Mark A Babizhayev

Summary

Country: Russia

Publications

  1. ncbi Biologic activities of molecular chaperones and pharmacologic chaperone imidazole-containing dipeptide-based compounds: natural skin care help and the ultimate challenge: implication for adaptive responses in the skin
    Mark A Babizhayev
    Innovation Vision Products, Inc, New Castle, DE, USA
    Am J Ther 19:e69-89. 2012
  2. ncbi Biomarkers and special features of oxidative stress in the anterior segment of the eye linked to lens cataract and the trabecular meshwork injury in primary open-angle glaucoma: challenges of dual combination therapy with N-acetylcarnosine lubricant eye d
    Mark A Babizhayev
    Innovative Vision Products, Inc, 3511 Silverside Road, New Castle, DE 19810, USA
    Fundam Clin Pharmacol 26:86-117. 2012
  3. ncbi Management of the virulent influenza virus infection by oral formulation of nonhydrolized carnosine and isopeptide of carnosine attenuating proinflammatory cytokine-induced nitric oxide production
    Mark A Babizhayev
    Innovative Vision Products Inc, County of New Castle, DE, USA
    Am J Ther 19:e25-47. 2012
  4. ncbi N-Acetylcarnosine, a natural histidine-containing dipeptide, as a potent ophthalmic drug in treatment of human cataracts
    M A Babizhayev
    Innovative Vision Products, Inc, County of New Castle, DE 19810, USA
    Peptides 22:979-94. 2001
  5. ncbi N-Acetylcarnosine sustained drug delivery eye drops to control the signs of ageless vision: glare sensitivity, cataract amelioration and quality of vision currently available treatment for the challenging 50,000-patient population
    Mark A Babizhayev
    Innovative Vision Products, Inc, County of New Castle, Delaware, USA
    Clin Interv Aging 4:31-50. 2009
  6. ncbi Telomere length is a biomarker of cumulative oxidative stress, biologic age, and an independent predictor of survival and therapeutic treatment requirement associated with smoking behavior
    Mark A Babizhayev
    Innovative Vision Products Inc, County of New Castle, DE, USA
    Am J Ther 18:e209-26. 2011
  7. ncbi Potentiation of intraocular absorption and drug metabolism of N-acetylcarnosine lubricant eye drops: drug interaction with sight threatening lipid peroxides in the treatment for age-related eye diseases
    Mark A Babizhayev
    Innovative Vision Products, Inc Delaware, USA
    Drug Metabol Drug Interact 24:275-323. 2009
  8. ncbi Telomere-dependent senescent phenotype of lens epithelial cells as a biological marker of aging and cataractogenesis: the role of oxidative stress intensity and specific mechanism of phospholipid hydroperoxide toxicity in lens and aqueous
    Mark A Babizhayev
    Innovation Vision Products, Inc, 3511 Silverside Road, Suite 105, County of New Castle, DE 19810, USA
    Fundam Clin Pharmacol 25:139-62. 2011
  9. ncbi Telomere attrition in lens epithelial cells - a target for N-acetylcarnosine therapy
    Mark A Babizhayev
    Innovation Vision Products, Inc, County of New Castle, Delaware 19810, USA
    Front Biosci 15:934-56. 2010
  10. ncbi A survey and analysis of the role of molecular chaperone proteins and imidazole-containing dipeptide-based compounds as molecular escorts into the skin during stress, injury, water structuring and other types of cutaneous pathophysiology
    M A Babizhayev
    Innovation Vision Products, Inc, 3511 Silverside Road, New Castle, DE 19810, U S A
    Int J Cosmet Sci 33:1-16. 2011

Detail Information

Publications35

  1. ncbi Biologic activities of molecular chaperones and pharmacologic chaperone imidazole-containing dipeptide-based compounds: natural skin care help and the ultimate challenge: implication for adaptive responses in the skin
    Mark A Babizhayev
    Innovation Vision Products, Inc, New Castle, DE, USA
    Am J Ther 19:e69-89. 2012
    ....
