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Species | Allan KalueffSummaryAffiliation: Medical School Country: Russia Publications
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Publications
Perspectives on genetic animal models of serotonin toxicityAllan V Kalueff
Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, MD 20892 1264, USA
Neurochem Int 52:649-58. 2008..Here we discuss current problems and perspectives regarding genetic animal models of serotonin-related syndromes, and outline the potential utility of these models in experimental neurochemistry and clinical research...- Refining psychiatric genetics: from 'mouse psychiatry' to understanding complex human disordersJustin L LaPorte
Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20892 1264, USA
Behav Pharmacol 19:377-84. 2008..Here, we outline recent concepts and approaches that can help refine the field and enable more precise dissection of the genetic mechanisms contributing to psychiatric disorders... - Hair barbering in mice: implications for neurobehavioural researchA V Kalueff
Department of Anatomy of the Medical School, University of Tampere, Tampere 33014, Finland
Behav Processes 71:8-15. 2006..We suggest that barbering may be an important complex multi-domain behaviour sensitive to various manipulations, and represent a useful index in neurobehavioural research... - Increased severity of chemically induced seizures in mice with partially deleted Vitamin D receptor geneAllan V Kalueff
Department of Anatomy, Medical School, University of Tampere, Tampere 33014, Finland
Neurosci Lett 394:69-73. 2006..Our findings suggest that VDRs modulate seizure susceptibility in mice, and that the Vitamin D/VDR endocrine system may be involved in the pathogenesis of epilepsy... - Behavioural anomalies in mice evoked by "Tokyo" disruption of the Vitamin D receptor geneAllan V Kalueff
Medical School, University of Tampere, Finland
Neurosci Res 54:254-60. 2006..Taken together, these findings confirm the important role postulated for the VDR in the regulation of behaviour, and suggest the mice lacking functional VDR may be a useful tool to model different brain disorders... - Temporal stability of novelty exploration in mice exposed to different open field testsAllan V Kalueff
Department of Anatomy, Medical School, University of Tampere, Tampere, Finland
Behav Processes 72:104-12. 2006..These results suggest that mice are characterised by stability of temporal organization of their exploration in different OF novelty situations... - Thalamic calcification in vitamin D receptor knockout miceAllan Kalueff
Department of Anatomy, Medical School, University of Tampere, Finland
Neuroreport 17:717-21. 2006..Our results suggest that nuclear vitamin D receptor deficiency leads to brain mineralization in vitamin D receptor knockout mice, which may represent an experimental model of intracranial calcification... - The vitamin D neuroendocrine system as a target for novel neurotropic drugsA V Kalueff
Department of Anatomy, Medical School, University of Tampere, Tampere, Finland
CNS Neurol Disord Drug Targets 5:363-71. 2006..Here we review the important role of the vitamin D neuroendocrine system in the brain, and outline perspectives for the search for novel neurotropic drugs to treat various vitamin D-related dysfunctions... - Neurosteroid hormone vitamin D and its utility in clinical nutritionAllan V Kalueff
Medical School, University of Tampere, Tampere, Finland
Curr Opin Clin Nutr Metab Care 10:12-9. 2007..We also outline perspectives for the use of vitamin D in clinical nutrition to prevent or treat various brain disorders... - Behavioral neuroscience, exploration, and K.C. Montgomery's legacyAllan V Kalueff
National Institute of Mental Health, Bethesda, MD 20892 1264, USA
Brain Res Rev 53:328-31. 2007..It is aimed at neuroscientists with strong interests in both theory of animal exploration and motivation, and the history of behavioral neuroscience... - Influence of paternal genotypes on F1 behaviors: lessons from several mouse strainsAllan V Kalueff
Department of Anatomy, Medical School, University of Tampere, Tampere, Finland
