Research Topics
Genomes and GenesSpecies | Adhemar Longatto-FilhoSummaryAffiliation: University of Minho Country: Portugal Publications
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Publications
The association of p16(INK4A) and fragile histidine triad gene expression and cervical lesionsAdhemar Longatto-Filho
Pathology Division of Adolfo Lutz Institute, Sao Paulo, Brazil
J Low Genit Tract Dis 11:151-7. 2007..This cross-sectional study was intended to assess the association between immunohistochemical analysis of p16 and fragile histidine triad (FHIT) and the presence of precancerous cervical lesions...- Molecular characterization of EGFR, PDGFRA and VEGFR2 in cervical adenosquamous carcinomaAdhemar Longatto-Filho
Life and Health Sciences Research Institute ICVS, School of Health Sciences, University of Minho, Braga, Portugal
BMC Cancer 9:212. 2009..The objective of this study was to investigate EGFR, PDGFRA and VEGFR2 RTKs overexpression and activating gene mutations in a cohort of 30 adenosquamous carcinomas of the uterine cervix... - How useful is the assessment of lymphatic vascular density in oral carcinoma prognosis?Adhemar Longatto Filho
Life and Health Sciences Research Institute ICVS, School of Health Sciences, University of Minho, Braga, Portugal
World J Surg Oncol 5:140. 2007..abstract:.. - Peritumoural, but not intratumoural, lymphatic vessel density and invasion correlate with colorectal carcinoma poor-outcome markersAdhemar Longatto-Filho
Life and Health Sciences Research Institute, University of Minho, 4710 057, Braga, Portugal
Virchows Arch 452:133-8. 2008..016), nodal metastasis (p = 0.022) and hepatic metastasis (p < 0.001). Peritumoural LVD and LVI are directly related to histopathological variables indicative of poor outcome such as lymph-node status and liver metastasis... - Lymphatic vessel density and epithelial D2-40 immunoreactivity in pre-invasive and invasive lesions of the uterine cervixAdhemar Longatto-Filho
Life and Health Sciences Research Institute, School of Health Sciences, University of Minho, Braga, Portugal
Gynecol Oncol 107:45-51. 2007..The correlation of LVD, lymphatic invasion and D2-40 positivity in tumor cells with EGFR and COX-2 expressions was also evaluated... - Self-sampling for human papillomavirus (HPV) testing as cervical cancer screening option. Experience from the LAMS studyA Longatto-Filho
Instituto Adolfo Lutz, Sao Paulo, Brazil
Eur J Gynaecol Oncol 29:327-32. 2008..To compare Hybrid Capture II (HC2) in detecting high-risk (HR) HPV in patient-collected vaginal samples with those obtained using gynaecologist collected samples... - Liquid-based cytology in DNA-based molecular research: viability and potential applicationAdhemar Longatto Filho
Institute of Investigation in Health and Life Sciences, School of Health Sciences, University of Minho, Braga, Portugal
Anal Quant Cytol Histol 31:395-400. 2009..To evaluate the effectiveness of UCM and PreservCyt liquid media in molecular analysis using exfoliated oral cells and analyze Tp53 codon 72 extracted from these cells... - Lymphatic vessel density in the normal-looking columnar epithelium adjacent to and distant from prostatic intraepithelial neoplasia and prostate cancer assessed in whole-mount sectionsAdhemar Longatto-Filho
Life and Health Sciences Research Institute, Health Sciences School, University of Minho, Braga, Portugal
Anal Quant Cytol Histol 31:269-75. 2009.... - Hormonal contraceptives and the length of their use are not independent risk factors for high-risk HPV infections or high-grade CINAdhemar Longatto-Filho
Life and Health Sciences Research Institute, School of Health Sciences, University of Minho, Braga, Portugal
Gynecol Obstet Invest 71:93-103. 2011.... - Increased expression of monocarboxylate transporters 1, 2, and 4 in colorectal carcinomasCeline Pinheiro
Life and Health Sciences Research Institute, University of Minho, Campus de Gualtar, 4710 057, Braga, Portugal
Virchows Arch 452:139-46. 2008..The increased expression of these transporters suggests an important role in CRC, which might justify their use, especially MCT1 and MCT4, as targets in CRC drug therapy... - Increasing expression of monocarboxylate transporters 1 and 4 along progression to invasive cervical carcinomaCeline Pinheiro