  2. ncbi Biomarkers and special features of oxidative stress in the anterior segment of the eye linked to lens cataract and the trabecular meshwork injury in primary open-angle glaucoma: challenges of dual combination therapy with N-acetylcarnosine lubricant eye d
    Mark A Babizhayev
    Innovative Vision Products, Inc, 3511 Silverside Road, New Castle, DE 19810, USA
    Fundam Clin Pharmacol 26:86-117. 2012
    ..The developed therapy is a prominent management care of the glaucomatous neurodegeneration...
  3. ncbi Management of the virulent influenza virus infection by oral formulation of nonhydrolized carnosine and isopeptide of carnosine attenuating proinflammatory cytokine-induced nitric oxide production
    Mark A Babizhayev
    Innovative Vision Products Inc, County of New Castle, DE, USA
    Am J Ther 19:e25-47. 2012
    ....
  4. ncbi N-Acetylcarnosine, a natural histidine-containing dipeptide, as a potent ophthalmic drug in treatment of human cataracts
    M A Babizhayev
    Innovative Vision Products, Inc, County of New Castle, DE 19810, USA
    Peptides 22:979-94. 2001
    ..The N-acetylated form of natural dipeptide L-carnosine appears to be suitable and physiologically acceptable for nonsurgical treatment for senile cataracts...
  5. ncbi N-Acetylcarnosine sustained drug delivery eye drops to control the signs of ageless vision: glare sensitivity, cataract amelioration and quality of vision currently available treatment for the challenging 50,000-patient population
    Mark A Babizhayev
    Innovative Vision Products, Inc, County of New Castle, Delaware, USA
    Clin Interv Aging 4:31-50. 2009
    ..Only the natural L-isomeric form of NAC raw material was specifically synthesized at the cGMP facility and employed for the manufacturing of Can-C eye drops...
  6. ncbi Telomere length is a biomarker of cumulative oxidative stress, biologic age, and an independent predictor of survival and therapeutic treatment requirement associated with smoking behavior
    Mark A Babizhayev
    Innovative Vision Products Inc, County of New Castle, DE, USA
    Am J Ther 18:e209-26. 2011
    ....
  7. ncbi Potentiation of intraocular absorption and drug metabolism of N-acetylcarnosine lubricant eye drops: drug interaction with sight threatening lipid peroxides in the treatment for age-related eye diseases
    Mark A Babizhayev
    Innovative Vision Products, Inc Delaware, USA
    Drug Metabol Drug Interact 24:275-323. 2009
    ....
  8. ncbi Telomere-dependent senescent phenotype of lens epithelial cells as a biological marker of aging and cataractogenesis: the role of oxidative stress intensity and specific mechanism of phospholipid hydroperoxide toxicity in lens and aqueous
    Mark A Babizhayev
    Innovation Vision Products, Inc, 3511 Silverside Road, Suite 105, County of New Castle, DE 19810, USA
    Fundam Clin Pharmacol 25:139-62. 2011
    ..Telomere length in the human crystalline lens cells is a reflection of aging, cataractogenesis, and lifespan in biogerontological studies...
  9. ncbi Telomere attrition in lens epithelial cells - a target for N-acetylcarnosine therapy
    Mark A Babizhayev
    Innovation Vision Products, Inc, County of New Castle, Delaware 19810, USA
    Front Biosci 15:934-56. 2010
    ....
  10. ncbi A survey and analysis of the role of molecular chaperone proteins and imidazole-containing dipeptide-based compounds as molecular escorts into the skin during stress, injury, water structuring and other types of cutaneous pathophysiology
    M A Babizhayev
    Innovation Vision Products, Inc, 3511 Silverside Road, New Castle, DE 19810, U S A
    Int J Cosmet Sci 33:1-16. 2011
    ....
