Costs and consequences of cytomegalovirus diseaseMark A Schnitzler
Washington University, 4547 Clayton Avenue, Box 8084, St Louis, MO 63110, USA
Am J Health Syst Pharm 60:S5-8. 2003
..The use of oral ganciclovir for CMV prophylaxis has reduced the incidence of CMV disease in kidney and liver transplant recipients...
- Racial variation in medical outcomes among living kidney donors
Krista L Lentine
Center for Outcomes Research and the Division of Nephrology, Saint Louis University School of Medicine, St Louis, MO 63104, USA
N Engl J Med 363:724-32. 2010
..Data regarding health outcomes among living kidney donors are lacking, especially among nonwhite persons...
- Increasing incidence of new-onset diabetes after transplant among pediatric renal transplant patients
Thomas E Burroughs
Department of Internal Medicine, Center for Outcomes Research, Saint Louis University, 3545 Lafayette Avenue, St Louis, MO 63104, USA
Transplantation 88:367-73. 2009
..Risk of new-onset diabetes after transplant (NODAT) is well characterized for adults but much less understood in pediatric transplant. This study examines the incidence and risk factors of NODAT in pediatric renal transplant patients...
- Early outcomes of thymoglobulin and basiliximab induction in kidney transplantation: application of statistical approaches to reduce bias in observational comparisons
Lisa M Willoughby
Department of Research Methodology, Saint Louis University, St Louis, MO 63130, USA
Transplantation 87:1520-9. 2009
..Retrospective comparison of treatment-related kidney transplant outcomes may be facilitated by multivariable statistical adjustments and case-matching...
- Associations of recipient illness history with hypertension and diabetes after living kidney donation
Krista L Lentine
Center for Outcomes Research, Saint Louis University School of Medicine, St Louis, MO, USA
Transplantation 91:1227-32. 2011
..Little is known about associations of family health history with outcomes after kidney donation...
- Cardioprotective medication use after acute myocardial infarction in kidney transplant recipients
Krista L Lentine
Center for Outcomes Research, Saint Louis University School of Medicine, St Louis, MO 63104, USA
Transplantation 91:1120-6. 2011
..Limited data are available on the use of potentially cardioprotective medications among U.S. kidney transplant recipients...
- Novel methods for tracking long-term maintenance immunosuppression regimens
Paula M Buchanan
Center for Outcomes Research, St Louis University School of Medicine, St Louis, Missouri, USA
Clin J Am Soc Nephrol 3:117-24. 2008
..This study assessed the accuracy of three potential sources of maintenance immunosuppression data...
- Joint association of hyperuricemia and reduced GFR on cardiovascular morbidity: a historical cohort study based on laboratory and claims data from a national insurance provider
Luca Neri
Center for Outcomes Research, Saint Louis University School of Medicine, St Louis, MO, USA
Am J Kidney Dis 58:398-408. 2011
..Hyperuricemia is common in patients with chronic kidney disease (CKD). We assessed the relationship of increased serum uric acid levels with cardiovascular risk across levels of kidney function...
- Variations in the risk for cerebrovascular events after kidney transplant compared with experience on the waiting list and after graft failure
Krista L Lentine
St Louis University Center for Outcomes Research, Salus Center 2nd Floor, 3545 Lafayette Avenue, St Louis, MO 63104, USA
Clin J Am Soc Nephrol 3:1090-101. 2008
..This study examined the risks, predictors, and mortality implications of cerebrovascular disease events after kidney transplantation in a national cohort...
- The life-years saved by a deceased organ donor
Mark A Schnitzler
Center for Outcomes Research, Department of Medicine, Saint Louis University School of Medicine, St Louis, Missouri, USA
Am J Transplant 5:2289-96. 2005
..Therefore, increasing organ donation should be considered among our most important public health concerns...
- Incremental value of the pancreas allograft to the survival of simultaneous pancreas-kidney transplant recipients
Paolo R Salvalaggio
Center for Outcomes Research, Saint Louis University School of Medicine, St Louis, Missouri, USA
Diabetes Care 32:600-2. 2009
..To quantify the incremental survival benefit of the pancreas allograft in simultaneous pancreas-kidney (SPK) transplant recipients...
