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Genomes and Genes | Yoshiaki ItoSummaryCountry: Singapore Publications
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Publications
Runx transcription factors in neuronal developmentKen ichi Inoue
Department of Medical Biochemistry, Aarhus University, DK 8000C, Aarhus, Denmark
Neural Dev 3:20. 2008..As a consequence, Runx contributes to diverse aspects of the sensory system in higher vertebrates. In this review, we summarize recent progress in determining the role of Runx in neuronal development...- Integrative analysis of RUNX1 downstream pathways and target genesJoelle Michaud
Molecular Medicine Division, The Walter and Eliza Hall Institute of Medical Research, Parkville 3050, Victoria, Australia
BMC Genomics 9:363. 2008..We have used multiple microarray platforms and bioinformatic techniques to help identify these biological pathways to aid in the understanding of why RUNX1 mutations lead to leukemia... - Pim-1 kinase phosphorylates RUNX family transcription factors and enhances their activityTeija L T Aho
Turku Centre for Biotechnology, University of Turku, Tykistökatu 6 B, 20520 Turku, Finland
BMC Cell Biol 7:21. 2006..The Runx genes encode alpha-subunits of heterodimeric transcription factors which regulate cell proliferation and differentiation in various tissues during development and which can become leukemogenic upon aberrant expression... - Oncogenic potential of the RUNX gene family: 'overview'Yoshiaki Ito
Institute of Molecular and Cell Biology and Oncology Research Institute, National University of Singapore, 30 Medical Drive, Singapore 117609, Singapore
Oncogene 23:4198-208. 2004..In this Overview, I will summarize how this growing field has been formed and what are the challenging new frontiers for better understanding of the oncogenic potential of this gene family... - Claudin-1 has tumor suppressive activity and is a direct target of RUNX3 in gastric epithelial cellsTi Ling Chang
Cancer Science Institute of Singapore, National University of Singapore, Singapore
Gastroenterology 138:255-65.e1-3. 2010..We aimed to identify RUNX3 target genes that promote cell-cell contact to improve our understanding of RUNX3's role in suppressing gastric carcinogenesis... - Genetic factors associated with intestinal metaplasia in a high risk Singapore-Chinese population: a cohort studyFeng Zhu
Department of Medicine, National University of Singapore, Singapore, Singapore
BMC Gastroenterol 9:76. 2009..A total of 18 polymorphisms in 14 candidate genes were evaluated in a Singapore-Chinese population at high risk of developing GC... - Role of RUNX3 in bone morphogenetic protein signaling in colorectal cancerCecilia Wei Lin Lee
Cancer Science Institute of Singapore and NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, Singapore
Cancer Res 70:4243-52. 2010..Evidence is presented suggesting that RUNX3 downregulates c-Myc expression by two parallel pathways-directly at the transcriptional level and through attenuation of beta-catenin/TCFs, downstream of BMPs in colorectal cancer cells... - Role of TAp73alpha in induction of apoptosis by transforming growth factor-beta in gastric cancer cellsYasuko Yamamura
Oncology Research Institute, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
FEBS Lett 582:2663-7. 2008..Our findings reveal a novel role of TAp73alpha in the induction of apoptosis by TGF-beta in cancer cells... - MicroRNA-130b regulates the tumour suppressor RUNX3 in gastric cancerKin Wai Lai
Cancer Science Institute of Singapore, Centre for Life Sciences 02 15, 28 Medical Drive, National University of Singapore, Singapore 117456, Singapore
Eur J Cancer 46:1456-63. 2010..Accumulating evidence indicates that RUNX3 is an important tumour suppressor that is inactivated in many cancer types. This study aimed to assess the role of microRNA (miRNA) in the regulation of RUNX3... - RUNX3 inactivation by frequent promoter hypermethylation and protein mislocalization constitute an early event in breast cancer progressionManish Mani Subramaniam
Oncology Research Institute, National University of Singapore, Singapore, Republic of Singapore
Breast Cancer Res Treat 113:113-21. 2009..Here, we hypothesize that inactivation of RUNX3 occurring in ductal carcinoma in situ (DCIS) represent early event in breast carcinogenesis... - Nomenclature for Runt-related (RUNX) proteinsAndre J Van Wijnen
Molecular and Cell Biology and Oncology Research Institute, Institute of Molecular and Cell Biology, 30 Medical Drive, Singapore 117609, Singapore
