Research Topics
| Wah Heng LeeSummaryCountry: Singapore Publications
| Collaborators
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Detail Information
Publications
Optimization and clinical validation of a pathogen detection microarrayChristopher W Wong
Genomic Technologies, Genome Institute of Singapore, Republic of Singapore
Genome Biol 8:R93. 2007..Our findings show that microarrays can be used for the robust and accurate diagnosis of pathogens, and further substantiate the use of microarray technology in clinical diagnostics...- Mutational dynamics of the SARS coronavirus in cell culture and human populations isolated in 2003Vinsensius B Vega
Genome Institute of Singapore, 60 Biopolis Street, Singapore 138672
BMC Infect Dis 4:32. 2004..The recent emergence of this new pathogen, the careful tracing of its transmission patterns, and the ability to propagate in culture allows the exploration of the mutational dynamics of the SARS-CoV in human populations... - LOMA: a fast method to generate efficient tagged-random primers despite amplification bias of random PCR on pathogensWah Heng Lee
Genome Institute of Singapore, Genome, Singapore
BMC Bioinformatics 9:368. 2008.... - RB-finder: an improved distance-based sliding window method to detect recombination breakpointsWah Heng Lee
Genome Institute of Singapore and School of Computing, National University of Singapore, Singapore, Singapore
J Comput Biol 15:881-98. 2008..We also show how our method has potential use in other related applications such as genotyping... - Heterogeneity detector: finding heterogeneous positions in Phred/Phrap assembliesW H Lee
Genome Institute of Singapore, Information and Mathematical Sciences, Singapore, 138672, Singapore
Bioinformatics 20:2863-4. 2004..AVAILABILITY: The package is made available at http://glscompute.gis.a-star.edu.sg/~charlie/DHetero.html.. - Fast and accurate probe selection algorithm for large genomesWing Kin Sung
Department of Computer Science, National University of Singapore, Singapore
Proc IEEE Comput Soc Bioinform Conf 2:65-74. 2003..Based on the new algorithm, optimal short (20 bases) or long (50 or 70 bases) probes can be computed efficiently for large genomes... - Comprehensive long-span paired-end-tag mapping reveals characteristic patterns of structural variations in epithelial cancer genomesAxel M Hillmer
Genome Technology and Biology, Genome Institute of Singapore, Singapore 138672, Singapore
Genome Res 21:665-75. 2011.... - DREAM2 challengeW H Lee
Department of Computer Science, National University of Singapore, Singapore
Ann N Y Acad Sci 1158:196-204. 2009..Using this approach, we are able to identify BCL6 targets with high accuracy, making us joint best performers of the challenge... - Human endogenous retrovirus HERV-W family: chromosomal localization, identification, and phylogenyH S Kim
Division of Biological Sciences, College of Natural Sciences, Pusan National University, Pusan 609 735, South Korea
AIDS Res Hum Retroviruses 17:643-8. 2001..In group IV, a clone (W-12-2) on chromosome 12 shared 100% sequence identity with a clone (W-17-5) on chromosome 17, suggesting either a retrotransposition or a chromosomal translocation in the last 2 to 5 million years... - Molecular models of the procoagulant factor VIIIa-factor IXa complexL Autin
INSERM U648, Paris 5 University, 4 Ave de l Observatoire, Paris, France
J Thromb Haemost 3:2044-56. 2005..The physiological relevance of the tenase complex is evident in hemophilia A or B patients who present with bleeding disorders... - Methods and evaluations of MRI content-adaptive finite element mesh generation for bioelectromagnetic problemsW H Lee
Department of Biomedical Engineering, Kyung Hee University, Korea
Phys Med Biol 51:6173-86. 2006..The results show that there is a significant gain in computation time with minor loss in numerical accuracy. We believe that cMeshes should be useful in the FEA of bioelectromagnetic problems... - Extraction and localization of alpha activity of the brain in EEG and fMRI using constrained ICAS H Ahn
Department of Biomedical Engineering, Kyung Hee University, Yongin, Gyeonggi, Republic of Korea
Conf Proc IEEE Eng Med Biol Soc 2007:5493-6. 2007..The use of cICA might provide a more effective means of extracting EEG alpha activity of the brain... - Color image detection by biomolecular photoreceptor using bacteriorhodopsin-based complex LB filmsH G Choi
Department of Chemical Engineering, Sogang University, CPO Box 1142, Seoul 100 611, Republic of Korea
Biosens Bioelectron 16:925-35. 2001..It is concluded that the proposed device has a capability of recognizing the color images and can be used as a model system to simulate the information processing function of the human visual system... - Cloning of cDNAs encoding C-type lectins from Elapidae snakes Bungarus fasciatus and Bungarus multicinctusH G Zha
Kunming Institute of Zoology, Chinese Academy of Sciences, 32 East JiaoChang Road, Kunming, Yunnan 650223, China