  11. ncbi Designation of imidazole-containing dipeptides as pharmacological chaperones
    Mark A Babizhayev
    Innovative Vision Products Inc, County of New Castle, Delaware, USA
    Hum Exp Toxicol 30:736-61. 2011
    ..Current efforts are being directed towards exploring therapeutic approaches of pharmacological targeting and human drug delivery for chaperone molecules based on innovative patented strategies...
  12. ncbi Smoking and health: association between telomere length and factors impacting on human disease, quality of life and life span in a large population-based cohort under the effect of smoking duration
    Mark A Babizhayev
    Innovative Vision Products, County of New Castle, DE 19810, USA
    Fundam Clin Pharmacol 25:425-42. 2011
    ..We conclude that a better therapeutic or nutritional maintenance of TL may confer healthy aging in smokers and exceptional longevity in regularly ROS-exposed human survivors...
  13. ncbi Advanced drug delivery of N-acetylcarnosine (N-acetyl-beta-alanyl-L-histidine), carcinine (beta-alanylhistamine) and L-carnosine (beta-alanyl-L-histidine) in targeting peptide compounds as pharmacological chaperones for use in tissue engineering, human di
    Mark A Babizhayev
    Innovative Vision Products, Inc, 3511 Silverside Road, Suite 105, County of New Castle, Delaware 19810, USA
    Recent Pat Drug Deliv Formul 4:198-230. 2010
    ....
  14. ncbi Mitochondria induce oxidative stress, generation of reactive oxygen species and redox state unbalance of the eye lens leading to human cataract formation: disruption of redox lens organization by phospholipid hydroperoxides as a common basis for cataract
    Mark A Babizhayev
    Innovative Vision Products, Inc, County of New Castle, Delaware, USA
    Cell Biochem Funct 29:183-206. 2011
    ..Combined in ophthalmic formulations with N-acetylcarnosine, mitochondria-targeted antioxidants are promising to become investigated as a potential tool for treating a number of ROS-related ocular diseases, including human cataracts...
  15. ncbi Water-structuring technology with the molecular chaperone proteins: indicated application of the ?-crystallin domains and imidazole-containing peptidomimetics in cosmetic skin care systems or dermatological therapeutic drug carrier formulations
    Mark A Babizhayev
    Innovative Vision Products, Inc, New Castle, DE, USA
    Crit Rev Ther Drug Carrier Syst 28:203-53. 2011
    ..The proposed biotechnology results in a superior therapeutic treatment using the studied skin-rejuvenating, water-structuring, visible smoothing, and revitalizing beauty-performance agents to meet current challenges in skin care...
  16. ncbi N-acetylcarnosine lubricant eyedrops possess all-in-one universal antioxidant protective effects of L-carnosine in aqueous and lipid membrane environments, aldehyde scavenging, and transglycation activities inherent to cataracts: a clinical study of the n
    Mark A Babizhayev
    Innovative Vision Products, New Castle, Delaware, USA
    Am J Ther 16:517-33. 2009
    ....
  17. ncbi State of the art clinical efficacy and safety evaluation of N-acetylcarnosine dipeptide ophthalmic prodrug. Principles for the delivery, self-bioactivation, molecular targets and interaction with a highly evolved histidyl-hydrazide structure in the treatm
    Mark A Babizhayev
    Innovative Vision Products, Inc, County of New Castle, Delaware 19810, USA
    Curr Clin Pharmacol 4:4-37. 2009
    ..Besides, histidine-containing dipeptides are believed to act as cytosolic buffering agents...
  18. ncbi Rejuvenation of visual functions in older adult drivers and drivers with cataract during a short-term administration of N-acetylcarnosine lubricant eye drops
    Mark A Babizhayev
    Innovative Vision Products, Inc Moscow Division, Ivanovskaya 20, Suite 74, Moscow 127434, Russian Federation
    Rejuvenation Res 7:186-98. 2004
    ..The developed ophthalmic drug NAC formula showed potential for the non-surgical treatment of age-related cataracts...