- Thymoglobulin induction is safe and effective in live-donor renal transplantation: a single center experience
Karen L Hardinger
Department of Pharmacy Practice, University of Missouri Kansas City, Kansas City, MO 64108 2792, and Department of Medicine, Barnes Jewish Hospital at Washington University School of Medicine, St Louis, MO, USA
Transplantation 81:1285-9. 2006
..This paper presents observational data of live-donor recipients who received Thymoglobulin induction and standard maintenance immunosuppressive therapy...
- Cardiac evaluation before kidney transplantation: a practice patterns analysis in Medicare-insured dialysis patients
Krista L Lentine
St Louis University Center for Outcomes Research, Salus Center, 2nd Floor, 3545 Lafayette Avenue, St Louis, MO 63104, USA
Clin J Am Soc Nephrol 3:1115-24. 2008
..Evaluation for ischemic heart disease (IHD) is a nonstandardized practice before kidney transplantation. We retrospectively studied pretransplant cardiac evaluation (CE) practices in a national sample of renal allograft recipients...
- Obesity and cardiac risk after kidney transplantation: experience at one center and comprehensive literature review
Krista L Lentine
Center for Outcomes Research, Saint Louis University School of Medicine, St Louis, MO 63104, USA
Transplantation 86:303-12. 2008
..The cardiac implications of obesity in kidney transplant recipients are not well-described...
- Influence of early posttransplantation prednisone and calcineurin inhibitor dosages on the incidence of new-onset diabetes
Thomas E Burroughs
Center for Outcomes Research, Department of Internal Medicine, Saint Louis University School of Medicine, St Louis, MO 63104, USA
Clin J Am Soc Nephrol 2:517-23. 2007
..48; P = 0.0012). Whereas the incidence of NOD is greatest with high Tac dosages, the increased risk versus CsA is sustained with lower Tac dosages. Higher steroid dosages increase the early diabetogenic effect of Tac but not of CsA...
- The impact of kidney transplantation on heart failure risk varies with candidate body mass index
Krista L Lentine
Center for Outcomes Research, Saint Louis University School of Medicine, St Louis, MO 63104, USA
Am Heart J 158:972-82. 2009
..The relationship of body mass index (BMI) with heart failure (HF) risk before and after kidney transplant is not well described...
- Bariatric surgery among kidney transplant candidates and recipients: analysis of the United States renal data system and literature review
Kian A Modanlou
Division of Abdominal Organ Transplantation, Department of Surgery, Saint Louis University Medical Center, St Louis, MO 63130, USA
Transplantation 87:1167-73. 2009
..Limited data exist on the safety and efficacy of bariatric surgery (BS) in patients with kidney failure...
- Associations of renal function at 1-year after kidney transplantation with subsequent return to dialysis, mortality, and healthcare costs
Mark A Schnitzler
Center for Outcomes Research, Saint Louis University, St Louis, MO 63104, USA
Transplantation 91:1347-56. 2011
..Quantifying the relationship of renal function at 1 year after transplant with subsequent clinical outcomes and healthcare costs may facilitate cost-benefit evaluations among transplant recipients...
- Delivery patterns of recommended chronic kidney disease care in clinical practice: administrative claims-based analysis and systematic literature review
Marie D Philipneri
Division of Nephrology, Saint Louis University School of Medicine, St Louis, MO 63104, USA
Clin Exp Nephrol 12:41-52. 2008
..Clinical practice guidelines for management of chronic kidney disease (CKD) have been developed within the Kidney Disease Outcomes Quality Initiative (K/DOQI). Adherence patterns may identify focus areas for quality improvement...
- The role of positive flow cytometry crossmatch in late renal allograft loss
Ralph J Graff
HLA Laboratory, Division of Abdominal Organ Transplantation, Department of Surgery, Saint Louis University Medical Center, St Louis, MO, USA
Hum Immunol 70:502-5. 2009
..The risks of positive FCXM persist beyond the peritransplant period for years after transplant. Damage by memory effector cells may explain the long-term risks associated with positive FCXM...
- Incidence, predictors, and associated outcomes of atrial fibrillation after kidney transplantation
Krista L Lentine
St Louis University Center for Outcomes Research, Salus Center 2nd Floor, 3545 Lafayette Avenue, St Louis, MO 63104, USA
Clin J Am Soc Nephrol 1:288-96. 2006
..Appropriate risk stratification may identify transplant recipients who are in need of close monitoring for and management of this adverse cardiovascular event...