Oncogene 23:4209-10. 2004 - RUNX3 functions as an oncogene in ovarian cancerCecilia Wei Lin Lee
Cancer Science Institute of Singapore, National University of Singapore, Singapore
Gynecol Oncol 122:410-7. 2011..Interestingly, an oncogenic role for RUNX3 has also been suggested in basal cell carcinoma and head and neck cancer. Here, we explore the role of RUNX3 in ovarian cancer... - Increased dosage of the RUNX1/AML1 gene: a third mode of RUNX leukemia?Motomi Osato
Institute of Molecular and Cell Biology, Oncology Research Institute, National University of Singapore
Crit Rev Eukaryot Gene Expr 15:217-28. 2005..The possibility that this mode might underlie Down syndrome-related leukemias caused by trisomy of chromosome 21 is discussed... - RUNX transcription factors as key targets of TGF-beta superfamily signalingYoshiaki Ito
Institute of Molecular and Cell Biology and Oncology Research Institute, National University of Singapore, Singapore
Curr Opin Genet Dev 13:43-7. 2003..A possible relationship between the TGF-beta-induced tumor-suppressor pathway and a postulated tumor suppressor gene on 1p36 must be examined... - Contribution of reactivated RUNX3 to inhibition of gastric cancer cell growth following suberoylanilide hydroxamic acid (vorinostat) treatmentCanhua Huang
Oncology Research Institute, National University of Singapore, Singapore
Biochem Pharmacol 73:990-1000. 2007.... - RUNX3 inactivation in colorectal polyps arising through different pathways of colonic carcinogenesisManish M Subramaniam
Faculty of Medicine, Oncology Research Institute, National University of Singapore, Singapore
Am J Gastroenterol 104:426-36. 2009..We hypothesized that RUNX3 inactivation by promoter hypermethylation in colorectal polyps is an early molecular event in colorectal carcinogenesis... - CDX2 expression is progressively decreased in human gastric intestinal metaplasia, dysplasia and cancerQiang Liu
Oncology Research Institute, Yong Loo Lin School of Medicine, National University of Singapore, 10 Medical Drive, Singapore
Mod Pathol 20:1286-97. 2007..Intestinal metaplasia or dysplasia with low expression of CDX2 may serve as predictive markers for gastric cancer... - RUNX3 cooperates with FoxO3a to induce apoptosis in gastric cancer cellsYasuko Yamamura
Oncology Research Institute, National University Medical Institutes, Institute of Molecular and Cell Biology, Graduate School for Integrative Sciences and Engineering, National University of Singapore, Singapore 117592, Singapore
J Biol Chem 281:5267-76. 2006..These findings show that RUNX3 cooperates with FoxO3a/FKHRL1 to participate in the induction of apoptosis by activating Bim and may play an important role in tumor suppression in gastric cancer... - Retroviral integration sites (RIS) mark cis-regulatory elementsCherry Ee Lin Ng
Institute of Molecular and Cell Biology, Singapore, Singapore
Crit Rev Oncol Hematol 71:1-11. 2009..In view of the abundance of electronically available RIS information, RIS mapping has an unrealized potential to aid in the discovery of novel cis-regulatory elements... - RUNX3 suppresses gastric epithelial cell growth by inducing p21(WAF1/Cip1) expression in cooperation with transforming growth factor {beta}-activated SMADXin Zi Chi
Department of Biochemistry, School of Medicine, and Institute for Tumor Research, Chungbuk National University, Cheongju 361 763, South Korea
Mol Cell Biol 25:8097-107. 2005..Our results suggest that at least part of the tumor suppressor activity of RUNX3 is associated with its ability to induce p21 expression... - Runx1 promotes angiogenesis by downregulation of insulin-like growth factor-binding protein-3Ken Iwatsuki
Department of Tumor Biochemistry, The Tokyo Metropolitan Institute of Medical Science, Tokyo Metropolitan Organization for Medical Research, 3 18 22 Honkomagome, Bunkyo ku, Tokyo 113 8613, Japan
Oncogene 24:1129-37. 2005..These results demonstrate that Runx1 is directly involved in angiogenesis by repression of IGFBP-3 mRNA expression... - Smad function and intranuclear targeting share a Runx2 motif required for osteogenic lineage induction and BMP2 responsive transcriptionFaiza Afzal
Department of Cell Biology and Cancer Center, University of Massachusetts Medical School, Worcester, Massachusetts, USA
J Cell Physiol 204:63-72. 2005..Our findings suggest that TGFbeta/ BMP2 signaling, MAPK dependent phosphorylation, and Runx2 subnuclear targeting converge to induce the osteogenic phenotype... - Frequent downregulation of the runt domain transcription factors RUNX1, RUNX3 and their cofactor CBFB in gastric cancerChouhei Sakakura