  19. ncbi Analysis of lipid peroxidation and electron microscopic survey of maturation stages during human cataractogenesis: pharmacokinetic assay of Can-C N-acetylcarnosine prodrug lubricant eye drops for cataract prevention
    Mark A Babizhayev
    Innovative Vision Products Inc, County of New Castle, Delaware 19810, USA
    Drugs R D 6:345-69. 2005
    ....
  20. ncbi Cataract halos: a driving hazard in aging populations. Implication of the Halometer DG test for assessment of intraocular light scatter
    Mark A Babizhayev
    Innovative Vision Products Inc, 3511 Silverside Road, Suite 105, County of New Castle, DE 19810, USA
    Appl Ergon 40:545-53. 2009
    ..The authors examined this visual impairment using a new Halometer DG test in the eyes of older adult drivers with and without cataract...
  21. ncbi N-Acetylcarnosine and histidyl-hydrazide are potent agents for multitargeted ophthalmic therapy of senile cataracts and diabetic ocular complications
    Mark A Babizhayev
    Innovative Vision Products, Inc, County of New Castle, DE 19810, USA
    J Drug Target 17:36-63. 2009
    ..SIGNIFICANCE: The bioactivating antioxidant NAC and histidyl-hydrazide are potent agents with the pleiotropic effects for ophthalmic therapy of senile cataracts and diabetic ocular complications...
  22. ncbi Therapeutic uses of drug-carrier systems for imidazole-containing dipeptide compounds that act as pharmacological chaperones and have significant impact on the treatment of chronic diseases associated with increased oxidative stress and the formation of a
    Mark A Babizhayev
    Innovative Vision Products, Inc, USA and Moscow Helmholtz Research Institute for Eye Diseases, Moscow, Russian Federation
    Crit Rev Ther Drug Carrier Syst 27:85-154. 2010
    ....
  23. ncbi Image analysis and glare sensitivity in human age-related cataracts
    Mark A Babizhayev
    Innovative Vision Products Inc, Ivanovskaya 20, Moscow, Russian Federation
    Clin Exp Optom 86:157-72. 2003
    ..The results indicate on agreement between clinical findings and applied quantitative techniques of analysis. This system has the potential to be a useful objective clinical assessment of cataract...
  24. ncbi Ocular drug metabolism of the bioactivating antioxidant N-acetylcarnosine for vision in ophthalmic prodrug and codrug design and delivery
    Mark A Babizhayev
    Innovative Vision Products, Silverside Road, Suite, County of New Castle, Delaware, USA markbabizhayev mail ru
    Drug Dev Ind Pharm 34:1071-89. 2008
    ....
  25. ncbi Biological activities of the natural imidazole-containing peptidomimetics n-acetylcarnosine, carcinine and L-carnosine in ophthalmic and skin care products
    Mark A Babizhayev
    Innovative Vision Products, Inc, 3511 Silverside Road, Suite 105, County of New Castle, Delaware 19810, USA
    Life Sci 78:2343-57. 2006
    ..The biologically significant applications of carnosine mimetics were patented by Dr. Babizhayev and the alliance Groups (WO 2004/028536 A1; WO 94/19325; WO 95/12581; WO 2004/064866 A1)...
  26. ncbi New concept in nutrition for the maintenance of the aging eye redox regulation and therapeutic treatment of cataract disease; synergism of natural antioxidant imidazole-containing amino acid-based compounds, chaperone, and glutathione boosting agents: a s
    Mark A Babizhayev
    Innovative Vision Products, Inc, County of New Castle, DE, USA
    Am J Ther 17:373-89. 2010
    ....