- Liver transplantation cost in the model for end-stage liver disease era: looking beyond the transplant admission
Paula Buchanan
Center for Outcomes Research, Saint Louis University School of Medicine, St Louis, MO, USA
Liver Transpl 15:1270-7. 2009
..In conclusion, high-MELD patients incur significantly higher costs prior to and at the time of LT. Following LT, the MELD score is not a significant predictor of cost or re-admission...
- The association of cytomegalovirus sero-pairing with outcomes and costs following cadaveric renal transplantation prior to the introduction of oral ganciclovir CMV prophylaxis
Mark A Schnitzler
Pharmaco economic Transplant Research, The Health Administration Program, Washington University School of Medicine, St Louis, Missouri, USA
Am J Transplant 3:445-51. 2003
..The outcomes associated with CMV-seropositive donors and seronegative recipients call for tailored management strategies which may include avoidance of such mismatching, antiviral therapy, immunization, or modified immunosuppression...
- De novo congestive heart failure after kidney transplantation: a common condition with poor prognostic implications
Krista L Lentine
Center for Outcomes Research, Division of Nephrology, Saint Louis University School of Medicine, St Louis, MO, USA
Am J Kidney Dis 46:720-33. 2005
..We aim to describe the risk, predictors, and outcomes associated with de novo congestive heart failure (CHF) after kidney transplantation...
- Renal function and healthcare costs in patients with polycystic kidney disease
Krista L Lentine
Center for Outcomes Research, Saint Louis University School of Medicine, St Louis, Missouri 63104, USA
Clin J Am Soc Nephrol 5:1471-9. 2010
..Characterizing relationships of kidney function to healthcare costs in polycystic kidney disease has applications for economic evaluations of standard and emerging therapies...
- Incidence and predictors of myocardial infarction after kidney transplantation
Krista L Lentine
Saint Louis University Center for Outcomes Research, 3545 Lafayette Avenue, Salus Center, 2nd Floor, St Louis, MO 63104, USA
J Am Soc Nephrol 16:496-506. 2005
..Risk factors for PTMI include potentially modifiable posttransplantation complications. Because PTMI in turn predicts graft failure and death, reducing the risk for PTMI may improve outcomes after kidney transplantation...
- Crossmatch testing in kidney transplantation: patterns of practice and associations with rejection and graft survival
Paolo R Salvalaggio
Divison of Abdominal Organ Transplantation, Department of Surgery, Sant Louis University Medical Center, Saint Louis University School of Medicine, St Louis, MO, USA
Saudi J Kidney Dis Transpl 20:577-89. 2009
..We conclude that current practice patterns have not aligned utilization of T&B FC crossmatch with associated benefits. Prospective evaluation of the relationship of crossmatch modality with outcomes is warranted...
- Cyclosporine minimization and cost reduction in renal transplant recipients receiving a C2-monitored, cyclosporine-based quadruple immunosuppressive regimen
Karen L Hardinger
Department of Pharmacy, Barnes-Jewish Hospital, Washington University, One Barnes-Jewish Hospital Plaza, St. Louis, MO 63110, USA
Transplantation 78:1198-203. 2004
..Lower cyclosporine doses were achieved in C2-monitored patients compared with C0-monitored patients, translating into lower immunosuppressive costs...
- Diabetic complications associated with new-onset diabetes mellitus in renal transplant recipients
Thomas E Burroughs
Center for Outcomes Research, Department of Internal Medicine, Saint Louis University, St Louis, MO 63104, USA
Transplantation 83:1027-34. 2007
..Data are scarce regarding the incidence and risk factors for complications of new-onset diabetes mellitus (NODM) in renal transplant patients...
- Health insurance considerations for adolescent transplant recipients as they transition to adulthood
Lisa M Willoughby
Department of Internal Medicine, Center for Outcomes Research, Saint Louis University, St Louis, MO 63104, USA
Pediatr Transplant 11:127-31. 2007
..The purpose of this article was to review these and other issues pertaining to medical insurance coverage and transplantation, particularly for adolescent recipients as they transition to adulthood...
