Research Topics
| M DowsettSummaryAffiliation: National University of Singapore Country: Singapore Publications
| Collaborators
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Detail Information
Publications
Biologic markers as predictors of clinical outcome from systemic therapy for primary operable breast cancerJ Chang
Departments of Medicine and Computing, The Royal Marsden Hospital, Sutton, Surrey, United Kingdom
J Clin Oncol 17:3058-63. 1999..To determine whether pretreatment clinical features and molecular markers, together with changes in these factors, can predict treatment response and survival in patients with primary operable breast cancer who receive neoadjuvant therapy...
Apoptosis and proliferation as predictors of chemotherapy response in patients with breast carcinomaJ Chang
Department of Biochemistry, Medicine and Computing, The Royal Marden Hospital, Sutton, Surrey, United Kingdom
Cancer 89:2145-52. 2000..The objective of this clinical study was to examine in vivo changes in apoptotic index (AI), Bcl-2 expression, proliferation (Ki-67 and S-phase fraction [SPF]), and ploidy as potential indicators of chemoresponsiveness...
Changes in hormone receptors and proliferation markers in tamoxifen treated breast cancer patients and the relationship with responseA Makris
Royal Marsden Hospital, Sutton, Surrey, UK
Breast Cancer Res Treat 48:11-20. 1998..To determine the effects of tamoxifen on the levels of hormone receptors and proliferation markers in the early phase of treatment and the relationship of the changes with tumor response in patients with primary breast cancer...
Studies of the potential utility of Ki67 as a predictive molecular marker of clinical response in primary breast cancerL Assersohn
Breast Unit, Royal Marsden Hospital, Sutton, Surrey, UK
Breast Cancer Res Treat 82:113-23. 2003..CONCLUSION: Ki67 is unlikely to be useful as a predictive marker in individual patients. Further molecular markers that predict lack of response continue to be required...
A pilot trial to evaluate the acute toxicity and feasibility of tamoxifen for prevention of breast cancerT J Powles
Royal Marsden Hospital, Sutton, Surrey, UK
Br J Cancer 60:126-31. 1989..At this stage no untoward long-term risks have been identified, and it is therefore proposed that a large multicentre trial should be started...
