Effect of QRS morphology on clinical event reduction with cardiac resynchronization therapy: meta-analysis of randomized controlled trialsIlke Sipahi
Harrington McLaughlin Heart and Vascular Institute, University Hospitals Case Medical Center, Cleveland, OH, USA
Am Heart J 163:260-7.e3. 2012
..Our objective was to examine this by performing a meta-analysis of all randomized controlled trials of CRT...
- Candidate mechanisms for regression of coronary atherosclerosis with high-dose statins: insight from intravascular ultrasonography trials
Ilke Sipahi
Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, Desk F25, 9500 Euclid Ave, Cleveland, OH 44195, USA
Am J Cardiovasc Drugs 8:365-71. 2008
..We conclude that, despite several potential mechanisms, reduction of low-density lipoprotein cholesterol appears to be the dominant mechanism responsible for regression of atherosclerosis...
- Angiotensin-receptor blockade and risk of cancer: meta-analysis of randomised controlled trials
Ilke Sipahi
Harrington McLaughlin Heart and Vascular Institute, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
Lancet Oncol 11:627-36. 2010
..We assessed whether ARBs affect cancer occurrence with a meta-analysis of randomised controlled trials of these drugs...
- Meta-analysis of randomized controlled trials on effect of angiotensin-converting enzyme inhibitors on cancer risk
Ilke Sipahi
Harrington McLaughlin Heart and Vascular Institute, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
Am J Cardiol 108:294-301. 2011
..95), or GI cancer (RR 1.09, 95% CI 0.88 to 1.35, p = 0.43). In conclusion, ACE inhibitors did not significantly increase or decrease occurrence of cancer or cancer death. There was also no significant difference in risk of GI cancer...
- Impact of QRS duration on clinical event reduction with cardiac resynchronization therapy: meta-analysis of randomized controlled trials
Ilke Sipahi
Harrington McLaughlin Heart and Vascular Institute, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
Arch Intern Med 171:1454-62. 2011
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- Effect of antihypertensive therapy on incident stroke in cohorts with prehypertensive blood pressure levels: a meta-analysis of randomized controlled trials
Ilke Sipahi
Heart Failure and Transplantation, Harrington McLaughlin Heart and Vascular Institute, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, 11100 Euclid Ave LKS 5038, Cleveland, OH 44106, USA
Stroke 43:432-40. 2012
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- Comparison of coronary atherosclerotic volume in patients with glomerular filtration rates < or = 60 versus > 60 ml/min/1.73 m(2): a meta-analysis of intravascular ultrasound studies
Stephen J Nicholls
Department of Cardiovascular Medicine, Center for Cardiovascular Diagnostics and Prevention, Cleveland Clinic Foundation, Cleveland, Ohio, USA
Am J Cardiol 99:813-6. 2007
..In conclusion, findings suggest that the increased incidence of clinical events in patients with impaired renal function may result from factors other than atherosclerotic burden...
- Intravascular ultrasound assessment of novel antiatherosclerotic therapies: rationale and design of the Acyl-CoA:Cholesterol Acyltransferase Intravascular Atherosclerosis Treatment Evaluation (ACTIVATE) Study
Stephen J Nicholls
Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
Am Heart J 152:67-74. 2006
..In this study, IVUS will be used to assess whether ACAT inhibition modifies progression of atherosclerotic plaque...
- Paradoxical increase in lumen size during progression of coronary atherosclerosis: observations from the REVERSAL trial
Ilke Sipahi
Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, Cleveland, OH, USA
Atherosclerosis 189:229-35. 2006
..Measurement of changes in lumen size may not be an accurate method to study progression and regression of atherosclerotic lesions with <50% stenosis...
- Effects of obesity on lipid-lowering, anti-inflammatory, and antiatherosclerotic benefits of atorvastatin or pravastatin in patients with coronary artery disease (from the REVERSAL Study)
Stephen J Nicholls
Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, Ohio, USA
Am J Cardiol 97:1553-7. 2006
..These results highlight the need for aggressive risk factor modification and a decrease in vascular inflammation in obese patients...
