Quercetin-mediated longevity in Caenorhabditis elegans: is DAF-16 involved?Nadine Saul
Humboldt Universitat zu Berlin, Department of Biology, Arboretum, Spaethstr 80 81, 12437 Berlin, Germany
Mech Ageing Dev 129:611-3. 2008
..Furthermore, quercetin-treated daf-16(mgDf50) worms show an enhanced resistance to thermal and oxidative stress. Our data reveal that DAF-16 is not obligatorily required for quercetin-mediated longevity and stress resistance...
- The longevity effect of tannic acid in Caenorhabditis elegans: Disposable Soma meets hormesis
Nadine Saul
Department of Biology, Laboratory of Freshwater and Stress Ecology, Humboldt Universitat zu Berlin, Spaethstr 80 81, 12437 Berlin, Germany
J Gerontol A Biol Sci Med Sci 65:626-35. 2010
..quot; This report underlines the uniqueness of TA-mediated longevity and facilitates a first glimpse into its complex mode of action...
- Catechin induced longevity in C. elegans: from key regulator genes to disposable soma
Nadine Saul
Humboldt Universitat zu Berlin, Department of Biology, Laboratory of Freshwater and Stress Ecology, Berlin, Germany
Mech Ageing Dev 130:477-86. 2009
..It is proposed that catechin modulates an energy-intensive stress response and repair system that results in reduced body length and an enhanced lifespan...
- Diversity of polyphenol action in Caenorhabditis elegans: between toxicity and longevity
Nadine Saul
Laboratory of Freshwater and Stress Ecology, Department of Biology, Humboldt Universität zu Berlin, Späthstrasse 80 81, 12437 Berlin, Germany
J Nat Prod 74:1713-20. 2011
..Furthermore, the prominent "disposable soma theory" is only partly reflected by these polyphenols. In summary, this study underlines the diversity of polyphenolic phytochemicals and their mechanistic background...
- Quercetin mediated lifespan extension in Caenorhabditis elegans is modulated by age-1, daf-2, sek-1 and unc-43
Kerstin Pietsch
Department of Biology, Humboldt Universitat zu Berlin, Germany
Biogerontology 10:565-78. 2009
..However, four genes were pinpointed to be required for the quercetin derived lifespan extension, namely age-1, daf-2, unc-43 and sek-1. The latter two have, to date, not been linked to quercetin-mediated lifespan extension...
- Hormetins, antioxidants and prooxidants: defining quercetin-, caffeic acid- and rosmarinic acid-mediated life extension in C. elegans
Kerstin Pietsch
Humboldt Universitat zu Berlin, Department of Biology, Laboratory of Freshwater and Stress Ecology, Späthstr 80 81, 12437, Berlin, Germany
Biogerontology 12:329-47. 2011
..Taken together, hormesis, in vivo antioxidative/prooxidative properties, modulation of genetic players, as well as the re-allocation of energy all contribute (to some extent and dependent on the polyphenol) to life extension...
- Meta-Analysis of Global Transcriptomics Suggests that Conserved Genetic Pathways are Responsible for Quercetin and Tannic Acid Mediated Longevity in C. elegans
Kerstin Pietsch
Laboratory of Freshwater and Stress Ecology, Department of Biology, Humboldt Universität zu Berlin Berlin, Germany
Front Genet 3:48. 2012
..It also supports the call to expand the generation of comparative and integrative databases, an effort that is currently still in its infancy...
- Enrichment of humic material with hydroxybenzene moieties intensifies its physiological effects on the nematode Caenorhabditis elegans
Ralph Menzel
Department of Biology, Freshwater and Stress Ecology, Humboldt Universitat zu Berlin, Berlin, Germany
Environ Sci Technol 45:8707-15. 2011
..elegans...
- Leaf litter leachates have the potential to increase lifespan, body size, and offspring numbers in a clone of Moina macrocopa
Sylva Hofmann
Humboldt Universitat zu Berlin, Department of Biology, Laboratory of Freshwater and Stress Ecology, Arboretum, 12437 Berlin, Germany
Chemosphere 86:883-90. 2012
..Overall, our results suggest that the potentially adverse effects of litter leachates can be overruled by either bacterial-growth supporting fractions in the leachates or an internal compensation mechanism in the Moina individuals...
