Research Topics
| M P HandeSummaryAffiliation: National University of Singapore Country: Singapore Publications
| Collaborators
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Detail Information
Publications
Telomere and telomerase modulation by the mammalian Rad9/Rad1/Hus1 DNA-damage-checkpoint complexSofia Francia
Italian Foundation for Cancer Research, Institute of Molecular Oncology Foundation, 20139 Milan, Italy
Curr Biol 16:1551-8. 2006..These findings identify an unanticipated function for the 911 checkpoint complex at telomeres in mammals and provide a mechanistic link between the activity of DNA-damage-checkpoint proteins and the telomere-maintenance machinery...- Anti-proliferative activity of silver nanoparticlesP V AshaRani
Department of Chemistry, Faculty of Science, 3 Science Drive 3, National University of Singapore, 117543 Singapore
BMC Cell Biol 10:65. 2009..No safety regulations are in practice for the use of these nanomaterials. The interactions of nanomaterials with cells, uptake mechanisms, distribution, excretion, toxicological endpoints and mechanism of action remain unanswered... - Hydrogen peroxide induced genomic instability in nucleotide excision repair-deficient lymphoblastoid cellsKalpana Gopalakrishnan
Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, 117597, Singapore
Genome Integr 1:16. 2010..abstract:.. - Inhibition of poly (ADP-Ribose) polymerase-1 in telomerase deficient mouse embryonic fibroblasts increases arsenite-induced genome instabilityResham L Gurung
Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597
Genome Integr 1:5. 2010..In this study, the effects of combined inhibition of PARP-1 and telomerase in mouse embryonic fibroblasts (MEFs) following sodium arsenite exposure (a carcinogen and potent DNA damaging agent), were evaluated... - DNA damage and p53-mediated growth arrest in human cells treated with platinum nanoparticlesP V AshaRani
Department of Chemistry, Faculty of Science, 3 Science Drive 3, National University of Singapore, Singapore
Nanomedicine (Lond) 5:51-64. 2010..This study investigates the uptake and bioactivity (e.g., cytotoxicity, genotoxicity and protein expression) of platinum nanoparticles (Pt-NPs, approximately 5-8 nm in size) in human cells... - A role for Brca1 in chromosome end maintenanceJ Peter McPherson
Advanced Medical Discovery Institute, Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada M5G 2C1
Hum Mol Genet 15:831-8. 2006..The telomere dysfunction phenotype in Brca1-deficient cells suggests that loss of telomere integrity might contribute to chromosome end dysfunction and permit the formation of potentially oncogenic translocations... - DNA repair factors and telomere-chromosome integrity in mammalian cellsM P Hande
Department of Physiology, Faculty of Medicine, National University of Singapore, and Oncology Research Institute, Singapore, Singapore
Cytogenet Genome Res 104:116-22. 2004..Because the maintenance of telomere function is crucial for genomic stability, our results will provide new insights into the mechanisms of chromosome instability and tumour formation... - The telomerase reverse transcriptase is limiting and necessary for telomerase function in vivoY Liu
Ontario Cancer Institute Amgen Institute, Department of Medical Biophysics, University of Toronto, 620 University Avenue, ON M5G 2C1, Toronto, Canada
Curr Biol 10:1459-62. 2000..ES cells heterozygous for the mTert disruption also showed telomere attrition, a phenotype that differs from heterozygous mTR cells [12]. Thus, telomere maintenance in mammals is carried out by a single, limiting TERT... - Telomerase-associated protein TEP1 is not essential for telomerase activity or telomere length maintenance in vivoY Liu
Ontario Cancer Institute Amgen Institute, Department of Medical Biophysics, University of Toronto, Toronto, Ontario M5G 2C1, Canada
Mol Cell Biol 20:8178-84. 2000..These results reveal that TEP1 is an RNA binding protein that is not restricted to the telomerase complex and that TEP1 plays a redundant role in the assembly or localization of the telomerase RNP in vivo... - Thymoquinone induces telomere shortening, DNA damage and apoptosis in human glioblastoma cellsResham Lal Gurung
Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
PLoS ONE 5:e12124. 2010..Much emphasis has been placed on discovering new compounds that target tumour cells more efficiently and selectively with minimal toxic effects on normal cells... - Isoform-specific activation of protein kinase c in irradiated human fibroblasts and their bystander cellsRajamanickam Baskar
Center for Radiological Research, Department of Radiation Oncology, College of Physicians and Surgeons, Columbia University, 630 W 168th Street, New York, NY 10032, USA
Int J Biochem Cell Biol 40:125-34. 2008.... - Functional interplay of p53 and Mus81 in DNA damage responses and cancerAshwin Pamidi