- Short-term mortality and cost associated with cardiac device implantation in patients hospitalized with heart failure
Jason Swindle
Center for Outcomes Research, Saint Louis University School of Medicine, St Louis, MO 63110, USA
Am Heart J 156:322-8. 2008
..Therefore, we evaluated the inhospital mortality and costs associated with patients with heart failure who received an implantable cardioverter defibrillator, cardiac resynchronization device, or device lead...
- Increased risk of graft failure in kidney transplant recipients after a diagnosis of dyspepsia or gastroesophageal reflux disease
Luca Neri
Center for Outcomes Research, Saint Louis University, St Louis, MO 63104, USA
Transplantation 85:344-52. 2008
..We examined the incidence and predictors of gastroesophageal reflux disease (GERD) and dyspepsia and their associations with graft survival and mortality after transplant...
- Sensitivity of billing claims for cardiovascular disease events among kidney transplant recipients
Krista L Lentine
Center for Outcomes Research and Division of Nephrology, School of Medicine, Saint Louis University, St Louis, MO 63104, USA
Clin J Am Soc Nephrol 4:1213-21. 2009
..Few studies have described the performance of billing claims as surrogate measures of clinical events among kidney transplant recipients...
- Chronic inotropic therapy in end-stage heart failure
Paul J Hauptman
Division of Cardiology, Department of Medicine, Saint Louis University School of Medicine, St Louis, MO, USA
Am Heart J 152:1096.e1-8. 2006
..However, little is known about associated mortality and cost. Therefore, we sought to describe the impact of chronic infusions on resource use and survival...
- Incidence of BK with tacrolimus versus cyclosporine and impact of preemptive immunosuppression reduction
Daniel C Brennan
Washington University School of Medicine, Department of Internal Medicine, St Louis, Missouri, USA
Am J Transplant 5:582-94. 2005
..Viruria was highest with FK506-MMF and lowest with CyA-MMF. Monitoring and preemptive withdrawal of immunosuppression were associated with resolution of viremia and absence of BK nephropathy without acute rejection or graft loss...
- Pharmacokinetics of tacrolimus in kidney transplant recipients: twice daily versus once daily dosing
Karen L Hardinger
Department of Pharmacy, Barnes Jewish Hospital at Washington University, St Louis, MO, USA
Am J Transplant 4:621-5. 2004
..Tacrolimus given once daily in the morning, at 85% of the twice daily dose, provides safe and equivalent drug exposure to twice daily dosing. This convenient dosing schedule may help to increase compliance and lower costs...
- Resource utilization in patients hospitalized with heart failure: insights from a contemporary national hospital database
Paul J Hauptman
Division of Cardiology, Department of Medicine, Saint Louis University School of Medicine, St Louis, MO 63110, USA
Am Heart J 155:978-985.e1. 2008
..However, little is known about the variability in and contributors to costs associated with HF hospitalizations. We examined the distribution of costs associated with a HF diagnosis in a large contemporary hospital database...
- The expanded criteria donor dilemma in cadaveric renal transplantation
Mark A Schnitzler
Health Administration Program, Washington University School of Medicine, St Louis, MO 63110, USA
Transplantation 75:1940-5. 2003
..There is wide variation in opinion concerning the composition of ECD wait lists. However, the relative benefits of accepting an ECD versus waiting for a standard donor have not been quantified...
- Mycophenolate mofetil is associated with less death with function than azathioprine in cadaveric renal transplantation
Mark A Schnitzler
Pharmaco economic Transplant Research, Washington University School of Medicine, St Louis, MI, USA
Nephrol Dial Transplant 18:1197-200. 2003
..This study was designed to verify this result because methodological issues bring these findings into question...
- Serial measurements of bone density at the lumbar spine do not predict fracture risk after liver transplantation
Karen L Hardinger
Department of Pharmacy, Barnes-Jewish Hospital/Washington University School of Medicine, St Louis, MO 63110, USA
Liver Transpl 9:857-62. 2003
..In conclusion, serial measurements of BMD at the lumbar spine do not appear to predict fracture risk; however, data suggest that female sex is the strongest predictor of fracture after liver transplantation...