- Determinants of arterial wall remodeling during lipid-lowering therapy: serial intravascular ultrasound observations from the Reversal of Atherosclerosis with Aggressive Lipid Lowering Therapy (REVERSAL) trial
Paul Schoenhagen
FAHA, Department of Cardiovascular Medicine, Cardiovascular Imaging, The Cleveland Clinic Foundation, HB 6, 9500 Euclid Ave, Cleveland OH 44195, USA
Circulation 113:2826-34. 2006
..However, the remodeling response during plaque-stabilizing therapy and its relationship to markers of lipid metabolism and inflammation are incompletely understood...
- Relationship between cardiovascular risk factors and atherosclerotic disease burden measured by intravascular ultrasound
Stephen J Nicholls
Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
J Am Coll Cardiol 47:1967-75. 2006
..Many risk factors did not predict angiographic disease severity, suggesting different mechanisms drive stenosis development and atheroma accumulation...
- Rate of progression of coronary atherosclerotic plaque in women
Stephen J Nicholls
Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
J Am Coll Cardiol 49:1546-51. 2007
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- Coronary artery calcification and changes in atheroma burden in response to established medical therapies
Stephen J Nicholls
Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, Ohio 44195, USA
J Am Coll Cardiol 49:263-70. 2007
..This study sought to determine the relationship between coronary calcification and plaque progression in response to established medical therapies...
- Statins, high-density lipoprotein cholesterol, and regression of coronary atherosclerosis
Stephen J Nicholls
Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, Ohio 44195, USA
JAMA 297:499-508. 2007
..However, no data exist describing the relationship between statin-induced changes in high-density lipoprotein cholesterol (HDL-C) and disease progression...
- Beta-blockers and progression of coronary atherosclerosis: pooled analysis of 4 intravascular ultrasonography trials
Ilke Sipahi
Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
Ann Intern Med 147:10-8. 2007
..However, whether a direct influence of beta-blockers on coronary atherosclerosis contributes to reduced recurrent myocardial infarction and total mortality rates is not known...
- Low levels of low-density lipoprotein cholesterol and blood pressure and progression of coronary atherosclerosis
Adnan K Chhatriwalla
Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, Ohio 44195, USA
J Am Coll Cardiol 53:1110-5. 2009
..We investigated coronary atheroma progression in patients with low levels of low-density lipoprotein cholesterol (LDL-C) and systolic blood pressure (SBP)...
- Coronary atherosclerosis can regress with very intensive statin therapy
Ilke Sipahi
Department of Cardiovascular Medicine, Cleveland Clinic Foundation, OH 44195, USA
Cleve Clin J Med 73:937-44. 2006
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- Static and serial assessments of coronary arterial remodeling are discordant: an intravascular ultrasound analysis from the Reversal of Atherosclerosis with Aggressive Lipid Lowering (REVERSAL) trial
Ilke Sipahi
Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
Am Heart J 152:544-50. 2006
..This is due to concomitant remodeling of the reference sites used in the static assessment. Intravascular ultrasound performed at a single point in time does not reflect the dynamic remodeling response...
- Effects of normal, pre-hypertensive, and hypertensive blood pressure levels on progression of coronary atherosclerosis
Ilke Sipahi
Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
J Am Coll Cardiol 48:833-8. 2006
..e., systolic BP <120 mm Hg and diastolic BP <80 mm Hg). This study suggests that in patients with coronary artery disease, the optimal BP goal may be substantially lower than the <140/90 mm Hg level...
- Relationship between atheroma regression and change in lumen size after infusion of apolipoprotein A-I Milano
Stephen J Nicholls
Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
J Am Coll Cardiol 47:992-7. 2006
..After infusion of rHDL containing AIM, regression of coronary atherosclerosis is accompanied by reverse remodeling of the EEM, resulting in no change in luminal dimensions...
- Compensatory enlargement of human coronary arteries during progression of atherosclerosis is unrelated to atheroma burden: serial intravascular ultrasound observations from the REVERSAL trial
Ilke Sipahi
Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Desk F25, Cleveland, OH 44195, USA
Eur Heart J 27:1664-70. 2006
..Atheroma burden is not a determinant of arterial enlargement during the progression of atherosclerosis...
- Effect of ACAT inhibition on the progression of coronary atherosclerosis
Steven E Nissen
Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
N Engl J Med 354:1253-63. 2006
..The enzyme acyl-coenzyme A:cholesterol acyltransferase (ACAT) esterifies cholesterol in a variety of tissues. In some animal models, ACAT inhibitors have antiatherosclerotic effects...