  27. ncbi Lipid peroxidation and cataracts: N-acetylcarnosine as a therapeutic tool to manage age-related cataracts in human and in canine eyes
    Mark A Babizhayev
    Innovative Vision Products Inc, County of New Castle, Delaware, USA
    Drugs R D 5:125-39. 2004
    ..These data showed that N-acetylcarnosine is effective in the management of age-related cataract reversal and prevention both in human and in canine eyes...
  28. ncbi Current ocular drug delivery challenges for N-acetylcarnosine: novel patented routes and modes of delivery, design for enhancement of therapeutic activity and drug delivery relationships
    Mark A Babizhayev
    Innovative Vision Products, Inc, 3511 Silverside Road, County of New Castle, Delaware USA
    Recent Pat Drug Deliv Formul 3:229-65. 2009
    ..The biologically significant applications of carnosine mimetics including those in ophthalmology were patented by Dr. Babizhayev and the alliance Groups (WO 2004/028536 A1; WO 94/19325; WO 95/12581; WO 2004/064866 A1)...
  29. ncbi 3D molecular modeling, free radical modulating and immune cells signaling activities of the novel peptidomimetic L-glutamyl-histamine: possible immunostimulating role
    Mark A Babizhayev
    Innovative Vision Products Inc, Delaware, USA
    Peptides 26:551-63. 2005
    ..The cited abilities and further obtained in vivo results make Immudilin ((INCI: glutamylamidoethyl imidazole, aqueous solution), L-Glu-Hist) a useful immunoregulatory agent...
  30. ncbi Glare disability and driving safety
    M A Babizhayev
    Innovative Vision Products Inc, Delaware, USA
    Ophthalmic Res 35:19-25. 2003
    ..The purpose of this article was to examine the type of visual impairment mediated by the increased glare sensitivity in adult drivers using the original halometer glare test...
  31. ncbi Olfactory dysfunction and cognitive impairment in age-related neurodegeneration: prevalence related to patient selection, diagnostic criteria and therapeutic treatment of aged clients receiving clinical neurology and community-based care
    Mark A Babizhayev
    Innovative Vision Products, Inc, County of New Castle, Delaware 19810, USA
    Curr Clin Pharmacol 6:236-59. 2011
    ..The olfactory system, anatomically, is right in the middle of the part of the brain that's very important for memory. There are strong neural connections between the two." ~ Donald Wilson...
  32. ncbi Efficacy of N-acetylcarnosine in the treatment of cataracts
    Mark A Babizhayev
    Innovative Vision Products, Inc, County of Newcastle, Delaware, USA
    Drugs R D 3:87-103. 2002
    ..To evaluate the effects of 1% N-acetylcarnosine (NAC) solution on lens clarity over 6 and 24 months in patients with cataracts...
  33. ncbi NMR spin-echo studies of hydration properties of the molecular chaperone alpha-crystallin in the bovine lens
    Mark A Babizhayev
    Moscow Helmholtz Research Institute of Eye Diseases, 14 19 Sadovaya Chernogryazskaya, Moscow, Russian Federation
    Biochim Biophys Acta 1598:46-54. 2002
    ..These results shed new light on structural properties of alpha-crystallin and have important implications for understanding the mechanism of the chaperone-like action of this protein in the lens and non-ocular tissues...
  34. ncbi Hydration properties of the molecular chaperone alpha-crystallin in the bovine lens
    M A Babizhayev
    Innovation Vision Products, Inc, County of New Castle, Delaware 19810, USA
    Biochemistry (Mosc) 68:1145-55. 2003
    ....
  35. ncbi Malondialdehyde scavenging and aldose-derived Schiff bases' transglycation properties of synthetic histidyl-hydrazide carnosine analogs
    Andrea Guiotto
    Institute of Biomolecular Chemistry of CNR, Department of Chemical Sciences, University of Padua, Via F Marzolo, 1 35131 Padova, Italy
    Bioorg Med Chem 15:6158-63. 2007
    ..The data obtained indicate that this class of compounds maintains the activity profile of carnosine and is a suitable candidate for the treatment of disorders caused by oxidative stress...