Cytochrome P450 aromatase expression in human seminomaVittoria Rago
Cell Biology Department, Faculty of Pharmacy, University of Calabria, Italy
Reprod Biol Endocrinol 3:72. 2005
..This study examined aromatase expression in human seminoma, which is the most common germ cell tumour of the testis...
- Nitric oxide involvement in the acrosome reaction triggered by leptin in pig sperm
Saveria Aquila
Department of Pharmaco Biology, University of Calabria 87036 Arcavacata di Rende Cosenza, Italy
Reprod Biol Endocrinol 9:133. 2011
..This free radical appears to affect sperm capacitation, a maturation step preceding acrosome reaction. Recent studies have reported leptin ability to promote capacitation and acrosome reaction in pig male gametes...
- Detection of estrogen receptors ER-alpha and ER-beta in human ejaculated immature spermatozoa with excess residual cytoplasm
Vittoria Rago
Department of Cell Biology, Faculty of Pharmacy, University of Calabria, Cosenza, Italy
Reprod Biol Endocrinol 4:36. 2006
..The aim of this work was to investigate the expression of estrogen receptors, ER-alpha and ER-beta, in human ejaculated immature spermatozoa with excess residual cytoplasm...
- Identification of ERbeta1 and ERbeta2 in human seminoma, in embryonal carcinoma and in their adjacent intratubular germ cell neoplasia
Vittoria Rago
Department of Cell Biology, Faculty of Pharmacy, University of Calabria, Cosenza, Italy
Reprod Biol Endocrinol 7:56. 2009
..Epidemiological studies evidenced an increased incidence of testicular germ cell cancer after elevated pre-natal estrogen exposure but the expression of estrogen receptors in these testicular neoplasms has not been well elucidated...
- Cytochrome P450arom, androgen and estrogen receptors in pig sperm
Vittoria Rago
Department of Cell Biology, Faculty of Pharmacy, University of Calabria, Arcavacata di Rende, Cosenza, Italy
Reprod Biol Endocrinol 5:23. 2007
..The purpose of the current study was to investigate the expression of aromatase (P450arom), estrogen (ERalpha/ERbeta) and androgen (AR) receptors in ejaculated spermatozoa of pig...
- Estrogen receptor (ER)alpha and ER beta are both expressed in human ejaculated spermatozoa: evidence of their direct interaction with phosphatidylinositol-3-OH kinase/Akt pathway
Saveria Aquila
Centro Sanitario, University of Calabria 87030 Arcavacata di Rende, Cosenza, Italy
J Clin Endocrinol Metab 89:1443-51. 2004
..However, it still remains to be elucidated whether the functional role of each of the ER subtypes in sperm survival signaling is redundant or distinct...
- Leptin induces, via ERK1/ERK2 signal, functional activation of estrogen receptor alpha in MCF-7 cells
Stefania Catalano
Centro Sanitario, University of Calabria, Arcavacata di Rende, Cosenza 87030, Italy
J Biol Chem 279:19908-15. 2004
..Thus, we are able to demonstrate that the amplification of estrogen signal induced by leptin occurs through an enhancing in situ E(2) production as well as a direct functional activation of ERalpha...
- Oestrogen receptor beta is required for androgen-stimulated proliferation of LNCaP prostate cancer cells
Marcello Maggiolini
Department of Pharmaco Biology, University of Calabria, 87036 Rende CS, Italy
J Mol Endocrinol 32:777-91. 2004
..Thus our findings implicate ERbeta as a potential target for the treatment of prostate tumours...
- G protein-coupled receptor 30 (GPR30) mediates gene expression changes and growth response to 17beta-estradiol and selective GPR30 ligand G-1 in ovarian cancer cells
Lidia Albanito
Departments of Pharmaco Biology and Cell Biology, University of Calabria, 87030 Rende Cosenza, Italy
Cancer Res 67:1859-66. 2007
....
- Leptin and leptin receptor in pig spermatozoa: evidence of their involvement in sperm capacitation and survival
Saveria Aquila
Department of Pharmaco Biology, Faculty of Pharmacy, University of Calabria, 87036 Arcavacata di Rende, Cosenza, Italy
Reproduction 136:23-32. 2008
..The presence of leptin and its receptor in pig sperm suggests that they, through an autocrine short loop, may induce signal transduction and molecular changes associated with sperm capacitation and survival...