Behav Brain Res 177:45-50. 2007..Our results imply complex interplay between parental genotypes in anxiety, activity, grooming, aggression and barbering of their F1 progeny, further confirming the utility of F1 hybrids in behavioral neurogenetics... - The regular and light-dark Suok tests of anxiety and sensorimotor integration: utility for behavioral characterization in laboratory rodentsAllan V Kalueff
Department of Anatomy, Medical School, University of Tampere, Tampere 33014, Finland
Nat Protoc 3:129-36. 2008.... - The role of hair in swimming of laboratory mice: implications for behavioural studies in animals with abnormal hairA V Kalueff
Department of Anatomy, Medical School, University of Tampere, Tampere 33014, Finland
Lab Anim 39:370-6. 2005..Our results indicate that hair condition is not an important factor in the forced swim test for this mouse strain, and suggest that this test may have wider utility for behavioural analyses of mice with abnormal hair... - Behavioural characterization in rats using the elevated alley Suok testAllan V Kalueff
Department of Anatomy, Medical School, University of Tampere, Tampere 33014, Finland
Behav Brain Res 165:52-7. 2005..This new behavioural paradigm may be widely used in neurobehavioural stress research, including modelling of stress-evoked states and pharmacological screening of psychotropic drugs... - Anticonvulsant effects of 1,25-dihydroxyvitamin D in chemically induced seizures in miceAllan V Kalueff
Department of Anatomy, Medical School, University of Tampere, Tampere 33014, Finland
Brain Res Bull 67:156-60. 2005..Our findings show that Vitamin D plays a direct anticonvulsant role in the brain and suggest that the Vitamin D endocrine system may represent a new target for the development of anticonvulsant drugs... - Impaired motor performance in mice lacking neurosteroid vitamin D receptorsAllan V Kalueff
Department of Anatomy, Medical School, University of Tampere, Tampere 33014, Finland
Brain Res Bull 64:25-9. 2004..This study confirms the important role of the vitamin D system in motor functions and suggests that animal genetic models targeting the vitamin D/VDR system may be a useful tool to study vitamin D-related motor/behavioural disorders... - Increased anxiety in mice lacking vitamin D receptor geneAllan V Kalueff
Department of Anatomy, Medical School, University of Tampere, FIN 33014 Tampere, Finland
Neuroreport 15:1271-4. 2004..These studies suggest that vitamin D and its receptors are an important factor in the brain, whose imbalance may significantly affect emotional behaviour... - Increased grooming behavior in mice lacking vitamin D receptorsA V Kalueff
Department of Anatomy, Medical School, Tampere University, 33014, Finland
Physiol Behav 82:405-9. 2004..In general, our results confirm the role of vitamin D and VDR in the regulation of behavior, including grooming, and suggest that increased grooming behavioral phenotype may be associated with genetic ablation of VDR in mutant mice... - Grooming analysis algorithm for neurobehavioural stress researchAllan V Kalueff
Medical School Anatomy Department and University Hospital, University of Tampere, Tampere 33014, Finland
Brain Res Brain Res Protoc 13:151-8. 2004..The protocol can be a useful tool in neurobehavioural stress research including modelling stress-evoked states, pharmacological screening of potential antistress drugs or behavioural phenotyping of genetically modified animals... - Contrasting grooming phenotypes in C57Bl/6 and 129S1/SvImJ miceAllan V Kalueff
Department of Anatomy, Medical School, University of Tampere, Tampere 33014, Finland
Brain Res 1028:75-82. 2004.... - Experimental modeling of anxiety and depressionAllan V Kalueff
Medical School, Tampere University Hospital, University of Tampere, Tampere 33014, Finland
Acta Neurobiol Exp (Wars) 64:439-48. 2004..We take an interdisciplinary approach and review the existing experimental models of anxiety and depression in order to promote further understanding of neurobiological aspects of anxiety and depression... - Intranasal administration of human IL-6 increases the severity of chemically induced seizures in ratsAllan V Kalueff
