Injectable treatments for adipose tissue: terminology, mechanism, and tissue interactionAdam M Rotunda
Division of Dermatology, David Geffen School of Medicine, University of California, Los Angeles, CA 92660, USA
Lasers Surg Med 41:714-20. 2009
..Just as injectable fillers have addressed the need for non-surgical methods to restore desired volume, a number of injectable therapies purpor to play a comparable role to reduce undesired volume...
Mesotherapy and phosphatidylcholine injections: historical clarification and reviewAdam M Rotunda
Department of Dermatology, University of Southern California School of Medicine, Los Angeles, California, USA
Dermatol Surg 32:465-80. 2006
..Despite their attraction as purported "fat-dissolving" injections, the safety and efficacy of these novel cosmetic treatments remain ambiguous to most patients and physicians...
Randomized double-blind clinical trial of subcutaneously injected deoxycholate versus a phosphatidylcholine-deoxycholate combination for the reduction of submental fatAdam M Rotunda
David Geffen School of Medicine, University of California at Los Angeles, 90095, USA
Dermatol Surg 35:792-803. 2009
..Subcutaneous injections consisting of the detergent, sodium deoxycholate, alone or in combination with the phospholipid, phosphatidylcholine, have been reported to reduce adipose tissue. The role of phosphatidylcholine remains unclear...
Detergent effects of sodium deoxycholate are a major feature of an injectable phosphatidylcholine formulation used for localized fat dissolutionAdam M Rotunda
Division of Dermatology, University of California Los Angeles, David Geffen School of Medicine, Los Angeles, California, USA
Dermatol Surg 30:1001-8. 2004
..Detergent substances may have a role in eliminating unwanted adipose tissue. It is advised that physicians use caution until adequate safety data are available...
Lipomas treated with subcutaneous deoxycholate injectionsAdam M Rotunda
Division of Dermatology, University of California Los Angeles, David Geffen School of Medicine, Los Angeles, California, USA
J Am Acad Dermatol 53:973-8. 2005
..Injections of phosphatidylcholine solubilized with deoxycholate, a bile salt, have been used to reduce unwanted accumulations of fat. Recent in vitro and ex vivo investigations indicate that deoxycholate alone causes adipocyte lysis...
Treatment of lower eyelid fat pads using phosphatidylcholine: clinical trial and reviewGlynis Ablon
West Los Angeles Veteran Administration Medical Center, Los Angeles, CA, USA
Dermatol Surg 30:422-7; discussion 428. 2004
..Current use internationally has led to a significant interest in this novel substance...
The new age of acne therapy: light, lasers, and radiofrequencyAdam M Rotunda
Division of Dermatology, David Geffen School of Medicine, UCLA Medical Center, Los Angeles, CA, USA
J Cosmet Laser Ther 6:191-200. 2004
..CONCLUSION: Research emphasizing long-term follow-up and comparative, randomized trials is necessary to determine whether these emerging technologies will become a viable alternative to standard therapies such as antibiotics...
Nasal tip wound repair using a rhombic transposition flap with a double Z-plasty at its baseAdam M Rotunda
Department of Dermatology, University of Southern California, School of Medicine, Los Angeles, CA, USA
Dermatol Surg 32:945-7. 2006