The Advanced Medical Discovery Institute, Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada
Cancer Res 67:8527-35. 2007..Furthermore, our data show that loss of Mus81, in addition to p53, is a key step in sarcoma development... - Oxidative damage induced genotoxic effects in human fibroblasts from Xeroderma Pigmentosum group A patientsGrace Kah Mun Low
Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, MD9, 2 Medical Drive, Singapore 117597, Singapore
Int J Biochem Cell Biol 40:2583-95. 2008..Lack of functional Xeroderma Pigmentosum A seems to increase the susceptibility of oxidative stress-induced genotoxicity while retaining cell viability posing as a potential cancer risk factor of Xeroderma Pigmentosum A patients... - Short dysfunctional telomeres impair the repair of arsenite-induced oxidative damage in mouse cellsJennifer P A Newman
Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
J Cell Physiol 214:796-809. 2008..Results from our studies imply that short dysfunctional telomeres impair the repair of oxidative damage caused by arsenite. The results will have implications in risk estimation as well as cancer chemotherapy... - Genomic imbalances in key ion channel genes and telomere shortening in sudden cardiac death victimsB Banerjee
Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
Cytogenet Genome Res 122:350-5. 2008..Identification of biomarkers of SCD is of great importance and thus the present study will facilitate the identification of some of the biomarkers... - Loss of Brca2 and p53 synergistically promotes genomic instability and deregulation of T-cell apoptosisAlison M Y Cheung
Ontario Cancer Institute and Department of Medical Biophysics, University of Toronto, Ontario, Canada M5G 2M9
Cancer Res 62:6194-204. 2002.... - Inhibition of telomerase activity and human telomerase reverse transcriptase gene expression by histone deacetylase inhibitor in human brain cancer cellsAik Kia Khaw
Genome Stability Laboratory, Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Republic of Singapore
Mutat Res 625:134-44. 2007..This study suggests that telomerase and hTERT might be the primary targets of TSA which may have the potential to be used as a telomerase inhibitor in cancer therapy... - Collaboration of Brca1 and Chk2 in tumorigenesisJohn Peter McPherson
Advanced Medical Discovery Institute, Ontario Cancer Institute, Toronto, Ontario M5G 2C1, Canada
Genes Dev 18:1144-53. 2004..Furthermore, inactivation of Chk2 and Brca1 was cooperative in breast cancer. Our findings identify a critical role for Chk2 as a component of the DNA damage-signaling pathway activated in response to Brca1 deficiency... - c-Jun N-terminal kinase mediates hydrogen peroxide-induced cell death via sustained poly(ADP-ribose) polymerase-1 activationS Zhang
Department of Community, Occupational and Family Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Republic of Singapore
Cell Death Differ 14:1001-10. 2007.... - Involvement of mammalian Mus81 in genome integrity and tumor suppressionJohn Peter McPherson
Ontario Cancer Institute, 620 University Avenue, Suite 706, Toronto, Ontario, Canada M5G 2C1
Science 304:1822-6. 2004..These studies demonstrate a critical role for the proper biallelic expression of the mammalian Mus81 in the maintenance of genomic integrity and tumor suppression... - Annexin-1 protects MCF7 breast cancer cells against heat-induced growth arrest and DNA damageSunitha Nair
Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, 28 Medical Drive, Singapore
Cancer Lett 294:111-7. 2010..This study demonstrates that ANXA1, which we recently reported as a possible tumor suppressor gene, can protect cells from heat-induced growth arrest and DNA damage... - Lack of poly(ADP-ribose) polymerase-1 gene product enhances cellular sensitivity to arseniteAnuradha Poonepalli
Genome Stability Laboratory, Department of Physiology, National University of Singapore
Cancer Res 65:10977-83. 2005..Our results suggest an important role for PARP-1 gene product in the maintenance of chromosome-genome stability in response to arsenite-induced DNA damage... - Progressive loss of epidermal growth factor receptor in a subpopulation of breast cancers: implications in target-directed therapeuticsLee Yee Choong
Oncology Research Institute, National University of Singapore, Singapore
Mol Cancer Ther 6:2828-42. 2007..Although no value of EGFR expression in prognosis was found, our findings are likely to have implications in the design of clinical trials targeting the EGFR family of proteins in breast cancer... - A role for Mus81 in the repair of chromium-induced DNA damageLaura Tamblyn
Department of Pharmacology, University of Toronto, Toronto, Ontario, Canada M5S 1A8
Mutat Res 660:57-65. 2009..Our findings support a role for Mus81 in the resolution of replication-associated DNA damage associated with this genotoxic agent, by converting Cr[VI]-DNA lesions into a form more amenable for homologous recombination... - Lats2/Kpm is required for embryonic development, proliferation control and genomic integrityJohn Peter McPherson