Medical School, University of Tampere, 33014, Finland
Neurosci Lett 365:106-10. 2004..Our findings show that IL-6 plays a pro-convulsant role in the brain and suggest that the IL-6 system may be a novel target for the development of anticonvulsant drugs... - Mouse grooming microstructure is a reliable anxiety marker bidirectionally sensitive to GABAergic drugsAllan V Kalueff
Medical School of the University of Tampere, Tampere University Hospital, Tampere 33014, Finland
Eur J Pharmacol 508:147-53. 2005..Our study also confirms that detailed ethological analyses of grooming microstructure can be a useful tool in behavioural pharmacology of anxiety... - Abnormal behavioral organization of grooming in mice lacking the vitamin D receptor geneAllan V Kalueff
Department of Anatomy, Medical School, University of Tampere, Tampere, Finland
J Neurogenet 19:1-24. 2005..Our results suggest that a neurosteroid vitamin D and VDR may play an important role in controlling sequencing of grooming in mice, and further confirm the important role of the vitamin D system and VDR in the regulation of behavior... - The Suok ("ropewalking") murine test of anxietyAllan V Kalueff
Department of Anatomy, Medical School, University of Tampere, Tampere, 33014 Finland
Brain Res Brain Res Protoc 14:87-99. 2005.... - The grooming analysis algorithm discriminates between different levels of anxiety in rats: potential utility for neurobehavioural stress researchAllan V Kalueff
Department of Anatomy of the Medical School, Department of Clinical Chemistry of the University Hospital, University of Tampere, Finland
J Neurosci Methods 143:169-77. 2005..Our results suggest that this method can be a useful tool in neurobehavioural stress research including modelling stress-evoked states, psychopharmacological or behavioural neurogenetics research in rats... - Contrasting grooming phenotypes in three mouse strains markedly different in anxiety and activity (129S1, BALB/c and NMRI)Allan V Kalueff
Department of Anatomy, Medical School, University of Tampere, Tampere 33014, Finland
Behav Brain Res 160:1-10. 2005..We suggest that ethological analysis of mouse grooming, such as that reported here, may be a useful tool in neurobehavioural research... - Locomotory patterns, spatiotemporal organization of exploration and spatial memory in serotonin transporter knockout miceAllan V Kalueff
Laboratory of Clinical Science, Building 10, Room 3D41, National Institute of Mental Health, 10 Center Dr MSC 1264, Bethesda, MD 20892 1264, USA
Brain Res 1169:87-97. 2007..Given the relevance of exploratory strategies to human personality traits and brain disorders, our data may be useful for developing further neurobehavioral models using these mice... - The importance of cognitive phenotypes in experimental modeling of animal anxiety and depressionAllan V Kalueff
Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, MD 20892 1264, USA
Neural Plast 2007:52087. 2007.... - Vestibular dysfunction in vitamin D receptor mutant miceAnna Minasyan
Department of Anatomy, Medical School, University of Tampere, Finland
J Steroid Biochem Mol Biol 114:161-6. 2009..These data suggest that VDR deficiency in mice is associated with decreased balance function, and may be relevant to poorer balance/posture control in humans with low levels of vitamin D... - Neophobia, sensory and cognitive functions, and hedonic responses in vitamin D receptor mutant miceAnna Minasyan
Department of Anatomy, Medical School, University of Tampere, Tampere 33014, Finland
J Steroid Biochem Mol Biol 104:274-80. 2007.... - Premature aging in vitamin D receptor mutant miceTiina Keisala
Department of Anatomy, Medical School, University of Tampere, Tampere 33014, Finland
J Steroid Biochem Mol Biol 115:91-7. 2009.... - Domain interplay concept in animal models of neuropsychiatric disorders: a new strategy for high-throughput neurophenotyping researchAllan V Kalueff
Laboratory of Clinical Science, National Institute of Mental Health, NIH, Bethesda, MD 20892 1264, USA
