Pretreatment with atorvastatin attenuates lung injury caused by high-stretch mechanical ventilation in an isolated rabbit lung modelIlias I Siempos
G P Livanos and M Simou Laboratories, Evangelismos Hospital, University of Athens Medical School, Athens, Greece
Crit Care Med 38:1321-8. 2010
..We hypothesized that pretreatment with atorvastatin improves alveolar capillary permeability and hemodynamics and, thus, confers protection against lung injury caused by high-stretch mechanical ventilation...
- Impact of catheter-related bloodstream infections on the mortality of critically ill patients: a meta-analysis
Ilias I Siempos
Critical Care Department, Attikon University Hospital, Athens, Greece
Crit Care Med 37:2283-9. 2009
..There is controversy on whether catheter-related bloodstream infections (CR-BSI) affect the mortality of critically ill patients...
- Impact of the administration of probiotics on the incidence of ventilator-associated pneumonia: a meta-analysis of randomized controlled trials
Ilias I Siempos
Alfa Institute of Biomedical Sciences, Athens, Greece
Crit Care Med 38:954-62. 2010
..Previous reviews showed no benefit for the administration of probiotics in critically ill patients, but they did not focus on ventilator-associated pneumonia...
- Inhaled colistin as monotherapy for multidrug-resistant gram (-) nosocomial pneumonia: a case series
Matthew E Falagas
Alfa Institute of Biomedical Sciences AIBS, Athens, Greece
Respir Med 103:707-13. 2009
..Reports of patients with polymyxin-only susceptible gram-negative nosocomial pneumonia treated with inhaled, but without concurrent intravenous, colistin are rare...
- Short-term administration of a high oxygen concentration is not injurious in an ex-vivo rabbit model of ventilator-induced lung injury
Petros Kopterides
Second Critical Care Department, Attiko University Hospital, University of Athens Medical School, Athens, Greece
Anesth Analg 108:556-64. 2009
..We conducted this study to evaluate the effect of a high inspired oxygen concentration on ventilator-induced lung injury...
- Respiratory fluoroquinolones for the treatment of community-acquired pneumonia: a meta-analysis of randomized controlled trials
Konstantinos Z Vardakas
Alfa Institute of Biomedical Sciences, Athens, Greece
CMAJ 179:1269-77. 2008
..We investigated whether the use of respiratory fluoroquinolones was associated with better clinical outcomes compared with the use of macrolides and beta- lactams among adults with pneumonia...
- Predictors of mortality in adult patients with ventilator-associated pneumonia: a meta-analysis
Ilias I Siempos
Alfa Institute of Biomedical Sciences, Henry Dunant Hospital, Athens, Greece
Shock 33:590-601. 2010
....
- Frequency, prevention, outcome and treatment of ventilator-associated tracheobronchitis: systematic review and meta-analysis
Michalis Agrafiotis
Alfa Institute of Biomedical Sciences AIBS, 151 23 Marousi, Athens, Greece
Respir Med 104:325-36. 2010
....
- Procalcitonin-guided algorithms of antibiotic therapy in the intensive care unit: a systematic review and meta-analysis of randomized controlled trials
Petros Kopterides
Second Critical Care Department, Attiko University Hospital, University of Athens Medical School, Athens, Greece
Crit Care Med 38:2229-41. 2010
..We sought to determine the effectiveness and safety of procalcitonin-guided algorithms in the management of septic patients in the intensive care unit...
- Prone positioning in hypoxemic respiratory failure: meta-analysis of randomized controlled trials
Petros Kopterides
2nd Critical Care Department, University of Athens Medical School, Attiko University Hospital, Athens 12462, Greece
J Crit Care 24:89-100. 2009
....
- Metabolic acidosis may be as protective as hypercapnic acidosis in an ex-vivo model of severe ventilator-induced lung injury: a pilot study
Theodoros Kapetanakis
G, P, Livanos and M, Simou Laboratories, Evangelismos General Hospital, University of Athens Medical School, Athens, Greece
BMC Anesthesiol 11:8. 2011
..abstract:..