Graduate School of Medical Science, Surgery and Regenerative Medicine, Surgery and Physiology of Digestive System, Kyoto Prefectural University of Medicine, Kamigyo ku, Kawaramachi dori, Kyoto 602, Japan
Int J Cancer 113:221-8. 2005..These findings suggest that RUNX1 and CBFBeta in addition to RUNX3 play some roles in gastric cancers and that roles of RUNX gene family in gastric cancer are more widespread and complex than previously realized... - Runx2 and Runx3 are essential for chondrocyte maturation, and Runx2 regulates limb growth through induction of Indian hedgehogCarolina A Yoshida
Department of Molecular Medicine, Osaka University Graduate School of Medicine, Suita, Osaka 565 0871, Japan
Genes Dev 18:952-63. 2004..These findings demonstrate that Runx2 and Runx3 are essential for chondrocyte maturation and that Runx2 regulates limb growth by organizing chondrocyte maturation and proliferation through the induction of Ihh expression... - Increased dosage of Runx1/AML1 acts as a positive modulator of myeloid leukemogenesis in BXH2 miceMasatoshi Yanagida
Institute of Molecular and Cell Biology, Singapore
Oncogene 24:4477-85. 2005.... - Expression pattern, regulation, and biological role of runt domain transcription factor, run, in Caenorhabditis elegansSeunghee Nam
Department of Biology, Yonsei University, Seoul 120 749, South Korea
Mol Cell Biol 22:547-54. 2002..elegans. The highly conserved role of the Runt domain transcription factor in gut development during evolution from nematodes to mammals is discussed... - Heterozygous PU.1 mutations are associated with acute myeloid leukemiaBeatrice U Mueller
Blood 101:2074. 2003 - Serine phosphorylation of RUNX2 with novel potential functions as negative regulatory mechanismsHee Jun Wee
Department of Viral Oncology, Kyoto University, Japan
EMBO Rep 3:967-74. 2002..One CCD mutation, S104R of RUNX2, appears to mimic the phosphorylation-dependent inhibition of heterodimerization, thereby rendering RUNX2 metabolically unstable... - Comment on Levanon et al., "Runx3 knockouts and stomach cancer", in EMBO reports (June 2003)Suk Chul Bae
EMBO Rep 4:538-9. 2003 - Functional analysis of RUNX2 mutations in Japanese patients with cleidocranial dysplasia demonstrates novel genotype-phenotype correlationsTaketoshi Yoshida
Department of Pediatrics, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Japan
Am J Hum Genet 71:724-38. 2002..Overall, these results suggest that CCD could result from much smaller losses in the RUNX2 function than has been envisioned on the basis of the conventional haploinsufficiency model... - Causal relationship between the loss of RUNX3 expression and gastric cancerQing Lin Li
Department of Biochemistry, College of Medicine, Institute of Medical Research, Chungbuk National University, 361 763, Cheongju, South Korea
Cell 109:113-24. 2002.... - The corepressor mSin3A regulates phosphorylation-induced activation, intranuclear location, and stability of AML1Yoichi Imai
Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, Bunkyo ku, Tokyo 113 8655, Japan
Mol Cell Biol 24:1033-43. 2004..This study provides a novel regulatory mechanism for the function of transcription factors mediated by protein modification and interaction with cofactors... - Frequent loss of RUNX3 gene expression in human bile duct and pancreatic cancer cell linesManabu Wada
Department of Gastroenterology and Hepatology, Graduate School of Internal Medicine, Kyoto University, Kyoto 606-8507, Japan
Oncogene 23:2401-7. 2004..These data suggest that the inactivation of RUNX3 plays an important role in bile duct and pancreatic carcinogenesis, and that methylation is a common mechanism by which the gene is inactivated... - Molecular basis for a dominant inactivation of RUNX1/AML1 by the leukemogenic inversion 16 chimeraGang Huang
Institute for Virus Research, Kyoto University, Kyoto, Japan
Blood 103:3200-7. 2004.... - Putative intermediate precursor between hematogenic endothelial cells and blood cells in the developing embryoStuart T Fraser
Department of Molecular Genetics, Faculty of Medicine and Graduate School of Medicine, Kyoto University, Shogoin Kawaharacho 53, Sakyo ku, Japan
Dev Growth Differ 45:63-75. 2003..Collectively, these results introduce a novel VE-cadherin+ population within the developing embryo, which may represent an intermediate cell type in the transition of hemogenic endothelial cells into blood... - In vitro analyses of known and novel RUNX1/AML1 mutations in dominant familial platelet disorder with predisposition to acute myelogenous leukemia: implications for mechanisms of pathogenesisJoelle Michaud