- Renal function following living, standard criteria deceased and expanded criteria deceased donor kidney transplantation: impact on graft failure and death
Mark A Schnitzler
Center for Outcomes Research, Saint Louis University, St Louis, MO 63104, USA
Transpl Int 25:179-91. 2012
..Post-transplant eGFR may be a useful end-point for discriminating benefits of care strategies that differentially affect renal function...
- Cytomegalovirus disease after prophylaxis with oral ganciclovir in renal transplantation: the importance of HLA-DR matching
Mark A Schnitzler
Pharmaco economic Transplant Research, The Health Administration Program, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Am Soc Nephrol 14:780-5. 2003
..In addition, organ allocation policies discouraging combining CMV-seropositive donors and zero HLA-DR matches may be worth consideration...
- Use of nesiritide before and after publications suggesting drug-related risks in patients with acute decompensated heart failure
Paul J Hauptman
Division of Cardiology, Department of Medicine, Saint Louis University School of Medicine, St Louis, MO, USA
JAMA 296:1877-84. 2006
....
- Prospective, pilot, open-label, short-term study of conversion to leflunomide reverses chronic renal allograft dysfunction
Karen L Hardinger
Department of Pharmacy, Barnes Jewish Hospital, Washington University, St Louis, MO, USA
Am J Transplant 2:867-71. 2002
..Mean CyA levels did not change, 146 +/- 72 ng/ mL pre-LEF vs. 132 +/- 51 ng/mL post-LEF, p = NS. Conversion to LEF reversed progression of chronic renal allograft dysfunction with minimal toxicity...
- Lifetime cost-effectiveness of calcineurin inhibitor withdrawal after de novo renal transplantation
Stephanie R Earnshaw
RTI Health Solutions, Research Triangle Park, North Carolina, USA
J Am Soc Nephrol 19:1807-16. 2008
....
- Renal graft survival and calcineurin inhibitor
Robert S Woodward
Department of Health Management and Policy, University of New Hampshire, Durham, 03824, USA
Transplantation 80:629-33. 2005
....
- Nomogram for predicting the likelihood of delayed graft function in adult cadaveric renal transplant recipients
William D Irish
Research Triangle Institute, Research Triangle Park, NC 27709, USA
J Am Soc Nephrol 14:2967-74. 2003
..The nomogram provides a useful tool for developing a pretransplantation index of the likelihood of DGF occurrence. With this index in hand, better informed treatment and allocation decisions can be made...
- Agreement of immunosuppression regimens described in Medicare pharmacy claims with the Organ Procurement and Transplantation Network survey
Paula M Stirnemann
Saint Louis University Center for Outcomes Research, Saint Louis University School of Medicine, St. Louis, MO 63104, USA
J Am Soc Nephrol 17:2299-306. 2006
..Low detection rates of OPTN-indicated corticosteroid use within claims require further examination...
- Mycophenolate mofetil dose reductions and discontinuations after gastrointestinal complications are associated with renal transplant graft failure
Suphamai Bunnapradist
Multi-Organ Transplant Program, Cedars-Sinai Medical Center, Los Angeles, CA, USA
Transplantation 82:102-7. 2006
..23-4.54) and those with MMF discontinuation (2.72, CI 1.60-4.64). CONCLUSION: Renal transplant recipients who underwent MMF dose reduction or withdrawal following GI diagnosis are associated with increased risk of graft failure...
- Incidence and cost of new onset diabetes mellitus among U.S. wait-listed and transplanted renal allograft recipients
Robert S Woodward
Department of Health Management and Policy, University of New Hampshire, Durham, NH, USA
Am J Transplant 3:590-8. 2003
..We estimated the cost of diabetes attributable to maintenance immunosuppression regimens to be $2025 and $3308 for each tacrolimus patient and $1137 and $1611 for each cyclosporine patient at 1 and 2 years post-transplant, respectively...
- The impact of human leukocyte antigen matching on transplant complications and immunosuppression dosage
Selda Emre Aydingoz
Center for Outcomes Research, Department of Internal Medicine, Saint Louis University, Saint Louis, MO 63104, USA
Hum Immunol 68:491-9. 2007
..However, HLA-matched deceased donor recipients received lower dosages of mycophenolate mofetil and manifested a lower risk of developing posttransplant diarrhea...