Behav Brain Res 188:243-9. 2008..Here we develop a new concept based on targeting the complex interplay between different behavioral domains, meant to foster high-throughput phenotyping and integrative modeling of psychiatric disorders... - Are serotonin transporter knockout mice 'depressed'?: hypoactivity but no anhedoniaAllan V Kalueff
Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20892 1264, USA
Neuroreport 17:1347-51. 2006..These results demonstrate that depression-like behavior (unlike hypoactivity) is not a baseline phenotypic feature of serotonin transporter knockout mice, suggesting anew that these mice do not represent a genetic model of depression... - Anxiety and otovestibular disorders: linking behavioral phenotypes in men and miceAllan V Kalueff
Laboratory of Clinical Science, Building 10, Room 3D41, National Institute of Mental Health, 10 Center Dr MSC 1264, NIH, Bethesda, MD 20892 1264, USA
Behav Brain Res 186:1-11. 2008..Animal experimental models that focus on the interplay between anxiety and vestibular disorders are needed to improve our understanding of this important biomedical problem... - Analyzing grooming microstructure in neurobehavioral experimentsAllan V Kalueff
Laboratory of Clinical Science, National Institute of Mental Health, NIMH NIH, Bethesda, Maryland 20892, USA
Nat Protoc 2:2538-44. 2007..Owing to the ever-increasing number of rodent models that have strong grooming phenotypes, this high-throughput in-depth analysis is becoming crucial for biomedical research... - BDNF in anxiety and depressionAllan V Kalueff
Science 312:1598-9; author reply 1598-9. 2006 - Hybridizing behavioral models: a possible solution to some problems in neurophenotyping research?Allan V Kalueff
Laboratory of Clinical Science, National Institute of Mental Health, NIH, Bethesda, Maryland 20892 1264, USA
Prog Neuropsychopharmacol Biol Psychiatry 32:1172-8. 2008.... - Aberrant nest building and prolactin secretion in vitamin D receptor mutant miceTiina Keisala
Department of Anatomy, Medical School, University of Tampere, Tampere 33014, Finland
J Steroid Biochem Mol Biol 104:269-73. 2007.... - The developing use of heterozygous mutant mouse models in brain monoamine transporter researchAllan V Kalueff
Laboratory of Clinical Science, Building 10, Room 3D41, National Institute of Mental Health, 10 Center Drive, 1264 Bethesda, MD 20892 1264, USA
Trends Pharmacol Sci 28:122-7. 2007..Here, we discuss why heterozygous mouse models, in addition to knockout mice, might be useful for brain monoamine transporter research... - 25-Hydroxyvitamin D(3) is an agonistic vitamin D receptor ligandYan Ru Lou
Department of Anatomy, Medical School, University of Tampere, Tampere, FIN 33014, Finland
J Steroid Biochem Mol Biol 118:162-70. 2010..In conclusion, 25-hydroxyvitamin D(3) is an agonistic vitamin D receptor ligand with gene regulatory and anti-proliferative properties... - Serum cholesterol and expression of ApoAI, LXRbeta and SREBP2 in vitamin D receptor knock-out miceJing Huan Wang
Department of Anatomy, Medical School, University of Tampere, Medisiinarinkatu 3, Tampere, Finland
J Steroid Biochem Mol Biol 113:222-6. 2009..Although VDR seems to regulate some of the genes involved in cholesterol metabolism, its role in the regulation of serum cholesterol seems to be minimal... - Role of GABA in anxiety and depressionAllan V Kalueff
Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland, USA
Depress Anxiety 24:495-517. 2007..The role of GABAergic agents in demonstrating this interrelationship and in pointing the way to future research is discussed... - Brain-derived neurotrophic factor, serotonin transporter, and depression: comment on Kaufman et alAllan V Kalueff
Biol Psychiatry 61:1112-3; author reply 1113-5. 2007 - Neurobiology of memory and anxiety: from genes to behaviorAllan V Kalueff
Laboratory of Clinical Science, Division of Intramural Research Program, National Institute of Mental Health, Bethesda, MD 20892 1264, USA
Neural Plast 2007:78171. 2007..The paper also assesses the putative role of different neurotransmitter systems and neuropeptides in the regulation of memory processes and anxiety, and discusses the role of neural plasticity in these mechanisms...