Pregnane glycosides from Hoodia gordoniiYatin J Shukla
Department of Pharmacognosy, School of Pharmacy, University of Mississippi, MS 38677, USA
Phytochemistry 70:675-83. 2009
..Their structures were elucidated by chemical degradation studies and spectroscopic methods, including 1D and 2D NMR and CD spectroscopic methods...
- A rapid method for chemical fingerprint analysis of Hoodia species, related genera, and dietary supplements using UPLC-UV-MS
Bharathi Avula
National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, The University of Mississippi, University, MS 38677, USA
J Pharm Biomed Anal 48:722-31. 2008
..Different sample matrices were successfully analyzed, providing the wide range of applicability of this method, including gels, capsules, tablets, sprays, tea bags, snack bars, powders and juices...
- Chemical fingerprint of Hoodia species, dietary supplements, and related genera by using HPTLC
Chidananda Swamy Rumalla
National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, The University of Mississippi, University, MS 38677, USA
J Sep Sci 31:3959-64. 2008
..The developed method was validated for specificity, stability, repeatability, and robustness. The results of HPTLC method were verified by LC-UV-MS method...
- Characterization of in vitro pharmacokinetic properties of hoodigogenin A from Hoodia gordonii
Vamsi Lakshmi Madgula
National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, University, MS 38677, USA
Planta Med 76:62-9. 2010
..The compound strongly inhibited CYP3A4 activity (IC(50) 3 microM), indicating a possibility of drug-herb/botanical interactions when products containing H. gordonii are used simultaneously with other botanicals/herbs/drugs...
- Quantitative determination of pregnanes from aerial parts of Caralluma species using HPLC-UV and identification by LC-ESI-TOF
Bharathi Avula
The University of Mississippi, School of Pharmacy, National Center for Natural Products Research, University, MS 38677, USA
J AOAC Int 94:1383-90. 2011
..fimbriata. An LCIMS coupled with electrospray ionization interface method was used for the identification of compounds and involved the use of [M+Na]+ ions in the positive ion mode with extracted ion chromatogram...
- New oxypregnane glycosides from appetite suppressant herbal supplement Hoodia gordonii
Rahul S Pawar
National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, University of Mississippi, University, MS 38677, USA
Steroids 72:524-34. 2007
..Cytotoxicity and antioxidant activities of these compounds were tested in cell based assays where they were found to be inactive...
- Chemical fingerprinting of Hoodia species and related genera: chemical analysis of oxypregnane glycosides using high-performance liquid chromatography with UV detection in Hoodia gordonii
Bharathi Avula
National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, The University of Mississippi, University, MS 38677, USA
J AOAC Int 90:1526-31. 2007
..The developed method was applied to the identification of oxypregnane glycosides in 3 different species of Hoodia and 23 related genera. The HPLC profiles of various plant samples were compared for the presence of oxypregnane glycosides...
- In vitro metabolic stability and intestinal transport of P57AS3 (P57) from Hoodia gordonii and its interaction with drug metabolizing enzymes
Vamsi L M Madgula
National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, University, MS, USA
Planta Med 74:1269-75. 2008
..In conclusion, intestinal transport of P57 was mediated by P-gp and MRP transporters. The compound was metabolically stable and showed weak inhibition of CYP 3A4...
- New calogenin glycosides from Hoodia gordonii
Rahul S Pawar
National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, University of Mississippi, University, MS 38677, USA
Steroids 72:881-91. 2007
..The structures of the glycosides were established by chemical degradation studies and extensive spectroscopic techniques that included one-dimensional and two-dimensional NMR...
- Determination of the appetite suppressant P57 in Hoodia gordonii plant extracts and dietary supplements by liquid chromatography/electrospray ionization mass spectrometry (LC-MSD-TOF) and LC-UV methods
Bharathi Avula
National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, The University of Mississippi, MS 38677, USA
J AOAC Int 89:606-11. 2006
..0%) and recovery (98.5-103.5%). The developed methods were applied to the determination of P57 for H. gordonii plant samples, one related genus (Opuntia ficus-indica), and dietary supplements that claim to contain H. gordonii...