Life and Health Sciences Research Institute ICVS, School of Health Sciences, University of Minho, Campus of Gualtar, Braga, Portugal
Int J Gynecol Pathol 27:568-74. 2008.... - Conventional Pap smear and liquid-based cytology as screening tools in low-resource settings in Latin America: experience of the Latin American screening studyAdhemar Longatto-Filho
Instituto Adolfo Lutz and Hospital Leonor M de Barros, Sao Paulo, Brazil
Acta Cytol 49:500-6. 2005.... - Increased risk of oncogenic human papillomavirus infections and incident high-grade cervical intraepithelial neoplasia among smokers: experience from the Latin American screening studyLuis Otavio Sarian
Department of Obstetrics and Gynecology, Faculty of Medical Sciences, University of Campinas, Sao Paulo, Brazil
Sex Transm Dis 36:241-8. 2009..The purpose of this study was to assess the effect of smoking on the prevalence and incidence of high-risk human papillomavirus (hr-HPV) infection and cervical intraepithelial neoplasia (CIN) in a large sample of Latin American women... - Expression of monocarboxylate transporters 1, 2, and 4 in human tumours and their association with CD147 and CD44Celine Pinheiro
Life and Health Sciences Research Institute ICVS, School of Health Sciences, University of Minho, Campus of Gualtar, 4710 057 Braga, Portugal
J Biomed Biotechnol 2010:427694. 2010..An important number of MCT1 positive cases are negative for both chaperones, suggesting that MCT plasma membrane expression in tumours may depend on a yet nonidentified regulatory protein... - Lymphangiogenic VEGF-C and VEGFR-3 expression in genetically characterised gastrointestinal stromal tumoursAntônio Talvane Torres De Oliveira
Department of Digestive Surgery and Pathology and Center for Researcher Support, Barretos Cancer Hospital, PIO XII Foundation, Barretos, Sao Paulo, Brazil
Histol Histopathol 26:1499-507. 2011..010) and high BVD showed a positive correlation with the occurrence of metastasis (p=0.049). The strong expression of VEGF-C and VEGFR-3 in GIST's cells was not correlated with the clinical parameters of aggressiveness, nor with high LVD... - Molecular characterization of PDGFR-alpha/PDGF-A and c-KIT/SCF in gliosarcomasRui M Reis
Life and Health Sciences Research Institute ICVS, School of Health Sciences, University of Minho, Braga, Portugal
Cell Oncol 27:319-26. 2005..Nevertheless, the presence of a PDGFR-a/PDGFA and c-Kit/SCF autocrine/paracrine stimulation loop in a proportion of cases, supports the potential role of specific tyrosine kinase inhibitors in the treatment of gliosarcomas... - Monocarboxylate transporters 1 and 4 are associated with CD147 in cervical carcinomaCeline Pinheiro
Life and Health Sciences Research Institute ICVS, School of Health Sciences, University of Minho, Campus of Gualtar, Braga, Portugal
Dis Markers 26:97-103. 2009..Our results show a close association between CD147 and MCT1 and MCT4 expressions in human cervical cancer and provided evidence for a prognostic value of CD147 and MCT1 co-expression... - Co-expression of monocarboxylate transporter 1 (MCT1) and its chaperone (CD147) is associated with low survival in patients with gastrointestinal stromal tumors (GISTs)Antônio Talvane Torres De Oliveira
Departments of Digestive Surgery and Pathology and Centre for Researcher Support, Barretos Cancer Hospital, PIO XII Foundation, Barretos, Sao Paulo, Brazil
J Bioenerg Biomembr 44:171-8. 2012..037). These findings suggest that co-expression of MCT1 with its chaperone CD147 is involved in GISTs aggressiveness, pointing to a contribution of cancer cell metabolic adaptations in GIST development and/or progression... - Analysis of human kallikrein 7 expression as a potential biomarker in cervical neoplasiaLara Termini
Ludwig Institute for Cancer Research, Sao Paulo, Brazil
Int J Cancer 127:485-90. 2010..Moreover, 92.5% of adenocarcinomas also exhibited intense hK7 staining. Differences in the expression of hK7 could potentially be used as a biomarker for the characterization of different stages of cervical disease... - KIT activation in uterine cervix adenosquamous carcinomas by KIT/SCF autocrine/paracrine stimulation loopsOlga Martinho
Life and Health Sciences Research Institute ICVS, School of Health Sciences, University of Minho, Campus de Gualtar, 4710 057 Braga, Portugal
