Measles, mumps and rubella -- the urologist's perspectiveR Singh
North Hampshire NHS Trust, Urology, Hampshire, UK
Int J Clin Pract 60:335-9. 2006
..The article reviews the pathophysiology, clinical symptoms, diagnosis, and long-term sequelae of this increasingly prevalent condition and provides a reference for all practising urologists treating this disease...
- Detection of malondialdehyde DNA adducts in human colorectal mucosa: relationship with diet and the presence of adenomas
Chiara Leuratti
Medical Research Council Toxicology Unit, University of Leicester, Leicester LE1 9HN, United Kingdom
Cancer Epidemiol Biomarkers Prev 11:267-73. 2002
..061). When levels of adducts were compared in individuals with and without adenomas, there was a trend for higher levels in individuals presenting with adenomas especially in the highest category of M(1)-dG adducts (P < 0.005)...
- Recent experience with fungaemia: change in species distribution and azole resistance
Arunaloke Chakrabarti
Departments of Medical Microbiology, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India
Scand J Infect Dis 41:275-84. 2009
..In conclusion, the study highlighted the rise of non-albicans Candida species in our hospital with differential distribution in paediatric and adult wards and emergence of azole resistance...
- Comorbidity assessment in localized prostate cancer: a review of currently available techniques
Rajinder Singh
Department of Urology, Guy s Hospital, Guy s and St Thomas NHS Trust, St Thomas Street, London SE1 9RT, UK
Eur Urol 46:28-41; discussion 41. 2004
..This review describes the available methods for objectively assessing comorbid risk and assesses their potential utility to men with localized prostate cancer being considered for radical treatment...
- Detection of O6-carboxymethyl-2'-deoxyguanosine in DNA following reaction of nitric oxide with glycine and in human blood DNA using a quantitative immunoslot blot assay
Belinda C Cupid
MRC Toxicology Unit, Hodgkin Building, University of Leicester, P.O. Box 138, Lancaster Road, Leicester LE1 9HN, United Kingdom
Chem Res Toxicol 17:294-300. 2004
..These studies provide further evidence that nitrosated amino acids may be risk factors for gastrointestinal tract cancers...
- The relationship between biomarkers of oxidative DNA damage, polycyclic aromatic hydrocarbon DNA adducts, antioxidant status and genetic susceptibility following exposure to environmental air pollution in humans
Rajinder Singh
Cancer Biomarkers and Prevention Group, Biocentre, University of Leicester, University Road, Leicester, LE1 7RH UK
Mutat Res 620:83-92. 2007
..This effect was not observed for individuals carrying the null variant...
- Detection of phosphodiester adducts formed by the reaction of benzo[a]pyrene diol epoxide with 2'-deoxynucleotides using collision-induced dissociation electrospray ionization tandem mass spectrometry
Margaret Gaskell
Cancer Biomarkers and Prevention Group, Biocentre, University of Leicester, University Road, Leicester, LE1 7RH, UK
Nucleic Acids Res 35:5014-27. 2007
..In conclusion, this investigation provides the first direct evidence for the formation of phosphodiester adducts by B[a]PDE following reaction with 2'-deoxynucleotides...
- Mechanical bowel preparation in elective colo-rectal surgery: a practice to purge or promote?
G R Verma
Indian J Gastroenterol 26:142-3. 2007
- Evidence that oxidative stress is a risk factor for the development of squamous cell carcinoma in renal transplant patients
Marcus S Cooke
Radiation and Oxidative Stress Group, Department of Cancer Studies and Molecular Medicine, Leicester LE2 7LX, UK
Free Radic Biol Med 43:1328-34. 2007
..02). These results demonstrate, for the first time, that a subpopulation of renal transplant patients is under greater oxidative burden, and it is this population that is particularly predisposed to skin cancer...
- Androgen manipulation alters oxidative DNA adduct levels in androgen-sensitive prostate cancer cells grown in vitro and in vivo
Sanjeev Pathak
Cancer Biomarkers and Prevention Group, Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester LE2 7LX, UK
Cancer Lett 261:74-83. 2008
..001 by Mann-Whitney Test) in flutamide-treated animals compared to controls. The changes demonstrated suggest that oxidative DNA adducts may serve as biomarkers of the efficacy of androgen manipulation in chemoprevention trials...
- Use of DNA adducts to identify human health risk from exposure to hazardous environmental pollutants: the increasing role of mass spectrometry in assessing biologically effective doses of genotoxic carcinogens
Peter B Farmer
Cancer Biomarkers and Prevention Group, Biocentre, University of Leicester, Leicester LE1 7RH, United Kingdom
Mutat Res 659:68-76. 2008
..phosphotriester adducts that are not repaired efficiently) seems important areas for the future assessment of the effects of human exposure to environmental genotoxins, together with studies of dose-response relationships at low doses...
