Magnesium deficiency: effect on bone mineral density in the mouse appendicular skeletonHelen E Gruber
Department of Orthopaedic Surgery, Cannon Bldg, 3rd Floor, Carolinas Medical Center, PO Box 32861, Charlotte, NC 28203, USA
BMC Musculoskelet Disord 4:7. 2003
..Dietary magnesium (Mg) deficiency in the mouse perturbs bone and mineral homeostasis. The objective of the present study was to evaluate bone mineral density of the femur in control and Mg-deficient mice...
- Magnesium deficiency and osteoporosis: animal and human observations
Robert K Rude
University of Southern California and the Orthopaedic Hospital, Los Angeles, CA 90089 9317, USA
J Nutr Biochem 15:710-6. 2004
..In this paper, we will review animal and human evidence of the association of Mg deficiency with osteoporosis and explore possible mechanisms by which this may occur...
- Magnesium deficiency-induced osteoporosis in the rat: uncoupling of bone formation and bone resorption
R K Rude
University of Southern California, Los Angeles, USA
Magnes Res 12:257-67. 1999
..While the fall in PTH and/or 1.25(OH)2-D may explain a decrease in osteoblast activity, the mechanism for increased osteoclast activity is unclear. These data suggest that Mg deficiency may be a risk factor for osteoporosis...
- TNFalpha receptor knockout in mice reduces adverse effects of magnesium deficiency on bone
Robert K Rude
Keck School of Medicine and Orthopaedic Hospital, University of Sourthern California, Los Angeles, CA, 90033, USA
Growth Factors 27:370-6. 2009
..No/B.Pm in the WT mice, with a trend toward greater eroded bone perimeter, as compared to TNF-r-KO. These findings suggest that TNFalpha may play a role in Mg deficiency-induced bone loss...
- Skeletal and hormonal effects of magnesium deficiency
Robert K Rude
USC Keck School of Medicine, Los Angeles, CA, USA
J Am Coll Nutr 28:131-41. 2009
..These data support the notion at dietary Mg intake at levels not uncommon in humans may perturb bone and mineral metabolism and be a risk factor for osteoporosis...
- Magnesium deficiency: effect on bone and mineral metabolism in the mouse
R K Rude
University of Southern California and the Orthopaedic Hospital, 2025 Zonal Ave, Los Angeles, CA 90033, USA
Calcif Tissue Int 72:32-41. 2003
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- Bone loss induced by dietary magnesium reduction to 10% of the nutrient requirement in rats is associated with increased release of substance P and tumor necrosis factor-alpha
Robert K Rude
University of Southern California and the Orthopaedic Hospital, Los Angeles, CA 90089 9317, USA
J Nutr 134:79-85. 2004
..These data demonstrated that a Mg intake of 10% of NR in rats causes bone loss that may be secondary to the increased release of substance P and TNF-alpha...
- Reduction of dietary magnesium by only 50% in the rat disrupts bone and mineral metabolism
R K Rude
University of Southern California and the Orthopaedic Hospital, 1975 Zonal Ave, GNH 6602, Los Angeles, CA 90089 9317, USA
Osteoporos Int 17:1022-32. 2006
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- Dietary magnesium reduction to 25% of nutrient requirement disrupts bone and mineral metabolism in the rat
Robert K Rude
University of Southern California and the Orthopaedic Hospital, 1975 Zonal Avenue, GNH 6602, Los Angeles, CA 90089 9317, USA
Bone 37:211-9. 2005
..These data demonstrate that Mg intake of 25% NR in the rat causes lower bone mass which may be related to increased release of substance P and TNFalpha...
- Variation of trabecular architecture in proximal femur of postmenopausal women
Maria Grazia Ascenzi
UCLA Orthopaedic Hospital Department of Orthopaedic Surgery, Biomechanics Research, University of California at Los Angeles, CA, USA
J Biomech 44:248-56. 2011
..This phenomenon may render the local tissue less able to carry out the expected mechanical function...
- Preservation of bone mineral density of the proximal femur following hemisurface arthroplasty
Harlan C Amstutz
Joint Replacement Institute, J. Vernon Luck, Sr Center for Orthopaedic Research, Los Angeles Orthopaedic Hospital, UCLA, 2400 S Flower St, Los Angeles, CA 90007-2697, USA
Orthopedics 27:1266-71. 2004
..012 to -0.0300 g/cm2 in operated hips. These results support bone conservation and preservation with hemiresurfacing arthroplasty in young patients with osteonecrosis of the femoral head...
- Oral magnesium supplementation inhibits platelet-dependent thrombosis in patients with coronary artery disease
M Shechter
Preventive and Rehabilitative Cardiac Center, Cedars Sinai Burns and Allen Research Institute, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
Am J Cardiol 84:152-6. 1999
..These findings suggest a potential mechanism whereby magnesium may beneficially alter outcomes in patients with CAD...
- Genetic heterogeneity in familial renal magnesium wasting
Vitaly Kantorovich
Burns and Allen Research Institute, University of Southern California, School of Medicine, Los Angeles, California 90033, USA
J Clin Endocrinol Metab 87:612-7. 2002
..In conclusion, our data demonstrate locus heterogeneity for the phenotype of isolated renal Mg wasting with hypomagnesemia and suggest that hypomagnesemia, at least in this pedigree, may be associated with low bone mass...
- Magnesium deficiency in critical illness
Garrison M Tong
University of Southern California, School of Medicine, Los Angeles, CA 90089-9317, USA
J Intensive Care Med 20:3-17. 2005
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- Bone mineral density screening: assessment of influence on prevention and treatment of osteoporosis
Catherine Anastasopoulou
University of Southern California, Keck School of Medicine and Orthopaedic Hospital, Los Angeles, California 90089-9317, USA
Endocr Pract 8:199-201. 2002
..CONCLUSION: These results suggest that low-cost BMD screening is highly effective in increasing awareness of osteoporosis, prompting medical consultation, and initiating measures for prevention and treatment of osteoporosis...