Division of Medical Genetics, Geneva University Medical School, Switzerland
Blood 99:1364-72. 2002.... - Tyrosine phosphorylation controls Runx2-mediated subnuclear targeting of YAP to repress transcriptionSayyed K Zaidi
Department of Cell Biology and Cancer Center, University of Massachusetts Medical School, Worcester, MA 01655-0106, USA
EMBO J 23:790-9. 2004..Our results suggest that Src/Yes signals are integrated through organization of Runx2-YAP transcriptional complexes at subnuclear sites to attenuate skeletal gene expression... - K-Ras mediates cytokine-induced formation of E-cadherin-based adherens junctions during liver developmentTakaaki Matsui
Institute of Molecular and Cellular Biosciences, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
EMBO J 21:1021-30. 2002..These results indicate that K-Ras specifically mediates cytokine signaling for formation of AJs during liver development... - Runx3 controls the axonal projection of proprioceptive dorsal root ganglion neuronsKen ichi Inoue
Laboratory of Cell Regulation, Department of Viral Oncology, Institute for Virus Research, Kyoto University, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
Nat Neurosci 5:946-54. 2002..Our data demonstrate that Runx3 is critical in regulating the axonal projections of a specific subpopulation of DRG neurons... - Inhibition of growth of mouse gastric cancer cells by Runx3, a novel tumor suppressorWei hui Guo
Department of Viral Oncology, Institute for Virus Research, Kyoto University, Shogoin, Sakyo ku Kyoto 606 8507, Japan
Oncogene 21:8351-5. 2002..These observations suggest that the mouse system described here may be useful as a model for the study of human gastric carcinogenesis... - Differential requirements for Runx proteins in CD4 repression and epigenetic silencing during T lymphocyte developmentIchiro Taniuchi
Howard Hughes Medical Institute, Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
Cell 111:621-33. 2002..Runx3-deficient cytotoxic T cells, but not helper cells, have defective responses to antigen, suggesting that Runx proteins have critical functions in lineage specification and homeostasis of CD8-lineage T lymphocytes... - Enhancer of zeste homologue 2 (EZH2) down-regulates RUNX3 by increasing histone H3 methylationSatoshi Fujii
Pathology Division, Research Center for Innovative Oncology, National Cancer Center at Kashiwa, 6 5 1, Kashiwanoha, Kashiwa, Chiba 277 857 7 Japan
J Biol Chem 283:17324-32. 2008..The results showed that RUNX3 is a target for repression by EZH2 and indicated an underlying mechanism of the functional role of EZH2 overexpression on cancer cell proliferation... - Heterozygous PU.1 mutations are associated with acute myeloid leukemiaBeatrice U Mueller
Harvard Institutes of Medicine, Harvard Medical School, Boston, MA, USA
Blood 100:998-1007. 2002..1 target genes. This is the first report of mutations in the PU.1 gene in human neoplasia and suggests that disruption of PU.1 function contributes to the block in differentiation found in AML patients... - PEBP2-beta/CBF-beta-dependent phosphorylation of RUNX1 and p300 by HIPK2: implications for leukemogenesisHee Jun Wee
Genomics and Genetics Division, Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, Proteos, Singapore
Blood 112:3777-87. 2008..Therefore, phosphorylation of RUNX1 appears a critical step in its association with and phosphorylation of p300, and its disruption may be a common theme in RUNX1-associated leukemogenesis... - RUNX genes in development and cancer: regulation of viral gene expression and the discovery of RUNX family genesYoshiaki Ito
Institute of Molecular and Cell Biology, 61 Biopolis Drive, Proteos, Singapore 138673, Singapore
Adv Cancer Res 99:33-76. 2008..RUNX2 is essential for skeletal development and has an oncogenic potential. RUNX3 is expressed in wider ranges of tissues and has multiple roles. Among others, RUNX3 is a major tumor suppressor of gastric and many other solid tumors... - The myeloid features of BXH2 leukemias may result from the lack of one copy of the repetitive sequence in the long terminal repeat viral enhancerLiqun Huang
Int J Hematol 85:170-2. 2007 - Identification of cooperative genes for NUP98-HOXA9 in myeloid leukemogenesis using a mouse modelMasayuki Iwasaki
Department of Carcinogenesis, Japanese Foundation for Cancer Research, Tokyo, Japan