- Adjunctive therapies for community-acquired pneumonia: a systematic review
Ilias I Siempos
Alfa Institute of Biomedical Sciences AIBS, Athens, Greece
J Antimicrob Chemother 62:661-8. 2008
....
- Meta-analyses on the prevention and treatment of respiratory tract infections
Ilias I Siempos
Alfa Institute of Biomedical Sciences, Marousi, Athens, Greece
Infect Dis Clin North Am 23:331-53. 2009
..Meta-analyses are useful tools to address clinically relevant questions; however, their inherent limitations should be taken into consideration when interpreting their findings...
- Patients included in randomised controlled trials do not represent those seen in clinical practice: focus on antimicrobial agents
Matthew E Falagas
Alfa Institute of Biomedical Sciences AIBS, 9 Neapoleos Street, 151 23 Marousi, Athens, Greece
Int J Antimicrob Agents 36:1-13. 2010
..The application of the findings of RCTs to the care of individual patients should be performed cautiously...
- Optimal duration of the antimicrobial treatment of ventilator-acquired pneumonia
Alexandros P Grammatikos
Alfa Institute of Biomedical Sciences, Athens, Greece
Expert Rev Anti Infect Ther 6:861-6. 2008
..In conclusion, the available evidence seems to support the use of short-course antimicrobial treatments (< or =10 days) for patients with ventilator-acquired pneumonia not caused by nonfermenting Gram-negative bacilli...
- Administration of antibiotics via the respiratory tract as monotherapy for pneumonia
Matthew E Falagas
Alfa Institute of Biomedical Sciences AIBS, 9 Neapoleos Street, 151 23 Marousi, Athens, Greece
Expert Rev Anti Infect Ther 6:447-52. 2008
..Clinicians are encouraged to publish any relevant experience in order for a considerable body of literature to be accumulated...
- Linezolid versus glycopeptide or beta-lactam for treatment of Gram-positive bacterial infections: meta-analysis of randomised controlled trials
Matthew E Falagas
Alfa Institute of Biomedical Sciences, Athens, Greece
Lancet Infect Dis 8:53-66. 2008
....
- Frequency and predictors of ventilator-associated pneumonia recurrence: a meta-analysis
Ilias I Siempos
Alfa Institute of Biomedical Sciences, Athens, Greece
Shock 30:487-95. 2008
..Recognition of these predictors may permit the timely implementation of measures to prevent recurrence of VAP...
- Non-physicians may reach correct diagnoses by using Google: a pilot study
Ilias I Siempos
Alfa Institute of Biomedical AIBS, Athens, Greece
Swiss Med Wkly 138:741-5. 2008
..We endeavoured to determine whether individuals who are not physicians are likely to arrive at correct diagnoses by using Internet resources...
- Treatment of acute bacterial exacerbations of chronic bronchitis
Ilias I Siempos
Alfa Institute of Biomedical Sciences, 9 Neapoleos Street, 151 23 Marousi, Greece
Expert Opin Pharmacother 10:1173-82. 2009
..Controversies persist regarding the optimal management of patients with acute exacerbations of chronic bronchitis (AECB)...
- Infections related to airway stenting: a systematic review
Michalis Agrafiotis
Alfa Institute of Biomedical Sciences, Athens, Greece
Respiration 78:69-74. 2009
..Airway stenting is nowadays an established method for the palliative and/or curative treatment of central airways obstruction. However, complications related to the use of airway stents have been reported...
- Impact of passive humidification on clinical outcomes of mechanically ventilated patients: a meta-analysis of randomized controlled trials
Ilias I Siempos
Alfa Institute of Biomedical Sciences, Athens, Greece
Crit Care Med 35:2843-51. 2007
..In addition, relevant data were recently published...
- Short- versus long-duration antimicrobial treatment for exacerbations of chronic bronchitis: a meta-analysis
Matthew E Falagas
Alfa Institute of Biomedical Sciences AIBS, Athens, Greece
J Antimicrob Chemother 62:442-50. 2008
..The aim of this study was to evaluate the comparative effectiveness and safety of short (5 days) and long (7 or 10 days) duration antimicrobial treatment of patients with acute exacerbations of chronic bronchitis (AECB)...