Gynecol Oncol 111:350-5. 2008..In the present study, we intended to molecularly characterize KIT in ASC... - Opportunistic screening for skin cancer using a mobile unit in BrazilEdmundo C Mauad
Barretos Cancer Hospital Pio XII Foundation, Sao Paulo, Brazil
BMC Dermatol 11:12. 2011..The aim of this study was to evaluate the use of a mobile unit in the diagnosis and treatment of skin cancer in several poor regions of Brazil... - Lymphatic vessel density and VEGF-C expression are significantly different among benign and malignant thyroid lesionsEduardo Anselmo Garcia
Medical Research Laboratory LIM26, Experimental Pathophysiology Program, School of Medicine, University of Sao Paulo, Sao Paulo, Brazil
Endocr Pathol 21:101-7. 2010.... - The prognostic value of CD147/EMMPRIN is associated with monocarboxylate transporter 1 co-expression in gastric cancerCeline Pinheiro
Life and Health Sciences Research Institute, School of Health Sciences, University of Minho, 4710 057 Braga, Portugal
Eur J Cancer 45:2418-24. 2009..Our results showed that the prognostic value of CD147 was associated with MCT1 co-expression in gastric cancer cells, supporting the view that CD147 plasma membrane activity is dependent on MCT co-expression... - Awareness and knowledge of HPV, cervical cancer, and vaccines in young women after first delivery in São Paulo, Brazil--a cross-sectional studyCristina H Rama
Hospital Maternidade Leonor Mendes de Barros, Sao Paulo, Brazil
BMC Womens Health 10:35. 2010.... - Human papillomavirus (HPV) infections as risk factors for cytological and histological abnormalities in baseline PAP smear-negative women followed-up for 2 years in the LAMS studyRenata C Gontijo
Department of Obstetrics and Gynecology, Universidade Estadual de Campinas UNICAMP Campinas, Sao Paulo, Brazil
Eur J Obstet Gynecol Reprod Biol 133:239-46. 2007.... - Loss of RKIP expression during the carcinogenic evolution of endometrial cancerOlga Martinho
Life and Health Sciences Research Institute ICVS, Health Sciences School, University of Minho, Braga, Portugal
J Clin Pathol 65:122-8. 2012..The aim of this study was to assess the expression levels of RKIP in endometrial cancer and determine whether this expression correlates with clinical outcome in these patients... - Lactate-induced IL-8 pathway in endothelial cells--letterCeline Pinheiro
Authors Affiliations Life and Health Sciences Research Institute ICVS, School of Health Sciences, University of Minho, Braga ICVS 3B s PT Government Associate Laboratory, Braga Guimarães, Portugal Laboratory of Medical Investigation LIM 14, Faculty of Medicine University São Paulo, Sao Paulo, Brazil IPATIMUP, Institute of Molecular Pathology and Immunology of the University of Porto, Porto, Portugal and Medical Faculty of the University of Porto, Porto, Portugal
Cancer Res 72:1901-2. 2012..By analyzing a total of 505 cases of human tumor samples immunostained for MCT1, we do not confirm plasma membrane expression of MCT1 in the endothelial cells of tumor-associated vessels. Cancer Res; 72(7); 1901-2. ©2012 AACR... - Role of monocarboxylate transporters in human cancers: state of the artCeline Pinheiro
Life and Health Sciences Research Institute ICVS, School of Health Sciences, University of Minho, Braga, Portugal
J Bioenerg Biomembr 44:127-39. 2012..Additional studies on MCT expression in other tumor types, confirmation of the results already published as well as additional functional studies are needed to deeply understand the role of MCTs in cancer maintenance and aggressiveness... - Adherence to cervical and breast cancer programs is crucial to improving screening performanceEdmundo C Mauad
Barretos Cancer Hospital Department of Cancer Screening, Sao Paulo, Brazil
Rural Remote Health 9:1241. 2009..This study compared various methods to improve compliance with mass screening for breast and cervical cancer among women in a remote, rural region of Brazil... - Immunocytochemical expression of p16INK4A and Ki-67 in cytologically negative and equivocal pap smears positive for oncogenic human papillomavirusAdhemar Longatto Filho
Pathology Division, Adolfo Lutz Institute, , Brazil
Int J Gynecol Pathol 24:118-24. 2005..The combination of these two markers can be a useful implement for management of women with equivocal cytology... - Seroprevalence of human papillomavirus 6, 11, 16, and 18 in young primiparous women in Sao Paulo, BrazilCristina Helena Rama