Blood 105:784-93. 2005..These genes cooperated with NUP98-HOXA9 in transforming NIH 3T3 cells. The system described here is a powerful tool to identify cooperative oncogenes and will assist in the clarification of the multistep process of carcinogenesis... - Frequent loss of RUNX3 expression by promoter hypermethylation in gastric carcinomaYasuhiro Oshimo
Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
Pathobiology 71:137-43. 2004..Our results overall suggest that transcriptional inactivation of RUNX3 by promoter hypermethylation may participate in the stomach carcinogenesis... - RUNX3, a novel tumor suppressor, is frequently inactivated in gastric cancer by protein mislocalizationKosei Ito
Institute of Molecular and Cell Biology, Proteos, Singapore
Cancer Res 65:7743-50. 2005..In addition to the deregulation of mechanisms controlling gene expression, there would also seem to be at least one other mechanism controlling nuclear translocation of RUNX3 that is impaired frequently in gastric cancer... - Haploinsufficiency of Runx1/AML1 promotes myeloid features and leukaemogenesis in BXH2 miceNamiko Yamashita
Institute of Molecular and Cell Biology, Singapore
Br J Haematol 131:495-507. 2005..In conclusion, the BXH2-Runx1+/- system is a promising mouse model to investigate the mechanism of leukaemogenesis in FPD/AML... - Transcriptional silencing of the RUNX3 gene by CpG hypermethylation is associated with lung cancerQing Lin Li
Department of Biochemistry, School of Medicine and Institute for Tumor Research, Chungbuk National University, Cheongju, Republic of Korea
Biochem Biophys Res Commun 314:223-8. 2004..RUNX3 methylation is tumor-specific, since it is not observed in surrounding normal lung tissues. Our results suggest that loss of RUNX3 expression by DNA hypermethylation is frequently associated with the evolution of lung cancer... - Functional analysis of RUNX2 mutations in cleidocranial dysplasia: novel insights into genotype-phenotype correlationsTaketoshi Yoshida
Department of Pediatrics, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Toyama 930 0194, Japan
Blood Cells Mol Dis 30:184-93. 2003..This makes an interesting contrast to the case of familial and sporadic leukemias mediated by RUNX1 mutations, in which mutants acting in a dominant negative manner have been suggested to confer a higher propensity to develop leukemia... - The RUNX3 tumor suppressor upregulates Bim in gastric epithelial cells undergoing transforming growth factor beta-induced apoptosisTakashi Yano
Institute of Molecular and Cell Biology, Proteos, 61 Biopolis Drive, Singapore 138673, Singapore
Mol Cell Biol 26:4474-88. 2006..These results demonstrate that RUNX3 is responsible for transcriptional up-regulation of Bim in TGF-beta-induced apoptosis... - Transcription factor Runx1 recruits the polyomavirus replication origin to replication factoriesYota Murakami
Department of Viral Oncology, Institute for Virus Research, Kyoto University, Sakyo ku, Kyoto 606 8507, Japan
J Cell Biochem 100:1313-23. 2007..These observations together suggest that Runx1 recruits the polyomavirus replication origin to the replication factory on the nuclear matrix, and that this requires the nuclear matrix-binding activity of Runx1... - Targets of genome copy number reduction in primary breast cancers identified by integrative genomicsWei Chen
Agenica Research, Singapore 169610, Republic of Singapore
Genes Chromosomes Cancer 46:288-301. 2007..This article contains Supplementary Material available at http://www.interscience.wiley.com/jpages/1045-2257/suppmat... - Concurrent transcriptional deregulation of AML1/RUNX1 and GATA factors by the AML1-TRPS1 chimeric gene in t(8;21)(q24;q22) acute myeloid leukemiaNorio Asou
Department of Hematology, Kumamoto University School of Medicine, 1 1 1 Honjo, Kumamoto 860 8556, Japan
Blood 109:4023-7. 2007.... - Runx3 is essential for the target-specific axon pathfinding of trkc-expressing dorsal root ganglion neuronsKen ichi Inoue
Laboratory of Cell Regulation, Department of Viral Oncology, Institute for Virus Research, Kyoto University, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
Blood Cells Mol Dis 30:157-60. 2003..Our results suggest that Runx3 controls the target-specific axon pathfinding of trkC-expressing DRG neurons in the spinal cord... - Runx3-/- gastric epithelial cells differentiate into intestinal type cellsHiroshi Fukamachi
Department of Biological Sciences, Graduate School of Science, University of Tokyo, Tokyo 113 0033, Japan
Biochem Biophys Res Commun 321:58-64. 2004..The relationship between loss of function of Runx3, formation of intestinal metaplasia, and gastric cancer was discussed...