Toxicon 39:1887-92. 2001..To our knowledge, these are the first cDNA cloning of group VII C-type lectins (Drickamer K. 1993. Prog. Nucleic Acid Res. Mol. Biol. 45, 207-232) from Elapidae snake venom glands... - Association of human Pur alpha with the retinoblastoma protein, Rb, regulates binding to the single-stranded DNA Pur alpha recognition elementE M Johnson
Department of Pathology, Mount Sinai School of Medicine, New York, New York 10029, USA
J Biol Chem 270:24352-60. 1995..Binding of Pur alpha to p56RB, the COOH-terminal portion of Rb, is inhibited by a synthetic peptide containing the T-antigen Rb-binding motif... - Characterization of a novel 350-kilodalton nuclear phosphoprotein that is specifically involved in mitotic-phase progressionX Zhu
Center for Molecular Medicine, University of Texas Health Science Center at San Antonio 78245, USA
Mol Cell Biol 15:5017-29. 1995..Overexpression of N-terminally truncated mutants blocks cell cycle progression mainly at G2/M. These results suggest that mitosin may play an important role in mitotic-phase progression... - Identification of a human homologue of yeast nuc2 which interacts with the retinoblastoma protein in a specific mannerP L Chen
Center for Molecular Medicine Institute of Biotechnology, University of Texas Health Science Center at San Antonio 78245, USA
Cell Growth Differ 6:199-210. 1995..In contrast to wild-type H-NUC, the mutant was temperature sensitive in binding to Rb protein. These results, taken together, suggest that the interaction between H-NUC and Rb may be significant... - A new member of the hsp90 family of molecular chaperones interacts with the retinoblastoma protein during mitosis and after heat shockC F Chen
Center for Molecular Medicine, Institute of Biotechnology, University of Texas Health Science Center at San Antonio 78245, USA
Mol Cell Biol 16:4691-9. 1996..The discovery of a heat shock protein that chaperones Rb identifies a mechanism, in addition to phosphorylation, by which Rb is regulated in response to progression of the cell cycle and to external stimuli... - A thyroid hormone receptor coactivator negatively regulated by the retinoblastoma proteinK H Chang
Department of Molecular Medicine and Institute of Biotechnology, University of Texas Health Science Center at San Antonio, 15355 Lambda Drive, San Antonio, TX 78245, USA
Proc Natl Acad Sci U S A 94:9040-5. 1997..These results not only identify a coactivator molecule that modulates TR activity, but also uncover a role for Rb in a pathway that responds to thyroid hormone... - HEC, a novel nuclear protein rich in leucine heptad repeats specifically involved in mitosisY Chen
Department of Molecular Medicine, Institute of Biotechnology, University of Texas Health Science Center at San Antonio, 78245, USA
Mol Cell Biol 17:6049-56. 1997..These results suggest that the HEC protein may play an important role in chromosome segregation during M phase... - Identification of a novel cytoplasmic protein that specifically binds to nuclear localization signal motifsS Li
Department of Molecular Medicine and Institute of Biotechnology, The University of Texas Health Science Center, San Antonio, Texas 78245 3207, USA
J Biol Chem 273:6183-9. 1998..Similarly, the yeast homolog of BRAP2 also binds to these NLS motifs in vitro. These results imply that BRAP2 may function as a cytoplasmic retention protein and play a role in regulating transport of nuclear proteins... - Hec1p, an evolutionarily conserved coiled-coil protein, modulates chromosome segregation through interaction with SMC proteinsL Zheng
Department of Molecular Medicine, Institute of Biotechnology, University of Texas Health Science Center San Antonio, San Antonio, Texas 78245, USA
Mol Cell Biol 19:5417-28. 1999..These results suggest that Hec1 proteins play a critical role in modulating chromosomal segregation, in part, through their interactions with SMC proteins... - Sequence-specific transcriptional corepressor function for BRCA1 through a novel zinc finger protein, ZBRK1L Zheng
Department of Molecular Medicine, Institute of Biotechnology, University of Texas Health Science Center at San Antonio, 78245, USA
Mol Cell 6:757-68. 2000..These results thus reveal a novel corepressor function for BRCA1 and provide a mechanistic basis for the biological activity of BRCA1 through sequence-specific transcriptional regulation... - High prevalence of VanB2 vancomycin-resistant Enterococcus faecium in TaiwanJ J Lu
Division of Clinical Pathology and Experimental Pathology, Department of Pathology, Tri Service General Hospital and National Defense Medical Center, No 325, Section 2, ChengKung Rd, Taipei 114, Taiwan, Republic of China
J Clin Microbiol 39:2140-5. 2001..This result suggests that intra- and interhospital dissemination of this E. faecium strain has occurred in Taiwan... - Human esterase D gene: complete cDNA sequence, genomic structure, and application in the genetic diagnosis of human retinoblastomaL J Young
Department of Pathology, School of Medicine, University of California at San Diego, La Jolla 92093
Hum Genet 79:137-41. 1988..A polymorphic site for Apa I, located within an intron of the esterase D gene, can be used to identify chromosome 13 carrying defective RB alleles within retinoblastoma families...