- Isolated roux loop pancreaticojejunostomy vs single loop pancreaticojejunostomy after pancreaticoduodenectomy
Lileswar Kaman
Department of General Surgery, Post Graduate Institute of Medical Education and Research, Chandigarh 160012, India
Int J Surg 6:306-10. 2008
..The aim of this study was to review the experience of single loop versus isolated Roux loop pancreaticojejunostomy in a series of patients undergoing pancreatic head resection...
- Effects of environmental air pollution on endogenous oxidative DNA damage in humans
Rajinder Singh
Cancer Biomarkers and Prevention Group, Biocentre, University of Leicester, University Road, Leicester LE1 7RH, UK
Mutat Res 620:71-82. 2007
....
- Effects of metabolic genotypes on intermediary biomarkers in subjects exposed to PAHS: results from the EXPAH study
Seymour Garte
University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA
Mutat Res 620:7-15. 2007
..that conferred significant resistance to the DNA damaging effects of benzo[a]pyrene, measured as the level of a benzo[a]pyrene-like adduct per unit of benzo[a]pyrene exposed...
- Effects of diet on biomarkers of exposure and effects, and on oxidative damage
Sara Raimondi
Fondazione Policlinico, Milano, Italy
Mutat Res 620:93-102. 2007
..The recent consumption of smoked or fried food was associated with an increase in total DNA adducts levels...
- An improved liquid chromatography/tandem mass spectrometry method for the determination of 8-oxo-7,8-dihydro-2'-deoxyguanosine in DNA samples using immunoaffinity column purification
Rajinder Singh
Cancer Biomarkers and Prevention Group, Biocentre, University of Leicester, University Road, UK
Rapid Commun Mass Spectrom 17:126-34. 2003
..8 +/- 1.2 8-oxodG per 10(6) unmodified nucleotides (n = 5) using 5 microg of digested DNA. The limit of detection of the microbore LC/MS/MS MRM for 8-oxodG was determined to be 25 fmol on-column with a signal-to-noise ratio of 3.5...
- Characterisation of Ercc1 deficiency in the liver and in conditional Ercc1-deficient primary hepatocytes in vitro
Kristina Kirschner
Sir Alastair Currie Cancer Research UK Laboratories, Molecular Medicine Centre, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, Scotland, UK
DNA Repair (Amst) 6:304-16. 2007
....
- Detection and quantitation of benzo[a]pyrene-derived DNA adducts in mouse liver by liquid chromatography-tandem mass spectrometry: comparison with 32P-postlabeling
Rajinder Singh
Cancer Biomarkers and Prevention Group, Biocenter, University of Leicester, UK
Chem Res Toxicol 19:868-78. 2006
..The LC-MS/MS method allowed the more precise quantitation of DNA adduct levels that were structurally characterized, in addition to a reduction in the time taken to perform the analysis when compared with the (32)P-postlabeling method...
- Pilot study of oral silibinin, a putative chemopreventive agent, in colorectal cancer patients: silibinin levels in plasma, colorectum, and liver and their pharmacodynamic consequences
Carmen Hoh
Cancer Biomarkers and Prevention Group, Department of Cancer Studies, University of Leicester, United Kingdom
Clin Cancer Res 12:2944-50. 2006
..The high silibinin levels achieved in the human colorectal mucosa after consumption of safe silibinin doses support its further exploration as a potential human colorectal cancer chemopreventive agent...
- Liquid chromatography-electrospray ionization-mass spectrometry: the future of DNA adduct detection
Rajinder Singh
Cancer Biomarkers and Prevention Group, Biocentre, University of Leicester, University Road, Leicester LE1 7RH, UK
Carcinogenesis 27:178-96. 2006
..In this review we will highlight the merits as well as discuss the progress made by liquid chromatography coupled to electrospray ionization mass spectrometry as a method for DNA adduct detection...
- Postoperative pulmonary function in laparoscopic versus open cholecystectomy: prospective, comparative study
S M Ravimohan
Department of Surgery, Post-Graduate Institute of Medical Education and Research, Chandigarh-160 012, India
Indian J Gastroenterol 24:6-8. 2005
..3%, 46.2% and 58.3%, respectively, after OC. Chest X-ray showed atelectasis in 15% of patients undergoing LC and 45% of those with OC. CONCLUSION: Impairment in pulmonary function after LC was less marked than after OC...
- Evaluation of enzyme-linked immunosorbent assay and liquid chromatography-tandem mass spectrometry methodology for the analysis of 8-oxo-7,8-dihydro-2'-deoxyguanosine in saliva and urine
Marcus S Cooke
Radiation and Oxidative Stress Group, Department of Cancer Studies and Molecular Medicine, Robert Kilpatrick Clinical Sciences Building, University of Leicester, Leicester, LE2 7LX, UK
Free Radic Biol Med 41:1829-36. 2006
..Ongoing investigation in our laboratories aims to identify the basis of the discrepancy between ELISA and LC-MS/MS...