Department of Family Planning, Hospital Maternidade Leonor Mendes de Barros, Av Celso Garcia 2477, Sao Paulo, Brazil
Int J Gynecol Cancer 20:1405-10. 2010..The aim of this study was to determine the prevalence of serum antibodies to HPV types 6, 11, 16, and 18 and associated factors among young women after birth of the first child... - Can mobile units improve the strategies for cervical cancer prevention?Edmundo Carvalho Mauad
Department of Cancer Screening, Barretos Cancer Hospital, Sao Paulo, Brazil
Diagn Cytopathol 38:727-30. 2010..05). MU can significantly overcome the chronic deficiency of public health system accessibility offering opportunity to these women to participate in screening programs... - Computer-assisted analysis of p53 and PCNA expression in oral lesions infected with human papillomavirusChristiane Pienna Soares
Department of Clinical Analysis, Faculty of Pharmaceutical Sciences, , , Centro, 14 801 902, Araraquara, , Brazil
Anal Quant Cytol Histol 25:19-24. 2003..Image analysis also demonstrated that PCNA expression was more intense in HPV DNA 16/18 OSCCs. These findings suggest involvement of high-risk HPV types in oral carcinogenesis... - Diet and serum micronutrients in relation to cervical neoplasia and cancer among low-income Brazilian womenLuciana Yuki Tomita
Department of Nutrition, School of Public Health, University of Sao Paulo USP, Sao Paulo, SP, Brazil
Int J Cancer 126:703-14. 2010..These results support the evidence that a healthy and balanced diet leading to provide high serum levels of antioxidants may reduce cervical neoplasia risk in low-income women... - Implementing human papillomavirus testing in a public health hospital: challenges and opportunitiesMariana Carmezim Beldi
Departments of Obstetrics and Gynecology, Clinics Hospital, School of Medicine, University of Sao Paulo, Brazil
Acta Cytol 56:160-5. 2012.... - Applicability of liquid-based cytology to the assessment of DNA content in cervical lesions using static cytometryNeuza Kasumi Shirata
Division of Pathology, Adolfo Lutz Institute, Avenida Dr. Arnaldo, 355, Cerqueira Cezar 01246-902, , SP, Brazil
Anal Quant Cytol Histol 25:210-4. 2003..Aneuploidy was closely associated with CIN 3 lesions... - VEGFR-3 expression in breast cancer tissue is not restricted to lymphatic vesselsAdhemar Longatto Filho
Life and Health Sciences Research Institute, Health Sciences School, University of Minho, Braga, Portugal
Pathol Res Pract 201:93-9. 2005..063); however, owing to the limited number of cases, statistical significance was not reached. VEGFR-3 lacks lymphatic vessel specificity and is also expressed in blood vessels, myoepithelial cells, and neoplastic cells... - Hybrid capture II and polymerase chain reaction for identifying HPV infections in samples collected in a new collection medium: a comparisonSuely Nonogaki
Pathology Division, Adolfo Lutz Institute, , Brazil
Acta Cytol 48:514-20. 2004..CONCLUSION: The data suggest that residual material from the DNACitoliq system adequately preserves HPV DNA for detection by HCII and PCR, with performance similar to that of specimen transport medium... - Immunohistochemical expression of VEGF-A and its ligands in non-neoplastic lesions of the breast sampling-assisted by dynamic angiothermographyAdhemar Longatto Filho
Life and Health Sciences Research Institute, School of Health Sciences, University of Minho, Campus of Gualtar, Braga, Portugal
Oncol Rep 18:1201-6. 2007..Our results, showing marked expression of VEGF by the epithelial proliferative lesions and neoangiogenesis at their periphery, confirm that these lesions can be detected by dynamic angiothermography... - Simultaneous Chlamydia trachomatis and HPV infection in pregnant womenSonia Maria Miranda Pereira
Patholgy Division, Adolfo Lutz Institute, Sao Paulo, SP, Brazil
Diagn Cytopathol 38:397-401. 2010..36% of the pregnant women (P < 0.001). The high rate of simultaneous CT and HPV infection in pregnant women favors the recommendation to screen pregnant women for both CT and HPV... - Differential Prox-1 and CD 31 expression in mucousae, cutaneous and soft tissue vascular lesions and tumorsRui M Reis
Life and Health Sciences Research Institute ICVS, School of Health Sciences, University of Minho, Braga, Portugal
Pathol Res Pract 201:771-6. 2005....