Division of Cellular and Molecular Biology, Department of Medical Biophysics, Ontario Cancer Institute, University of Toronto, Toronto, Ontario, Canada
EMBO J 23:3677-88. 2004..These findings indicate an essential role of Lats2 in the integrity of processes that govern centrosome duplication, maintenance of mitotic fidelity and genomic stability... - Eme1 is involved in DNA damage processing and maintenance of genomic stability in mammalian cellsJacinth Abraham
Advanced Medical Discovery Institute, Ontario Cancer Institute, 620 University Avenue, Suite 706, Toronto, Ontario M5G 2C1, Canada
EMBO J 22:6137-47. 2003..Most importantly, Eme1 deficiency led to spontaneous genomic instability. These results reveal that mammalian Eme1 plays a key role in DNA repair and the maintenance of genome integrity... - Telomere-mediated genomic instability and the clinico-pathological parameters in breast cancerAnuradha Poonepalli
Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
Genes Chromosomes Cancer 47:1098-109. 2008..The data support the notion that telomere dysfunction might be of value as a marker of aggressiveness of the tumors in breast cancer patients... - Deletion of mouse rad9 causes abnormal cellular responses to DNA damage, genomic instability, and embryonic lethalityKevin M Hopkins
Center for Radiological Research, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
Mol Cell Biol 24:7235-48. 2004..These investigations establish Mrad9 as a key mammalian genetic element of pathways that regulate the cellular response to DNA damage, maintenance of genomic integrity, and proper embryonic development... - Synergistic role of Ku80 and poly(ADP-ribose) polymerase in suppressing chromosomal aberrations and liver cancer formationWei Min Tong
International Agency for Research on Cancer IARC, 69008 Lyon, France
Cancer Res 62:6990-6. 2002.... - TAp73 is a downstream target of p53 in controlling the cellular defense against stressJianli Wang
Department of Radiation Oncology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
J Biol Chem 282:29152-62. 2007..Our data reveal a new pathway for cellular protection against oxidative damage and provide evidence that TAp73 is a stress-response gene and a downstream effector in the p53 pathway... - Yeast Nhp6A/B and mammalian Hmgb1 facilitate the maintenance of genome stabilitySabrina Giavara
The Wellcome Trust and Cancer Research UK Gurdon Institute and Department of Zoology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, United Kingdom
Curr Biol 15:68-72. 2005..Taken together, these data indicate that Nhp6A/B and Hmgb1 protect DNA from damaging agents and thus guard against the generation of genomic aberrations... - Past exposure to densely ionizing radiation leaves a unique permanent signature in the genomeM Prakash Hande
Center for Radiological Research, Columbia University, New York, NY 10032, USA
Am J Hum Genet 72:1162-70. 2003..Quantification of this large-scale chromosomal damage in human populations exposed many years earlier will lead to new insights into the mechanisms and risks of cytogenetic damage... - Ectopic mTERT expression in mouse embryonic stem cells does not affect differentiation but confers resistance to differentiation- and stress-induced p53-dependent apoptosisMing Kei Lee
National Cancer Centre, 11, Hospital Drive, Singapore 169610, Republic of Singapore
J Cell Sci 118:819-29. 2005.... - Human embryonic stem cells may display higher resistance to genotoxic stress as compared to primary explanted somatic cellsKumar Jayaseelan Vinoth
Stem Cell Program, Faculty of Dentistry, National University of Singapore, 119074 Singapore
Stem Cells Dev 17:599-607. 2008..These results highlight possible intrinsic differences in response to damaging agents between hES cells and normal somatic cells... - Complex chromosome aberrations persist in individuals many years after occupational exposure to densely ionizing radiation: an mFISH studyM Prakash Hande
Center for Radiological Research, Columbia University Medical Center, New York, USA
Genes Chromosomes Cancer 44:1-9. 2005..The results suggest that stable complex chromosomal translocations represent a long-lived, quantitative, low-background biomarker of densely ionizing radiation for human populations exposed many years ago... - The difference in LET and ion species dependence for induction of initially measured and non-rejoined chromatin breaks in normal human fibroblastsChizuru Tsuruoka
Heavy Ion Radiobiology Research Group, National Institute of Radiological Sciences, 4 9 1 Anagawa, Chiba, Japan
Radiat Res 170:163-71. 2008..This suggests that the LET-dependent structure in the biological effects is reflected in biological consequences of repair processes...