Risk assessment of engineered nanomaterials and nanotechnologies--a reviewKai Savolainen
Finnish Institute of Occupational Health, New Technologies and Risks, Topeliuksenkatu 41 aA, 00250 Helsinki, Finland
Toxicology 269:92-104. 2010
..The special features of ENM do not, however, create a need to amend the current overall approach to the risk assessment of chemicals...
- Inhalation exposure to nanosized and fine TiO2 particles inhibits features of allergic asthma in a murine model
Elina M Rossi
Unit of Excellence for Immunotoxicology, Finnish Institute of Occupational Health, Helsinki, Finland
Part Fibre Toxicol 7:35. 2010
..In the present study we investigated the modulatory effects of titanium dioxide particle exposure in an experimental allergic asthma...
- Proteomic characterization of engineered nanomaterial-protein interactions in relation to surface reactivity
Jukka Sund
Unit for Immunotoxicology, Health and Work Ability, Finnish Institute of Occupational Health, Helsinki, Finland
ACS Nano 5:4300-9. 2011
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- Airway exposure to silica-coated TiO2 nanoparticles induces pulmonary neutrophilia in mice
Elina M Rossi
Unit of Excellence for Immunotoxicology, Finnish Institute of Occupational Health, Helsinki, Finland
Toxicol Sci 113:422-33. 2010
..Our findings emphasize that it is vitally important to take into account in the risk assessment that alterations of nanoparticles, e.g., by surface coating, may drastically change their toxicological potential...
- Wood dusts induce the production of reactive oxygen species and caspase-3 activity in human bronchial epithelial cells
Lea Pylkkanen
Finnish Institute of Occupational Health, Topeliuksenkatu 41 A, 00280 Helsinki, Finland
Toxicology 262:265-70. 2009
..It is though tempting to speculate that redox-regulated transcription factors such as NFkappaB or AP-1 may play a role in this wood dust-evoked process leading to apparently induced apoptosis of target cells...
- Long, needle-like carbon nanotubes and asbestos activate the NLRP3 inflammasome through a similar mechanism
Jaana Palomäki
Unit of Immunotoxicology, Finnish Institute of Occupational Health, 00250, Helsinki, Finland
ACS Nano 5:6861-70. 2011
..These results provide new information about the mechanisms by which long, needle-like materials may cause their harmful health effects. Furthermore, the techniques used here may be of use in future risk assessments of nanomaterials...
- Nano-specific genotoxic effects
Hannu Norppa
Nanosafety Research Center, Finnish Institute of Occupational Health, FI 00250 Helsinki, Finland
J Biomed Nanotechnol 7:19. 2011
..Information on nanoparticle characteristics associated with genotoxicity, carcinogenicity and mechanisms involved can probably be used in risk assessment...
- Occupational exposure to inhalable wood dust in the member states of the European Union
Timo Kauppinen
Finnish Institute of Occupational Health, Helsinki, Finland
Ann Occup Hyg 50:549-61. 2006
..This kind of assessment procedure integrating measurement data, company data, country-specific data and expert judgement could also serve as one model for the assessment of other occupational exposures...
- Immunomodulatory effects of oak dust exposure in a murine model of allergic asthma
Juha Määttä
Unit of Excellence in Immunotoxicology, Team for Biological Mechanisms and Prevention of Work related Diseases, Finnish Institute of Occupational Health, Helsinki, Finland
Toxicol Sci 99:260-6. 2007
..The present results suggest that repeated airway exposure to oak dust can regulate pulmonary inflammation and airway responses depending on the immunological status of the animal...
- Mutations in TP53 tumor suppressor gene in wood dust-related sinonasal cancer
Reetta Holmila
Finnish Institute of Occupational Health, Helsinki, Finland
Int J Cancer 127:578-88. 2010
..Our results indicate that mutational mechanisms, in particular TP53 mutations, are associated with work-related exposure to wood dust in sinonasal cancer...
- Genotoxicity of nanomaterials: DNA damage and micronuclei induced by carbon nanotubes and graphite nanofibres in human bronchial epithelial cells in vitro
Hanna K Lindberg
New Technologies and Risks, Work Environment Development, Finnish Institute of Occupational Health, FI 00250 Helsinki, Finland
Toxicol Lett 186:166-73. 2009
..This activity may be due to the fibrous nature of these carbon nanomaterials with a possible contribution by catalyst metals present in the materials-Co and Mo in CNTs (<5wt.%) and Fe (<3wt.%) in GNFs...