- Effect of diabetes on progression of coronary atherosclerosis and arterial remodeling: a pooled analysis of 5 intravascular ultrasound trials
Stephen J Nicholls
Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, Ohio 44195, USA
J Am Coll Cardiol 52:255-62. 2008
..Our goal was to characterize coronary atherosclerosis progression and arterial remodeling in diabetic patients...
- Cardiac allograft vasculopathy: an update
Ilke Sipahi
Kaufman Center for Heart Failure, Cleveland, OH 44195, USA
Heart Fail Clin 3:87-95. 2007
..A better understanding of CAV is needed to develop targeted preventive therapies. Ongoing research in native atherosclerosis and vascular biology may provide answers within the next decade...
- Application of intravascular ultrasound in anti-atherosclerotic drug development
Stephen J Nicholls
Department of Cardiovascular Medicine, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA
Nat Rev Drug Discov 5:485-92. 2006
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- Intravascular ultrasound in cardiovascular medicine
Stephen J Nicholls
Department of Cardiovascular Medicine, Cleveland Clinic, Mail Code JJ65, 9500 Euclid Ave, Cleveland, Ohio 44195, USA
Circulation 114:e55-9. 2006
- Coronary angiography for follow-up of heart transplant recipients: insights from TIMI frame count and TIMI myocardial perfusion grade
Nezihi Baris
Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
J Heart Lung Transplant 26:593-7. 2007
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- Effect of very high-intensity statin therapy on regression of coronary atherosclerosis: the ASTEROID trial
Steven E Nissen
Department of Cardiovascular Medicine, Cleveland Clinic Lerner School of Medicine, Cleveland, Ohio 44195, USA
JAMA 295:1556-65. 2006
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- [Assessment of progression and regression of coronary atherosclerosis by intravascular ultrasound. A new paradigm shift?]
Stephen J Nicholls
Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, Cleveland, OH, USA
Rev Esp Cardiol 59:57-66. 2006
..This heralds a paradigm shift that emphasizes plaque regression as a potential target in the development of preventive strategies...
- Intravascular ultrasound in the current percutaneous coronary intervention era
Ilke Sipahi
Intravascular Ultrasound Core Laboratory, Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
Cardiol Clin 24:163-73, v. 2006
..It remains unknown whether the use of emerging IVUS-based technologies such as elastography or spectral analysis is feasible for identification of vulnerable plaques...
- Recent trends in coronary intravascular ultrasound: tracking atherosclerosis, pursuit of vulnerable plaques, and beyond
Ilke Sipahi
Intravascular Ultrasound Core Laboratory, Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
J Nucl Cardiol 13:91-6. 2006
..Whether radiofrequency signal analysis or elastography will become clinically useful tools for detecting vulnerable plaques remains an unanswered, burning question...
- Treatment of heart failure with preserved ejection fraction: have we been pursuing the wrong paradigm?
Gerard O Oghlakian
Division of Cardiovascular Medicine, University Hospitals of Cleveland, Case Medical Center, Cleveland, OH, USA
Mayo Clin Proc 86:531-9. 2011
..Perhaps heart failure as we traditionally think of it is the wrong paradigm to pursue as we try to understand this condition of volume overload known as HF-PEF...
- Successful combined use of Impella Recover 2.5 device and intra-aortic balloon pump support in cardiogenic shock from acute myocardial infarction
Dominik M Wiktor
Department of Internal Medicine, University Hospitals Case Medical Center, Cleveland, Ohio 44106 5011, USA
ASAIO J 56:519-21. 2010
..The Impella Recover 2.5 is a percutaneous VAD that provides temporary circulatory support. We report the case of a patient who required the combined support of both an IABP and the Impella device...
- Emerging role of intravascular ultrasound in the assessment of experimental anti-atherosclerotic therapies
Stephen J Nicholls
Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland OH 44195, USA
Curr Med Chem 13:1727-34. 2006
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- Effect of atorvastatin (80 mg/day) versus pravastatin (40 mg/day) on arterial remodeling at coronary branch points (from the REVERSAL study)
Stephen J Nicholls
Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, Cleveland, Ohio, USA
Am J Cardiol 96:1636-9. 2005
..These results suggest that intensive lipid lowering can have a dramatic effect on atheroma-prone regions and that remodeling in response to changes in plaque is a heterogenous process...