- Five-year follow up of thymoglobulin versus ATGAM induction in adult renal transplantation
Karen L Hardinger
Department of Pharmacy, Washington University School of Medicine, St. Louis, MO, USA
Transplantation 78:136-41. 2004
..The prolonged and profound lymphopenia may contribute to the long-term results associated with Thymoglobulin...
- Cost-effectiveness of extending Medicare coverage of immunosuppressive medications to the life of a kidney transplant
Eugene F Yen
Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO, USA
Am J Transplant 4:1703-8. 2004
..Extended Medicare immunosuppression coverage to the life of a kidney transplant should result in better transplant and economic outcomes, and should be considered by policy makers...
- Donor origin of BK virus in renal transplantation and role of HLA C7 in susceptibility to sustained BK viremia
Daniel L Bohl
Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri, USA
Am J Transplant 5:2213-21. 2005
..Our data support donor origin for early BKV infection in kidney transplant recipients, and suggest that a specific HLA C locus may be associated with failure to control BKV infection...
- Consequences of eliminating HLA-B in deceased donor kidney allocation to increase minority transplantation
Nzisa Mutinga
Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA
Am J Transplant 5:1090-8. 2005
..0%, each producing large cost savings and QALY gains. Policies to increase minority transplants by increasing donation rates may prove more cost effective than the elimination of HLA-B matching from deceased donor kidney allocation...
- A randomized, prospective, pharmacoeconomic trial of tacrolimus versus cyclosporine in combination with thymoglobulin in renal transplant recipients
Karen L Hardinger
The Department of Pharmacy Practice, University of Missouri-Kansas City, Kansas City, Missouri, USA
Transplantation 80:41-6. 2005
..16,515 +/- 10,189 dollars CsA). CONCLUSIONS: When combined with Thymoglobulin induction, an antimetabolite, and corticosteroids, TAC and CsA are comparable in safety, efficacy, and cost in renal transplantation...
- A prospective, randomized, double-blinded comparison of thymoglobulin versus Atgam for induction immunosuppressive therapy: 10-year results
Karen L Hardinger
Department of Pharmacy Practice, University of Missouri Kansas City, Kansas City, MO, USA
Transplantation 86:947-52. 2008
..Use of induction for renal transplantation is controversial because of the concerns about long-term safety and efficacy...
- Incidence and risk factors for diarrhea following kidney transplantation and association with graft loss and mortality
Suphamai Bunnapradist
David Geffen School of Medicine, University of California, Los Angeles, CA, USA
Am J Kidney Dis 51:478-86. 2008
..Gastrointestinal complications after kidney transplantation are associated with inferior graft outcomes. We examined the incidence, risk factors, and outcomes of posttransplantation diarrhea...
- Maintenance immunosuppression use and the associated risk of avascular necrosis after kidney transplantation in the United States
Kevin C Abbott
Nephrology Service, Walter Reed Army Medical Center, Washington, DC, USA
Transplantation 79:330-6. 2005
..We hypothesized that maintenance immunosuppressive medications known to be associated with these risk factors for AVN would also be associated with a higher risk of AVN...
- Impact of diabetes and hepatitis after kidney transplantation on patients who are affected by hepatitis C virus
Kevin C Abbott
Nephrology Service, Walter Reed Army Medical Center, Washington, DC 20307 5001, USA
J Am Soc Nephrol 15:3166-74. 2004
..Because HCV infection acquired after transplantation is so difficult to treat, methods that have been shown to reduce viral transmission warrant renewed attention...
- The impact of transplantation with deceased donor hepatitis c-positive kidneys on survival in wait-listed long-term dialysis patients
Kevin C Abbott
Nephrology Service, Walter Reed Army Medical Center, Washington, D C, USA
Am J Transplant 4:2032-7. 2004
..However, transplantation of DHCV+ kidneys is associated with improved patient survival compared to remaining wait-listed and dialysis dependent...
- Long-term outcome of gastrointestinal complications in renal transplant patients treated with mycophenolate mofetil
Karen L Hardinger
St. Louis College of Pharmacy, St. Louis, Missouri, USA
Transpl Int 17:609-16. 2004
....
- Long-term results of rabbit antithymocyte globulin and basiliximab induction
Daniel C Brennan
N Engl J Med 359:1736-8. 2008
