transducer and activator of transcription-Bcl-xL signaling pathways...
- Potential for protection and repair following injury to the developing brain: a role for erythropoietin?
Augusto Sola
Division of Neonatal Perinatal Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
Pediatr Res 57:110R-117R. 2005
..In addition we review several potential neuroprotective strategies specific to the developing nervous system, with a focus on erythropoietin (Epo) because of its potential role in protection as well as repair...
- Low doses of ethanol and hypoxia administered together act synergistically to promote the death of cortical neurons
Thomas Genetta
Department of Pediatrics, Division of Neonatal Perinatal Medicine, Children s Research Center, Emory University School of Medicine, Atlanta, Georgia, USA
J Neurosci Res 85:131-8. 2007
..We further show that one indicator of apoptotic cell death, activated caspase 3, undetectable in neurons subjected to low levels of either insult alone, is detectable when they are administered together...
- Glucocorticoid receptor expression in the cortex of the neonatal rat brain with and without focal cerebral ischemia
Ben H Lee
Division of Neonatal Perinatal Medicine, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA
Neonatology 91:12-9. 2007
..Our aim was to describe GR ontogeny in the developing rat brain cortex and changes in GR expression after permanent neonatal focal cerebral ischemia (FCI)...
- The impact of neonatal intensive care practices on the developing brain
Pierre Gressens
, , Paris, France
J Pediatr 140:646-53. 2002