- 17beta-estradiol, genistein, and 4-hydroxytamoxifen induce the proliferation of thyroid cancer cells through the g protein-coupled receptor GPR30
Adele Vivacqua
Department of Pharmaco-Biology, University of Calabria, 87030 Rende (CS, Italy
Mol Pharmacol 70:1414-23. 2006
..Our findings provide new insight into the molecular mechanisms through which estrogens may induce the progression of TC...
- Identification of the estrogen receptor GPER in neoplastic and non-neoplastic human testes
Vittoria Rago
Department of Cell Biology, Faculty of Pharmacy, University of Calabria, Italy
Reprod Biol Endocrinol 9:135. 2011
..Recently, a G-protein-coupled-receptor (GPER) has been suggested as being involved in rapid responses to estrogens in different normal and tumor cells...
- The food contaminants bisphenol A and 4-nonylphenol act as agonists for estrogen receptor alpha in MCF7 breast cancer cells
Adele Vivacqua
Department of Pharmaco-Biology, University of Calabria, 87036 Rende (CS, Italy
Endocrine 22:275-84. 2003
..The estrogenic effects of such industrial agents together with an increasing widespread human exposure should be taken into account for the potential influence also on hormone-dependent breast cancer disease...
- Detection of aromatase and estrogen receptors (ERalpha, ERbeta1, ERbeta2) in human Leydig cell tumor
Amalia Carpino
Department of Cell Biology, University of Calabria, Arcavacata di Rende, Italy
Eur J Endocrinol 157:239-44. 2007
....
- Estrogenic and antiproliferative activities of isoliquiritigenin in MCF7 breast cancer cells
Marcello Maggiolini
Department of Pharmaco-Biology, University of Calabria, 87036 Rende (CS, Italy
J Steroid Biochem Mol Biol 82:315-22. 2002
..Thus, the activity of ISL and the balance between risk or chemopreventive factor for estrogen-dependent breast cancer may depend on dietary intake...
- Differential expression of estrogen receptors (ERalpha/ERbeta) in testis of mature and immature pigs
Vittoria Rago
Department of Cell Biology, University of Calabria, 87030 Arcavacata di Rendi, Cosenza, Italy
Anat Rec A Discov Mol Cell Evol Biol 281:1234-9. 2004
..The differential ERalpha/ERbeta expression in germ and somatic cells of the gonads suggest a role of estrogens in function and in development of pig testis...
- Inhibition of cyclooxygenase-2 down-regulates aromatase activity and decreases proliferation of Leydig tumor cells
Rosa Sirianni
Department of Pharmaco Biology, University of Calabria, 87036 Arcavacata di Rende CS, Italy
J Biol Chem 284:28905-16. 2009
..These novel findings clarify the mechanisms involved in the growth of Leydig cell tumors and should be taken into account in determining new therapeutic approaches...
- Leptin and its receptor are expressed in the testis and in the epididymis of young and adult pigs
Vittoria Rago
Department of Cell Biology, Faculty of Pharmacy, University of Calabria, 87036 Arcavacata di Rende, Cosenza, Italy
Anat Rec (Hoboken) 292:736-45. 2009
..Therefore, our findings suggest a possible involvement of leptin in endocrine or autocrine/paracrine control of porcine male reproductive structures...
- Evidence of aromatase localization in cytoplasmic droplet of human immature ejaculated spermatozoa
Vittoria Rago
Department of Cell Biology, University of Calabria, Cosenza, Italy
Folia Histochem Cytobiol 41:23-7. 2003
....
- Towards a physiological role for cytochrome P450 aromatase in ejaculated human sperm
Saveria Aquila
Centro Sanitario, University of Calabria, 87030 Arcavacata di Rende, Cosenza, Italy
Hum Reprod 18:1650-9. 2003
..The induction of both events by aromatizable androgens in the absence of exogenous mediators suggests that estrogen biosynthesis in ejaculated sperm is a process that may influence the intrinsic sperm fertilizing capability...
- Aromatase overexpression enhances the stimulatory effects of adrenal androgens on MCF7 breast cancer cells
Marcello Maggiolini
Department of Pharmaco Biology, Facolta di Farmacia, University of Calabria, I 87036 Rende, CS, Italy
Mol Cell Endocrinol 193:13-8. 2002
..Our results suggest that in postmenopausal women aromatase inhibitors might be considered as an adjuvant approach to the treatment of hormone-dependent breast tumors that overexpress aromatase...
